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The map label for this gene is hmp [H]

Identifier: 238024036

GI number: 238024036

Start: 709583

End: 710728

Strand: Direct

Name: hmp [H]

Synonym: bglu_2g05900

Alternate gene names: 238024036

Gene position: 709583-710728 (Clockwise)

Preceding gene: 238024035

Following gene: 238024037

Centisome position: 25.1

GC content: 68.67

Gene sequence:

>1146_bases
ATGATGCGAGATGCCGCCAATTTCGAACCGGTGGACAGCCGCGTGACGCAGCCCGATTTCTGGCGCGCGCTGCCCGAGCG
CTGGAGCAGCGACGCCGAGGAGACGCTGACCTGCTGCCACGTGCGGCAGGAGACGCACGACGTGAAGAGCTTCTTCTTCC
GCTCGCCCACCGGCCGCTCGTTCGCCTTCGAGCCGGGCCAGTTCGTCACGCTCGAACTCGAGATCGACGGCGAGACGATC
AACCGCTGCTACACGATCTCGTCGTCGCCGGCGCGCCCGCACACGCTGTCCATCACGGTCAAGCGCGTGCCGGGCGGGCG
CGTGTCGAACTGGCTGCACGACAACCTGCAGGCGGGTGCCGCGGTGCGCGTGCTCGGCCCGGCCGGCGACTTCACCTGCG
CGCGCCACCCGGCGCGCAAGTACCTGTTCCTGTCGGCCGGCTCGGGCATCACGCCGCTGATGTCGATGAGCCGCGCGCAC
TACGATCTCGCCGAGGATCGCGACATCGTGTTCGTCCACAGCGCGCGCACGCCCGACGACATCATCTTCGCGCGCGAGCT
CGACCTGATGGCCGCGAGCCAGGCCAATTTCCGCACCTCGTTCGTCTGCGAGCGGATCGGCACGCGCACCAACTGGCACG
GCGTGACGGGCTACCTGTCGCTGCCGCTGCTCAAGCTGATCGCGCCGGACTTCATGGAGCGCGAGGTGTTCACCTGCGGG
CCGGCGCCGTACATGAAGGCGGTGCGCGAGCTGCTCGACGAGGCCGGCTTCGACCGCAGGCAGTATCACGAGGAAAGCTT
CTCGTTCGAGACGCTGCTCGACGAGGCCGCGCCCGAGGTGGTCGAGACGCTGGTCGAGGAAGGCGTGCCGGTGCCCGCCA
CCACGCATCACACCGTCACCTTCACGAGGAGCCACCGCGAGATCAGCTGCGGCGCCGACCAGCACGTGCTCGACGCGGCG
CGCCAGGCCGGCGTGCGGCTGCCCTCCTCGTGCTCGCAGGGCATGTGCGGCACCTGCAAGGTCAAGCTCGTGTCGGGGCA
GGTGGAGATGAAGCACAACGGCGGCATCCGCCAGCGCGAAATCGACCAGGGCATGGTGCTGCTCTGCTGCAGCAAGCCGC
TGTCGGACCTCGTGGTCGACAAGTGA

Upstream 100 bases:

>100_bases
GTATTCGCCGTACACGGAAGGGCTGGTCGAGAAGTTCTCGGCCTGGTACATCGGCCGCATGGCCGCCTATCTGGGCGCTT
GACGCGACGCGGAGCGAGAC

Downstream 100 bases:

>100_bases
CGCCTGCCGTTCCGGGGCCGGCACGCGGCTGTCGCTTATGGGCAAGCGCGTGTCGGAAAACGACGATACCGGGGAATTGT
GGCCGCGGAACCTAGAGACA

Product: ferredoxin

Products: NA

Alternate protein names: Rieske-type oxygenase; RO [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MMRDAANFEPVDSRVTQPDFWRALPERWSSDAEETLTCCHVRQETHDVKSFFFRSPTGRSFAFEPGQFVTLELEIDGETI
NRCYTISSSPARPHTLSITVKRVPGGRVSNWLHDNLQAGAAVRVLGPAGDFTCARHPARKYLFLSAGSGITPLMSMSRAH
YDLAEDRDIVFVHSARTPDDIIFARELDLMAASQANFRTSFVCERIGTRTNWHGVTGYLSLPLLKLIAPDFMEREVFTCG
PAPYMKAVRELLDEAGFDRRQYHEESFSFETLLDEAAPEVVETLVEEGVPVPATTHHTVTFTRSHREISCGADQHVLDAA
RQAGVRLPSSCSQGMCGTCKVKLVSGQVEMKHNGGIRQREIDQGMVLLCCSKPLSDLVVDK

Sequences:

>Translated_381_residues
MMRDAANFEPVDSRVTQPDFWRALPERWSSDAEETLTCCHVRQETHDVKSFFFRSPTGRSFAFEPGQFVTLELEIDGETI
NRCYTISSSPARPHTLSITVKRVPGGRVSNWLHDNLQAGAAVRVLGPAGDFTCARHPARKYLFLSAGSGITPLMSMSRAH
YDLAEDRDIVFVHSARTPDDIIFARELDLMAASQANFRTSFVCERIGTRTNWHGVTGYLSLPLLKLIAPDFMEREVFTCG
PAPYMKAVRELLDEAGFDRRQYHEESFSFETLLDEAAPEVVETLVEEGVPVPATTHHTVTFTRSHREISCGADQHVLDAA
RQAGVRLPSSCSQGMCGTCKVKLVSGQVEMKHNGGIRQREIDQGMVLLCCSKPLSDLVVDK
>Mature_381_residues
MMRDAANFEPVDSRVTQPDFWRALPERWSSDAEETLTCCHVRQETHDVKSFFFRSPTGRSFAFEPGQFVTLELEIDGETI
NRCYTISSSPARPHTLSITVKRVPGGRVSNWLHDNLQAGAAVRVLGPAGDFTCARHPARKYLFLSAGSGITPLMSMSRAH
YDLAEDRDIVFVHSARTPDDIIFARELDLMAASQANFRTSFVCERIGTRTNWHGVTGYLSLPLLKLIAPDFMEREVFTCG
PAPYMKAVRELLDEAGFDRRQYHEESFSFETLLDEAAPEVVETLVEEGVPVPATTHHTVTFTRSHREISCGADQHVLDAA
RQAGVRLPSSCSQGMCGTCKVKLVSGQVEMKHNGGIRQREIDQGMVLLCCSKPLSDLVVDK

Specific function: Catalyzes the opening of ring B of 1,4-androstadiene- 3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta- cleavage [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI84875541, Length=238, Percent_Identity=29.4117647058824, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1787098, Length=343, Percent_Identity=31.7784256559767, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1787658, Length=357, Percent_Identity=30.5322128851541, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1788104, Length=332, Percent_Identity=23.4939759036145, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788903, Length=242, Percent_Identity=26.4462809917355, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323552, Length=196, Percent_Identity=27.5510204081633, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323510, Length=220, Percent_Identity=26.3636363636364, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322146, Length=223, Percent_Identity=25.1121076233184, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322699, Length=225, Percent_Identity=24.8888888888889, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 42468; Mature: 42468

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRDAANFEPVDSRVTQPDFWRALPERWSSDAEETLTCCHVRQETHDVKSFFFRSPTGRS
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FAFEPGQFVTLELEIDGETINRCYTISSSPARPHTLSITVKRVPGGRVSNWLHDNLQAGA
EEECCCCEEEEEEEECCCEECEEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCC
AVRVLGPAGDFTCARHPARKYLFLSAGSGITPLMSMSRAHYDLAEDRDIVFVHSARTPDD
EEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCC
IIFARELDLMAASQANFRTSFVCERIGTRTNWHGVTGYLSLPLLKLIAPDFMEREVFTCG
EEEEEHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHCCEEECC
PAPYMKAVRELLDEAGFDRRQYHEESFSFETLLDEAAPEVVETLVEEGVPVPATTHHTVT
CCHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
FTRSHREISCGADQHVLDAARQAGVRLPSSCSQGMCGTCKVKLVSGQVEMKHNGGIRQRE
EEECCCEEECCCCHHHHHHHHHCCCCCCCHHCCCCCCEEEEEEEECEEEEECCCCCCHHE
IDQGMVLLCCSKPLSDLVVDK
CCCCEEEEEECCCHHHHHCCC
>Mature Secondary Structure
MMRDAANFEPVDSRVTQPDFWRALPERWSSDAEETLTCCHVRQETHDVKSFFFRSPTGRS
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FAFEPGQFVTLELEIDGETINRCYTISSSPARPHTLSITVKRVPGGRVSNWLHDNLQAGA
EEECCCCEEEEEEEECCCEECEEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCC
AVRVLGPAGDFTCARHPARKYLFLSAGSGITPLMSMSRAHYDLAEDRDIVFVHSARTPDD
EEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCC
IIFARELDLMAASQANFRTSFVCERIGTRTNWHGVTGYLSLPLLKLIAPDFMEREVFTCG
EEEEEHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHCCEEECC
PAPYMKAVRELLDEAGFDRRQYHEESFSFETLLDEAAPEVVETLVEEGVPVPATTHHTVT
CCHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
FTRSHREISCGADQHVLDAARQAGVRLPSSCSQGMCGTCKVKLVSGQVEMKHNGGIRQRE
EEECCCEEECCCCHHHHHHHHHCCCCCCCHHCCCCCCEEEEEEEECEEEEECCCCCCHHE
IDQGMVLLCCSKPLSDLVVDK
CCCCEEEEEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]