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The map label for this gene is gnd [H]

Identifier: 238024189

GI number: 238024189

Start: 931819

End: 933228

Strand: Direct

Name: gnd [H]

Synonym: bglu_2g07680

Alternate gene names: 238024189

Gene position: 931819-933228 (Clockwise)

Preceding gene: 238024188

Following gene: 238024190

Centisome position: 32.96

GC content: 66.03

Gene sequence:

>1410_bases
ATGGGCAAGCAAGCAATCGGCGTGGTCGGGATGGCCGTCATGGGCCGCAATCTGGCATTGAACATCGAGAGCCGCGGCCA
TGCCGTGTCCGTGTACAACCGCAGCCGAGACAAGACCGACGAGCTGATCGCCGAATTCCCCGACCGCCAACTGGTGCCGA
CCTACACGCTGGAGGAATTCGTCGGGTCGCTCGAGACGCCGCGCAAGATTCTGCTGATGGTCAAGGCCGGCGAGGCGACG
GACGCCACCATCGCGGCGCTCAAGCCGCTGCTCGGCAAGGGCGACGTGCTGATCGACGGCGGCAACACGCATTTCACCGA
CACCATCCGCCGCAATCAGGAGCTCGCGCAATCGGGCCTGCACTTCATCGGCACCGGCGTGTCGGGCGGCGAGGAGGGCG
CCTTGCACGGCCCGTCGATCATGCCTGGCGGCCAGCGCGATGCCTACGACCTGGTCGAGCCGATCCTCAAGCAGATCGCC
GCGAAGGCGCCCGACGGCGAGCCTTGCGTGGCCTACATGGGGCCGGACGGCGCCGGCCATTTCGTGAAGATGGTCCACAA
CGGCATCGAGTACGGCGACATGCAGCTGATCGCCGAAAGCTACGCCGTGCTCAAGCAGGTGGCCGGCCTTTCGAACGAGG
AGCTGGGCCGCGTCTACACCGAGTGGAACCAGGGCGAGCTCGACAGCTACCTGATCGAGATCACCTCGAAGATCTTCGGC
AAGAAGGACGACGAGACCGGCGAATACCTGGTGGACGTGATCCTCGATCGCGCCGCGCAAAAGGGCACCGGCAAGTGGAC
CAGCCAGAACGCGCTGGATCTCGGCGTGCCGCTGCCGCTCATCACCGAATCGGTGTTCGCGCGCGTGCTGTCGTCGCTGA
AGACGCAGCGCGTGGCTGCGAGCAAGGTGTTGAGCGGCCCGGCCGCGGGCAAGCTCGACGGCGATCGGGCCGCGTTCATC
GAGGCGGTGCGCCGCGCGCTGTACCTGAGCAAGGTGATCTCGTATGCGCAGGGCTTCGCGCAGCTGGACACGGCCTCGAA
GGAGTACGGCTGGAAGCTCAACCTCGGCGAGATCGCACGGATCTTCCGCGCGGGCTGCATCATCCGTGCGCGTTTCCTGC
AGAAGATCACCGACGCCTATACGGCCAATCCGGAGCTCGCGAACCTGCTGCTCGATCCGTACTTCAAGGAGATTTCGGCG
AACTACCAGGCGGCGCTGCGCGACGTGGTGGTGGCCGCGGTCAAGGCCGGCGTGCCGGTGCCGGCCTTCTCGTCGGCGAT
CGCCTATTTCGACAGCTACCGTTCGGCGCGGCTGCCGGCGAACCTGGTGCAGGCGCAGCGCGACTTCTTCGGCGCGCATA
CCTTCGAACGTACCGACAAGCCCGGCAGCTTCCACGCCAATTGGGCCTGA

Upstream 100 bases:

>100_bases
CTGAGCGCGCCGCAGCGTCGCCATGCGGTTTTCCCGTATCCTTGCGGCTTGTGCGCGCGGCTCGGTCGGGCCGCGCCGTG
ATTTGATCGGAGAGTGAACA

Downstream 100 bases:

>100_bases
GCCGCGGCGAGGCGGTAATTGTTGCAAATAACCACGCTATCCAGCGGGTCAATCGCGTTGGAGATTCGTGATTAGTGTCT
TTAACGAAACAGTGTTTTCG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MGKQAIGVVGMAVMGRNLALNIESRGHAVSVYNRSRDKTDELIAEFPDRQLVPTYTLEEFVGSLETPRKILLMVKAGEAT
DATIAALKPLLGKGDVLIDGGNTHFTDTIRRNQELAQSGLHFIGTGVSGGEEGALHGPSIMPGGQRDAYDLVEPILKQIA
AKAPDGEPCVAYMGPDGAGHFVKMVHNGIEYGDMQLIAESYAVLKQVAGLSNEELGRVYTEWNQGELDSYLIEITSKIFG
KKDDETGEYLVDVILDRAAQKGTGKWTSQNALDLGVPLPLITESVFARVLSSLKTQRVAASKVLSGPAAGKLDGDRAAFI
EAVRRALYLSKVISYAQGFAQLDTASKEYGWKLNLGEIARIFRAGCIIRARFLQKITDAYTANPELANLLLDPYFKEISA
NYQAALRDVVVAAVKAGVPVPAFSSAIAYFDSYRSARLPANLVQAQRDFFGAHTFERTDKPGSFHANWA

Sequences:

>Translated_469_residues
MGKQAIGVVGMAVMGRNLALNIESRGHAVSVYNRSRDKTDELIAEFPDRQLVPTYTLEEFVGSLETPRKILLMVKAGEAT
DATIAALKPLLGKGDVLIDGGNTHFTDTIRRNQELAQSGLHFIGTGVSGGEEGALHGPSIMPGGQRDAYDLVEPILKQIA
AKAPDGEPCVAYMGPDGAGHFVKMVHNGIEYGDMQLIAESYAVLKQVAGLSNEELGRVYTEWNQGELDSYLIEITSKIFG
KKDDETGEYLVDVILDRAAQKGTGKWTSQNALDLGVPLPLITESVFARVLSSLKTQRVAASKVLSGPAAGKLDGDRAAFI
EAVRRALYLSKVISYAQGFAQLDTASKEYGWKLNLGEIARIFRAGCIIRARFLQKITDAYTANPELANLLLDPYFKEISA
NYQAALRDVVVAAVKAGVPVPAFSSAIAYFDSYRSARLPANLVQAQRDFFGAHTFERTDKPGSFHANWA
>Mature_468_residues
GKQAIGVVGMAVMGRNLALNIESRGHAVSVYNRSRDKTDELIAEFPDRQLVPTYTLEEFVGSLETPRKILLMVKAGEATD
ATIAALKPLLGKGDVLIDGGNTHFTDTIRRNQELAQSGLHFIGTGVSGGEEGALHGPSIMPGGQRDAYDLVEPILKQIAA
KAPDGEPCVAYMGPDGAGHFVKMVHNGIEYGDMQLIAESYAVLKQVAGLSNEELGRVYTEWNQGELDSYLIEITSKIFGK
KDDETGEYLVDVILDRAAQKGTGKWTSQNALDLGVPLPLITESVFARVLSSLKTQRVAASKVLSGPAAGKLDGDRAAFIE
AVRRALYLSKVISYAQGFAQLDTASKEYGWKLNLGEIARIFRAGCIIRARFLQKITDAYTANPELANLLLDPYFKEISAN
YQAALRDVVVAAVKAGVPVPAFSSAIAYFDSYRSARLPANLVQAQRDFFGAHTFERTDKPGSFHANWA

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=52.3404255319149, Blast_Score=493, Evalue=1e-139,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=72.8632478632479, Blast_Score=707, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=472, Percent_Identity=50, Blast_Score=478, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6321695, Length=462, Percent_Identity=51.0822510822511, Blast_Score=481, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6321977, Length=473, Percent_Identity=50.7399577167019, Blast_Score=469, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24639279, Length=469, Percent_Identity=52.4520255863539, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 50816; Mature: 50685

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKQAIGVVGMAVMGRNLALNIESRGHAVSVYNRSRDKTDELIAEFPDRQLVPTYTLEEF
CCCHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHHH
VGSLETPRKILLMVKAGEATDATIAALKPLLGKGDVLIDGGNTHFTDTIRRNQELAQSGL
HCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
HFIGTGVSGGEEGALHGPSIMPGGQRDAYDLVEPILKQIAAKAPDGEPCVAYMGPDGAGH
EEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHH
FVKMVHNGIEYGDMQLIAESYAVLKQVAGLSNEELGRVYTEWNQGELDSYLIEITSKIFG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCC
KKDDETGEYLVDVILDRAAQKGTGKWTSQNALDLGVPLPLITESVFARVLSSLKTQRVAA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SKVLSGPAAGKLDGDRAAFIEAVRRALYLSKVISYAQGFAQLDTASKEYGWKLNLGEIAR
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEECHHHHHH
IFRAGCIIRARFLQKITDAYTANPELANLLLDPYFKEISANYQAALRDVVVAAVKAGVPV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
PAFSSAIAYFDSYRSARLPANLVQAQRDFFGAHTFERTDKPGSFHANWA
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKQAIGVVGMAVMGRNLALNIESRGHAVSVYNRSRDKTDELIAEFPDRQLVPTYTLEEF
CCHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHHH
VGSLETPRKILLMVKAGEATDATIAALKPLLGKGDVLIDGGNTHFTDTIRRNQELAQSGL
HCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
HFIGTGVSGGEEGALHGPSIMPGGQRDAYDLVEPILKQIAAKAPDGEPCVAYMGPDGAGH
EEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHH
FVKMVHNGIEYGDMQLIAESYAVLKQVAGLSNEELGRVYTEWNQGELDSYLIEITSKIFG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCC
KKDDETGEYLVDVILDRAAQKGTGKWTSQNALDLGVPLPLITESVFARVLSSLKTQRVAA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SKVLSGPAAGKLDGDRAAFIEAVRRALYLSKVISYAQGFAQLDTASKEYGWKLNLGEIAR
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEECHHHHHH
IFRAGCIIRARFLQKITDAYTANPELANLLLDPYFKEISANYQAALRDVVVAAVKAGVPV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
PAFSSAIAYFDSYRSARLPANLVQAQRDFFGAHTFERTDKPGSFHANWA
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042 [H]