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The map label for this gene is cynR [H]

Identifier: 237813828

GI number: 237813828

Start: 3482727

End: 3483662

Strand: Reverse

Name: cynR [H]

Synonym: GBP346_A3606

Alternate gene names: 237813828

Gene position: 3483662-3482727 (Counterclockwise)

Preceding gene: 237813833

Following gene: 237813825

Centisome position: 85.0

GC content: 68.59

Gene sequence:

>936_bases
ATGCTGCTCCGACATATCCGCTATTTTCTCGCCGTTGCCGAGCAAGGCAACTTCACGCGCGCGGCCGAGTCGCTGCACGT
GTCGCAACCCACGCTGTCGCAGCAGATCCGGCAGCTCGAGGGCGTGCTCGGCGTGCAGTTGTTCGATCGCTCGGCGCGCG
CGGTGCGATTGACCGAATTCGGCACCGCGTACGCGCGGCATGCGCGCGCCGCGTTGCAGCAGCTCGAGGCGGGGCGCCGC
GCGGTGCACGACGTCGAGAATCTGCAGAGCGGCTCGCTGCGGCTCGCGATGACGCCCACTTTCTCCGCATATCTGATCGG
CTGGCTGATCGATGGCTTCAATGCGCGCTATCCGAACCTGAAACTGACGATCCGCGAGATGCCGCAGGAGCAGATCGAGC
CGCTTCTCGCCGACGACGAACTCGACGTCGGAATCGCGTTCGACGCGACGCAGTCGCCGGAAATCGAGACGATGCCGCTC
TGGATCGAGACGCTCGCGCTCGTCGTCGGCCGTGACCATCGCCATGCGCGTCGCCGCAAGCCGCTTTCGCCCGACGAAGC
CGCCGGCGAGCCGCTGATCCTGCTGAGCCGCGCCTTCGCGACGCGCGGCAAGGTCGACCAGTACTTCCATCGCAACGGCG
TCACGCCGCGCGTCGCGATCGAGGTGAACTCGATCAGCGCGATGCTCGAGATGGTGCGCGGTGGGCGGATTGCGACGGTG
CTGCCGTCGGCGATCGCCGAGCGCCGCGACGACTTGTGCGCGATCCGGCTCGATCCGCCGCTGCCGCAACGCACGGCGGC
GCTGCTGATGCGCAAGGGCGGGTATCGAAGCGCGGCGATGCGCGCGTTCGTCGACCATATGCTCGCGAGGCGGCACGAGA
TCGGGCGCCGCGAAGGGGCGCGGGCACGCGACGGCGTGCCGTCGGACGGCGAGTAG

Upstream 100 bases:

>100_bases
TCGATGGCGAGTGCCGATGACCGAAGCATGAGGCAAACGATTCATAGCGTCCAAGACCGGTTTATTATTGTTCGCATAGG
CAACGCCAATATCCGGGACA

Downstream 100 bases:

>100_bases
CGGCGCGGAACGATTGGCGGGGGAAGGCGTCGGCTGCGGGCTGCGGGCTGCGGGCTGCGGGCTGCGGGGCGCAGGCGCAC
GGCAAGCGGCAAGCGGCAAA

Product: DNA-binding transcriptional regulator CynR

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MLLRHIRYFLAVAEQGNFTRAAESLHVSQPTLSQQIRQLEGVLGVQLFDRSARAVRLTEFGTAYARHARAALQQLEAGRR
AVHDVENLQSGSLRLAMTPTFSAYLIGWLIDGFNARYPNLKLTIREMPQEQIEPLLADDELDVGIAFDATQSPEIETMPL
WIETLALVVGRDHRHARRRKPLSPDEAAGEPLILLSRAFATRGKVDQYFHRNGVTPRVAIEVNSISAMLEMVRGGRIATV
LPSAIAERRDDLCAIRLDPPLPQRTAALLMRKGGYRSAAMRAFVDHMLARRHEIGRREGARARDGVPSDGE

Sequences:

>Translated_311_residues
MLLRHIRYFLAVAEQGNFTRAAESLHVSQPTLSQQIRQLEGVLGVQLFDRSARAVRLTEFGTAYARHARAALQQLEAGRR
AVHDVENLQSGSLRLAMTPTFSAYLIGWLIDGFNARYPNLKLTIREMPQEQIEPLLADDELDVGIAFDATQSPEIETMPL
WIETLALVVGRDHRHARRRKPLSPDEAAGEPLILLSRAFATRGKVDQYFHRNGVTPRVAIEVNSISAMLEMVRGGRIATV
LPSAIAERRDDLCAIRLDPPLPQRTAALLMRKGGYRSAAMRAFVDHMLARRHEIGRREGARARDGVPSDGE
>Mature_311_residues
MLLRHIRYFLAVAEQGNFTRAAESLHVSQPTLSQQIRQLEGVLGVQLFDRSARAVRLTEFGTAYARHARAALQQLEAGRR
AVHDVENLQSGSLRLAMTPTFSAYLIGWLIDGFNARYPNLKLTIREMPQEQIEPLLADDELDVGIAFDATQSPEIETMPL
WIETLALVVGRDHRHARRRKPLSPDEAAGEPLILLSRAFATRGKVDQYFHRNGVTPRVAIEVNSISAMLEMVRGGRIATV
LPSAIAERRDDLCAIRLDPPLPQRTAALLMRKGGYRSAAMRAFVDHMLARRHEIGRREGARARDGVPSDGE

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=305, Percent_Identity=53.1147540983606, Blast_Score=305, Evalue=2e-84,
Organism=Escherichia coli, GI1790399, Length=278, Percent_Identity=30.5755395683453, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787530, Length=289, Percent_Identity=29.0657439446367, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1788887, Length=287, Percent_Identity=30.3135888501742, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788297, Length=254, Percent_Identity=30.7086614173228, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI145693105, Length=283, Percent_Identity=27.5618374558304, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788748, Length=285, Percent_Identity=27.3684210526316, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1789204, Length=299, Percent_Identity=30.1003344481605, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1787879, Length=296, Percent_Identity=31.0810810810811, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081904, Length=255, Percent_Identity=29.4117647058824, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788481, Length=292, Percent_Identity=29.1095890410959, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI2367136, Length=266, Percent_Identity=30.0751879699248, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789173, Length=166, Percent_Identity=34.3373493975904, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788296, Length=206, Percent_Identity=29.6116504854369, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786401, Length=179, Percent_Identity=31.2849162011173, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787806, Length=287, Percent_Identity=24.390243902439, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787601, Length=143, Percent_Identity=32.1678321678322, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790208, Length=251, Percent_Identity=28.6852589641434, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790262, Length=251, Percent_Identity=24.7011952191235, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789639, Length=150, Percent_Identity=31.3333333333333, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082132, Length=168, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786713, Length=185, Percent_Identity=30.2702702702703, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34753; Mature: 34753

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRHIRYFLAVAEQGNFTRAAESLHVSQPTLSQQIRQLEGVLGVQLFDRSARAVRLTEF
CHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHH
GTAYARHARAALQQLEAGRRAVHDVENLQSGSLRLAMTPTFSAYLIGWLIDGFNARYPNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCE
KLTIREMPQEQIEPLLADDELDVGIAFDATQSPEIETMPLWIETLALVVGRDHRHARRRK
EEEHHHCCHHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCC
PLSPDEAAGEPLILLSRAFATRGKVDQYFHRNGVTPRVAIEVNSISAMLEMVRGGRIATV
CCCCCHHCCCCEEEHHHHHHHCCCHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCEEHHH
LPSAIAERRDDLCAIRLDPPLPQRTAALLMRKGGYRSAAMRAFVDHMLARRHEIGRREGA
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
RARDGVPSDGE
CCCCCCCCCCC
>Mature Secondary Structure
MLLRHIRYFLAVAEQGNFTRAAESLHVSQPTLSQQIRQLEGVLGVQLFDRSARAVRLTEF
CHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHHH
GTAYARHARAALQQLEAGRRAVHDVENLQSGSLRLAMTPTFSAYLIGWLIDGFNARYPNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCE
KLTIREMPQEQIEPLLADDELDVGIAFDATQSPEIETMPLWIETLALVVGRDHRHARRRK
EEEHHHCCHHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCC
PLSPDEAAGEPLILLSRAFATRGKVDQYFHRNGVTPRVAIEVNSISAMLEMVRGGRIATV
CCCCCHHCCCCEEEHHHHHHHCCCHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCEEHHH
LPSAIAERRDDLCAIRLDPPLPQRTAALLMRKGGYRSAAMRAFVDHMLARRHEIGRREGA
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
RARDGVPSDGE
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]