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The map label for this gene is ilvB [H]

Identifier: 238025774

GI number: 238025774

Start: 107566

End: 109287

Strand: Reverse

Name: ilvB [H]

Synonym: bglu_1g00980

Alternate gene names: 238025774

Gene position: 109287-107566 (Counterclockwise)

Preceding gene: 238025775

Following gene: 238025773

Centisome position: 2.8

GC content: 73.87

Gene sequence:

>1722_bases
ATGTCGATCGTCCCGGAGTCCGCCGTCCCCGCCGCCAGCGCCAGCGTCACCGGCGCCCGCCTGCTCGTCGAGGCCCTGCT
CGCGAACCGCGTCGAGCGCGTGTTCTGCGTACCCGGCGAGAGCTTTCTCGCCGTGCTCGACGCGCTGGCCGACGAAACCG
AACGGATCGGCACCGTCGTCTGCCGCCACGAGGCCGCCGCCGCGCACATGGCCGAGGCGGTCGGCAAGCTGACCGGCCGG
CCCGGCATCGCGCTCGTCACGCGCGGCCCCGGCGCCACCCACGCGTCGATCGGCGTCCACACCGCGTTCCAGGATTCCAC
GCCGATGATCCTGCTGGTCGGCCAGTGCGCGCGCGGGCATCTCGACCGCGAGGCGTTCCAGGAGATCGACTACCGCCGCA
TGTTCGGCGAACTCGCCAAGTGGGTCGCGCAGATCGACGACGCGCGCCGCATCCCCGAATATCTGAGCCATGCGTTCCAC
CTCGCCACTTCGGGCCGGCCCGGCCCGGTGGTGCTCGCGCTGCCCGAGGACGTGCTGTCCGAGCCCTGCGCGCCGCAGCC
GGCGCCGCCGGCGGCCAAGCGGATCGCCGCCGCACCGTCCGAGGCGCAGCTCGCCGAGCTGCGCGAGCGGCTCGCGCGCG
CCGAGCGGCCGATGGTGATCGCGGGCGGCAGCGGCTGGAGCGTGGACGCCTGCGCCGACCTGCGCCGCTTCGCCGAGGCC
TGGCAGCTGCCGGTGGCCTGCGCGTTCCGCTATCAGGACTGCTTCGACAACGAGCATCCGCTCTACGCCGGCGACGTCGG
GCTCGGCATCAACCCCGCGCTCGCGCGGCGCATCCACGCGGCGGACCTGCTGCTCGTGCTCGGCCCCCGGCTCGGCGAAG
CCACCACCGGCGGCTACGTGCTGCTGGAGATCCCGAAGACGCGGCAGACGCTGGTCCACGTTCACCAGGGCGCCGACGAA
CTGGGGCGCGTCTACGCCGCCGACCTGCCGATCGTCTCGGGCATGCCCGAAATCGCGTCCCGGCTGGCCGCGCTCGCCCC
GCCCGAGCGGCTGCCGTGGGCCGGCAGCGCGGCCGAGGCGCACGCGGCCTGCCTCGCGTGGCGCCGGCCGCTGCCGATGC
CGGGCCGCGTCCAGCTCGGCGAGATCATCCAGCAGCTGCGCGAGCGGCTGCCGCACGACGCGATCGTCACCAACGGCGCC
GGCAATTACGCGATCTGGCTGCACCGCCACTACGCCTACCGGCAGTTCCGCTCGCAGCTCGCCCCCACCAGCGGCGCGAT
GGGCTACGGGGTGCCGGCCGCGCTCGCCGCGAAATCGCTCTATCCGCAGCGCGTGGCCGTGGCGCTGGCCGGCGACGGCT
GCTTCATGATGGCCGGCAACGAACTCGCCACCGCGATGCAGTACGGGCTCGCGATCGTCGTGATCGTCGTCAACAACGGC
CATTTCGGCACGATCCGCATGCATCAGGAGCGTCATTACCCGCACCGCGTCCACGGCACCGCACTGACCAATCCCGATTT
CGCCGCCTACGCACGCGCGTTCGGCGCGCACGGCGAGACCGTGGTCGAGACCGCCGGCTTCCTGCCGGCGCTCGAGCGCG
CGCTGGCGAGCGGGCTGCCCGCGCTGATCGAGATCCGGGTCCCGCAGGAGGCCTGCACGCCGGCCGCGACGCTCGAGCAG
ATCCGCGAACAGGGGCGGCGCGCGCGCGGCGAGGCGCCGTGA

Upstream 100 bases:

>100_bases
TCGCCTCCGCCGCGTTTGCGGGGCGTCCCGCGCTGCTCCGCCACGCCCCCGCGCATCCGGCGTAAGCTATCCGTCCCGCC
ACCGAGGGAGCCCGCCAGTC

Downstream 100 bases:

>100_bases
GGCGGCGCGACGGCGCGCCGGCCGGGCCGCCGCCGCCGGCCGGACGAGGCGCCCGCCCTGGTCCGCCCCTCTCGCCCGCC
CCGCTCGCCCGCCGCGCCGC

Product: thiamine pyrophosphate protein

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MSIVPESAVPAASASVTGARLLVEALLANRVERVFCVPGESFLAVLDALADETERIGTVVCRHEAAAAHMAEAVGKLTGR
PGIALVTRGPGATHASIGVHTAFQDSTPMILLVGQCARGHLDREAFQEIDYRRMFGELAKWVAQIDDARRIPEYLSHAFH
LATSGRPGPVVLALPEDVLSEPCAPQPAPPAAKRIAAAPSEAQLAELRERLARAERPMVIAGGSGWSVDACADLRRFAEA
WQLPVACAFRYQDCFDNEHPLYAGDVGLGINPALARRIHAADLLLVLGPRLGEATTGGYVLLEIPKTRQTLVHVHQGADE
LGRVYAADLPIVSGMPEIASRLAALAPPERLPWAGSAAEAHAACLAWRRPLPMPGRVQLGEIIQQLRERLPHDAIVTNGA
GNYAIWLHRHYAYRQFRSQLAPTSGAMGYGVPAALAAKSLYPQRVAVALAGDGCFMMAGNELATAMQYGLAIVVIVVNNG
HFGTIRMHQERHYPHRVHGTALTNPDFAAYARAFGAHGETVVETAGFLPALERALASGLPALIEIRVPQEACTPAATLEQ
IREQGRRARGEAP

Sequences:

>Translated_573_residues
MSIVPESAVPAASASVTGARLLVEALLANRVERVFCVPGESFLAVLDALADETERIGTVVCRHEAAAAHMAEAVGKLTGR
PGIALVTRGPGATHASIGVHTAFQDSTPMILLVGQCARGHLDREAFQEIDYRRMFGELAKWVAQIDDARRIPEYLSHAFH
LATSGRPGPVVLALPEDVLSEPCAPQPAPPAAKRIAAAPSEAQLAELRERLARAERPMVIAGGSGWSVDACADLRRFAEA
WQLPVACAFRYQDCFDNEHPLYAGDVGLGINPALARRIHAADLLLVLGPRLGEATTGGYVLLEIPKTRQTLVHVHQGADE
LGRVYAADLPIVSGMPEIASRLAALAPPERLPWAGSAAEAHAACLAWRRPLPMPGRVQLGEIIQQLRERLPHDAIVTNGA
GNYAIWLHRHYAYRQFRSQLAPTSGAMGYGVPAALAAKSLYPQRVAVALAGDGCFMMAGNELATAMQYGLAIVVIVVNNG
HFGTIRMHQERHYPHRVHGTALTNPDFAAYARAFGAHGETVVETAGFLPALERALASGLPALIEIRVPQEACTPAATLEQ
IREQGRRARGEAP
>Mature_572_residues
SIVPESAVPAASASVTGARLLVEALLANRVERVFCVPGESFLAVLDALADETERIGTVVCRHEAAAAHMAEAVGKLTGRP
GIALVTRGPGATHASIGVHTAFQDSTPMILLVGQCARGHLDREAFQEIDYRRMFGELAKWVAQIDDARRIPEYLSHAFHL
ATSGRPGPVVLALPEDVLSEPCAPQPAPPAAKRIAAAPSEAQLAELRERLARAERPMVIAGGSGWSVDACADLRRFAEAW
QLPVACAFRYQDCFDNEHPLYAGDVGLGINPALARRIHAADLLLVLGPRLGEATTGGYVLLEIPKTRQTLVHVHQGADEL
GRVYAADLPIVSGMPEIASRLAALAPPERLPWAGSAAEAHAACLAWRRPLPMPGRVQLGEIIQQLRERLPHDAIVTNGAG
NYAIWLHRHYAYRQFRSQLAPTSGAMGYGVPAALAAKSLYPQRVAVALAGDGCFMMAGNELATAMQYGLAIVVIVVNNGH
FGTIRMHQERHYPHRVHGTALTNPDFAAYARAFGAHGETVVETAGFLPALERALASGLPALIEIRVPQEACTPAATLEQI
REQGRRARGEAP

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=576, Percent_Identity=25, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI21361361, Length=554, Percent_Identity=24.187725631769, Blast_Score=97, Evalue=5e-20,
Organism=Escherichia coli, GI87081685, Length=519, Percent_Identity=30.8285163776493, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1790104, Length=559, Percent_Identity=29.1592128801431, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1786717, Length=529, Percent_Identity=28.3553875236295, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1787096, Length=568, Percent_Identity=25.7042253521127, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI1788716, Length=597, Percent_Identity=23.9530988274707, Blast_Score=102, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17542570, Length=562, Percent_Identity=25.0889679715303, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531301, Length=494, Percent_Identity=26.7206477732794, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531299, Length=494, Percent_Identity=26.7206477732794, Blast_Score=113, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6323755, Length=577, Percent_Identity=26.5164644714038, Blast_Score=223, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6320816, Length=528, Percent_Identity=21.4015151515152, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323163, Length=510, Percent_Identity=21.7647058823529, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922626, Length=494, Percent_Identity=26.5182186234818, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 61343; Mature: 61212

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVPESAVPAASASVTGARLLVEALLANRVERVFCVPGESFLAVLDALADETERIGTVV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
CRHEAAAAHMAEAVGKLTGRPGIALVTRGPGATHASIGVHTAFQDSTPMILLVGQCARGH
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEECCHHCCC
LDREAFQEIDYRRMFGELAKWVAQIDDARRIPEYLSHAFHLATSGRPGPVVLALPEDVLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHC
EPCAPQPAPPAAKRIAAAPSEAQLAELRERLARAERPMVIAGGSGWSVDACADLRRFAEA
CCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHH
WQLPVACAFRYQDCFDNEHPLYAGDVGLGINPALARRIHAADLLLVLGPRLGEATTGGYV
HCCCHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCCEE
LLEIPKTRQTLVHVHQGADELGRVYAADLPIVSGMPEIASRLAALAPPERLPWAGSAAEA
EEECCCHHHHHHHHHCCHHHHHHEEECCCCHHCCCHHHHHHHHHCCCCCCCCCCCCCHHH
HAACLAWRRPLPMPGRVQLGEIIQQLRERLPHDAIVTNGAGNYAIWLHRHYAYRQFRSQL
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEHHHHHHHHHHHH
APTSGAMGYGVPAALAAKSLYPQRVAVALAGDGCFMMAGNELATAMQYGLAIVVIVVNNG
CCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCEEEEECHHHHHHHHCCEEEEEEEEECC
HFGTIRMHQERHYPHRVHGTALTNPDFAAYARAFGAHGETVVETAGFLPALERALASGLP
CEEEEEECCCCCCCCEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
ALIEIRVPQEACTPAATLEQIREQGRRARGEAP
EEEEEECCHHHCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SIVPESAVPAASASVTGARLLVEALLANRVERVFCVPGESFLAVLDALADETERIGTVV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
CRHEAAAAHMAEAVGKLTGRPGIALVTRGPGATHASIGVHTAFQDSTPMILLVGQCARGH
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEECCHHCCC
LDREAFQEIDYRRMFGELAKWVAQIDDARRIPEYLSHAFHLATSGRPGPVVLALPEDVLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHC
EPCAPQPAPPAAKRIAAAPSEAQLAELRERLARAERPMVIAGGSGWSVDACADLRRFAEA
CCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHH
WQLPVACAFRYQDCFDNEHPLYAGDVGLGINPALARRIHAADLLLVLGPRLGEATTGGYV
HCCCHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCCEE
LLEIPKTRQTLVHVHQGADELGRVYAADLPIVSGMPEIASRLAALAPPERLPWAGSAAEA
EEECCCHHHHHHHHHCCHHHHHHEEECCCCHHCCCHHHHHHHHHCCCCCCCCCCCCCHHH
HAACLAWRRPLPMPGRVQLGEIIQQLRERLPHDAIVTNGAGNYAIWLHRHYAYRQFRSQL
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEHHHHHHHHHHHH
APTSGAMGYGVPAALAAKSLYPQRVAVALAGDGCFMMAGNELATAMQYGLAIVVIVVNNG
CCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCEEEEECHHHHHHHHCCEEEEEEEEECC
HFGTIRMHQERHYPHRVHGTALTNPDFAAYARAFGAHGETVVETAGFLPALERALASGLP
CEEEEEECCCCCCCCEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
ALIEIRVPQEACTPAATLEQIREQGRRARGEAP
EEEEEECCHHHCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]