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The map label for this gene is lpxC [H]

Identifier: 237813912

GI number: 237813912

Start: 3559291

End: 3560208

Strand: Reverse

Name: lpxC [H]

Synonym: GBP346_A3691

Alternate gene names: 237813912

Gene position: 3560208-3559291 (Counterclockwise)

Preceding gene: 237813913

Following gene: 237813909

Centisome position: 86.86

GC content: 63.83

Gene sequence:

>918_bases
ATGTTGAAGCAGCGCACCATCAAATCGATCGTCAAGACCGTCGGCATCGGCGTGCATTCGGGCCGCAAGGTCGAACTGAC
GCTTCGCCCCGCGGCGCCCGATACGGGCATCGTGTTCTCGCGCGTCGATCTGCCGACGCCCGTCGACATTCCCGCTTCGG
CGCTGTCGATCGGCGACACGCGGCTCGCGTCCGTGCTGCAGAAGGACGGCGTGCGCGTGTCGACGGTCGAGCACCTGATG
TCGGCGTGCGCGGGCCTCGGCATCGACAACCTCTACGTCGACGTGACGGCCGAGGAAATTCCGATCATGGACGGCAGCGC
GGCGACGTTCGTGTTTCTGATCCAGTCGGCCGGCATCGAAGAGCAGAACGCGGCGAAGAAGTTCATCAAGGTGACGAAGC
CCGTCGAGATCCGCGACGGCGATAAATTCGCGCGTCTCGATCCGTACTTCGGTTTCAGGCTGAAGTTCACGATCGATTTC
CGCCATCCGGCCGTCGACAAGACGGGCCAGGAGCTCGAGGTCGATTTCGCGAACACGTCGTACGTGCGCGAGATCGCGCG
CGCGCGCACGTTCGGCTTCGCGCACGAGGTCGAGATGATGCGCGAGCTGGGGCTCGCGCGCGGCGGCAGCATGGACAACG
CGATCGTGCTCGACGAGTACCGGATCCTCAACAACGACGGCCTTCGCTACGACGACGAGTTCGTCAAGCACAAGATGCTC
GACGCGATCGGTGATCTGTACGTGATCGGCCACCCGCTGCTCGCGTCTTACACGGCGTACAAGTCGGGCCACGGGCTGAA
CAACGCGTTGCTGCGCGAATTGCTCGCGCATGAGCAAGCGTATGAGATCGTCACGTTCGACGATCCGAAGACGGCGCCGA
CGGGGTTCGGCTTCGACGCGCAGACGGCGTTCGCGTGA

Upstream 100 bases:

>100_bases
GAAACGTCGATCATCACGACGCGAAATAGGGAATTACGCTATAATCTCACCTATCGAATAAAACTCCTGATTGATATCCT
CAATCAAGAAGACTGTGACC

Downstream 100 bases:

>100_bases
TGCGCGGGCGCGCCGGCGCGTGATGGCGCGGACGGCGACAAACAAGAAAGAGCGGCTTGCGGGCCGCTTTTTTGTTGCTT
GTTGCGCGCGGCGGCTTCGC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MLKQRTIKSIVKTVGIGVHSGRKVELTLRPAAPDTGIVFSRVDLPTPVDIPASALSIGDTRLASVLQKDGVRVSTVEHLM
SACAGLGIDNLYVDVTAEEIPIMDGSAATFVFLIQSAGIEEQNAAKKFIKVTKPVEIRDGDKFARLDPYFGFRLKFTIDF
RHPAVDKTGQELEVDFANTSYVREIARARTFGFAHEVEMMRELGLARGGSMDNAIVLDEYRILNNDGLRYDDEFVKHKML
DAIGDLYVIGHPLLASYTAYKSGHGLNNALLRELLAHEQAYEIVTFDDPKTAPTGFGFDAQTAFA

Sequences:

>Translated_305_residues
MLKQRTIKSIVKTVGIGVHSGRKVELTLRPAAPDTGIVFSRVDLPTPVDIPASALSIGDTRLASVLQKDGVRVSTVEHLM
SACAGLGIDNLYVDVTAEEIPIMDGSAATFVFLIQSAGIEEQNAAKKFIKVTKPVEIRDGDKFARLDPYFGFRLKFTIDF
RHPAVDKTGQELEVDFANTSYVREIARARTFGFAHEVEMMRELGLARGGSMDNAIVLDEYRILNNDGLRYDDEFVKHKML
DAIGDLYVIGHPLLASYTAYKSGHGLNNALLRELLAHEQAYEIVTFDDPKTAPTGFGFDAQTAFA
>Mature_305_residues
MLKQRTIKSIVKTVGIGVHSGRKVELTLRPAAPDTGIVFSRVDLPTPVDIPASALSIGDTRLASVLQKDGVRVSTVEHLM
SACAGLGIDNLYVDVTAEEIPIMDGSAATFVFLIQSAGIEEQNAAKKFIKVTKPVEIRDGDKFARLDPYFGFRLKFTIDF
RHPAVDKTGQELEVDFANTSYVREIARARTFGFAHEVEMMRELGLARGGSMDNAIVLDEYRILNNDGLRYDDEFVKHKML
DAIGDLYVIGHPLLASYTAYKSGHGLNNALLRELLAHEQAYEIVTFDDPKTAPTGFGFDAQTAFA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=297, Percent_Identity=55.2188552188552, Blast_Score=357, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 33555; Mature: 33555

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKQRTIKSIVKTVGIGVHSGRKVELTLRPAAPDTGIVFSRVDLPTPVDIPASALSIGDT
CCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHCCHH
RLASVLQKDGVRVSTVEHLMSACAGLGIDNLYVDVTAEEIPIMDGSAATFVFLIQSAGIE
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCCCCHHEEEEEEHHCCCC
EQNAAKKFIKVTKPVEIRDGDKFARLDPYFGFRLKFTIDFRHPAVDKTGQELEVDFANTS
HHHHHHHHHHHCCCEEECCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCEEEEEECCHH
YVREIARARTFGFAHEVEMMRELGLARGGSMDNAIVLDEYRILNNDGLRYDDEFVKHKML
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCEEEEECEEEECCCCCCCCHHHHHHHHH
DAIGDLYVIGHPLLASYTAYKSGHGLNNALLRELLAHEQAYEIVTFDDPKTAPTGFGFDA
HHHCCEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCC
QTAFA
CCCCC
>Mature Secondary Structure
MLKQRTIKSIVKTVGIGVHSGRKVELTLRPAAPDTGIVFSRVDLPTPVDIPASALSIGDT
CCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHCCHH
RLASVLQKDGVRVSTVEHLMSACAGLGIDNLYVDVTAEEIPIMDGSAATFVFLIQSAGIE
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCCCCHHEEEEEEHHCCCC
EQNAAKKFIKVTKPVEIRDGDKFARLDPYFGFRLKFTIDFRHPAVDKTGQELEVDFANTS
HHHHHHHHHHHCCCEEECCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCEEEEEECCHH
YVREIARARTFGFAHEVEMMRELGLARGGSMDNAIVLDEYRILNNDGLRYDDEFVKHKML
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCEEEEECEEEECCCCCCCCHHHHHHHHH
DAIGDLYVIGHPLLASYTAYKSGHGLNNALLRELLAHEQAYEIVTFDDPKTAPTGFGFDA
HHHCCEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCC
QTAFA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA