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The map label for this gene is tdh [H]

Identifier: 238023510

GI number: 238023510

Start: 10912

End: 11955

Strand: Direct

Name: tdh [H]

Synonym: bglu_2g00100

Alternate gene names: 238023510

Gene position: 10912-11955 (Clockwise)

Preceding gene: 238023509

Following gene: 238023513

Centisome position: 0.39

GC content: 67.05

Gene sequence:

>1044_bases
ATGAAGGCGCTGGCAAAGCTCGAACGAGGCCCCGGCCTCACGCTGACCGACGTGAAGATGCCCGAGGTCGGCCACAACGA
CGTGCTGATCCGGATCCGCCGCACGGCGATCTGCGGCACCGACATCCACATCTGGAAGTGGGACGACTGGGCGCAGAAGA
CGATCCCGGTGCCGATGCACGTCGGCCACGAATACGTCGGCGAGATCGTCGAGATGGGGCAGGAGGTGCGCGGCTTCGCG
ATCGGCGATCGCGTGTCGGGCGAAGGCCACATCACCTGCGGCTTCTGCCGCAACTGCCGCGCCGGGCGGCGGCACCTGTG
CCGCAACACGGTGGGGGTGGGCGTGAACCGCGAGGGCGCGTTCGCCGAATACCTGGCGATTCCGGCCTTCAACGCGTTCA
AGATCCCGCCCGAGATCTCCGACGATCTGGCCGCGATCTTCGATCCGTTCGGCAATGCCACGCACACCGCGCTGTCGTTC
AACCTGGTCGGCGAGGACGTGCTGATCACGGGCGCCGGGCCGATCGGCATCATGGCCGTGGCGATCGCGCGGCACGTGGG
CGCGCGCAACGTGGTGATCACCGACGTCAACGACTACCGGCTCGAACTCGCGCGCAAGATGGGCGCCACCCGCGCCGTGA
ACGTCTCGCGCGAGTCGCTGCGCGAGGTGATGCACGCGCTGCACATGACGGAAGGCTTCGACGTGGGCCTGGAGATGTCG
GGCGTGCCGAGCGCGTTTACGAGCCTGCTCGATGCGATGAACCACGGCGGCAAAGTGGCGCTGCTCGGCATTCCGCCCGC
GCAGACCGCGATCGACTGGAACCAGGTGATCTTCAAGGGGCTCGAGATCAAGGGCATTTACGGCCGCGAGATGTTCGAGA
CCTGGTACAAGATGGTGGCGATGCTGCAAAGCGGCCTCGACCTCTCGCCGATCCTCACCCACCGCTACGCGGTGGCCGAC
TACCAGCAGGCGTTCGCGTCGATGCTCTCGGGCGAGAGCGGCAAGGTGATCCTCGACTGGAGCACCGTGCCGGCCGCCGC
CTGA

Upstream 100 bases:

>100_bases
GCAGATGAGCGCGGCGCACACGCCCGAGCAGATCGACCGGGCCGTGGACGCCTTCGTGCGCGTGGGCAAGTCGCTCGGCG
TGATCTGAGGAGAAGGCACG

Downstream 100 bases:

>100_bases
GCCCTGCCGCCGGCATTTTTCATCGAGGCGCCGAGCCGGCGCGCTGCCGCCGTCGCGGCCTTTATCGCCGGCGCCCGCAC
GAGGCCAGCGTGACGAGGCG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKALAKLERGPGLTLTDVKMPEVGHNDVLIRIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFA
IGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSF
NLVGEDVLITGAGPIGIMAVAIARHVGARNVVITDVNDYRLELARKMGATRAVNVSRESLREVMHALHMTEGFDVGLEMS
GVPSAFTSLLDAMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPILTHRYAVAD
YQQAFASMLSGESGKVILDWSTVPAAA

Sequences:

>Translated_347_residues
MKALAKLERGPGLTLTDVKMPEVGHNDVLIRIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFA
IGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSF
NLVGEDVLITGAGPIGIMAVAIARHVGARNVVITDVNDYRLELARKMGATRAVNVSRESLREVMHALHMTEGFDVGLEMS
GVPSAFTSLLDAMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPILTHRYAVAD
YQQAFASMLSGESGKVILDWSTVPAAA
>Mature_347_residues
MKALAKLERGPGLTLTDVKMPEVGHNDVLIRIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFA
IGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSF
NLVGEDVLITGAGPIGIMAVAIARHVGARNVVITDVNDYRLELARKMGATRAVNVSRESLREVMHALHMTEGFDVGLEMS
GVPSAFTSLLDAMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPILTHRYAVAD
YQQAFASMLSGESGKVILDWSTVPAAA

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=341, Percent_Identity=27.8592375366569, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI4501929, Length=364, Percent_Identity=23.0769230769231, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI71743840, Length=373, Percent_Identity=24.3967828418231, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI262073058, Length=373, Percent_Identity=24.3967828418231, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=24.7282608695652, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=24.585635359116, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI71565154, Length=379, Percent_Identity=23.4828496042216, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=75.366568914956, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1788075, Length=367, Percent_Identity=28.3378746594005, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788073, Length=339, Percent_Identity=27.1386430678466, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1787863, Length=226, Percent_Identity=32.7433628318584, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082125, Length=353, Percent_Identity=30.3116147308782, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI226510992, Length=311, Percent_Identity=27.3311897106109, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788407, Length=334, Percent_Identity=27.2455089820359, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI87081918, Length=325, Percent_Identity=28.6153846153846, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1786825, Length=223, Percent_Identity=32.7354260089686, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1790718, Length=308, Percent_Identity=25.6493506493506, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1786552, Length=380, Percent_Identity=26.8421052631579, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1786518, Length=280, Percent_Identity=26.4285714285714, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=30.4477611940298, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17562878, Length=335, Percent_Identity=30.4477611940298, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71988145, Length=200, Percent_Identity=31.5, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=347, Percent_Identity=25.9365994236311, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=281, Percent_Identity=25.6227758007117, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=376, Percent_Identity=24.468085106383, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=362, Percent_Identity=24.8618784530387, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=327, Percent_Identity=29.6636085626911, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322619, Length=322, Percent_Identity=27.3291925465839, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=322, Percent_Identity=27.0186335403727, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6319258, Length=299, Percent_Identity=27.7591973244147, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=294, Percent_Identity=27.2108843537415, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319621, Length=340, Percent_Identity=28.5294117647059, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=364, Percent_Identity=24.4505494505494, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=309, Percent_Identity=30.0970873786408, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=351, Percent_Identity=27.9202279202279, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=308, Percent_Identity=27.9220779220779, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=288, Percent_Identity=28.4722222222222, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319949, Length=350, Percent_Identity=26.2857142857143, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737897, Length=330, Percent_Identity=27.2727272727273, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17137530, Length=323, Percent_Identity=26.0061919504644, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17737895, Length=378, Percent_Identity=26.4550264550265, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45551930, Length=168, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45550770, Length=168, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221457811, Length=168, Percent_Identity=29.1666666666667, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37811; Mature: 37811

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALAKLERGPGLTLTDVKMPEVGHNDVLIRIRRTAICGTDIHIWKWDDWAQKTIPVPMH
CCHHHHHHCCCCCEEEECCCCCCCCCCEEEEEEEEEEECCCEEEEECCCHHHCCCCCCHH
VGHEYVGEIVEMGQEVRGFAIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGA
CCHHHHHHHHHHHHHHCCEEECCEECCCCCEEEHHHHCCHHHHHHHHHHHHCCCCCCCCC
FAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNLVGEDVLITGAGPIGIMAV
HHHHHHCCCCCCEECCCCCCHHHHHHHCCCCCCEEEEEEEEEECCEEEEECCCHHHHHHH
AIARHVGARNVVITDVNDYRLELARKMGATRAVNVSRESLREVMHALHMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCCCCEECC
GVPSAFTSLLDAMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVA
CCCHHHHHHHHHHCCCCEEEEEECCCCCHHCCHHHHHHCCCEEEEECCHHHHHHHHHHHH
MLQSGLDLSPILTHRYAVADYQQAFASMLSGESGKVILDWSTVPAAA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MKALAKLERGPGLTLTDVKMPEVGHNDVLIRIRRTAICGTDIHIWKWDDWAQKTIPVPMH
CCHHHHHHCCCCCEEEECCCCCCCCCCEEEEEEEEEEECCCEEEEECCCHHHCCCCCCHH
VGHEYVGEIVEMGQEVRGFAIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGA
CCHHHHHHHHHHHHHHCCEEECCEECCCCCEEEHHHHCCHHHHHHHHHHHHCCCCCCCCC
FAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNLVGEDVLITGAGPIGIMAV
HHHHHHCCCCCCEECCCCCCHHHHHHHCCCCCCEEEEEEEEEECCEEEEECCCHHHHHHH
AIARHVGARNVVITDVNDYRLELARKMGATRAVNVSRESLREVMHALHMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCCCCEECC
GVPSAFTSLLDAMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVA
CCCHHHHHHHHHHCCCCEEEEEECCCCCHHCCHHHHHHCCCEEEEECCHHHHHHHHHHHH
MLQSGLDLSPILTHRYAVADYQQAFASMLSGESGKVILDWSTVPAAA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA