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The map label for this gene is holA [H]

Identifier: 237813815

GI number: 237813815

Start: 3469939

End: 3471027

Strand: Reverse

Name: holA [H]

Synonym: GBP346_A3593

Alternate gene names: 237813815

Gene position: 3471027-3469939 (Counterclockwise)

Preceding gene: 237813816

Following gene: 237813814

Centisome position: 84.69

GC content: 73.19

Gene sequence:

>1089_bases
ATGCAACTGCGACTTGACGCGCTGGAGCCGCATCTCTCCAAGGGCCTGGCCGGACTGTACGTCGTCTACGGCGACGAACC
GCTGCTCGCGCAGGAGGCGTGCGACAAGATCCGCGCCGCCGCGCGCGCGGCGGGCTTCACCGAGCGCTCGGTGCACACCG
TCGAGCGCGGCTTCGACTGGAGCACGCTGATCGGCGCGAGCCAGGCGATGTCGCTGTTCGGCGAGCGGCAGCTCGTCGAG
CTGCGGATTCCGTCCGGCAAGCCCGGCAAGGACGGCGCCGACGCGCTGAAGACGCTCGCCGGCGCGGCCAACCCGGACGT
GCTGATGCTCGTCACGCTGCCGCGGCTCGATGCGGCGACGCAGAAGTCCGCGTGGTTCACGGCGCTCGCGAACGGCGGCG
TCGCGCTGAAGATCGACCCCGTCGAGCGCGCGCAGTTGCCGAACTGGATCGGTCAGCGGCTCGCGCTGCAGGGGCAGCGG
GTCGCCCCGGGCGACGACGGACGGCGCGCGCTCGCGTTCGTCGCCGAGCGGGTCGAAGGCAATCTGCTCGCCGCGCATCA
GGAAATCCAGAAGCTCGGCCTGCTGTATCCGGCCGGCGCGCTGACGTTCGAGCAGATCCACGACGCGGTGCTGAACGTCG
CGCGCTACGACGTGTTCAAGCTCAACGAGGCGATGCTCGCGGGCGACGCCGCGCGGCTTTCGCGGATGATCGACGGCCTG
AAGGGCGAGGGCGAGGCGCTCGTGCTCGTGCTGTGGGCGGTCGTCGAGGAGTTGCGCACGCTGTTGCGGATCAAGCGCGG
CGTCGCGGCCGGCAAGCCGCTTGCCGTGCTCGTGCGCGAGAACCGCGTGTGGGGGCCGCGCGAGCGGCTCGTCGGGCCCG
CGCTTTCGCGCGTATCGGAAGCGGCGCTCGAGCACGCGCTCGCGTTCGCCGCGCGGCTCGACCGGCAGGTCAAGGGGTTG
TCGGCCGTGTCGCGCGGCGCGGCGCGCGGCGAGCCGCCGCCCGATCCGTGGGACGGCCTGTTCCAGCTCGCGATGACCGT
CGCGCGCGCGGCCGGGCCAGGCGGCGACGCGCCGCGCCGGCCCGCCTGA

Upstream 100 bases:

>100_bases
CGAGGGCGTGCCGGCCGTCGCGCCGCGCGCGCCGCTGCCGCCGCCGCCGCTGTGATCGCCGCGTTCGCCATTCCCCGTTC
AACGATCGACGCACGAACCG

Downstream 100 bases:

>100_bases
GCGGGCTTTCGCGCCGGCGCTTACAATCTGCGTGAACGGGCGGGACGGCCGCGAGTGCGCACGCGGCACCCGGCGCGCCC
GTTTTCCGACAATCGTTTTT

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MQLRLDALEPHLSKGLAGLYVVYGDEPLLAQEACDKIRAAARAAGFTERSVHTVERGFDWSTLIGASQAMSLFGERQLVE
LRIPSGKPGKDGADALKTLAGAANPDVLMLVTLPRLDAATQKSAWFTALANGGVALKIDPVERAQLPNWIGQRLALQGQR
VAPGDDGRRALAFVAERVEGNLLAAHQEIQKLGLLYPAGALTFEQIHDAVLNVARYDVFKLNEAMLAGDAARLSRMIDGL
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGPRERLVGPALSRVSEAALEHALAFAARLDRQVKGL
SAVSRGAARGEPPPDPWDGLFQLAMTVARAAGPGGDAPRRPA

Sequences:

>Translated_362_residues
MQLRLDALEPHLSKGLAGLYVVYGDEPLLAQEACDKIRAAARAAGFTERSVHTVERGFDWSTLIGASQAMSLFGERQLVE
LRIPSGKPGKDGADALKTLAGAANPDVLMLVTLPRLDAATQKSAWFTALANGGVALKIDPVERAQLPNWIGQRLALQGQR
VAPGDDGRRALAFVAERVEGNLLAAHQEIQKLGLLYPAGALTFEQIHDAVLNVARYDVFKLNEAMLAGDAARLSRMIDGL
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGPRERLVGPALSRVSEAALEHALAFAARLDRQVKGL
SAVSRGAARGEPPPDPWDGLFQLAMTVARAAGPGGDAPRRPA
>Mature_362_residues
MQLRLDALEPHLSKGLAGLYVVYGDEPLLAQEACDKIRAAARAAGFTERSVHTVERGFDWSTLIGASQAMSLFGERQLVE
LRIPSGKPGKDGADALKTLAGAANPDVLMLVTLPRLDAATQKSAWFTALANGGVALKIDPVERAQLPNWIGQRLALQGQR
VAPGDDGRRALAFVAERVEGNLLAAHQEIQKLGLLYPAGALTFEQIHDAVLNVARYDVFKLNEAMLAGDAARLSRMIDGL
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGPRERLVGPALSRVSEAALEHALAFAARLDRQVKGL
SAVSRGAARGEPPPDPWDGLFQLAMTVARAAGPGGDAPRRPA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=313, Percent_Identity=34.185303514377, Blast_Score=164, Evalue=8e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 38727; Mature: 38727

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRLDALEPHLSKGLAGLYVVYGDEPLLAQEACDKIRAAARAAGFTERSVHTVERGFDW
CCEECCHHCHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCH
STLIGASQAMSLFGERQLVELRIPSGKPGKDGADALKTLAGAANPDVLMLVTLPRLDAAT
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCHH
QKSAWFTALANGGVALKIDPVERAQLPNWIGQRLALQGQRVAPGDDGRRALAFVAERVEG
HHHHHHHHCCCCCEEEEECCHHHHHCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPAGALTFEQIHDAVLNVARYDVFKLNEAMLAGDAARLSRMIDGL
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGPRERLVGPALSRVSE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
AALEHALAFAARLDRQVKGLSAVSRGAARGEPPPDPWDGLFQLAMTVARAAGPGGDAPRR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
PA
CC
>Mature Secondary Structure
MQLRLDALEPHLSKGLAGLYVVYGDEPLLAQEACDKIRAAARAAGFTERSVHTVERGFDW
CCEECCHHCHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCH
STLIGASQAMSLFGERQLVELRIPSGKPGKDGADALKTLAGAANPDVLMLVTLPRLDAAT
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCHH
QKSAWFTALANGGVALKIDPVERAQLPNWIGQRLALQGQRVAPGDDGRRALAFVAERVEG
HHHHHHHHCCCCCEEEEECCHHHHHCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPAGALTFEQIHDAVLNVARYDVFKLNEAMLAGDAARLSRMIDGL
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGPRERLVGPALSRVSE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
AALEHALAFAARLDRQVKGLSAVSRGAARGEPPPDPWDGLFQLAMTVARAAGPGGDAPRR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
PA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]