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The map label for this gene is spsK [H]

Identifier: 238023766

GI number: 238023766

Start: 347589

End: 348533

Strand: Direct

Name: spsK [H]

Synonym: bglu_2g02980

Alternate gene names: 238023766

Gene position: 347589-348533 (Clockwise)

Preceding gene: 238023757

Following gene: 238023767

Centisome position: 12.29

GC content: 75.24

Gene sequence:

>945_bases
ATGAATCTCGCCCTGATCGGCGCCTCGGGCCTGCTCGGCCGCGCCGTGGCCGCCGCGCTCGCGCCGCGTCGCGAATGGCG
GCTGGTCGCGACGGTGCGCGATCCGCACGGCGCGCCGGCCCGCGCGGCCGCGCGCCTCGCGGGCCTTGGCCCGGACGCGC
TGACGCCGCTCGACGTGCTCGATGCGCGCGCGCTCGACCGCTTCTTCGCCGAACATCGCCCCGACGCCGTGATCGTCTGC
GCGGCCGAGCGCCGGCCCGACGTCTGCGAGCACGAGCCGGCCGCCGCGCGCGCCATCAACGTCGAGGCGCTGGCCGCGCT
GGCCGCACGCGCCGATGCGCTCGGCGCCTGGACGCTCGCGATGTCCACCGACTACGTGTTCGACGGCCGCGCGGCGCCCT
ACCGCGAAACCGATCCGCCCGCACCGCTGAACGCTTACGGCCGCAGCAAGGCCGACGGCGAGGCGGCGCTGCTGGACGCC
TCCGCGCGCGCCTGCGTGCTGCGCCTGCCGCTGCTGTACGGGCCGGTGTTCGGCTGGGGCGACTCGGCCGTCACGAGCCT
GGTGCCGCCCGTCGTCGCGTCGGCGCAGCCCGGTGCCGCGGCCGCCGACATGGACGCCTGGGCGATCCGCTATCCGACCT
GGACGCCCGACGTCGCATACGTGATCACGCAACTGGTCGCGCGCCATGCGGCCGGCGAGGCCGTGACGGGCCGCTGCCAT
TGGTCCGGCGACGAGCCCATGACCAAGCACGAAATCGCCACGCGGATCGGCCGCGCGCTCGGCCTGAGGCCGCGGCTGAA
CGCGATTGCCGAGCCGCGCGATGCGACGCCGCGGCCCTACGACTGCCACCTCGATTCGACGCGGTTGGAAGCGCTCGGCA
TCGGCCGCCGCACACGCTTCGACGCGGCGATTCGCGAAGTATTGCGCGACGGCCCTGCGATCTGA

Upstream 100 bases:

>100_bases
GCCCTGTCGCGGCCGCCACCGCAGGCCAGCGTCGCGGCGCCGCGAACGCGGCACAATGGCGGCCTGCCCGCTTGCCGGGC
GTATCTGGAGACCCCTCGGC

Downstream 100 bases:

>100_bases
CGGCCGGCTGCGTGCGCGGCGGATCCCGGGCAACCATACGGCGCGATGCGCGCCGTATGGGAGTGTCCGCTCGCCGTTTG
GGCGCGTCGCACGCCCCCTT

Product: dTDP-4-dehydrorhamnose reductase

Products: phosphate; diphosphate; S-adenosyl-L-methionine

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MNLALIGASGLLGRAVAAALAPRREWRLVATVRDPHGAPARAAARLAGLGPDALTPLDVLDARALDRFFAEHRPDAVIVC
AAERRPDVCEHEPAAARAINVEALAALAARADALGAWTLAMSTDYVFDGRAAPYRETDPPAPLNAYGRSKADGEAALLDA
SARACVLRLPLLYGPVFGWGDSAVTSLVPPVVASAQPGAAAADMDAWAIRYPTWTPDVAYVITQLVARHAAGEAVTGRCH
WSGDEPMTKHEIATRIGRALGLRPRLNAIAEPRDATPRPYDCHLDSTRLEALGIGRRTRFDAAIREVLRDGPAI

Sequences:

>Translated_314_residues
MNLALIGASGLLGRAVAAALAPRREWRLVATVRDPHGAPARAAARLAGLGPDALTPLDVLDARALDRFFAEHRPDAVIVC
AAERRPDVCEHEPAAARAINVEALAALAARADALGAWTLAMSTDYVFDGRAAPYRETDPPAPLNAYGRSKADGEAALLDA
SARACVLRLPLLYGPVFGWGDSAVTSLVPPVVASAQPGAAAADMDAWAIRYPTWTPDVAYVITQLVARHAAGEAVTGRCH
WSGDEPMTKHEIATRIGRALGLRPRLNAIAEPRDATPRPYDCHLDSTRLEALGIGRRTRFDAAIREVLRDGPAI
>Mature_314_residues
MNLALIGASGLLGRAVAAALAPRREWRLVATVRDPHGAPARAAARLAGLGPDALTPLDVLDARALDRFFAEHRPDAVIVC
AAERRPDVCEHEPAAARAINVEALAALAARADALGAWTLAMSTDYVFDGRAAPYRETDPPAPLNAYGRSKADGEAALLDA
SARACVLRLPLLYGPVFGWGDSAVTSLVPPVVASAQPGAAAADMDAWAIRYPTWTPDVAYVITQLVARHAAGEAVTGRCH
WSGDEPMTKHEIATRIGRALGLRPRLNAIAEPRDATPRPYDCHLDSTRLEALGIGRRTRFDAAIREVLRDGPAI

Specific function: DTDP-L-RHAMNOSE BIOSYNTHESIS WITHIN THE O ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE BIOSYNTHESIS. [C]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=306, Percent_Identity=41.1764705882353, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI33519455, Length=306, Percent_Identity=41.1764705882353, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1788352, Length=305, Percent_Identity=30.4918032786885, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: 2.5.1.6

Molecular weight: Translated: 33342; Mature: 33342

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLALIGASGLLGRAVAAALAPRREWRLVATVRDPHGAPARAAARLAGLGPDALTPLDVL
CCEEEEECCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHH
DARALDRFFAEHRPDAVIVCAAERRPDVCEHEPAAARAINVEALAALAARADALGAWTLA
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHEECHHHHHHHHHHHHHHHEEEEE
MSTDYVFDGRAAPYRETDPPAPLNAYGRSKADGEAALLDASARACVLRLPLLYGPVFGWG
EECCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHEEHHHHHCCCCCCC
DSAVTSLVPPVVASAQPGAAAADMDAWAIRYPTWTPDVAYVITQLVARHAAGEAVTGRCH
CHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
WSGDEPMTKHEIATRIGRALGLRPRLNAIAEPRDATPRPYDCHLDSTRLEALGIGRRTRF
ECCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCEECCCCCHHHHHHCCCCHHHH
DAAIREVLRDGPAI
HHHHHHHHHCCCCC
>Mature Secondary Structure
MNLALIGASGLLGRAVAAALAPRREWRLVATVRDPHGAPARAAARLAGLGPDALTPLDVL
CCEEEEECCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHH
DARALDRFFAEHRPDAVIVCAAERRPDVCEHEPAAARAINVEALAALAARADALGAWTLA
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHEECHHHHHHHHHHHHHHHEEEEE
MSTDYVFDGRAAPYRETDPPAPLNAYGRSKADGEAALLDASARACVLRLPLLYGPVFGWG
EECCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHEEHHHHHCCCCCCC
DSAVTSLVPPVVASAQPGAAAADMDAWAIRYPTWTPDVAYVITQLVARHAAGEAVTGRCH
CHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
WSGDEPMTKHEIATRIGRALGLRPRLNAIAEPRDATPRPYDCHLDSTRLEALGIGRRTRF
ECCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCEECCCCCHHHHHHCCCCHHHH
DAAIREVLRDGPAI
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-methionine; H2O

Specific reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377; 10568751 [H]