Click here to switch to the map view.

The map label for this gene is pyrE [H]

Identifier: 238025902

GI number: 238025902

Start: 239089

End: 239775

Strand: Reverse

Name: pyrE [H]

Synonym: bglu_1g02280

Alternate gene names: 238025902

Gene position: 239775-239089 (Counterclockwise)

Preceding gene: 238025904

Following gene: 238025901

Centisome position: 6.14

GC content: 63.61

Gene sequence:

>687_bases
ATGACAGGCTTCGATCGTCAAACGATCTCCGACACCACCGCCAAAATCCTGCTCGAAGTGCAGGCGGTACACTTCAACGC
CGAAAAGCCGTTCATCTTCACGTCCGGCTGGGCGAGCCCCGTCTATATCGACTGCCGCAAGCTGATCTCGTATCCGCGCG
TGCGCCGCGGCCTGATGGAGATGGCGGAAGCGACGATCCTGCGCGACGTCGGCTTCGAGCAGATCGACGCCGTGGCGGGC
GGCGAAACCGCCGGTATTCCGTTCGCGGCCTGGATCGCCGACCGGATGATGCTGCCGATGCAGTACGTGCGGAAAAAGCC
GAAGGGCTTCGGCCGCAACGCGCAAATCGAGGGCCATCTCGAGGAAGGGTCGCGCGTGCTGCTGGTGGAAGACCTGACCA
CCGACAGCCGCAGCAAGGTGAACTTCATCAACGCGCTGCGCACGGCCGGCGCCACGGTGAACCACTGCTTCGTGCTGTTC
CACTACAACATCTTCAAGGAAAGCGTCTCGGTCCTGAAGGACATCGATGTCGATCTGCACGCGCTGGCCACCTGGTGGGA
CGTGCTGCGCGTCGCCAAGGCCTCGGGCTACTTCGAGACGAAGACGCTCGACGAGGTCGAGAAATTCCTGCATGCGCCGG
CCGAGTGGTCGGCCGCGCACGGCGGCGCCACCTCGCCGAAGGAGTAA

Upstream 100 bases:

>100_bases
CCGCCGGCCGACCCGCCGGCCCGCCCTTCCGGCAGGAATTCCGTCGCCGCGCCACGGTGCCCCGCGCCCGGCCTCTGAGC
TCATCACCCAAGGAATGCCC

Downstream 100 bases:

>100_bases
GCGGCCCGGCGCCAGCCGTGGCGCGCCGGCCGACGACGCCCGTCAGCGACGGGCGTTTTTTTTCGCGCATTGCGCACGCC
CCGCGCGTAGCCCGTCAGCG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTGFDRQTISDTTAKILLEVQAVHFNAEKPFIFTSGWASPVYIDCRKLISYPRVRRGLMEMAEATILRDVGFEQIDAVAG
GETAGIPFAAWIADRMMLPMQYVRKKPKGFGRNAQIEGHLEEGSRVLLVEDLTTDSRSKVNFINALRTAGATVNHCFVLF
HYNIFKESVSVLKDIDVDLHALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATSPKE

Sequences:

>Translated_228_residues
MTGFDRQTISDTTAKILLEVQAVHFNAEKPFIFTSGWASPVYIDCRKLISYPRVRRGLMEMAEATILRDVGFEQIDAVAG
GETAGIPFAAWIADRMMLPMQYVRKKPKGFGRNAQIEGHLEEGSRVLLVEDLTTDSRSKVNFINALRTAGATVNHCFVLF
HYNIFKESVSVLKDIDVDLHALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATSPKE
>Mature_227_residues
TGFDRQTISDTTAKILLEVQAVHFNAEKPFIFTSGWASPVYIDCRKLISYPRVRRGLMEMAEATILRDVGFEQIDAVAGG
ETAGIPFAAWIADRMMLPMQYVRKKPKGFGRNAQIEGHLEEGSRVLLVEDLTTDSRSKVNFINALRTAGATVNHCFVLFH
YNIFKESVSVLKDIDVDLHALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATSPKE

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=217, Percent_Identity=26.7281105990783, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17508631, Length=131, Percent_Identity=33.587786259542, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17554964, Length=169, Percent_Identity=27.810650887574, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17933654, Length=198, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 25479; Mature: 25348

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFDRQTISDTTAKILLEVQAVHFNAEKPFIFTSGWASPVYIDCRKLISYPRVRRGLME
CCCCCCCHHHHHHHHHHHHHHEEEECCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHH
MAEATILRDVGFEQIDAVAGGETAGIPFAAWIADRMMLPMQYVRKKPKGFGRNAQIEGHL
HHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
EEGSRVLLVEDLTTDSRSKVNFINALRTAGATVNHCFVLFHYNIFKESVSVLKDIDVDLH
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHEEEEEHHHHHHHHHHHHHHCCCHHH
ALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATSPKE
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGFDRQTISDTTAKILLEVQAVHFNAEKPFIFTSGWASPVYIDCRKLISYPRVRRGLME
CCCCCCHHHHHHHHHHHHHHEEEECCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHH
MAEATILRDVGFEQIDAVAGGETAGIPFAAWIADRMMLPMQYVRKKPKGFGRNAQIEGHL
HHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
EEGSRVLLVEDLTTDSRSKVNFINALRTAGATVNHCFVLFHYNIFKESVSVLKDIDVDLH
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHEEEEEHHHHHHHHHHHHHHCCCHHH
ALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATSPKE
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA