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The map label for this gene is cobA [H]

Identifier: 238024406

GI number: 238024406

Start: 1270424

End: 1271236

Strand: Reverse

Name: cobA [H]

Synonym: bglu_2g09990

Alternate gene names: 238024406

Gene position: 1271236-1270424 (Counterclockwise)

Preceding gene: 238024412

Following gene: 238024405

Centisome position: 44.96

GC content: 76.75

Gene sequence:

>813_bases
ATGACGACCCCTACCGAAACGACCGGCAAGGTCACCCTGCTCGGCGCCGGCCCGGGCGCCGCCGACCTGCTGACGCTGCG
CGCCGCGAAAGTGCTGGCGAGCGCCGACGTCGTGCTGCTCGACGATCTGGTCGACCCGGCGATCGCCGCGCTCGCGCCGC
GCGCGCGCATCGTCCGCGTCGGCAAGCGCGGCGGCTGCCGCTCCACCCCGCAGGCCTTCATCGAGAAGCTGATGTGCCGC
TACGCCGCGCGCGGCCAGCACGTGGTGCGCGTGAAGGGCGGCGACGCGCTGCTGTTCGGCCGCGCCGGCGAGGAGCTGGC
CGCGCTGCACGCGGCCGGCGTGCCGGTGACGATCGTGAGCGGGATCTCGTCGGGCTTCGCGGCCGCGGCCGAGCTGGGCG
TCTCGCTCACCCACCGCCGCCACTGCCAGGGCGTCACGTTCGTCACCGCGCACCTGCAGGATCATGGCGAGCCCGACTGG
GCCGCGCTCGGCGCGACCGGCACCACGCTCGTCGTCTACATGGGCATGAACCGCATCGAGCGCGTGGCCGCCGGCCTGCT
CGCGACGCTCGACGCGGCCACCCCGGCCGCCGTGGTGCAATGGGCCGGCACGCCGCGCGCGCGGCGCTGGACCGGCACGC
TCGCCGCGCTGGCTGCCGAGCCCGCCGCGGCCGGCCTCGGCAGCCCGGCCGTGATCCTGGTCGGCACGGCGATCGGCGAG
GCGCTCGCGATGCTGCCGCCCGCGGCCTCCGCTGCCGCCGGGATCGAAGCCGGCGCCGCGCCGGATCGGGAGCCGCTGTC
CGATGCCGCGTAA

Upstream 100 bases:

>100_bases
ACAACGGCGAGCCCAACGCCCGGCCTCGCGTCCGGCGCGCGGCGCCGTACGGTTCCGGCGGCGCGCGCCGCGTCGCGCGC
CACACTGGAACTGAACGAGA

Downstream 100 bases:

>100_bases
GCCTCACGCCGCCCCGCGCGCGCCGTTGCTCGCCCCGCGCGCGCCGTTCCTCGCCCTGGCCCGGGCCGGCGGCCGCGCCG
CGCCGCGCGCCCGGCCCGCG

Product: Uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTTPTETTGKVTLLGAGPGAADLLTLRAAKVLASADVVLLDDLVDPAIAALAPRARIVRVGKRGGCRSTPQAFIEKLMCR
YAARGQHVVRVKGGDALLFGRAGEELAALHAAGVPVTIVSGISSGFAAAAELGVSLTHRRHCQGVTFVTAHLQDHGEPDW
AALGATGTTLVVYMGMNRIERVAAGLLATLDAATPAAVVQWAGTPRARRWTGTLAALAAEPAAAGLGSPAVILVGTAIGE
ALAMLPPAASAAAGIEAGAAPDREPLSDAA

Sequences:

>Translated_270_residues
MTTPTETTGKVTLLGAGPGAADLLTLRAAKVLASADVVLLDDLVDPAIAALAPRARIVRVGKRGGCRSTPQAFIEKLMCR
YAARGQHVVRVKGGDALLFGRAGEELAALHAAGVPVTIVSGISSGFAAAAELGVSLTHRRHCQGVTFVTAHLQDHGEPDW
AALGATGTTLVVYMGMNRIERVAAGLLATLDAATPAAVVQWAGTPRARRWTGTLAALAAEPAAAGLGSPAVILVGTAIGE
ALAMLPPAASAAAGIEAGAAPDREPLSDAA
>Mature_269_residues
TTPTETTGKVTLLGAGPGAADLLTLRAAKVLASADVVLLDDLVDPAIAALAPRARIVRVGKRGGCRSTPQAFIEKLMCRY
AARGQHVVRVKGGDALLFGRAGEELAALHAAGVPVTIVSGISSGFAAAAELGVSLTHRRHCQGVTFVTAHLQDHGEPDWA
ALGATGTTLVVYMGMNRIERVAAGLLATLDAATPAAVVQWAGTPRARRWTGTLAALAAEPAAAGLGSPAVILVGTAIGEA
LAMLPPAASAAAGIEAGAAPDREPLSDAA

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=241, Percent_Identity=40.2489626556017, Blast_Score=169, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322922, Length=236, Percent_Identity=31.7796610169492, Blast_Score=86, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 27136; Mature: 27004

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTETTGKVTLLGAGPGAADLLTLRAAKVLASADVVLLDDLVDPAIAALAPRARIVRV
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCCEEEEE
GKRGGCRSTPQAFIEKLMCRYAARGQHVVRVKGGDALLFGRAGEELAALHAAGVPVTIVS
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHCCCCEEEEH
GISSGFAAAAELGVSLTHRRHCQGVTFVTAHLQDHGEPDWAALGATGTTLVVYMGMNRIE
HCCCHHHHHHHHCHHHHHHHHCCCEEEEEEEHHCCCCCCEEEECCCCCEEEEEECHHHHH
RVAAGLLATLDAATPAAVVQWAGTPRARRWTGTLAALAAEPAAAGLGSPAVILVGTAIGE
HHHHHHHHHHCCCCCHHEEEECCCCCCHHHHHHHHHHHCCCHHCCCCCCEEEEEEHHHHH
ALAMLPPAASAAAGIEAGAAPDREPLSDAA
HHHHCCCCCHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTPTETTGKVTLLGAGPGAADLLTLRAAKVLASADVVLLDDLVDPAIAALAPRARIVRV
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCCEEEEE
GKRGGCRSTPQAFIEKLMCRYAARGQHVVRVKGGDALLFGRAGEELAALHAAGVPVTIVS
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHCCCCEEEEH
GISSGFAAAAELGVSLTHRRHCQGVTFVTAHLQDHGEPDWAALGATGTTLVVYMGMNRIE
HCCCHHHHHHHHCHHHHHHHHCCCEEEEEEEHHCCCCCCEEEECCCCCEEEEEECHHHHH
RVAAGLLATLDAATPAAVVQWAGTPRARRWTGTLAALAAEPAAAGLGSPAVILVGTAIGE
HHHHHHHHHHCCCCCHHEEEECCCCCCHHHHHHHHHHHCCCHHCCCCCCEEEEEEHHHHH
ALAMLPPAASAAAGIEAGAAPDREPLSDAA
HHHHCCCCCHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]