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The map label for this gene is sdhA [H]

Identifier: 238024243

GI number: 238024243

Start: 1003204

End: 1004979

Strand: Direct

Name: sdhA [H]

Synonym: bglu_2g08250

Alternate gene names: 238024243

Gene position: 1003204-1004979 (Clockwise)

Preceding gene: 238024242

Following gene: 238024244

Centisome position: 35.48

GC content: 66.5

Gene sequence:

>1776_bases
ATGGCTGCAATCAACACTTCCCTGCCGCGTCGCAAGTTCGACGTGGTCATCGTCGGCGCGGGCGGCTCGGGGATGCGCGC
ATCGCTGCAACTCGCGCGCGCGGGCCTGTCGGTCTGCGTGCTCTCGAAAGTGTTTCCGACGCGTTCGCACACGGTTGCCG
CCCAGGGCGGGATCGGCGCCTCGCTCGGCAACATGAGCGAAGACAACTGGCACTACCACTTCTACGACACGATCAAGGGC
TCCGACTGGCTCGGCGACCAGGACGCGATCGAATTCATGTGCCGTGAAGCACCCAACGCCGTCTACGAGCTCGAGCACTT
CGGCATGCCGTTCGACCGCAACGCGGACGGCACCATCTACCAGCGCCCGTTCGGCGGCCATACCGCGAACTACGGCGAGA
AGCCGGTGCAGCGCGCCTGCGCGGCGGCCGACCGTACCGGCCACGCGCTGCTGCACACGCTGTATCAGCAGAACGTCGCG
GCCAAGACGCAGTTCTTCGTCGAATGGATGGCGCTCGACCTGATCCGCGACGCGGACGGCGACGTGCTCGGCGTGACCGC
CCTCGAAATGGAAACGGGCGACGTCTACATCCTCGAAGGCAAGACCACGCTGTTCGCCACGGGCGGCGCCGGCCGCATCT
TCGCGGCCTCGACCAATGCGTTCATCAACACCGGCGACGGCCTCGGGATGGCCGCGCGCGCCGGCATCGCGCTGCAGGAC
ATGGAGTTCTGGCAGTTCCACCCGACCGGCGTGGCCGGCGCGGGCGTGCTGATCACCGAGGGCGTGCGCGGCGAAGGCGG
CATCCTGCGCAACTCGGACGGCGAGCGCTTCATGGAGCGCTATGCGCCGACGCTGAAGGATCTGGCGCCGCGCGACTTCG
TCTCGCGCTCGATGGACCAGGAAATCAAGGAAGGCCGCGGGGTCGGTCCGAACAAGGACCACGTGCTGCTCGACCTGTCG
CACATCGGTGCCGAGACGATCATGAAGCGTCTGCCGTCGATCCGCGAAATCGCGCTGAAGTTCGCGAACGTCGACTGCAT
CAAGGAGCCGATCCCGGTCGTGCCGACCATCCACTACCAGATGGGCGGCATCCCGACCAACATCCACGGCCAGGTCGTCG
GCACGCCGCGCGGCCACGAAGAGCCCGTCAACGGCTTCTATGCCGTGGGCGAGTGCTCGTGCGTGTCGGTGCACGGCGCC
AACCGCCTGGGCACGAACTCGCTGCTCGACCTGGTGGTGTTCGGCCGCGCAGCCGGCAACCACATCGTCGAACACGTCAA
GCAGCAGCGCGAGCACAAGCCGCTGCCGAAGGACGCGGCCGACTTCTCGCTTGCGCGTCTGGCCAAGCTCGACAGCTCGA
GTTCGGGCGAGTACGCGCAAAGCGTCGCCAACGAGATTCGCGGCTCGATGCAGAAGCATGCCGGCGTGTTCCGCACCTCG
GCGCTGCTGGCCGAAGGCGTGCAGGACATCAAGAAGCTCGCGGAACGTGCCCAGCACATCCACCTGAAGGACAAGTCGAA
GGTGTTCAACACCGCGCGCGTCGAAGCGCTCGAAGTGGCGAACCTGGTCGAAGCGGCGCGCGCCACCATGGTGTCGGCCG
AAGCCCGCAAGGAAAGCCGCGGCGCGCACGCGCAGGACGACTACCCGCAACGCGACGACGAAAACTGGATGCGTCATACG
CTGTGGTTCAGCGAAGGCGATCGTCTCGACTACAAGCCGGTGCACATGCAGCCGCTGACGGTCGAATCCGTGCCGCCCAA
GGCGCGTACGTTCTAA

Upstream 100 bases:

>100_bases
AAGCCTGTCGGCGTGCGGCTGGTGCTGCAATCGCTGACCATCGTCTGGCTGCTCGCGTGCGCGGGCTACGCTGCGCAGAT
TCTCTGGAGAGTTTAAAAGC

Downstream 100 bases:

>100_bases
GCCGAATTCGAGGAATCTGACATGGCAAAACGCATTTTCGAACTCTATCGTTACGATCCGGACAAGGACGCGGCGCCGCG
CATGCAGACGTACGAAGTCG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MAAINTSLPRRKFDVVIVGAGGSGMRASLQLARAGLSVCVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCREAPNAVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVA
AKTQFFVEWMALDLIRDADGDVLGVTALEMETGDVYILEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARAGIALQD
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNSDGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGVGPNKDHVLLDLS
HIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQMGGIPTNIHGQVVGTPRGHEEPVNGFYAVGECSCVSVHGA
NRLGTNSLLDLVVFGRAAGNHIVEHVKQQREHKPLPKDAADFSLARLAKLDSSSSGEYAQSVANEIRGSMQKHAGVFRTS
ALLAEGVQDIKKLAERAQHIHLKDKSKVFNTARVEALEVANLVEAARATMVSAEARKESRGAHAQDDYPQRDDENWMRHT
LWFSEGDRLDYKPVHMQPLTVESVPPKARTF

Sequences:

>Translated_591_residues
MAAINTSLPRRKFDVVIVGAGGSGMRASLQLARAGLSVCVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCREAPNAVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVA
AKTQFFVEWMALDLIRDADGDVLGVTALEMETGDVYILEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARAGIALQD
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNSDGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGVGPNKDHVLLDLS
HIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQMGGIPTNIHGQVVGTPRGHEEPVNGFYAVGECSCVSVHGA
NRLGTNSLLDLVVFGRAAGNHIVEHVKQQREHKPLPKDAADFSLARLAKLDSSSSGEYAQSVANEIRGSMQKHAGVFRTS
ALLAEGVQDIKKLAERAQHIHLKDKSKVFNTARVEALEVANLVEAARATMVSAEARKESRGAHAQDDYPQRDDENWMRHT
LWFSEGDRLDYKPVHMQPLTVESVPPKARTF
>Mature_590_residues
AAINTSLPRRKFDVVIVGAGGSGMRASLQLARAGLSVCVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKGS
DWLGDQDAIEFMCREAPNAVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVAA
KTQFFVEWMALDLIRDADGDVLGVTALEMETGDVYILEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARAGIALQDM
EFWQFHPTGVAGAGVLITEGVRGEGGILRNSDGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGVGPNKDHVLLDLSH
IGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQMGGIPTNIHGQVVGTPRGHEEPVNGFYAVGECSCVSVHGAN
RLGTNSLLDLVVFGRAAGNHIVEHVKQQREHKPLPKDAADFSLARLAKLDSSSSGEYAQSVANEIRGSMQKHAGVFRTSA
LLAEGVQDIKKLAERAQHIHLKDKSKVFNTARVEALEVANLVEAARATMVSAEARKESRGAHAQDDYPQRDDENWMRHTL
WFSEGDRLDYKPVHMQPLTVESVPPKARTF

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=586, Percent_Identity=51.5358361774744, Blast_Score=585, Evalue=1e-167,
Organism=Escherichia coli, GI1786942, Length=586, Percent_Identity=55.6313993174061, Blast_Score=632, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=574, Percent_Identity=39.5470383275261, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=560, Percent_Identity=32.1428571428571, Blast_Score=236, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17550100, Length=587, Percent_Identity=51.9591141396934, Blast_Score=592, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17505833, Length=617, Percent_Identity=50.2431118314425, Blast_Score=572, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6322701, Length=590, Percent_Identity=52.0338983050847, Blast_Score=600, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6322416, Length=590, Percent_Identity=51.864406779661, Blast_Score=595, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6320788, Length=482, Percent_Identity=26.1410788381743, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI17137288, Length=604, Percent_Identity=51.158940397351, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24655642, Length=604, Percent_Identity=51.158940397351, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24655647, Length=604, Percent_Identity=51.158940397351, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24663005, Length=612, Percent_Identity=47.7124183006536, Blast_Score=545, Evalue=1e-155,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64469; Mature: 64337

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAINTSLPRRKFDVVIVGAGGSGMRASLQLARAGLSVCVLSKVFPTRSHTVAAQGGIGA
CCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCREAPNAVYELEHFGMPFDRNADGTIY
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCEE
QRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVAAKTQFFVEWMALDLIRDADG
ECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DVLGVTALEMETGDVYILEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARAGIALQD
CEEEEEEEEEECCCEEEEECCEEEEEECCCCEEEEEECCCEEECCCCCCHHHHCCCEEEC
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNSDGERFMERYAPTLKDLAPRDFVSRSMDQ
CHHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGVGPNKDHVLLDLSHIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEHHHCCHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCCEEEEE
MGGIPTNIHGQVVGTPRGHEEPVNGFYAVGECSCVSVHGANRLGTNSLLDLVVFGRAAGN
CCCCCCCCCCEEEECCCCCCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCH
HIVEHVKQQREHKPLPKDAADFSLARLAKLDSSSSGEYAQSVANEIRGSMQKHAGVFRTS
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALLAEGVQDIKKLAERAQHIHLKDKSKVFNTARVEALEVANLVEAARATMVSAEARKESR
HHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAHAQDDYPQRDDENWMRHTLWFSEGDRLDYKPVHMQPLTVESVPPKARTF
CCCCCCCCCCCCCHHHHHHHEEECCCCCCCCCCCCCCCEEECCCCCCCCCC
>Mature Secondary Structure 
AAINTSLPRRKFDVVIVGAGGSGMRASLQLARAGLSVCVLSKVFPTRSHTVAAQGGIGA
CCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCREAPNAVYELEHFGMPFDRNADGTIY
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCEE
QRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVAAKTQFFVEWMALDLIRDADG
ECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DVLGVTALEMETGDVYILEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARAGIALQD
CEEEEEEEEEECCCEEEEECCEEEEEECCCCEEEEEECCCEEECCCCCCHHHHCCCEEEC
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNSDGERFMERYAPTLKDLAPRDFVSRSMDQ
CHHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGVGPNKDHVLLDLSHIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEHHHCCHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCCEEEEE
MGGIPTNIHGQVVGTPRGHEEPVNGFYAVGECSCVSVHGANRLGTNSLLDLVVFGRAAGN
CCCCCCCCCCEEEECCCCCCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCH
HIVEHVKQQREHKPLPKDAADFSLARLAKLDSSSSGEYAQSVANEIRGSMQKHAGVFRTS
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALLAEGVQDIKKLAERAQHIHLKDKSKVFNTARVEALEVANLVEAARATMVSAEARKESR
HHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAHAQDDYPQRDDENWMRHTLWFSEGDRLDYKPVHMQPLTVESVPPKARTF
CCCCCCCCCCCCCHHHHHHHEEECCCCCCCCCCCCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]