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The map label for this gene is gdhA [H]

Identifier: 237813799

GI number: 237813799

Start: 3455599

End: 3456903

Strand: Reverse

Name: gdhA [H]

Synonym: GBP346_A3577

Alternate gene names: 237813799

Gene position: 3456903-3455599 (Counterclockwise)

Preceding gene: 237813801

Following gene: 237813798

Centisome position: 84.34

GC content: 65.98

Gene sequence:

>1305_bases
ATGTCTTCGCAATCGCAGTCCCCGTCCGTCGCGCAGTCCATTCCGTCGTACCTGCACGCGGACGATCTCGGCCCCTGGGG
CAACTATTTGCAGCAAGTCGATCGCGTCGCGCCGTATCTCGGCTCGCTGTCGCGCTGGATCGAGACGCTCAAGCGCCCGA
AACGCATCCTGATCGTCGACGTGCCGATCGAGCTGGACAACGGCACCGTCGCGCACTTCGAGGGCTATCGCGTGCAGCAC
AACGTGTCGCGCGGCCCGGGCAAGGGCGGCGTGCGCTACCACCAGGACGTGACGCTGTCCGAGGTGATGGCGCTGTCCGC
ATGGATGTCGGTGAAGAACGCGGCCGTGAACGTGCCGTACGGCGGCGCGAAGGGCGGTATCCGCGTCGATCCGCGCAAGC
TCTCGCGCGGCGAGCTCGAGCGCGTGACGCGCCGCTACACGAGCGAAATCGGCATCATCATCGGCCCGAACACCGATATC
CCCGCGCCTGACGTCAACACGAACGAGCAGATCATGGCGTGGATGATGGACACGTACTCGATGAACCAGGGCCAGACGGC
CACGGGCGTCGTGACCGGCAAGCCGATCTCGCTCGGCGGCTCGCTCGGCCGCAAGGAAGCGACGGGCCGCGGCGTGTTCG
TCGTCGGCTGCGAGGCGGCGAAGAAGAAGGGGCTCGAGATCGAAGGCGCGCGCATTGCGGTCCAGGGCTTCGGCAATGTC
GGCGGGATCGCCGCGAAGCTGTTCCAGGAAGCGGGCGCGAAGGTGATCGCGGTGCAGGATCACACGGGCACGATTCACCA
GCCGGCGGGCGTCGATACGGTCAAGCTGCTCGAGCACGTCGGCCGCACGGGCGGCGTCGCGGGCTTCGAAGGCGCGGAAC
CGATGCCGAACGACGAGTTCTGGACCGTCGAAACCGATATCCTGATTCCGGCCGCGCTGGAAAACCAGATCACCGAGAAG
AACGCGTCGAAGATCCGCACGAAGATCATCGTCGAGGGCGCGAACGGCCCGACGACGACGGCCGCGGACGATATCCTGAG
CGCGAACGGCGTGCTCGTGATCCCCGACGTGATCGCGAACGCGGGCGGCGTGACCGTGTCGTACTTCGAATGGGTGCAGG
ATTTCTCGAGCTTCTTCTGGACGGAGGACGAGATCAATCACCGTCTCGAGCGCGTGATGCGCGAGGCGTTCGCCGGCGTA
TGGGCGGTGGCCGAAGAGCACAACGTGTCGGTGCGCACGGCGGCGTTCATCGTTGCATGCAAGCGCATCCTGATGGCGCG
CGAAATGCGCGGTCTGTACCCCTGA

Upstream 100 bases:

>100_bases
CCGATCATGCACGAAACGCATAATCGAATAAGCAAACGGCATTGGATTTCGAAATTCGCTTTTTCGACAATGTGCGCATT
CTTCGACCGTTGGAGATTCC

Downstream 100 bases:

>100_bases
TCGAAGGGATTGTTTCGATCTGCGACGCGCAAGGTTGGAGGCCGCGTCGCGCCGCACTCGCGGGCGGCACCGCAACGGTG
TCGCCCGCGTGCGTATCCGG

Product: glutamate dehydrogenase (GDH)

Products: NA

Alternate protein names: GDH [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSSQSQSPSVAQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWIETLKRPKRILIVDVPIELDNGTVAHFEGYRVQH
NVSRGPGKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDI
PAPDVNTNEQIMAWMMDTYSMNQGQTATGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGLEIEGARIAVQGFGNV
GGIAAKLFQEAGAKVIAVQDHTGTIHQPAGVDTVKLLEHVGRTGGVAGFEGAEPMPNDEFWTVETDILIPAALENQITEK
NASKIRTKIIVEGANGPTTTAADDILSANGVLVIPDVIANAGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGV
WAVAEEHNVSVRTAAFIVACKRILMAREMRGLYP

Sequences:

>Translated_434_residues
MSSQSQSPSVAQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWIETLKRPKRILIVDVPIELDNGTVAHFEGYRVQH
NVSRGPGKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDI
PAPDVNTNEQIMAWMMDTYSMNQGQTATGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGLEIEGARIAVQGFGNV
GGIAAKLFQEAGAKVIAVQDHTGTIHQPAGVDTVKLLEHVGRTGGVAGFEGAEPMPNDEFWTVETDILIPAALENQITEK
NASKIRTKIIVEGANGPTTTAADDILSANGVLVIPDVIANAGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGV
WAVAEEHNVSVRTAAFIVACKRILMAREMRGLYP
>Mature_433_residues
SSQSQSPSVAQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWIETLKRPKRILIVDVPIELDNGTVAHFEGYRVQHN
VSRGPGKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDIP
APDVNTNEQIMAWMMDTYSMNQGQTATGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGLEIEGARIAVQGFGNVG
GIAAKLFQEAGAKVIAVQDHTGTIHQPAGVDTVKLLEHVGRTGGVAGFEGAEPMPNDEFWTVETDILIPAALENQITEKN
ASKIRTKIIVEGANGPTTTAADDILSANGVLVIPDVIANAGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGVW
AVAEEHNVSVRTAAFIVACKRILMAREMRGLYP

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=371, Percent_Identity=42.8571428571429, Blast_Score=281, Evalue=9e-76,
Organism=Homo sapiens, GI4885281, Length=371, Percent_Identity=42.0485175202156, Blast_Score=275, Evalue=6e-74,
Organism=Escherichia coli, GI1788059, Length=366, Percent_Identity=34.6994535519126, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17544676, Length=392, Percent_Identity=40.3061224489796, Blast_Score=270, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6319256, Length=390, Percent_Identity=29.7435897435897, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6324951, Length=374, Percent_Identity=29.9465240641711, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45553475, Length=362, Percent_Identity=42.2651933701657, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI45549226, Length=354, Percent_Identity=42.9378531073446, Blast_Score=278, Evalue=6e-75,
Organism=Drosophila melanogaster, GI24649283, Length=388, Percent_Identity=41.2371134020619, Blast_Score=271, Evalue=5e-73,
Organism=Drosophila melanogaster, GI24649460, Length=301, Percent_Identity=43.1893687707641, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.3 [H]

Molecular weight: Translated: 46893; Mature: 46762

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQSQSPSVAQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWIETLKRPKRILIVD
CCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
VPIELDNGTVAHFEGYRVQHNVSRGPGKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPY
EEEEECCCEEEEEECEEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCEEECCC
GGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDIPAPDVNTNEQIMAWMMDTYS
CCCCCCCEECHHHCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHC
MNQGQTATGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGLEIEGARIAVQGFGNV
CCCCCCEEEEEECCCEECCCCCCCCCCCCCEEEEEECHHHHHCCCEECCCEEEEEECCCC
GGIAAKLFQEAGAKVIAVQDHTGTIHQPAGVDTVKLLEHVGRTGGVAGFEGAEPMPNDEF
HHHHHHHHHHCCCEEEEEECCCCCEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCE
WTVETDILIPAALENQITEKNASKIRTKIIVEGANGPTTTAADDILSANGVLVIPDVIAN
EEEEECEEECHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCHHHHHCCCCEEEECHHHCC
AGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGVWAVAEEHNVSVRTAAFIVAC
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEHHCCCCCHHHHHHHHHH
KRILMAREMRGLYP
HHHHHHHHHHCCCC
>Mature Secondary Structure 
SSQSQSPSVAQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWIETLKRPKRILIVD
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
VPIELDNGTVAHFEGYRVQHNVSRGPGKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPY
EEEEECCCEEEEEECEEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCEEECCC
GGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDIPAPDVNTNEQIMAWMMDTYS
CCCCCCCEECHHHCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHC
MNQGQTATGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGLEIEGARIAVQGFGNV
CCCCCCEEEEEECCCEECCCCCCCCCCCCCEEEEEECHHHHHCCCEECCCEEEEEECCCC
GGIAAKLFQEAGAKVIAVQDHTGTIHQPAGVDTVKLLEHVGRTGGVAGFEGAEPMPNDEF
HHHHHHHHHHCCCEEEEEECCCCCEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCE
WTVETDILIPAALENQITEKNASKIRTKIIVEGANGPTTTAADDILSANGVLVIPDVIAN
EEEEECEEECHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCHHHHHCCCCEEEECHHHCC
AGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGVWAVAEEHNVSVRTAAFIVAC
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEHHCCCCCHHHHHHHHHH
KRILMAREMRGLYP
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9680336; 10360571; 9135121; 9654452; 10366510 [H]