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The map label for this gene is hbd [H]

Identifier: 238024053

GI number: 238024053

Start: 738255

End: 739220

Strand: Direct

Name: hbd [H]

Synonym: bglu_2g06130

Alternate gene names: 238024053

Gene position: 738255-739220 (Clockwise)

Preceding gene: 238024052

Following gene: 238024054

Centisome position: 26.11

GC content: 72.36

Gene sequence:

>966_bases
ATGACCTTGCTTACCGACATCAGGACCTTCGCCGTGATCGGCACCGGCGTGACCGGCAGCGGCTGGGCGGCGCGCGCGCT
CGCGAACGGGCTCGACGTGGTGGTGTGGGACCCGGCCGAGGGCGCCGAGTCGCAGCTGCGCGCCAACCTGGCGAACGCGT
GGCCCGCGCTGGAGCGCGCCGGCCTGAAGCCCGGCGCCGCGCCCGAGCGGCTGCGTTTCGCGCGCACCGTCGAGGCCTGC
GTGGCCGACGCCGACTTCATCCAGGAGAGCGCGCCCGAGCGCGAGGCGCTCAAGCTCGACCTGCACGAACGGATCAGCCG
CGCCGCGCGGCCCGGGGCGATCATCGCGTCGTCCACCTCAGGCCTGCTGCCCACCGGGTTCTACGCGCGCGCGACCCATC
CCGAGCGCTGCGTGGTCGGCCATCCGTTCAACCCGGTCTATCTGCTGCCGCTCGTCGAGGTGCTCGGCGGCGAACGCACC
TCGGCCGAGGCGGTGGACGCCGCGATCGCGATCTACGCCGGGCTCGGCATGCGGCCGCTGAAGGTGCGCAAGGAAGTGCC
GGGCTTCATCGCCGACCGCCTGCTCGAAGCGCTGTGGCGCGAGGCGCTGCATCTGGTCAACGACGGCGTGGCGACCACCG
GCGAGATCGACGACGCGATCCGCTTCGGCGCCGGCATCCGCTGGTCGTTCATGGGCACCTTCCTGACCTATACGCTCGCG
GGTGGCGAGCCCGGCATGCGCCATTTCATGAAGCAGTTCGGGCCGGCGCTGGCACTGCCGTGGACCAGGCTGGCGGCGCC
GGCGCTGAGCGACGCGCTGATCGACCGCGTGGTGGACGGCACCGCCCGGCAGCAGGGCGAGCGCAGCATCAAGGCACTCG
AACGCTATCGCGACGACTGCATCACCGAGGTGATCGCCGCGGTCGCGCGCGTGAAGGCGCGCCACGGCATGCGCGACGAG
GACTGA

Upstream 100 bases:

>100_bases
CGCGCCCGCCGTCTACGCGTGACGCATGCGCCGGGCGGCGCCGCTCGCGGTGCCCGGCAATCCGTCATCACCTCATCGGG
ACAACGAAGGACGATCATTC

Downstream 100 bases:

>100_bases
CGATGGCCACCGGCACCCCCGACGCGCCCGTTATCGGCCCGACGCTCCATCGCGACGTCGTGCGCGCCGAATGGGTCGAC
TACAACGGGCACCTGCGCGA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MTLLTDIRTFAVIGTGVTGSGWAARALANGLDVVVWDPAEGAESQLRANLANAWPALERAGLKPGAAPERLRFARTVEAC
VADADFIQESAPEREALKLDLHERISRAARPGAIIASSTSGLLPTGFYARATHPERCVVGHPFNPVYLLPLVEVLGGERT
SAEAVDAAIAIYAGLGMRPLKVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLA
GGEPGMRHFMKQFGPALALPWTRLAAPALSDALIDRVVDGTARQQGERSIKALERYRDDCITEVIAAVARVKARHGMRDE
D

Sequences:

>Translated_321_residues
MTLLTDIRTFAVIGTGVTGSGWAARALANGLDVVVWDPAEGAESQLRANLANAWPALERAGLKPGAAPERLRFARTVEAC
VADADFIQESAPEREALKLDLHERISRAARPGAIIASSTSGLLPTGFYARATHPERCVVGHPFNPVYLLPLVEVLGGERT
SAEAVDAAIAIYAGLGMRPLKVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLA
GGEPGMRHFMKQFGPALALPWTRLAAPALSDALIDRVVDGTARQQGERSIKALERYRDDCITEVIAAVARVKARHGMRDE
D
>Mature_320_residues
TLLTDIRTFAVIGTGVTGSGWAARALANGLDVVVWDPAEGAESQLRANLANAWPALERAGLKPGAAPERLRFARTVEACV
ADADFIQESAPEREALKLDLHERISRAARPGAIIASSTSGLLPTGFYARATHPERCVVGHPFNPVYLLPLVEVLGGERTS
AEAVDAAIAIYAGLGMRPLKVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLAG
GEPGMRHFMKQFGPALALPWTRLAAPALSDALIDRVVDGTARQQGERSIKALERYRDDCITEVIAAVARVKARHGMRDED

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=321, Percent_Identity=27.7258566978193, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI296179429, Length=228, Percent_Identity=30.2631578947368, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI296179427, Length=245, Percent_Identity=28.1632653061224, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787661, Length=226, Percent_Identity=30.0884955752212, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1788682, Length=143, Percent_Identity=31.4685314685315, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=221, Percent_Identity=32.579185520362, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI193203623, Length=221, Percent_Identity=32.579185520362, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17553560, Length=232, Percent_Identity=28.448275862069, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17549919, Length=231, Percent_Identity=29.004329004329, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17563036, Length=227, Percent_Identity=27.3127753303965, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=214, Percent_Identity=28.5046728971963, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=214, Percent_Identity=28.5046728971963, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508953, Length=214, Percent_Identity=28.5046728971963, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45549573, Length=303, Percent_Identity=28.3828382838284, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20129993, Length=252, Percent_Identity=27.3809523809524, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI19921000, Length=220, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24583077, Length=220, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24583079, Length=220, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 34630; Mature: 34499

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLTDIRTFAVIGTGVTGSGWAARALANGLDVVVWDPAEGAESQLRANLANAWPALERA
CCHHHHHHHHHHEECCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHC
GLKPGAAPERLRFARTVEACVADADFIQESAPEREALKLDLHERISRAARPGAIIASSTS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCC
GLLPTGFYARATHPERCVVGHPFNPVYLLPLVEVLGGERTSAEAVDAAIAIYAGLGMRPL
CCCCCCCEEECCCCCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHH
KVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLA
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHEEC
GGEPGMRHFMKQFGPALALPWTRLAAPALSDALIDRVVDGTARQQGERSIKALERYRDDC
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITEVIAAVARVKARHGMRDED
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLLTDIRTFAVIGTGVTGSGWAARALANGLDVVVWDPAEGAESQLRANLANAWPALERA
CHHHHHHHHHHEECCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHC
GLKPGAAPERLRFARTVEACVADADFIQESAPEREALKLDLHERISRAARPGAIIASSTS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCC
GLLPTGFYARATHPERCVVGHPFNPVYLLPLVEVLGGERTSAEAVDAAIAIYAGLGMRPL
CCCCCCCEEECCCCCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHH
KVRKEVPGFIADRLLEALWREALHLVNDGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLA
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHEEC
GGEPGMRHFMKQFGPALALPWTRLAAPALSDALIDRVVDGTARQQGERSIKALERYRDDC
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITEVIAAVARVKARHGMRDED
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA