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The map label for this gene is proA [H]

Identifier: 237813814

GI number: 237813814

Start: 3468531

End: 3469802

Strand: Reverse

Name: proA [H]

Synonym: GBP346_A3592

Alternate gene names: 237813814

Gene position: 3469802-3468531 (Counterclockwise)

Preceding gene: 237813815

Following gene: 237813813

Centisome position: 84.66

GC content: 68.95

Gene sequence:

>1272_bases
ATGGATATCGACCAGTACATGACGGACGTCGGCCGCCGCGCGCGGCGCGCCTCGCGCGAGATCGCACGCGCGTCCACCGC
GGCGAAGAACGCCGCGCTCGAAGCGGTCGCGCGGGCAATCGGGCGCAACGCCGACGCGCTGAAGGCCGCCAACGCGCGCG
ACGTCGCGCGCGCGAAGGACAAGGGGCACGACGCGGCGTTCGTCGATCGCCTGACGCTGTCGGACAAGGCGCTGAAGACG
ATGATCGAAGGGCTGCGCCAGGTCGCGACGCTGGCGGACCCGATCGGCGAGATGAGCAATCTCAAATACCGCCCGAGCGG
AATCCAGGTCGGCCAGATGCGCGTGCCGCTCGGCGTGATCGGGATCATCTACGAATCGCGGCCGAACGTGACGATCGACG
CGGCCGCGCTGTGCCTGAAGTCCGGCAACGCGACGATCCTGCGCGGCGGCTCGGAGGCGCTCGAATCGAACACCGCGCTC
GCGAAGCTGATCGGCGAAGGGCTGGCGGCGGCGGGGCTGCCGCAGGACGCGGTGCAGGTCGTCGGCACGGCCGATCGGGC
GGCGGTCGGCAAGTTGATCACGATGACCGAATACGTCGACGTGATCGTGCCGCGCGGCGGCAAGAGCCTGATCGAGCGGC
TGATCAACGAGGCGCGCGTGCCGATGATCAAGCACCTCGACGGCATCTGCCACGTGTATGTCGACGATCGCGCGAGCGTG
GCGAAGGCGCTCGCCGTCTGCGACAACGCGAAGACGCATCGCTACGGCACCTGCAACACGATGGAGACGCTGCTCGTCGC
GCGCGGGATCGCGCCCGCGGTGCTGACGCCGCTCGGCCGGCTGTATCGCGAGAAGGGCGTCGAGCTGCGCGTCGACGCCG
ACGCGCGCGCGGTGCTCGAGGCGGCGGGCGTCGGTCCGCTCGTCGACGCGACCGACGAAGACTGGCGCACCGAATATCTC
GCGCCGGTGCTCGCGATCAAGATCGTCGACGGCATCGACGCCGCGATCGAACACATCAACGAGTACGGCTCGCATCACAC
CGATGCGATCGTCACCGAGGATCACGACCGCGCGATGCGCTTCCTGCGCGAAGTCGATTCGGCGAGTGTGATGGTGAACG
CGTCGACGCGCTTCGCGGACGGCTTCGAGTTCGGGCTCGGCGCGGAGATCGGCATCTCGAACGACAAGCTGCACGCGCGC
GGCCCGGTCGGGCTCGAAGGTCTCACGTCGCTGAAGTACGTGGTGCTCGGGCACGGCGAAGGGCGTGAGTGA

Upstream 100 bases:

>100_bases
CGGGCGGGACGGCCGCGAGTGCGCACGCGGCACCCGGCGCGCCCGTTTTCCGACAATCGTTTTTTCGCCGCTCGACGCGG
CTTGCATTGCGAGTCTCACG

Downstream 100 bases:

>100_bases
CGGCGGGGGAACGATCGATGGCGATGCTCTGGGTCAAGACTTTTCATATCGTGCTGATCGCGTCGTGGTTCGCGGGGCTG
TTCTATTTGCCGCGCATCTA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MDIDQYMTDVGRRARRASREIARASTAAKNAALEAVARAIGRNADALKAANARDVARAKDKGHDAAFVDRLTLSDKALKT
MIEGLRQVATLADPIGEMSNLKYRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTAL
AKLIGEGLAAAGLPQDAVQVVGTADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRASV
AKALAVCDNAKTHRYGTCNTMETLLVARGIAPAVLTPLGRLYREKGVELRVDADARAVLEAAGVGPLVDATDEDWRTEYL
APVLAIKIVDGIDAAIEHINEYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRE

Sequences:

>Translated_423_residues
MDIDQYMTDVGRRARRASREIARASTAAKNAALEAVARAIGRNADALKAANARDVARAKDKGHDAAFVDRLTLSDKALKT
MIEGLRQVATLADPIGEMSNLKYRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTAL
AKLIGEGLAAAGLPQDAVQVVGTADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRASV
AKALAVCDNAKTHRYGTCNTMETLLVARGIAPAVLTPLGRLYREKGVELRVDADARAVLEAAGVGPLVDATDEDWRTEYL
APVLAIKIVDGIDAAIEHINEYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRE
>Mature_423_residues
MDIDQYMTDVGRRARRASREIARASTAAKNAALEAVARAIGRNADALKAANARDVARAKDKGHDAAFVDRLTLSDKALKT
MIEGLRQVATLADPIGEMSNLKYRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTAL
AKLIGEGLAAAGLPQDAVQVVGTADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRASV
AKALAVCDNAKTHRYGTCNTMETLLVARGIAPAVLTPLGRLYREKGVELRVDADARAVLEAAGVGPLVDATDEDWRTEYL
APVLAIKIVDGIDAAIEHINEYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRE

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=38.2926829268293, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=38.2926829268293, Blast_Score=253, Evalue=3e-67,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=45.0121654501217, Blast_Score=350, Evalue=8e-98,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=34.5323741007194, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=34.5323741007194, Blast_Score=248, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6324899, Length=428, Percent_Identity=38.0841121495327, Blast_Score=284, Evalue=2e-77,
Organism=Drosophila melanogaster, GI21357643, Length=412, Percent_Identity=36.6504854368932, Blast_Score=256, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45115; Mature: 45115

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDQYMTDVGRRARRASREIARASTAAKNAALEAVARAIGRNADALKAANARDVARAKD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHC
KGHDAAFVDRLTLSDKALKTMIEGLRQVATLADPIGEMSNLKYRPSGIQVGQMRVPLGVI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEECEEECCCEEE
GIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTALAKLIGEGLAAAGLPQDAVQV
EEEEECCCCEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VGTADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRASV
HCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEECCHHHH
AKALAVCDNAKTHRYGTCNTMETLLVARGIAPAVLTPLGRLYREKGVELRVDADARAVLE
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHH
AAGVGPLVDATDEDWRTEYLAPVLAIKIVDGIDAAIEHINEYGSHHTDAIVTEDHDRAMR
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHH
FLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGE
HHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHCCEEEEEEECCC
GRE
CCC
>Mature Secondary Structure
MDIDQYMTDVGRRARRASREIARASTAAKNAALEAVARAIGRNADALKAANARDVARAKD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHC
KGHDAAFVDRLTLSDKALKTMIEGLRQVATLADPIGEMSNLKYRPSGIQVGQMRVPLGVI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEECEEECCCEEE
GIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTALAKLIGEGLAAAGLPQDAVQV
EEEEECCCCEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VGTADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRASV
HCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEECCHHHH
AKALAVCDNAKTHRYGTCNTMETLLVARGIAPAVLTPLGRLYREKGVELRVDADARAVLE
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHH
AAGVGPLVDATDEDWRTEYLAPVLAIKIVDGIDAAIEHINEYGSHHTDAIVTEDHDRAMR
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHH
FLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGE
HHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHCCEEEEEEECCC
GRE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA