Click here to switch to the map view.

The map label for this gene is gyrB [H]

Identifier: 237814478

GI number: 237814478

Start: 4093216

End: 4095684

Strand: Reverse

Name: gyrB [H]

Synonym: GBP346_A4276

Alternate gene names: 237814478

Gene position: 4095684-4093216 (Counterclockwise)

Preceding gene: 237814479

Following gene: 237814474

Centisome position: 99.93

GC content: 64.32

Gene sequence:

>2469_bases
ATGACTGAACAGCATAATTCGCAGCCCGAAAATAGCTACGGCGCGTCGTCGATCCAGATCCTCGAAGGCCTGGAAGCGGT
GCGCAAGCGACCCGGGATGTACATCGGCGACACGTCGGACGGCACCGGTCTGCACCACCTCGTGTTCGAGGTGCTCGACA
ACTCGATCGACGAGGCGCTCGCCGGCTACTGCAACGACATCCACGTGACCATACACGCGGACAATTCGATCTCCGTGACC
GACAACGGCCGCGGCATCCCGACCGACGTCAAGCTCAACGACAAGCACGAGCCGAAGCGCTCGGCCGCCGAAATCGTGAT
GACCGAGCTGCATGCGGGCGGCAAGTTCGACCAGAACAGCTACAAGGTGTCGGGCGGCCTGCACGGCGTCGGCGTGTCGT
GCGTGAACGCGCTCTCGAGCTGGCTGCGCCTCATCGTGCGCCGCGATGGCAAGAAGCACTTCATGGAATTCCATCGCGGC
ATCGCGCAGAACCGCGTGCTCGAGGAGCGCGACGGCGAGCAGGTCTCGCCGATGCAGGTGATCGGCGAGACCGAGAACCG
CGGCACCGAAGTGCACTTCATGGCCGATCCGACGATCTTCGGCACCGTCGAATACCACTACGACATTCTCGCGAAGCGCA
TCCGCGAGCTCTCGTTCCTGAACAACGGCGTGCGCATCCGCCTGACCGACCTGCGCTCCGGCAAGGAAGACGATTTCGCG
TTCGCGGGCGGCGTGAAGGGCTTCGTCGAGTACATCAACAAGACGAAGAGCGTGCTGCACCCGACGATCTTCCACATCAA
CGGCGAGAAGGACAGCGTGGGCGTGGAAGTAGCGATGCAGTGGAACGACAGCTACAACGAAAACGTGCTGTGCTTCACGA
ACAACATCCCGCAGCGCGACGGCGGCACGCACTTGACCGGCCTGCGCGCGGCGATGACGCGCGTGATCAACAAGTACATC
GCCGACAACGAGATCGCGAAGAAGGCGAAGGTCGAGACGACCGGCGACGACATGCGCGAAGGGCTTTCGTGCGTGCTCTC
CGTGAAGGTGCCGGAGCCGAAGTTCAGCTCGCAGACGAAGGACAAGCTGGTTTCGTCCGAAGTGCGCGCGCCGGTGGAGG
AAGTGGTGGCGAAGGCGCTCGAGGAGTTTCTGCTCGAAACGCCGAACGACGCGAAGATCATCTGCGGCAAGATCGTCGAA
GCGGCGCGCGCGCGCGATGCCGCGCGCAAGGCGCGCGAGATGACGCGCCGCAAGGGCGTGCTCGACGGCGTGGGCCTGCC
GGGCAAGCTCGCGGACTGCCAGGAGAAGGACCCGGCGAAGTCGGAAATCTACATTGTCGAGGGCGACTCGGCGGGCGGCT
CAGCCAAGCAGGGGCGCGACCGCAAGTTCCAGGCGATCCTGCCGCTGCGCGGCAAGGTGCTGAACGTCGAGAAGGCGCGC
TACGACAAGCTGCTGTCGTCCGAGCAGATCGTCACGCTCGTGACCGCGCTCGGCTGCGGGATCGGCAAGGACGACTACAA
CCTCGACAAGCTGCGCTACCACCGGATCATCATCATGACCGATGCGGACGTGGACGGCGCGCACATCCGCACGCTGCTGC
TGACGTTCTTCTACCGGCAGATGCCGGAGATGATCGAGCGCGGCTACGTGTACATCGCGCAGCCGCCGCTTTACAAGGTG
AAGGCGGGCCGCGACGAGCGCTACCTGAAGGACGACACCGAGCTGAACGCGCACATGCTGCGCCTCGCGCTGCAGGGCTC
GGAGCTCGTGCCGACCGAGAACGGCACGCCGATCTCGGGCGACGCGCTCGGCGAGCTCGCGCGCTCGTATCTGCTCGCGC
GGGGCGTGGTGGAGCGGTTGAGCCGCCTGTACGACCCGGCCGCGCTCGAGGCGGTCATGGACGGTGTCGCGATCGATCTG
TCGAGCGAGGCATCGACGGAGGCGTCGGCGAAGGCGCTGGCCGCCATGCTATCCGACGATTCGAAGACCGAAGTGCGCGT
CGTGCCGGCTTACGATGCGGTACGCGAGCAGCGCTCGCTGCGCGTGGAGCGCACGCATCACGGCAACGTGCGCGTATCGG
TGATCGACGAGGAATTCCAGCACACGGCCGATTATCAGCAGCTCGTGAACACCGCGAATACGTTCAAGGGCTTGATCGGC
GCGGGGGCGGCGATCAAGCGCGGCGAGCGGAGCTCGAACGTGACGGACTTCAAGGAAGCGATGAAGTGGCTGATGGCCGA
CGCCGAGCGGAACCTGTCTAAGCAGCGGTATAAGGGATTGGGCGAGATGAACCCCGAGCAGCTGTGGGAAACGACGATGG
ACCCGGCGGTGCGGCGGTTGCTGCGCGTGCAGATCGAGGATGCGATTGCGGCCGATGGGATCTTTACCACCCTCATGGGG
GATGAGGTCGAGCCGCGTAGGGCGTTTATCGAGAATAATGCGCTAAGGGCGGGGAATATTGATGTTTGA

Upstream 100 bases:

>100_bases
GCCGGCCCCCGAAAGGGGCGAAAAACCCGAGGCGGCCCGGTTTTTTCGGCGGAAGCACCCCGCCGCCACTCGAGTAGCCC
AGCAGAACCGGAAGACATCC

Downstream 100 bases:

>100_bases
GGTTGTCGGTTGCCACAGAAAGTGAAAAGCTCCGATCAAAGTAGAAAGCAAACGCCCGGTGCTACCGGGCGTTTGCTTTT
GATGTAGTGAATAGTCTGAC

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 822; Mature: 821

Protein sequence:

>822_residues
MTEQHNSQPENSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEALAGYCNDIHVTIHADNSISVT
DNGRGIPTDVKLNDKHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLRLIVRRDGKKHFMEFHRG
IAQNRVLEERDGEQVSPMQVIGETENRGTEVHFMADPTIFGTVEYHYDILAKRIRELSFLNNGVRIRLTDLRSGKEDDFA
FAGGVKGFVEYINKTKSVLHPTIFHINGEKDSVGVEVAMQWNDSYNENVLCFTNNIPQRDGGTHLTGLRAAMTRVINKYI
ADNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVE
AARARDAARKAREMTRRKGVLDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKAR
YDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPEMIERGYVYIAQPPLYKV
KAGRDERYLKDDTELNAHMLRLALQGSELVPTENGTPISGDALGELARSYLLARGVVERLSRLYDPAALEAVMDGVAIDL
SSEASTEASAKALAAMLSDDSKTEVRVVPAYDAVREQRSLRVERTHHGNVRVSVIDEEFQHTADYQQLVNTANTFKGLIG
AGAAIKRGERSSNVTDFKEAMKWLMADAERNLSKQRYKGLGEMNPEQLWETTMDPAVRRLLRVQIEDAIAADGIFTTLMG
DEVEPRRAFIENNALRAGNIDV

Sequences:

>Translated_822_residues
MTEQHNSQPENSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEALAGYCNDIHVTIHADNSISVT
DNGRGIPTDVKLNDKHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLRLIVRRDGKKHFMEFHRG
IAQNRVLEERDGEQVSPMQVIGETENRGTEVHFMADPTIFGTVEYHYDILAKRIRELSFLNNGVRIRLTDLRSGKEDDFA
FAGGVKGFVEYINKTKSVLHPTIFHINGEKDSVGVEVAMQWNDSYNENVLCFTNNIPQRDGGTHLTGLRAAMTRVINKYI
ADNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVE
AARARDAARKAREMTRRKGVLDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKAR
YDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPEMIERGYVYIAQPPLYKV
KAGRDERYLKDDTELNAHMLRLALQGSELVPTENGTPISGDALGELARSYLLARGVVERLSRLYDPAALEAVMDGVAIDL
SSEASTEASAKALAAMLSDDSKTEVRVVPAYDAVREQRSLRVERTHHGNVRVSVIDEEFQHTADYQQLVNTANTFKGLIG
AGAAIKRGERSSNVTDFKEAMKWLMADAERNLSKQRYKGLGEMNPEQLWETTMDPAVRRLLRVQIEDAIAADGIFTTLMG
DEVEPRRAFIENNALRAGNIDV
>Mature_821_residues
TEQHNSQPENSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEALAGYCNDIHVTIHADNSISVTD
NGRGIPTDVKLNDKHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLRLIVRRDGKKHFMEFHRGI
AQNRVLEERDGEQVSPMQVIGETENRGTEVHFMADPTIFGTVEYHYDILAKRIRELSFLNNGVRIRLTDLRSGKEDDFAF
AGGVKGFVEYINKTKSVLHPTIFHINGEKDSVGVEVAMQWNDSYNENVLCFTNNIPQRDGGTHLTGLRAAMTRVINKYIA
DNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVEA
ARARDAARKAREMTRRKGVLDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKARY
DKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPEMIERGYVYIAQPPLYKVK
AGRDERYLKDDTELNAHMLRLALQGSELVPTENGTPISGDALGELARSYLLARGVVERLSRLYDPAALEAVMDGVAIDLS
SEASTEASAKALAAMLSDDSKTEVRVVPAYDAVREQRSLRVERTHHGNVRVSVIDEEFQHTADYQQLVNTANTFKGLIGA
GAAIKRGERSSNVTDFKEAMKWLMADAERNLSKQRYKGLGEMNPEQLWETTMDPAVRRLLRVQIEDAIAADGIFTTLMGD
EVEPRRAFIENNALRAGNIDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=558, Percent_Identity=24.1935483870968, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI19913408, Length=573, Percent_Identity=23.9092495636998, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI48994957, Length=818, Percent_Identity=59.2909535452323, Blast_Score=952, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=561, Percent_Identity=37.4331550802139, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17535065, Length=604, Percent_Identity=23.841059602649, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI212645845, Length=518, Percent_Identity=24.3243243243243, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI212645657, Length=155, Percent_Identity=30.9677419354839, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=608, Percent_Identity=24.0131578947368, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17136538, Length=554, Percent_Identity=23.2851985559567, Blast_Score=108, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91117; Mature: 90986

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQHNSQPENSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEAL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
AGYCNDIHVTIHADNSISVTDNGRGIPTDVKLNDKHEPKRSAAEIVMTELHAGGKFDQNS
HHCCCEEEEEEEECCEEEECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCC
YKVSGGLHGVGVSCVNALSSWLRLIVRRDGKKHFMEFHRGIAQNRVLEERDGEQVSPMQV
EEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCHHH
IGETENRGTEVHFMADPTIFGTVEYHYDILAKRIRELSFLNNGVRIRLTDLRSGKEDDFA
CCCCCCCCCEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
FAGGVKGFVEYINKTKSVLHPTIFHINGEKDSVGVEVAMQWNDSYNENVLCFTNNIPQRD
HHCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCCC
GGTHLTGLRAAMTRVINKYIADNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQTK
CCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHCCEEEEEECCCCCCCCHHH
DKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVEAARARDAARKAREMTRRKGV
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKAR
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCEECHHHHH
YDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQ
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHH
MPEMIERGYVYIAQPPLYKVKAGRDERYLKDDTELNAHMLRLALQGSELVPTENGTPISG
HHHHHHCCEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCH
DALGELARSYLLARGVVERLSRLYDPAALEAVMDGVAIDLSSEASTEASAKALAAMLSDD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCC
SKTEVRVVPAYDAVREQRSLRVERTHHGNVRVSVIDEEFQHTADYQQLVNTANTFKGLIG
CCCEEEEEECHHHHHHHHHCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AGAAIKRGERSSNVTDFKEAMKWLMADAERNLSKQRYKGLGEMNPEQLWETTMDPAVRRL
CCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LRVQIEDAIAADGIFTTLMGDEVEPRRAFIENNALRAGNIDV
HHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TEQHNSQPENSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEAL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
AGYCNDIHVTIHADNSISVTDNGRGIPTDVKLNDKHEPKRSAAEIVMTELHAGGKFDQNS
HHCCCEEEEEEEECCEEEECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCC
YKVSGGLHGVGVSCVNALSSWLRLIVRRDGKKHFMEFHRGIAQNRVLEERDGEQVSPMQV
EEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCHHH
IGETENRGTEVHFMADPTIFGTVEYHYDILAKRIRELSFLNNGVRIRLTDLRSGKEDDFA
CCCCCCCCCEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
FAGGVKGFVEYINKTKSVLHPTIFHINGEKDSVGVEVAMQWNDSYNENVLCFTNNIPQRD
HHCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCCC
GGTHLTGLRAAMTRVINKYIADNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQTK
CCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHCCEEEEEECCCCCCCCHHH
DKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVEAARARDAARKAREMTRRKGV
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKAR
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCEECHHHHH
YDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQ
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHH
MPEMIERGYVYIAQPPLYKVKAGRDERYLKDDTELNAHMLRLALQGSELVPTENGTPISG
HHHHHHCCEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCH
DALGELARSYLLARGVVERLSRLYDPAALEAVMDGVAIDLSSEASTEASAKALAAMLSDD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCC
SKTEVRVVPAYDAVREQRSLRVERTHHGNVRVSVIDEEFQHTADYQQLVNTANTFKGLIG
CCCEEEEEECHHHHHHHHHCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AGAAIKRGERSSNVTDFKEAMKWLMADAERNLSKQRYKGLGEMNPEQLWETTMDPAVRRL
CCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LRVQIEDAIAADGIFTTLMGDEVEPRRAFIENNALRAGNIDV
HHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1906260 [H]