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The map label for this gene is dltE [H]

Identifier: 238023663

GI number: 238023663

Start: 208358

End: 209140

Strand: Direct

Name: dltE [H]

Synonym: bglu_2g01840

Alternate gene names: 238023663

Gene position: 208358-209140 (Clockwise)

Preceding gene: 238023662

Following gene: 238023669

Centisome position: 7.37

GC content: 67.31

Gene sequence:

>783_bases
ATGAAGCTGAGCGGAAATACCGTCTTCATCACCGGCAGCACGTCGGGCATCGGGCGCGCGATGGCCGAAGCGCTCTATCG
GCGCGGCAACCAGGTGATCATCGCCAGCCGCCGCCGCGCGCTGCTCGACGAGATCGCGCGTGCCAACCCCGGCATCGACA
CGGTGGAGCTCGACATCGGCGACGCCGCTGGCATCCGGCGCGCCGCGCAGCAGGTGATCGAACGCCATCCGTCGTTGAAC
GTGGTCATCAACAACGCCGGCATCATGCCGTTCGACGACGCTGCCGGCGCGCTCGACGACGCTGCCGGCGCGCTCGACGA
CGAGCAGGCGGTGCGGCTCATCGACACCAACCTGCTCGGCCCGGTGCGCGTGAGCGCTGCGTTCGTCGGGCACCTGAAGC
GCCAGCCTGCCTCATATTTGATCAACAACAGCTCGGTGCTCGCCTATGTACCGCTTGCGGCGACCGCGCTGTATTCGGCG
ACCAAGGCGGCAATCCATTCCTACACGCTGTCGCAGCGGTTTGCGTTGCGCGATACCAGCGTGACGGTGCTCGAGATCGT
ACCGCCGTGGGTGGACACCGATCTTGTCCGCAAGAGCGGCGACCCGCGCGCGATGCCGCTCGATGCTTTCATTGCCGAGC
TGCTCGAGCGGCTCGAGACGGCCGAACACGAGGTGGTGGTGGAGGCAGCACGGGCGTTCCGCGACAATGCCGGCCCGCGC
GAGCACGGGCTCGTCGCGCAGTTCAACCAGGCGGTGGTCGAGAACCCGATTCCGGTGGCGTGA

Upstream 100 bases:

>100_bases
GCGATTTGCCGGCACCGCGTTATGCGGTGGCGCGATGAGGTGGTAAGGCGGAACTTTTCATCAAATCGATAGCTAACGGT
AAAACAGAGGATAACGAATC

Downstream 100 bases:

>100_bases
GCGCGACGGCGGCGCTGCAGCGCGGCTCGAATCGCAGCGGTCCCGGCTTGTCGGTCAGCTCGGACGCGGTCGCGGCACAT
TGCACCATGCCGCCCGACAG

Product: Short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKLSGNTVFITGSTSGIGRAMAEALYRRGNQVIIASRRRALLDEIARANPGIDTVELDIGDAAGIRRAAQQVIERHPSLN
VVINNAGIMPFDDAAGALDDAAGALDDEQAVRLIDTNLLGPVRVSAAFVGHLKRQPASYLINNSSVLAYVPLAATALYSA
TKAAIHSYTLSQRFALRDTSVTVLEIVPPWVDTDLVRKSGDPRAMPLDAFIAELLERLETAEHEVVVEAARAFRDNAGPR
EHGLVAQFNQAVVENPIPVA

Sequences:

>Translated_260_residues
MKLSGNTVFITGSTSGIGRAMAEALYRRGNQVIIASRRRALLDEIARANPGIDTVELDIGDAAGIRRAAQQVIERHPSLN
VVINNAGIMPFDDAAGALDDAAGALDDEQAVRLIDTNLLGPVRVSAAFVGHLKRQPASYLINNSSVLAYVPLAATALYSA
TKAAIHSYTLSQRFALRDTSVTVLEIVPPWVDTDLVRKSGDPRAMPLDAFIAELLERLETAEHEVVVEAARAFRDNAGPR
EHGLVAQFNQAVVENPIPVA
>Mature_260_residues
MKLSGNTVFITGSTSGIGRAMAEALYRRGNQVIIASRRRALLDEIARANPGIDTVELDIGDAAGIRRAAQQVIERHPSLN
VVINNAGIMPFDDAAGALDDAAGALDDEQAVRLIDTNLLGPVRVSAAFVGHLKRQPASYLINNSSVLAYVPLAATALYSA
TKAAIHSYTLSQRFALRDTSVTVLEIVPPWVDTDLVRKSGDPRAMPLDAFIAELLERLETAEHEVVVEAARAFRDNAGPR
EHGLVAQFNQAVVENPIPVA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG3967

COG function: function code M; Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=198, Percent_Identity=24.7474747474747, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI166795268, Length=258, Percent_Identity=26.3565891472868, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI31542939, Length=209, Percent_Identity=23.9234449760766, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI7705925, Length=197, Percent_Identity=28.9340101522843, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=209, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=26.9230769230769, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786812, Length=197, Percent_Identity=26.3959390862944, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082160, Length=198, Percent_Identity=25.7575757575758, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507613, Length=250, Percent_Identity=26.8, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32563809, Length=250, Percent_Identity=26.8, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323882, Length=211, Percent_Identity=27.0142180094787, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI23397609, Length=201, Percent_Identity=29.8507462686567, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24651139, Length=199, Percent_Identity=31.1557788944724, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358495, Length=202, Percent_Identity=26.2376237623762, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24647946, Length=229, Percent_Identity=31.8777292576419, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI45553409, Length=228, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24647948, Length=228, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27866; Mature: 27866

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSGNTVFITGSTSGIGRAMAEALYRRGNQVIIASRRRALLDEIARANPGIDTVELDIG
CCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCCCEEEEECC
DAAGIRRAAQQVIERHPSLNVVINNAGIMPFDDAAGALDDAAGALDDEQAVRLIDTNLLG
CHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCC
PVRVSAAFVGHLKRQPASYLINNSSVLAYVPLAATALYSATKAAIHSYTLSQRFALRDTS
HHHHHHHHHHHHHCCCHHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
VTVLEIVPPWVDTDLVRKSGDPRAMPLDAFIAELLERLETAEHEVVVEAARAFRDNAGPR
EEEEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EHGLVAQFNQAVVENPIPVA
CCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKLSGNTVFITGSTSGIGRAMAEALYRRGNQVIIASRRRALLDEIARANPGIDTVELDIG
CCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCCCEEEEECC
DAAGIRRAAQQVIERHPSLNVVINNAGIMPFDDAAGALDDAAGALDDEQAVRLIDTNLLG
CHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCC
PVRVSAAFVGHLKRQPASYLINNSSVLAYVPLAATALYSATKAAIHSYTLSQRFALRDTS
HHHHHHHHHHHHHCCCHHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
VTVLEIVPPWVDTDLVRKSGDPRAMPLDAFIAELLERLETAEHEVVVEAARAFRDNAGPR
EEEEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EHGLVAQFNQAVVENPIPVA
CCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377; 7797557 [H]