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The map label for this gene is garD [H]

Identifier: 238023835

GI number: 238023835

Start: 443679

End: 445226

Strand: Direct

Name: garD [H]

Synonym: bglu_2g03740

Alternate gene names: 238023835

Gene position: 443679-445226 (Clockwise)

Preceding gene: 238023833

Following gene: 238023837

Centisome position: 15.69

GC content: 70.03

Gene sequence:

>1548_bases
ATGTCCCAGTCCCCTCTCTACATTCGCGTCCACCCGGACGACAACGTCGCGATCGTGGTCAACGACGGCGGGCTGCCCGC
CGGCTCGCAGTTCGCCGACGGGCTGACGCTCTGCGAAGGCGTCCCGCAAGGGCACAAGGTTGCGCTGGTCGATCTGAAGG
AAGGCGATCCGGTGCTGCGCTACCACGTCGTGATCGGCTACGCGGCGAAGGACCTGCCGCGCGGCAGCTGGGTGAACGAG
CGCACGCTGCGCATGCCCGAGCCGCCCGGCCTGGACGACCTGCCGCTCGCCACCAGGAAGGCCCCCGAGCAGGCCCCGCT
CGAGGGCTACACGTTCGAGGGCTACCGCAACGCGGACGGCTCGGTCGGCACGCGCAACATCCTGGCGATCACCACCACCG
TGCAGTGCGTGTCGGGCGTGGTGGAGTTCGCCGTCGAGCGAATCCGGCGCGAGCTGCTGCCGCGCTACCCGAACGTCGAC
GGGGTGGTGGGGCTCGAGCACACCTACGGCTGCGGCGTCGCGATCGAGGCGCCCGGCGCCGAGATTCCGATCCGCACGCT
GCGCAACATCAGCATGAATCCGAACTTCGGCGGCGAGGTGATGGTGGTGAGCCTCGGCTGCGAGAAGCTGCAGCCCGAGC
GGCTGCTGCCGGCCGGCGTGATCCCGGTGGCGGCGGACAAGCCCGACAACGGCGGCGTGGTGTGCCTGCAGGATGCGGCG
CACGTCGGCTTCATGTCGATGATAGACTCGATCGTGACGATGGCCGAGCAGCATCTGGAGCGCCTGAACCGGCGCCGCCG
CGAGACCGTGCCGGCCGCGGAGCTGGTGGTGGGCGTGCAGTGCGGCGGCAGCGACGCGTTCTCGGGCCTGACCGCGAATC
CGGCGGTGGGCTTCGCGGCCGACCTGCTGGTGCGCGCCGGCGCGACCATCATGTTCTCGGAGGTGACCGAAGTGCGCGAC
GGCGTGGCCCAGCTCACCTCGCGGGCCGCGAACGAGCAGGTCGCGCGCGAGATCATCCGCGAGATGGCCTGGTACGACGC
CTATCTGCAGCGCGGTCGGGTGGATCGCAGCGCCAACACCACGCCCGGCAACAAGAAGGGCGGACTGTCCAACATCGTCG
AAAAGGCGATGGGCTCGATCGTGAAGTCGGGCAGCTCGGCGATCTCGGGCGTGGTGAGCCCGGGCGAGCGCGCCAGGGGC
AAGGGGCTGCTCTACACCGCCACGCCGGCCAGCGACTTCATCTGCGGCACCCTGCAGCTCGCCGCCGGCATGAACCTGCA
CATCTTCACGACGGGCCGCGGCACGCCCTACGGCCTGGCCCAGGTGCCGGTGATCAAGGTCGCCACGCGCAGCGACCTGG
CGCGCCGCTGGCACGATCTGATGGACCTGAACGCCGGCAGCATCGCCACCGGCGAGAAGACCATCGAGGAGGTGGGCTGG
GAGCTGTTCCACCTGATGCTCGACGTCGCGAGCGGGCGCAAGACCTGGGCCGAGCAGTGGAAGCTGGCCAACGCGCTGAC
GCTGTTCAACCCGGCCCCGGTGACCTGA

Upstream 100 bases:

>100_bases
CTGCCTTTCGGCATCAGGGTTTACGCACAATCACGGAGGCTTCGCCAATGTTGTATGATGACTGTCAATTCACTGCGCGT
TGCAACGAGGATTTCCCCTG

Downstream 100 bases:

>100_bases
TCGGCCGGGGCCGGCGCGGCCGTCACTCGGACGGCCTCGAACCCGTCACGCCCGCCGCGCTCCGGCGGGCGTTGTCATTG
GGGCGCGCAACATGGGCGGC

Product: Galactarate dehydratase

Products: NA

Alternate protein names: GalcD [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MSQSPLYIRVHPDDNVAIVVNDGGLPAGSQFADGLTLCEGVPQGHKVALVDLKEGDPVLRYHVVIGYAAKDLPRGSWVNE
RTLRMPEPPGLDDLPLATRKAPEQAPLEGYTFEGYRNADGSVGTRNILAITTTVQCVSGVVEFAVERIRRELLPRYPNVD
GVVGLEHTYGCGVAIEAPGAEIPIRTLRNISMNPNFGGEVMVVSLGCEKLQPERLLPAGVIPVAADKPDNGGVVCLQDAA
HVGFMSMIDSIVTMAEQHLERLNRRRRETVPAAELVVGVQCGGSDAFSGLTANPAVGFAADLLVRAGATIMFSEVTEVRD
GVAQLTSRAANEQVAREIIREMAWYDAYLQRGRVDRSANTTPGNKKGGLSNIVEKAMGSIVKSGSSAISGVVSPGERARG
KGLLYTATPASDFICGTLQLAAGMNLHIFTTGRGTPYGLAQVPVIKVATRSDLARRWHDLMDLNAGSIATGEKTIEEVGW
ELFHLMLDVASGRKTWAEQWKLANALTLFNPAPVT

Sequences:

>Translated_515_residues
MSQSPLYIRVHPDDNVAIVVNDGGLPAGSQFADGLTLCEGVPQGHKVALVDLKEGDPVLRYHVVIGYAAKDLPRGSWVNE
RTLRMPEPPGLDDLPLATRKAPEQAPLEGYTFEGYRNADGSVGTRNILAITTTVQCVSGVVEFAVERIRRELLPRYPNVD
GVVGLEHTYGCGVAIEAPGAEIPIRTLRNISMNPNFGGEVMVVSLGCEKLQPERLLPAGVIPVAADKPDNGGVVCLQDAA
HVGFMSMIDSIVTMAEQHLERLNRRRRETVPAAELVVGVQCGGSDAFSGLTANPAVGFAADLLVRAGATIMFSEVTEVRD
GVAQLTSRAANEQVAREIIREMAWYDAYLQRGRVDRSANTTPGNKKGGLSNIVEKAMGSIVKSGSSAISGVVSPGERARG
KGLLYTATPASDFICGTLQLAAGMNLHIFTTGRGTPYGLAQVPVIKVATRSDLARRWHDLMDLNAGSIATGEKTIEEVGW
ELFHLMLDVASGRKTWAEQWKLANALTLFNPAPVT
>Mature_514_residues
SQSPLYIRVHPDDNVAIVVNDGGLPAGSQFADGLTLCEGVPQGHKVALVDLKEGDPVLRYHVVIGYAAKDLPRGSWVNER
TLRMPEPPGLDDLPLATRKAPEQAPLEGYTFEGYRNADGSVGTRNILAITTTVQCVSGVVEFAVERIRRELLPRYPNVDG
VVGLEHTYGCGVAIEAPGAEIPIRTLRNISMNPNFGGEVMVVSLGCEKLQPERLLPAGVIPVAADKPDNGGVVCLQDAAH
VGFMSMIDSIVTMAEQHLERLNRRRRETVPAAELVVGVQCGGSDAFSGLTANPAVGFAADLLVRAGATIMFSEVTEVRDG
VAQLTSRAANEQVAREIIREMAWYDAYLQRGRVDRSANTTPGNKKGGLSNIVEKAMGSIVKSGSSAISGVVSPGERARGK
GLLYTATPASDFICGTLQLAAGMNLHIFTTGRGTPYGLAQVPVIKVATRSDLARRWHDLMDLNAGSIATGEKTIEEVGWE
LFHLMLDVASGRKTWAEQWKLANALTLFNPAPVT

Specific function: D-galactarate metabolism; first step. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789516, Length=511, Percent_Identity=65.3620352250489, Blast_Score=708, Evalue=0.0,
Organism=Escherichia coli, GI1789475, Length=511, Percent_Identity=31.8982387475538, Blast_Score=220, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR017654
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.42 [H]

Molecular weight: Translated: 55124; Mature: 54992

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSPLYIRVHPDDNVAIVVNDGGLPAGSQFADGLTLCEGVPQGHKVALVDLKEGDPVLR
CCCCCEEEEECCCCCEEEEECCCCCCCCCHHHCCHHHHHCCCCCCEEEEEEECCCCCEEE
YHVVIGYAAKDLPRGSWVNERTLRMPEPPGLDDLPLATRKAPEQAPLEGYTFEGYRNADG
EEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCC
SVGTRNILAITTTVQCVSGVVEFAVERIRRELLPRYPNVDGVVGLEHTYGCGVAIEAPGA
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEECCCC
EIPIRTLRNISMNPNFGGEVMVVSLGCEKLQPERLLPAGVIPVAADKPDNGGVVCLQDAA
CCCHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCH
HVGFMSMIDSIVTMAEQHLERLNRRRRETVPAAELVVGVQCGGSDAFSGLTANPAVGFAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCHHCCCCCCCCCHHHHH
DLLVRAGATIMFSEVTEVRDGVAQLTSRAANEQVAREIIREMAWYDAYLQRGRVDRSANT
HHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TPGNKKGGLSNIVEKAMGSIVKSGSSAISGVVSPGERARGKGLLYTATPASDFICGTLQL
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHH
AAGMNLHIFTTGRGTPYGLAQVPVIKVATRSDLARRWHDLMDLNAGSIATGEKTIEEVGW
HCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
ELFHLMLDVASGRKTWAEQWKLANALTLFNPAPVT
HHHHHHHHHHCCHHHHHHHHHHHCEEEECCCCCCC
>Mature Secondary Structure 
SQSPLYIRVHPDDNVAIVVNDGGLPAGSQFADGLTLCEGVPQGHKVALVDLKEGDPVLR
CCCCEEEEECCCCCEEEEECCCCCCCCCHHHCCHHHHHCCCCCCEEEEEEECCCCCEEE
YHVVIGYAAKDLPRGSWVNERTLRMPEPPGLDDLPLATRKAPEQAPLEGYTFEGYRNADG
EEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCC
SVGTRNILAITTTVQCVSGVVEFAVERIRRELLPRYPNVDGVVGLEHTYGCGVAIEAPGA
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEECCCC
EIPIRTLRNISMNPNFGGEVMVVSLGCEKLQPERLLPAGVIPVAADKPDNGGVVCLQDAA
CCCHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCH
HVGFMSMIDSIVTMAEQHLERLNRRRRETVPAAELVVGVQCGGSDAFSGLTANPAVGFAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCHHCCCCCCCCCHHHHH
DLLVRAGATIMFSEVTEVRDGVAQLTSRAANEQVAREIIREMAWYDAYLQRGRVDRSANT
HHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TPGNKKGGLSNIVEKAMGSIVKSGSSAISGVVSPGERARGKGLLYTATPASDFICGTLQL
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHH
AAGMNLHIFTTGRGTPYGLAQVPVIKVATRSDLARRWHDLMDLNAGSIATGEKTIEEVGW
HCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
ELFHLMLDVASGRKTWAEQWKLANALTLFNPAPVT
HHHHHHHHHHCCHHHHHHHHHHHCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 2407727; 9772162; 10762278 [H]