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The map label for this gene is fhuB [H]

Identifier: 238024386

GI number: 238024386

Start: 1214477

End: 1216489

Strand: Direct

Name: fhuB [H]

Synonym: bglu_2g09790

Alternate gene names: 238024386

Gene position: 1214477-1216489 (Clockwise)

Preceding gene: 238024385

Following gene: 238024387

Centisome position: 42.95

GC content: 74.12

Gene sequence:

>2013_bases
ATGGCCTTGCCCCGTCACGCCGCGCCGCGCGAGTTCCGCTGGTGGCTGGTGGGCGCGCTGCTGGCCGTCTCGCTGCTGCT
CGCGGCGCTCGGCATCCGCGCCGAGCTCGACGGCGCGCCGTTCTGGCAGGCGCTGTTGGCGCCCGATCCGCGCGACCTGC
ACCAGATCCTGGTGCGCGACAGCATGCTGCCGCGCATCGCGATGACGCTGCTCTGCGGCGGCGCGCTCGCGCTGGCCGGC
ACGCTCGCGCAGCAGGTGCTGCGCAATCCGCTCGCCGAGCCGATGACGCTCGGCGTGTTTCCCGGCGCCTATCTCGCGCT
GGTGCTCGCCGATCTGTGGGCGCCGTCGTGGCTCGCGCTGGGCCGCCCCGCGGTCGCGCTGGCGGGCGGCACCGTCGCGA
TGCTGATCGTGTTCGCGCTGTCCGCGCGGCAGAAGATGGCGCCGCTCGCGGTGGTGCTGTCGGGCATGATCGTCAACCTC
TACTGCGGGGCGATCTGCCTCGCGCTGTCGATGGCGCACTTCGAGCTGCTGCGCGGCCTGATGATCTGGGGCGGCGGCGC
GCTCGACCAGACCGGCTGGCACGAGAGCCGGATGCTCGCGCTGGCGGTGCTCGGCTGCGCGCTCGTCACCGCGCTGCTGC
GGCGTCCGCTCGGCGTGTTCGACGCCGGCGACGCGACGGTGCGCAGCCTCGGCGTGGGCCTGCATCGCACGCGCGTCGCG
GCGCTGCTGGTCTCGGTGGTGCTGACCGCGGCGGTGGTCTCCACGGTCGGCGTGATCGGCTTCGTCGGGCTGGCCGCGCC
CACGCTCGCGCGGCTCGCCGGCGCGCGCCGCATCGGCCAGCGCCTGATCTGGGCGCCGTGCCTCGGCGCCGCGCTGCTGT
GGCTGACCGACGAGCTGGTGCGCGTGGCCTCGTCGGCCGAACTGTTCTCGGCGCACCTGATTCCCACCGGCACCGTCACC
TCGCTGGTGGGCGTGCCGCTGTTGCTGCTGCTGCTGCCCAAGCTGCGCGCGCAGCCGGACCTGCACGCGGCCGGCATCGC
CGCCGGCCCGCCCGCGCGGCTCGCGCGCCGGCTGCCGGTCGCGCTCGTCGCGCTGGTGCTGGTGATGGGGCTGAGCTTCG
GCGTCACGCGCACGCTCGACGGCTGGCGCATCGGCGATCTCGAGCAGATGCGCGCGATCCTGTTCTGGCGCGCGCCGCAC
ACCATCGCGGCGGCCGCGGCCGGCGTGCTGCTGGCGATCGGCGGCACGCTGATCCAGCGCATCACCGCCAACCCGATGGC
GAGCCCGGACCTGCTCGGCGTCAGCTCGGGCGGCATGCTCGGCATCGTGGCGGTGCTGTTCGCCGGCGTGCTGCCGAGCC
CGGGCGTGCTGTTCGCGAGCTGCCTGGGCGGCGTGATCGTCACGCTCGCGCTGCTGATGTGGCTCGGCTCGCGGGCCGCG
TTCGCGCCGGAGCGGCTGCTGCTGATCGGCGTGGCGATCAGCGCGCTGCTGCAGGCGATCGTCAGCGCGATGATGTCGAG
CGGCGACTCGCGCGTCGGAATGGTGCTGAACTTCATCGTCGGCTCGACCTACTACGTGCAGGCGCCGATCGCCTATGGCG
CCACCGTGATCGCGCTGCTCGGCCTGGCTGGCGCGCCGCTGCTGAGCCGCTGGGTCGAGGCGCTCGGGCTCGGTGCCGGC
GTGGCGGGCGGCCTCGGCGTGCCGGTCGCCCGCGCCCGCGTGACGATCCTGCTGCTCGCCTCGGTGCTGACGGCCGCCTC
GACCATGCTGGTCGGCCCGCTGTCGTTCGTCGGCCTGATCGCGCCGCATATCGCGCGCTTCTCCGGCGCGCGCCGGCCGG
CTTCGCAGATCCTCGTCGCGGCCGTGATCGGCGCCTTGCTGATGACCTTCGCCGAGTGGCTCGGCCGCCAGCTGGTGTTC
CCGGAGGAGGTCGCCTCGGGGCTCGTCGCCACGCTGATCGGCGGCCCGTATCTGATCGCGCTGATGCTGCGCAAGACGCT
CACCTCCACCTGA

Upstream 100 bases:

>100_bases
GCGCCTTACGGAGGACTGGTATCGATGCAACGCTTCGCCGGGGCGATCGAGGCGGCGCTGACGGCGATCGACGCGGGAGG
GGGCGGTGTTGCGTAATCCC

Downstream 100 bases:

>100_bases
GCGGCCCGCCGCCGCGCCGCCGCCGCGTCCGCGCGCGGCGGGGCGGGGCGCGCGGCGCCGCCGGTCGGCGCGGCCGCTTC
CGGCGCGGCCCGCCGCGCGT

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 670; Mature: 669

Protein sequence:

>670_residues
MALPRHAAPREFRWWLVGALLAVSLLLAALGIRAELDGAPFWQALLAPDPRDLHQILVRDSMLPRIAMTLLCGGALALAG
TLAQQVLRNPLAEPMTLGVFPGAYLALVLADLWAPSWLALGRPAVALAGGTVAMLIVFALSARQKMAPLAVVLSGMIVNL
YCGAICLALSMAHFELLRGLMIWGGGALDQTGWHESRMLALAVLGCALVTALLRRPLGVFDAGDATVRSLGVGLHRTRVA
ALLVSVVLTAAVVSTVGVIGFVGLAAPTLARLAGARRIGQRLIWAPCLGAALLWLTDELVRVASSAELFSAHLIPTGTVT
SLVGVPLLLLLLPKLRAQPDLHAAGIAAGPPARLARRLPVALVALVLVMGLSFGVTRTLDGWRIGDLEQMRAILFWRAPH
TIAAAAAGVLLAIGGTLIQRITANPMASPDLLGVSSGGMLGIVAVLFAGVLPSPGVLFASCLGGVIVTLALLMWLGSRAA
FAPERLLLIGVAISALLQAIVSAMMSSGDSRVGMVLNFIVGSTYYVQAPIAYGATVIALLGLAGAPLLSRWVEALGLGAG
VAGGLGVPVARARVTILLLASVLTAASTMLVGPLSFVGLIAPHIARFSGARRPASQILVAAVIGALLMTFAEWLGRQLVF
PEEVASGLVATLIGGPYLIALMLRKTLTST

Sequences:

>Translated_670_residues
MALPRHAAPREFRWWLVGALLAVSLLLAALGIRAELDGAPFWQALLAPDPRDLHQILVRDSMLPRIAMTLLCGGALALAG
TLAQQVLRNPLAEPMTLGVFPGAYLALVLADLWAPSWLALGRPAVALAGGTVAMLIVFALSARQKMAPLAVVLSGMIVNL
YCGAICLALSMAHFELLRGLMIWGGGALDQTGWHESRMLALAVLGCALVTALLRRPLGVFDAGDATVRSLGVGLHRTRVA
ALLVSVVLTAAVVSTVGVIGFVGLAAPTLARLAGARRIGQRLIWAPCLGAALLWLTDELVRVASSAELFSAHLIPTGTVT
SLVGVPLLLLLLPKLRAQPDLHAAGIAAGPPARLARRLPVALVALVLVMGLSFGVTRTLDGWRIGDLEQMRAILFWRAPH
TIAAAAAGVLLAIGGTLIQRITANPMASPDLLGVSSGGMLGIVAVLFAGVLPSPGVLFASCLGGVIVTLALLMWLGSRAA
FAPERLLLIGVAISALLQAIVSAMMSSGDSRVGMVLNFIVGSTYYVQAPIAYGATVIALLGLAGAPLLSRWVEALGLGAG
VAGGLGVPVARARVTILLLASVLTAASTMLVGPLSFVGLIAPHIARFSGARRPASQILVAAVIGALLMTFAEWLGRQLVF
PEEVASGLVATLIGGPYLIALMLRKTLTST
>Mature_669_residues
ALPRHAAPREFRWWLVGALLAVSLLLAALGIRAELDGAPFWQALLAPDPRDLHQILVRDSMLPRIAMTLLCGGALALAGT
LAQQVLRNPLAEPMTLGVFPGAYLALVLADLWAPSWLALGRPAVALAGGTVAMLIVFALSARQKMAPLAVVLSGMIVNLY
CGAICLALSMAHFELLRGLMIWGGGALDQTGWHESRMLALAVLGCALVTALLRRPLGVFDAGDATVRSLGVGLHRTRVAA
LLVSVVLTAAVVSTVGVIGFVGLAAPTLARLAGARRIGQRLIWAPCLGAALLWLTDELVRVASSAELFSAHLIPTGTVTS
LVGVPLLLLLLPKLRAQPDLHAAGIAAGPPARLARRLPVALVALVLVMGLSFGVTRTLDGWRIGDLEQMRAILFWRAPHT
IAAAAAGVLLAIGGTLIQRITANPMASPDLLGVSSGGMLGIVAVLFAGVLPSPGVLFASCLGGVIVTLALLMWLGSRAAF
APERLLLIGVAISALLQAIVSAMMSSGDSRVGMVLNFIVGSTYYVQAPIAYGATVIALLGLAGAPLLSRWVEALGLGAGV
AGGLGVPVARARVTILLLASVLTAASTMLVGPLSFVGLIAPHIARFSGARRPASQILVAAVIGALLMTFAEWLGRQLVFP
EEVASGLVATLIGGPYLIALMLRKTLTST

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=629, Percent_Identity=41.1764705882353, Blast_Score=352, Evalue=5e-98,
Organism=Escherichia coli, GI1790741, Length=274, Percent_Identity=30.6569343065693, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI1790740, Length=292, Percent_Identity=32.1917808219178, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786805, Length=278, Percent_Identity=33.8129496402878, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786804, Length=281, Percent_Identity=32.3843416370107, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788004, Length=225, Percent_Identity=32, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 69287; Mature: 69156

Theoretical pI: Translated: 11.38; Mature: 11.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALPRHAAPREFRWWLVGALLAVSLLLAALGIRAELDGAPFWQALLAPDPRDLHQILVRD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHCCCHHHHHHHHHHH
SMLPRIAMTLLCGGALALAGTLAQQVLRNPLAEPMTLGVFPGAYLALVLADLWAPSWLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHCCCHHHHC
GRPAVALAGGTVAMLIVFALSARQKMAPLAVVLSGMIVNLYCGAICLALSMAHFELLRGL
CCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIWGGGALDQTGWHESRMLALAVLGCALVTALLRRPLGVFDAGDATVRSLGVGLHRTRVA
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHH
ALLVSVVLTAAVVSTVGVIGFVGLAAPTLARLAGARRIGQRLIWAPCLGAALLWLTDELV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVASSAELFSAHLIPTGTVTSLVGVPLLLLLLPKLRAQPDLHAAGIAAGPPARLARRLPV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
ALVALVLVMGLSFGVTRTLDGWRIGDLEQMRAILFWRAPHTIAAAAAGVLLAIGGTLIQR
HHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ITANPMASPDLLGVSSGGMLGIVAVLFAGVLPSPGVLFASCLGGVIVTLALLMWLGSRAA
HHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
FAPERLLLIGVAISALLQAIVSAMMSSGDSRVGMVLNFIVGSTYYVQAPIAYGATVIALL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHH
GLAGAPLLSRWVEALGLGAGVAGGLGVPVARARVTILLLASVLTAASTMLVGPLSFVGLI
HHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APHIARFSGARRPASQILVAAVIGALLMTFAEWLGRQLVFPEEVASGLVATLIGGPYLIA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHH
LMLRKTLTST
HHHHHHHCCC
>Mature Secondary Structure 
ALPRHAAPREFRWWLVGALLAVSLLLAALGIRAELDGAPFWQALLAPDPRDLHQILVRD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHCCCHHHHHHHHHHH
SMLPRIAMTLLCGGALALAGTLAQQVLRNPLAEPMTLGVFPGAYLALVLADLWAPSWLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHCCCHHHHC
GRPAVALAGGTVAMLIVFALSARQKMAPLAVVLSGMIVNLYCGAICLALSMAHFELLRGL
CCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIWGGGALDQTGWHESRMLALAVLGCALVTALLRRPLGVFDAGDATVRSLGVGLHRTRVA
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHH
ALLVSVVLTAAVVSTVGVIGFVGLAAPTLARLAGARRIGQRLIWAPCLGAALLWLTDELV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVASSAELFSAHLIPTGTVTSLVGVPLLLLLLPKLRAQPDLHAAGIAAGPPARLARRLPV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
ALVALVLVMGLSFGVTRTLDGWRIGDLEQMRAILFWRAPHTIAAAAAGVLLAIGGTLIQR
HHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ITANPMASPDLLGVSSGGMLGIVAVLFAGVLPSPGVLFASCLGGVIVTLALLMWLGSRAA
HHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
FAPERLLLIGVAISALLQAIVSAMMSSGDSRVGMVLNFIVGSTYYVQAPIAYGATVIALL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHH
GLAGAPLLSRWVEALGLGAGVAGGLGVPVARARVTILLLASVLTAASTMLVGPLSFVGLI
HHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APHIARFSGARRPASQILVAAVIGALLMTFAEWLGRQLVFPEEVASGLVATLIGGPYLIA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHH
LMLRKTLTST
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]