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The map label for this gene is hisA [H]

Identifier: 238026010

GI number: 238026010

Start: 355195

End: 355950

Strand: Direct

Name: hisA [H]

Synonym: bglu_1g03360

Alternate gene names: 238026010

Gene position: 355195-355950 (Clockwise)

Preceding gene: 238026009

Following gene: 238026011

Centisome position: 9.09

GC content: 64.55

Gene sequence:

>756_bases
ATGCTGCTGATTCCGGCCATCGATCTTAAAGACGGTCAGTGTGTGCGCCTCAAACAGGGCGATATGGACCAGGCGACGAT
TTTCTCCGAGGATCCCGCGGCCATGGCCCGCAAATGGGTCGATCTCGGTGCACGACGCCTGCACCTGGTGGACCTGAACG
GCGCGTTCGCCGGCAAGCCGAAGAACCTCGAGGCGATCGAGGCGATCCTGGCCGAGGTCGGCGACGAGATCCCCGTCCAG
CTCGGCGGCGGCATCCGCAGTCTCGAGACGATCGAGAAGTATCTCGACGCGGGCCTGTCCTACGTGATCATCGGCACCGC
GGCCGTCAAGGACCCGGGTTTCCTGCAGGACGCCTGCACGGCGTTCGCGGGCAGCATCATCGTCGGGCTCGACGCCAAGG
ACGGCAAGGTCGCCACCGACGGCTGGAGCAAGCTGACGGGCCACGAGGTGATCGATCTCGCGCAGAAGTTCGAGGACTAC
GGCGTCGAATCGATCGTCTATACCGACATCGGCCGCGACGGCATGCTTCAGGGCATCAACATCGAGGCGACGGTGAAGCT
CGCGCAGGCAGTCGGGATTCCCGTGATCGCGAGCGGCGGCCTGTCGAACCTGAGCGACATCGAGCAGCTCTGCGGCGTGG
AGGACGAAGGGATCGAAGGCGTGATTTGCGGCCGCGCGATCTACTCCGGCGATCTCGATTTCTCGGCCGCGCAAAAGCGT
GCCGACGAACTGAACGGCGAGCTCGACGACGCCTGA

Upstream 100 bases:

>100_bases
ACCCGGAAAGACTTGTACTAAACTAGCAGACAGCGCGGTGCCGGTTGGGCCGGCCGCGGCGCGTCACCCCCTTCCTCTCT
CCAGACGACTTCCGATTGCT

Downstream 100 bases:

>100_bases
GCCGCGGCGGCCCAGCGCCGCGTGCGTCATCGCCCAAGCCGCCCGCGCCGCGGGCGGCCTCACCTGCGGCACCTGTGTAC
CATCATGGCTCTAGCTAAAC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILAEVGDEIPVQ
LGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACTAFAGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAQKFEDY
GVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNLSDIEQLCGVEDEGIEGVICGRAIYSGDLDFSAAQKR
ADELNGELDDA

Sequences:

>Translated_251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILAEVGDEIPVQ
LGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACTAFAGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAQKFEDY
GVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNLSDIEQLCGVEDEGIEGVICGRAIYSGDLDFSAAQKR
ADELNGELDDA
>Mature_251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILAEVGDEIPVQ
LGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACTAFAGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAQKFEDY
GVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNLSDIEQLCGVEDEGIEGVICGRAIYSGDLDFSAAQKR
ADELNGELDDA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1788336, Length=213, Percent_Identity=28.169014084507, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26493; Mature: 26493

Theoretical pI: Translated: 4.08; Mature: 4.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNLEAIEAILAEVGDEIPVQLGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACT
CCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
AFAGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAQKFEDYGVESIVYTDIGRDGMLQGIN
HHHCCEEEEECCCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCC
IEATVKLAQAVGIPVIASGGLSNLSDIEQLCGVEDEGIEGVICGRAIYSGDLDFSAAQKR
HHHHHHHHHHCCCCEEECCCCCCHHHHHHHHCCCCCCCCEEEECCEEECCCCCHHHHHHH
ADELNGELDDA
HHHCCCCCCCC
>Mature Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNLEAIEAILAEVGDEIPVQLGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACT
CCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
AFAGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAQKFEDYGVESIVYTDIGRDGMLQGIN
HHHCCEEEEECCCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCC
IEATVKLAQAVGIPVIASGGLSNLSDIEQLCGVEDEGIEGVICGRAIYSGDLDFSAAQKR
HHHHHHHHHHCCCCEEECCCCCCHHHHHHHHCCCCCCCCEEEECCEEECCCCCHHHHHHH
ADELNGELDDA
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA