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The map label for this gene is hisI

Identifier: 237814059

GI number: 237814059

Start: 3697237

End: 3697650

Strand: Reverse

Name: hisI

Synonym: GBP346_A3844

Alternate gene names: 237814059

Gene position: 3697650-3697237 (Counterclockwise)

Preceding gene: 237814060

Following gene: 237814058

Centisome position: 90.22

GC content: 63.53

Gene sequence:

>414_bases
ATGAATGCAGAAGCGAAGCCGGGCGACTGGCTGGGCAAGGTCCGCTGGGACGCGAACGGCCTCGTGCCGGTGATCGCGCA
GGACGCGGCGACGAACGACGTGCTGATGTTCGCATGGATGAACCGCGACGCGCTCGCGAAGACGATCGAACTCAAGCGCG
CGGTGTACTACTCGCGCTCGCGGCAGCGCCTGTGGTTCAAGGGCGAGGAATCGGGCCACGTGCAGCATGTGCACGAAGTG
CGCCTCGACTGCGACGAGGACGTCGTGCTGCTGAAGGTCGAGCAGGTCGAAGGCATCGCGTGCCACACGGGCCGGCGCTC
GTGCTTTTTCCAGAAATTCGAGGGCACCGTCGACGACGGCGAATGGGTCGCGGTCGATCCGGTGCTCAAAGATCCCGAAC
ATATCTACAAATGA

Upstream 100 bases:

>100_bases
CGGACGCCGTGCTCGCCGCGAGCATCTTCCATTACGGCGAGCACACGGTCGGCGAGGCGAAGCGCTTCATGGCCGAGCGC
GGCATTGCAGTGAGGTTGTG

Downstream 100 bases:

>100_bases
CGCAATCGACGACCGAAGACACGCTGCTGCGTCTCGCCGCCGTGATCGACAGCCGCAAGGGCGGCGATCCCGAGCAATCG
TACGTGTCGCGCCTCTTTCA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MNAEAKPGDWLGKVRWDANGLVPVIAQDAATNDVLMFAWMNRDALAKTIELKRAVYYSRSRQRLWFKGEESGHVQHVHEV
RLDCDEDVVLLKVEQVEGIACHTGRRSCFFQKFEGTVDDGEWVAVDPVLKDPEHIYK

Sequences:

>Translated_137_residues
MNAEAKPGDWLGKVRWDANGLVPVIAQDAATNDVLMFAWMNRDALAKTIELKRAVYYSRSRQRLWFKGEESGHVQHVHEV
RLDCDEDVVLLKVEQVEGIACHTGRRSCFFQKFEGTVDDGEWVAVDPVLKDPEHIYK
>Mature_137_residues
MNAEAKPGDWLGKVRWDANGLVPVIAQDAATNDVLMFAWMNRDALAKTIELKRAVYYSRSRQRLWFKGEESGHVQHVHEV
RLDCDEDVVLLKVEQVEGIACHTGRRSCFFQKFEGTVDDGEWVAVDPVLKDPEHIYK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=44.5652173913043, Blast_Score=91, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=108, Percent_Identity=38.8888888888889, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_BURPS (Q63Q93)

Other databases:

- EMBL:   BX571965
- RefSeq:   YP_109725.1
- ProteinModelPortal:   Q63Q93
- SMR:   Q63Q93
- GeneID:   3094021
- GenomeReviews:   BX571965_GR
- KEGG:   bps:BPSL3132
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- BioCyc:   BPSE272560:BPSL3132-MONOMER
- BRENDA:   3.5.4.19
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 15699; Mature: 15699

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAEAKPGDWLGKVRWDANGLVPVIAQDAATNDVLMFAWMNRDALAKTIELKRAVYYSRS
CCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCC
RQRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVEGIACHTGRRSCFFQKFEGTVDDG
CCEEEEECCCCCCEEEEEEEECCCCCCEEEEEEECCCCEEEECCCCCEEEEECCCCCCCC
EWVAVDPVLKDPEHIYK
CEEEECCCCCCHHHHCC
>Mature Secondary Structure
MNAEAKPGDWLGKVRWDANGLVPVIAQDAATNDVLMFAWMNRDALAKTIELKRAVYYSRS
CCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCC
RQRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVEGIACHTGRRSCFFQKFEGTVDDG
CCEEEEECCCCCCEEEEEEEECCCCCCEEEEEEECCCCEEEECCCCCEEEEECCCCCCCC
EWVAVDPVLKDPEHIYK
CEEEECCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA