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The map label for this gene is kbl [C]

Identifier: 238023509

GI number: 238023509

Start: 9700

End: 10899

Strand: Direct

Name: kbl [C]

Synonym: bglu_2g00090

Alternate gene names: 238023509

Gene position: 9700-10899 (Clockwise)

Preceding gene: 238023505

Following gene: 238023510

Centisome position: 0.34

GC content: 70.5

Gene sequence:

>1200_bases
ATGCGTGATGCCTTCCTCGCCCACGTGCGCGGGACCCTCGACCAGATCCGCGCCGACGGTTTCTACAAGACCGAGCGCGA
GATCGCCAGCCCGCAGGCGGCGGCCGTGACGCTGGCCGACGGCGCCGGCGTGCTCAATTTCTGCGCCAACAACTACCTCG
GCCTCGCCAACGACGCGCGGCTCGTCGCGGCCGCGCGCGCGGGCCTCGAGCGCGACGGCTTCGGCATGGCGTCGGTGCGC
TTCATCTGCGGCACGCAGACGGTCCACAAGCGGCTCGAGGCGGCGATCTCGGCATTCCTCGGCACCGACGACACGATCCT
CTATTCGAGCTGCTTCGACGCGAACGGCGGCCTGTTCGAGACGCTGCTCGGCGAGGAGGACGCGATCATCAGCGACGAGC
TGAACCACGCCAGCATCATCGACGGCGTGCGGCTGTCGAAAGCCAAACGGTTTCGTTACAAGAACAACGACCTGCGGGAC
CTGGAGGCGAAGCTGCAGGAGGCCGACGCGGCCGGCGCGCGCTTCAAGCTGGTGGCCACCGACGGCGTGTTCTCGATGGA
CGGCATCATCGCCGACCTGAAGGGCATCTGCGAGCTGGCCGAGCGCTACGGCGCGCTGGTGATGGTCGACGATTCGCACG
CGGTCGGCTTCATCGGCGAGCACGGCCGCGGCACGCCCGAGTATTGCGGCGTGGCCGACCGCGTCGACATCGTCACCGGC
ACGCTCGGCAAGGCGCTCGGCGGCGCCTCGGGCGGCTATGTGGCCGCGCGCAGGGAGATCGTCGAGCTGCTGCGCCAGCG
TTCGCGCCCGTACCTGTTCTCGAACACGCTCGCGCCGAGCATCGCCGAAGCCTCGCTCGCCGTGCTCGAACTGCTCGCGA
GCGACGAGGGCGCGCGGCTGCGCGCGCAGGTGCGCGAGAACGGCGCGCGGTTTCGCGCGAAGATGAGCGCGGCCGGCTTC
ACGCTGGTGCCGGGCGAGCATCCGATCATCCCGGTGATGCTCGGCGACGCGCAGGTGGCCACGCGCATGGCCGACGCGCT
GCTGGCCGAGGGCGTCTACGTGATCGGCTTCTCGTTCCCGGTGGTGCCGCGCGGGCGCGCGCGGATCCGCACGCAGATGA
GCGCGGCGCACACGCCCGAGCAGATCGACCGGGCCGTGGACGCCTTCGTGCGCGTGGGCAAGTCGCTCGGCGTGATCTGA

Upstream 100 bases:

>100_bases
ATACGTTAAACCCGACGGGCGACTATAACAGTAGCAGGCCGTGCGGCGGCCGCCACGAGCGAGGGCACCGCGCGCCGATT
GCCCTCCCAGGAGCGAACAG

Downstream 100 bases:

>100_bases
GGAGAAGGCACGATGAAGGCGCTGGCAAAGCTCGAACGAGGCCCCGGCCTCACGCTGACCGACGTGAAGATGCCCGAGGT
CGGCCACAACGACGTGCTGA

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MRDAFLAHVRGTLDQIRADGFYKTEREIASPQAAAVTLADGAGVLNFCANNYLGLANDARLVAAARAGLERDGFGMASVR
FICGTQTVHKRLEAAISAFLGTDDTILYSSCFDANGGLFETLLGEEDAIISDELNHASIIDGVRLSKAKRFRYKNNDLRD
LEAKLQEADAAGARFKLVATDGVFSMDGIIADLKGICELAERYGALVMVDDSHAVGFIGEHGRGTPEYCGVADRVDIVTG
TLGKALGGASGGYVAARREIVELLRQRSRPYLFSNTLAPSIAEASLAVLELLASDEGARLRAQVRENGARFRAKMSAAGF
TLVPGEHPIIPVMLGDAQVATRMADALLAEGVYVIGFSFPVVPRGRARIRTQMSAAHTPEQIDRAVDAFVRVGKSLGVI

Sequences:

>Translated_399_residues
MRDAFLAHVRGTLDQIRADGFYKTEREIASPQAAAVTLADGAGVLNFCANNYLGLANDARLVAAARAGLERDGFGMASVR
FICGTQTVHKRLEAAISAFLGTDDTILYSSCFDANGGLFETLLGEEDAIISDELNHASIIDGVRLSKAKRFRYKNNDLRD
LEAKLQEADAAGARFKLVATDGVFSMDGIIADLKGICELAERYGALVMVDDSHAVGFIGEHGRGTPEYCGVADRVDIVTG
TLGKALGGASGGYVAARREIVELLRQRSRPYLFSNTLAPSIAEASLAVLELLASDEGARLRAQVRENGARFRAKMSAAGF
TLVPGEHPIIPVMLGDAQVATRMADALLAEGVYVIGFSFPVVPRGRARIRTQMSAAHTPEQIDRAVDAFVRVGKSLGVI
>Mature_399_residues
MRDAFLAHVRGTLDQIRADGFYKTEREIASPQAAAVTLADGAGVLNFCANNYLGLANDARLVAAARAGLERDGFGMASVR
FICGTQTVHKRLEAAISAFLGTDDTILYSSCFDANGGLFETLLGEEDAIISDELNHASIIDGVRLSKAKRFRYKNNDLRD
LEAKLQEADAAGARFKLVATDGVFSMDGIIADLKGICELAERYGALVMVDDSHAVGFIGEHGRGTPEYCGVADRVDIVTG
TLGKALGGASGGYVAARREIVELLRQRSRPYLFSNTLAPSIAEASLAVLELLASDEGARLRAQVRENGARFRAKMSAAGF
TLVPGEHPIIPVMLGDAQVATRMADALLAEGVYVIGFSFPVVPRGRARIRTQMSAAHTPEQIDRAVDAFVRVGKSLGVI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=393, Percent_Identity=55.9796437659033, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI284448556, Length=418, Percent_Identity=52.3923444976077, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI83977442, Length=357, Percent_Identity=34.733893557423, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI83977440, Length=357, Percent_Identity=34.733893557423, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI83977444, Length=357, Percent_Identity=34.733893557423, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4502025, Length=355, Percent_Identity=34.0845070422535, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI40316939, Length=355, Percent_Identity=34.0845070422535, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI4758668, Length=368, Percent_Identity=32.6086956521739, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI119220554, Length=369, Percent_Identity=32.7913279132791, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI5454084, Length=279, Percent_Identity=28.3154121863799, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1790046, Length=399, Percent_Identity=68.1704260651629, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI1786993, Length=353, Percent_Identity=33.7110481586402, Blast_Score=190, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71994529, Length=400, Percent_Identity=55, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=30.6233062330623, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17560914, Length=398, Percent_Identity=31.1557788944724, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17560912, Length=398, Percent_Identity=31.1557788944724, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71982617, Length=374, Percent_Identity=25.668449197861, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=374, Percent_Identity=25.668449197861, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=368, Percent_Identity=33.1521739130435, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=28.5326086956522, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323954, Length=268, Percent_Identity=27.6119402985075, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24662918, Length=399, Percent_Identity=56.140350877193, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI17137420, Length=385, Percent_Identity=30.3896103896104, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=30.8108108108108, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24653280, Length=382, Percent_Identity=26.7015706806283, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24653276, Length=382, Percent_Identity=26.7015706806283, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24653278, Length=382, Percent_Identity=26.7015706806283, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42608; Mature: 42608

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAFLAHVRGTLDQIRADGFYKTEREIASPQAAAVTLADGAGVLNFCANNYLGLANDAR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEECCCCHHHHHHCCCCCCCCCHH
LVAAARAGLERDGFGMASVRFICGTQTVHKRLEAAISAFLGTDDTILYSSCFDANGGLFE
HHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHH
TLLGEEDAIISDELNHASIIDGVRLSKAKRFRYKNNDLRDLEAKLQEADAAGARFKLVAT
HHCCCCCCEECCCCCCHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEE
DGVFSMDGIIADLKGICELAERYGALVMVDDSHAVGFIGEHGRGTPEYCGVADRVDIVTG
CCCEEHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCHHHCCCCCCHHHHHH
TLGKALGGASGGYVAARREIVELLRQRSRPYLFSNTLAPSIAEASLAVLELLASDEGARL
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHH
RAQVRENGARFRAKMSAAGFTLVPGEHPIIPVMLGDAQVATRMADALLAEGVYVIGFSFP
HHHHHHCCHHEEEECCCCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEEECC
VVPRGRARIRTQMSAAHTPEQIDRAVDAFVRVGKSLGVI
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRDAFLAHVRGTLDQIRADGFYKTEREIASPQAAAVTLADGAGVLNFCANNYLGLANDAR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEECCCCHHHHHHCCCCCCCCCHH
LVAAARAGLERDGFGMASVRFICGTQTVHKRLEAAISAFLGTDDTILYSSCFDANGGLFE
HHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHH
TLLGEEDAIISDELNHASIIDGVRLSKAKRFRYKNNDLRDLEAKLQEADAAGARFKLVAT
HHCCCCCCEECCCCCCHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEE
DGVFSMDGIIADLKGICELAERYGALVMVDDSHAVGFIGEHGRGTPEYCGVADRVDIVTG
CCCEEHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCHHHCCCCCCHHHHHH
TLGKALGGASGGYVAARREIVELLRQRSRPYLFSNTLAPSIAEASLAVLELLASDEGARL
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHH
RAQVRENGARFRAKMSAAGFTLVPGEHPIIPVMLGDAQVATRMADALLAEGVYVIGFSFP
HHHHHHCCHHEEEECCCCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEEECC
VVPRGRARIRTQMSAAHTPEQIDRAVDAFVRVGKSLGVI
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]