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The map label for this gene is cytR [H]

Identifier: 238024300

GI number: 238024300

Start: 1073655

End: 1074713

Strand: Reverse

Name: cytR [H]

Synonym: bglu_2g08870

Alternate gene names: 238024300

Gene position: 1074713-1073655 (Counterclockwise)

Preceding gene: 238024301

Following gene: 238024299

Centisome position: 38.01

GC content: 71.67

Gene sequence:

>1059_bases
TTGCCGGCCCAGCGCTCGACCGGCGCACGCGCGCGCCGCGGCAGCGGGCGGGCGGTCCTGTCCGACGTGGCGAAGCGCGC
CGGGGTGTCGACCGCCACGGTCTCGCGCGTCTACAACGAGCCCGGCAAGGTGTCGGAGCGCGTGCGCGCGCGCGTCGAGC
AGGCCGCGCTGGAACTGAACTGGTTCCCCAATGCGGCCGGGCGAGCGCTGGCCTCCACCCGCAGCCATATCGCCGGCATC
GTCATCCCCACGCTCGACGATCAGGTGTTCGCCTCGCTGGTCAGCGGCATGCAGGCCAGCTTCGCCGCGCGCGGCATCAC
GCTGTTTCTCGGCTGCTCGAACTACGACCCGAACGAGGCGCTGTCGCAGGTTCATGCGATGCTCGCGCGCGGCGTGGAAG
CGATCGCGGTGGTGGGCGAGGCGCATCCGCCGGCGCTGTTCGATGCGCTGCGCGTCTGGCGGGTGCCCTATGTGGTGCTG
TACGCGTGGCGCGAGGGCAGCCCGCACGACTGCATCGGCTTCGACAACCACGCCGCCTACGGCGAGATCACCGAGCACCT
GGTCGGGCTGGGCCATCGCGCTTTCGCGGTCTGCCTCCAGTCGACCCACGGCAACGACCGCGTGCAGGCCCGGCTGGCGG
GCATCGGCGCGGCGCTTGCGCGCCATGGCCTGACGGTGCGGCCGGAGCATCGGTTCGAGGGAGACGCCACGCTCGATTTC
GGCCGGCGCGCCCTGCGCTCGATCTGGCAGCAAGCCGGACCGCGGCCGAGCGCGATCATCTGCGGCAACGACCATATCGC
GCTGGGGGTGCTGCGGGAAGCGGAAGAGCTGGGGATTGCCGTGCCCGGGCAGTTGTCCGTGACCGGCTTCGACGATTTGG
CGATCGCGCGCGAGGCGCGGCCGTCGCTGACCACGATGCATGTGGATACGCGCGAGATCGGCGTGGTAGCGGCGCGGCAT
CTGCTGGATGCGCTGGACGGCAAGCCGCGGCGGCACGGGCATGTGGTGCCGGCGGTCTTGAAGATGCGCGGGTCGACGGG
GCCTTGCAGCGGCAGCTAG

Upstream 100 bases:

>100_bases
CCGCAGCGGGTAAGATGGCGAACCGCCTGCACGAAACCGACTGTCGATGCCCCGCTCCTCCGATTCCGCCGCCGCCCCGG
CCCCTGAAGACGGCGAACCG

Downstream 100 bases:

>100_bases
TGCCGTGTTCAGGGCCCGCCCCGGGCATCCCCGCATCGCGAGCCGATGACGTCGCGTTGCGCAGCCGGAAACGGCCCCGT
TCGAGCCTGGCGGCTCAGCG

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MPAQRSTGARARRGSGRAVLSDVAKRAGVSTATVSRVYNEPGKVSERVRARVEQAALELNWFPNAAGRALASTRSHIAGI
VIPTLDDQVFASLVSGMQASFAARGITLFLGCSNYDPNEALSQVHAMLARGVEAIAVVGEAHPPALFDALRVWRVPYVVL
YAWREGSPHDCIGFDNHAAYGEITEHLVGLGHRAFAVCLQSTHGNDRVQARLAGIGAALARHGLTVRPEHRFEGDATLDF
GRRALRSIWQQAGPRPSAIICGNDHIALGVLREAEELGIAVPGQLSVTGFDDLAIAREARPSLTTMHVDTREIGVVAARH
LLDALDGKPRRHGHVVPAVLKMRGSTGPCSGS

Sequences:

>Translated_352_residues
MPAQRSTGARARRGSGRAVLSDVAKRAGVSTATVSRVYNEPGKVSERVRARVEQAALELNWFPNAAGRALASTRSHIAGI
VIPTLDDQVFASLVSGMQASFAARGITLFLGCSNYDPNEALSQVHAMLARGVEAIAVVGEAHPPALFDALRVWRVPYVVL
YAWREGSPHDCIGFDNHAAYGEITEHLVGLGHRAFAVCLQSTHGNDRVQARLAGIGAALARHGLTVRPEHRFEGDATLDF
GRRALRSIWQQAGPRPSAIICGNDHIALGVLREAEELGIAVPGQLSVTGFDDLAIAREARPSLTTMHVDTREIGVVAARH
LLDALDGKPRRHGHVVPAVLKMRGSTGPCSGS
>Mature_351_residues
PAQRSTGARARRGSGRAVLSDVAKRAGVSTATVSRVYNEPGKVSERVRARVEQAALELNWFPNAAGRALASTRSHIAGIV
IPTLDDQVFASLVSGMQASFAARGITLFLGCSNYDPNEALSQVHAMLARGVEAIAVVGEAHPPALFDALRVWRVPYVVLY
AWREGSPHDCIGFDNHAAYGEITEHLVGLGHRAFAVCLQSTHGNDRVQARLAGIGAALARHGLTVRPEHRFEGDATLDFG
RRALRSIWQQAGPRPSAIICGNDHIALGVLREAEELGIAVPGQLSVTGFDDLAIAREARPSLTTMHVDTREIGVVAARHL
LDALDGKPRRHGHVVPAVLKMRGSTGPCSGS

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=341, Percent_Identity=29.3255131964809, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1790194, Length=307, Percent_Identity=31.2703583061889, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1787948, Length=318, Percent_Identity=31.4465408805031, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI48994940, Length=335, Percent_Identity=27.1641791044776, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790715, Length=320, Percent_Identity=28.4375, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789202, Length=289, Percent_Identity=30.4498269896194, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786540, Length=332, Percent_Identity=30.1204819277108, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788474, Length=293, Percent_Identity=31.740614334471, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789068, Length=314, Percent_Identity=30.5732484076433, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1787580, Length=332, Percent_Identity=26.5060240963855, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787906, Length=322, Percent_Identity=25.776397515528, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790689, Length=329, Percent_Identity=23.1003039513678, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789456, Length=343, Percent_Identity=25.6559766763848, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786268, Length=128, Percent_Identity=31.25, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37572; Mature: 37441

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAQRSTGARARRGSGRAVLSDVAKRAGVSTATVSRVYNEPGKVSERVRARVEQAALELN
CCCCCCCCCCHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
WFPNAAGRALASTRSHIAGIVIPTLDDQVFASLVSGMQASFAARGITLFLGCSNYDPNEA
CCCCHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHH
LSQVHAMLARGVEAIAVVGEAHPPALFDALRVWRVPYVVLYAWREGSPHDCIGFDNHAAY
HHHHHHHHHCCHHEEEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHH
GEITEHLVGLGHRAFAVCLQSTHGNDRVQARLAGIGAALARHGLTVRPEHRFEGDATLDF
HHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
GRRALRSIWQQAGPRPSAIICGNDHIALGVLREAEELGIAVPGQLSVTGFDDLAIAREAR
HHHHHHHHHHHCCCCCCEEEECCCCEEEHHHHHHHHCCEECCCCEEECCCCHHHHHHHCC
PSLTTMHVDTREIGVVAARHLLDALDGKPRRHGHVVPAVLKMRGSTGPCSGS
CCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PAQRSTGARARRGSGRAVLSDVAKRAGVSTATVSRVYNEPGKVSERVRARVEQAALELN
CCCCCCCCCHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
WFPNAAGRALASTRSHIAGIVIPTLDDQVFASLVSGMQASFAARGITLFLGCSNYDPNEA
CCCCHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHH
LSQVHAMLARGVEAIAVVGEAHPPALFDALRVWRVPYVVLYAWREGSPHDCIGFDNHAAY
HHHHHHHHHCCHHEEEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHH
GEITEHLVGLGHRAFAVCLQSTHGNDRVQARLAGIGAALARHGLTVRPEHRFEGDATLDF
HHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
GRRALRSIWQQAGPRPSAIICGNDHIALGVLREAEELGIAVPGQLSVTGFDDLAIAREAR
HHHHHHHHHHHCCCCCCEEEECCCCEEEHHHHHHHHCCEECCCCEEECCCCHHHHHHHCC
PSLTTMHVDTREIGVVAARHLLDALDGKPRRHGHVVPAVLKMRGSTGPCSGS
CCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]