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The map label for this gene is mutL [H]

Identifier: 237813666

GI number: 237813666

Start: 3324330

End: 3326375

Strand: Direct

Name: mutL [H]

Synonym: GBP346_A3443

Alternate gene names: 237813666

Gene position: 3324330-3326375 (Clockwise)

Preceding gene: 237813663

Following gene: 237813667

Centisome position: 81.11

GC content: 72.39

Gene sequence:

>2046_bases
ATGTCCGAATTCACCGATTCCGCCGCGGGCCGCTCGAGCACGCCGCCCGCCGACGCGCCGTCGCCCGCCTCGCGCCCGCT
GCGCGCGATCCAGCCGCTGCCCGACCAGTTGATCAGCCAGATCGCGGCGGGCGAAGTGGTCGAGCGGCCCGCCTCCGTCG
TCAAGGAGCTCGTCGAGAACGCGCTCGACGCCGGCGCGGGCACGCTGCGCATCCTGCTCGACGAAGGCGGCGTCAAGCGC
ATCTCGATCACCGACGACGGCTGCGGGATTCCCGCCGACGAGCTGCCGCTCGCGCTGATGCGCCACGCGACGAGCAAGAT
CCGCTCGCTCGCCGAGCTCGAGGCGGTCGCGACGCTCGGGTTCCGCGGCGAAGCGCTCGCATCGATCGCGTCGGTCGCCG
AGATGTTCATCACGAGCCGCACCGAGGACGCCGCGCACGCGACGCGCATCGACGCGCAGACGGGCGTCGTCGGGCCCGCG
GCCGGCACGCGCGGCACGACGATCGAAGTGCGCGAGCTGTACTTCAGCACGCCCGCGCGCCGCAAGTTCCTGAAGAGCGA
GCAGACCGAGTTCGGCCATTGCCTCGAGATGATTCGCCGCGCGGCGCTCGCGCGGCCGGACGTCGCGATCTCGGTGCTGC
ACAACGGCCGCGCGGTCGAGCACTGGAACGCGAGCGAGCCCGCCGCGCGCGTCGCGAAGATCCTCGGCGACGGTTTCGCC
ACCGCCCATCTGCCGCTCGACGAGCGCGCCGGCCCGCTCGCCGTCTACGGCTGCGCGGGGCTGCCGACCGCGAGCCGCGG
CCGCGCGGACCAGCAATACTTCTTCGTCAACGGCCGCTTCGTGCGCGACAAACTGCTCACGCACGCGGTGCGCGCCGCGT
ACGAGGACGTGCTGCACGGCGACCGCTATCCGTCGTACGTGCTGTTCCTCGACCTGCCGCCGGAAGCCGTCGACGTGAAC
GTCCATCCGTCGAAGATCGAGGTGCGCTTCCGCGATTCGCGCTCGATCCACCAGTTCGTGTTCCACGCGGTGCAGCGCGC
GCTCGCGCGGCACGCGGGCGCGTCGCCCGAGACGACGGCGGGCGGCCACGCCGCGCATCTTGCGCCCATCGTGCCGGCAT
CGGCCGACTCGGCGGCCGCGCCGGGCGCCTCGTTTGTCCGCTCGGGCCCGACGGCGGGCGCGGGCGTCGGTCAGCCCGCG
TCCGGCAATACATGGCTGCGCCAGTCGCGGATGACGCAGGGCACGCTGCCCGTCGCGCAGCCGCTCGCGCTGTACGACGC
GCTGTTCGGCCGCAAGGACACGGGCGCGGGCACCCCGCACGGCGCGACGCTCGCGCTCGAAGCGCATGACGCGCCGGACG
GGGCGAATGCGCCGGGCGCGCCGCTCTACGCGACCATGCCGGGCGGCGACGCGACGCCCGCGTTCTCCCCGGCGGGTGCA
GCCGGTCTTCCGATGCACGACGAGCAGCCGCTCGGCTTCGCGGTCGGCCAGATCCACGGCATTTACGTGCTCGCGCAGAA
CGCGCGCGGGCTCGTGATCGTCGACATGCACGCCGCGCACGAGCGGATCCTGTACGAGCAGTTCAAGCGCGCGCTCGCCG
ATCGCACGATCGCCGTGCAGACGCTGCTGATTCCGGTGTCGATGACGGCGACGCCCGTCGAGGTCGGCACCGCGGAGGAG
GAGCGCGAGACGCTCGACGCGCTCGGCTTCGATCTCGCGGTGCTGTCACCGACGACGCTCGCGATCCGCGCGGTGCCCGC
CTTGCTGAAGGACGCCGACCTGCAAGCGCTCGCGCGCGCGGTGCTCGCGGATCTGCATGCGTTCGGCGGCTCGCGGGTGC
TGACCGAGCGCCAGCACGAGCTGCTCGGCACGCTCGCGTGCCATCACGCGGTGCGCGCGAACCGGCGTCTCACGCTCGAC
GAGATGAACGCGCTGCTGCGGCAGATGGAGGCGACCGAGCGCGCGGATCAGTGCAACCATGGCCGGCCGACCTGGTATCA
ACTGACGCTCGGCGATCTCGACAAGCTTTTCATGCGCGGCCAATGA

Upstream 100 bases:

>100_bases
CCGAAAGTGCCTTAAGCGACCGTGAAATTCGGCCGACGAGCGACGTCGCGCACCGAACGCGGCACGCGCCGCGCCACGCG
GCCTCGCTATAATCCCCGTC

Downstream 100 bases:

>100_bases
GCGAACGCAACGCGGCGTCCGCGCGCACGGTCGCGTGCCTGCTCGGCCCCACCGCCTCCGGCAAGACAGCCGCCGCGCTC
GCGCTCGCCGCGCGCCGGCC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 681; Mature: 680

Protein sequence:

>681_residues
MSEFTDSAAGRSSTPPADAPSPASRPLRAIQPLPDQLISQIAAGEVVERPASVVKELVENALDAGAGTLRILLDEGGVKR
ISITDDGCGIPADELPLALMRHATSKIRSLAELEAVATLGFRGEALASIASVAEMFITSRTEDAAHATRIDAQTGVVGPA
AGTRGTTIEVRELYFSTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASEPAARVAKILGDGFA
TAHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVN
VHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLAPIVPASADSAAAPGASFVRSGPTAGAGVGQPA
SGNTWLRQSRMTQGTLPVAQPLALYDALFGRKDTGAGTPHGATLALEAHDAPDGANAPGAPLYATMPGGDATPAFSPAGA
AGLPMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRTIAVQTLLIPVSMTATPVEVGTAEE
ERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLD
EMNALLRQMEATERADQCNHGRPTWYQLTLGDLDKLFMRGQ

Sequences:

>Translated_681_residues
MSEFTDSAAGRSSTPPADAPSPASRPLRAIQPLPDQLISQIAAGEVVERPASVVKELVENALDAGAGTLRILLDEGGVKR
ISITDDGCGIPADELPLALMRHATSKIRSLAELEAVATLGFRGEALASIASVAEMFITSRTEDAAHATRIDAQTGVVGPA
AGTRGTTIEVRELYFSTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASEPAARVAKILGDGFA
TAHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVN
VHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLAPIVPASADSAAAPGASFVRSGPTAGAGVGQPA
SGNTWLRQSRMTQGTLPVAQPLALYDALFGRKDTGAGTPHGATLALEAHDAPDGANAPGAPLYATMPGGDATPAFSPAGA
AGLPMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRTIAVQTLLIPVSMTATPVEVGTAEE
ERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLD
EMNALLRQMEATERADQCNHGRPTWYQLTLGDLDKLFMRGQ
>Mature_680_residues
SEFTDSAAGRSSTPPADAPSPASRPLRAIQPLPDQLISQIAAGEVVERPASVVKELVENALDAGAGTLRILLDEGGVKRI
SITDDGCGIPADELPLALMRHATSKIRSLAELEAVATLGFRGEALASIASVAEMFITSRTEDAAHATRIDAQTGVVGPAA
GTRGTTIEVRELYFSTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASEPAARVAKILGDGFAT
AHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVNV
HPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLAPIVPASADSAAAPGASFVRSGPTAGAGVGQPAS
GNTWLRQSRMTQGTLPVAQPLALYDALFGRKDTGAGTPHGATLALEAHDAPDGANAPGAPLYATMPGGDATPAFSPAGAA
GLPMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRTIAVQTLLIPVSMTATPVEVGTAEEE
RETLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDE
MNALLRQMEATERADQCNHGRPTWYQLTLGDLDKLFMRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=34.2424242424242, Blast_Score=189, Evalue=9e-48,
Organism=Homo sapiens, GI4505911, Length=351, Percent_Identity=27.9202279202279, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI189458898, Length=351, Percent_Identity=27.9202279202279, Blast_Score=143, Evalue=7e-34,
Organism=Homo sapiens, GI4505913, Length=347, Percent_Identity=26.8011527377522, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI310128478, Length=347, Percent_Identity=26.8011527377522, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI189458896, Length=341, Percent_Identity=29.3255131964809, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=31.063829787234, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI310128480, Length=293, Percent_Identity=23.8907849829352, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI91992162, Length=267, Percent_Identity=24.7191011235955, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI91992160, Length=267, Percent_Identity=24.7191011235955, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1790612, Length=331, Percent_Identity=51.0574018126888, Blast_Score=312, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=34.375, Blast_Score=157, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17562796, Length=364, Percent_Identity=25, Blast_Score=135, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=313, Percent_Identity=33.8658146964856, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324247, Length=345, Percent_Identity=26.3768115942029, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=717, Percent_Identity=20.0836820083682, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=373, Percent_Identity=23.8605898123324, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17136968, Length=313, Percent_Identity=34.185303514377, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI17136970, Length=368, Percent_Identity=25.8152173913043, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 72306; Mature: 72175

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFTDSAAGRSSTPPADAPSPASRPLRAIQPLPDQLISQIAAGEVVERPASVVKELVEN
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDAGAGTLRILLDEGGVKRISITDDGCGIPADELPLALMRHATSKIRSLAELEAVATLG
HHHCCCCEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FRGEALASIASVAEMFITSRTEDAAHATRIDAQTGVVGPAAGTRGTTIEVRELYFSTPAR
CCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHCCHHH
RKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASEPAARVAKILGDGFA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHCCCCE
TAHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHG
EEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCC
DRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTA
CCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
GGHAAHLAPIVPASADSAAAPGASFVRSGPTAGAGVGQPASGNTWLRQSRMTQGTLPVAQ
CCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHH
PLALYDALFGRKDTGAGTPHGATLALEAHDAPDGANAPGAPLYATMPGGDATPAFSPAGA
HHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCC
AGLPMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRTIAVQ
CCCCCCCCCCCCEEHHCEEEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHCCHHEEE
TLLIPVSMTATPVEVGTAEEERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARA
EEEEEEECCCCCEECCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHH
VLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNH
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GRPTWYQLTLGDLDKLFMRGQ
CCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
SEFTDSAAGRSSTPPADAPSPASRPLRAIQPLPDQLISQIAAGEVVERPASVVKELVEN
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDAGAGTLRILLDEGGVKRISITDDGCGIPADELPLALMRHATSKIRSLAELEAVATLG
HHHCCCCEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FRGEALASIASVAEMFITSRTEDAAHATRIDAQTGVVGPAAGTRGTTIEVRELYFSTPAR
CCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHCCHHH
RKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASEPAARVAKILGDGFA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHCCCCE
TAHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHG
EEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCC
DRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTA
CCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
GGHAAHLAPIVPASADSAAAPGASFVRSGPTAGAGVGQPASGNTWLRQSRMTQGTLPVAQ
CCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHH
PLALYDALFGRKDTGAGTPHGATLALEAHDAPDGANAPGAPLYATMPGGDATPAFSPAGA
HHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCC
AGLPMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRTIAVQ
CCCCCCCCCCCCEEHHCEEEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHCCHHEEE
TLLIPVSMTATPVEVGTAEEERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARA
EEEEEEECCCCCEECCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHH
VLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNH
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GRPTWYQLTLGDLDKLFMRGQ
CCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]