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The map label for this gene is mlaA [H]

Identifier: 237814074

GI number: 237814074

Start: 3709327

End: 3710337

Strand: Reverse

Name: mlaA [H]

Synonym: GBP346_A3859

Alternate gene names: 237814074

Gene position: 3710337-3709327 (Counterclockwise)

Preceding gene: 237814075

Following gene: 237814073

Centisome position: 90.53

GC content: 69.93

Gene sequence:

>1011_bases
GTGAACGCCGCGCAAGCGGCATACGAGAGAAGAAAAGAGGGGAAGAACATCATGCAGACGATCCGCATCAGCCCAGCGGT
GCTGGCGATCACGGCCGCCGCGGCATTGAGCGGTTGCGCGACAGTCCAGACGCCGACCAAGGGCGACCCGTTCGAAGGCT
TCAACCGGACGATGTACACGTTCAACGACAAGGTCGACCAGTACGCGCTCAAGCCGGTCGCGCGCGGCTATCAGTGGGCG
GTGCCGCAGCCGATGCGCGACAGCGTGACGAACTTCTTCTCGAACATCGGCGACGTCTACATCGCCGCGAACAACCTCGT
GCAGCTGAAGATCGCCGACGGCGTCGGCGACATCATGCGGGTCGTGATCAACACGGTGTTCGGCGTGGGCGGCCTGTTCG
ACGTCGCGACGCTCGCGAAGCTGCCGAAACACGCGAACGACTTCGGCGTGACGCTCGGCCACTACGGCGTGCCGAGCGGC
CCGTACCTCGTGCTGCCGCTGCTCGGCCCGAGCACCGTGCGCGACACGGCGGGCCTCGCCGTCGACTACGCGGGCAACCC
GCTTACCTATGTACGGCCCGACGGCGTGAGCTGGGGCCTGTTCGGGCTGAACCTCGTGAACACGCGCGCGAACCTGCTCG
GCGCGGGCGACGTGCTCGAGGCAGCCGCGATCGACAAGTATTCGTTCGTGCGCAACGCGTACCTGCAGCGCCGCCAGGCG
CTGATCGGCGGCGCCACGGGCGCGCAGTCGAACCTGCCGGATTACGGCAGCGAGGCGCCGCCGCCGAATTACGAGATGCC
GGAAGAGGGCGCCGCGGCGCCCGCGAGCGGCGCGGCATCGGCGCCGGCCGCCGCTTCCGCGCCCACGGCGGCGTCCGGTG
CGGCGCCGGGCGCGGCCGAGCCCGCATCGGCCGCGGCGCCGAATCCGAGCAGCGCGACGAACGTGCCCGCTCAGCAGGTC
GTGCCGCCGTCGCCGGGCGGCATCCGTTTCCCGAGCATCCGGCTGCACTGA

Upstream 100 bases:

>100_bases
AGGCCGCGGACGCGGGCGGCGCGAAGCCGGGCGCCGCCGCATCGGGCGCGCCGGCGCCCGCGCCGGTGGCGGCATCGGCG
GCATCGGGCGCGGCGGCACA

Downstream 100 bases:

>100_bases
CCCGACACTTACATCGGTTACAGCCGGAAACGATTCTGACGGCGGCCGGCGCGAACTTGCGCCGGCGTCGACGGTTCCAA
GTCTGGCATCGACTCATACA

Product: lipoprotein, VacJ family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MNAAQAAYERRKEGKNIMQTIRISPAVLAITAAAALSGCATVQTPTKGDPFEGFNRTMYTFNDKVDQYALKPVARGYQWA
VPQPMRDSVTNFFSNIGDVYIAANNLVQLKIADGVGDIMRVVINTVFGVGGLFDVATLAKLPKHANDFGVTLGHYGVPSG
PYLVLPLLGPSTVRDTAGLAVDYAGNPLTYVRPDGVSWGLFGLNLVNTRANLLGAGDVLEAAAIDKYSFVRNAYLQRRQA
LIGGATGAQSNLPDYGSEAPPPNYEMPEEGAAAPASGAASAPAAASAPTAASGAAPGAAEPASAAAPNPSSATNVPAQQV
VPPSPGGIRFPSIRLH

Sequences:

>Translated_336_residues
MNAAQAAYERRKEGKNIMQTIRISPAVLAITAAAALSGCATVQTPTKGDPFEGFNRTMYTFNDKVDQYALKPVARGYQWA
VPQPMRDSVTNFFSNIGDVYIAANNLVQLKIADGVGDIMRVVINTVFGVGGLFDVATLAKLPKHANDFGVTLGHYGVPSG
PYLVLPLLGPSTVRDTAGLAVDYAGNPLTYVRPDGVSWGLFGLNLVNTRANLLGAGDVLEAAAIDKYSFVRNAYLQRRQA
LIGGATGAQSNLPDYGSEAPPPNYEMPEEGAAAPASGAASAPAAASAPTAASGAAPGAAEPASAAAPNPSSATNVPAQQV
VPPSPGGIRFPSIRLH
>Mature_336_residues
MNAAQAAYERRKEGKNIMQTIRISPAVLAITAAAALSGCATVQTPTKGDPFEGFNRTMYTFNDKVDQYALKPVARGYQWA
VPQPMRDSVTNFFSNIGDVYIAANNLVQLKIADGVGDIMRVVINTVFGVGGLFDVATLAKLPKHANDFGVTLGHYGVPSG
PYLVLPLLGPSTVRDTAGLAVDYAGNPLTYVRPDGVSWGLFGLNLVNTRANLLGAGDVLEAAAIDKYSFVRNAYLQRRQA
LIGGATGAQSNLPDYGSEAPPPNYEMPEEGAAAPASGAASAPAAASAPTAASGAAPGAAEPASAAAPNPSSATNVPAQQV
VPPSPGGIRFPSIRLH

Specific function: Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane [H]

COG id: COG2853

COG function: function code M; Surface lipoprotein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mlaA family [H]

Homologues:

Organism=Escherichia coli, GI1788688, Length=258, Percent_Identity=37.2093023255814, Blast_Score=135, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007428 [H]

Pfam domain/function: PF04333 VacJ [H]

EC number: NA

Molecular weight: Translated: 34751; Mature: 34751

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAAQAAYERRKEGKNIMQTIRISPAVLAITAAAALSGCATVQTPTKGDPFEGFNRTMYT
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEE
FNDKVDQYALKPVARGYQWAVPQPMRDSVTNFFSNIGDVYIAANNLVQLKIADGVGDIMR
ECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCEEEEEECCCHHHHHH
VVINTVFGVGGLFDVATLAKLPKHANDFGVTLGHYGVPSGPYLVLPLLGPSTVRDTAGLA
HHHHHHHCCCHHHHHHHHHHHCCCCCHHCEEECCCCCCCCCEEEEECCCCCHHHHCCCEE
VDYAGNPLTYVRPDGVSWGLFGLNLVNTRANLLGAGDVLEAAAIDKYSFVRNAYLQRRQA
EEECCCCEEEECCCCCEECHHHEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LIGGATGAQSNLPDYGSEAPPPNYEMPEEGAAAPASGAASAPAAASAPTAASGAAPGAAE
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PASAAAPNPSSATNVPAQQVVPPSPGGIRFPSIRLH
CCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCEEEC
>Mature Secondary Structure
MNAAQAAYERRKEGKNIMQTIRISPAVLAITAAAALSGCATVQTPTKGDPFEGFNRTMYT
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEE
FNDKVDQYALKPVARGYQWAVPQPMRDSVTNFFSNIGDVYIAANNLVQLKIADGVGDIMR
ECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCEEEEEECCCHHHHHH
VVINTVFGVGGLFDVATLAKLPKHANDFGVTLGHYGVPSGPYLVLPLLGPSTVRDTAGLA
HHHHHHHCCCHHHHHHHHHHHCCCCCHHCEEECCCCCCCCCEEEEECCCCCHHHHCCCEE
VDYAGNPLTYVRPDGVSWGLFGLNLVNTRANLLGAGDVLEAAAIDKYSFVRNAYLQRRQA
EEECCCCEEEECCCCCEECHHHEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LIGGATGAQSNLPDYGSEAPPPNYEMPEEGAAAPASGAASAPAAASAPTAASGAAPGAAE
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PASAAAPNPSSATNVPAQQVVPPSPGGIRFPSIRLH
CCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]