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The map label for this gene is pcaK_1 [H]

Identifier: 237813578

GI number: 237813578

Start: 3241623

End: 3242978

Strand: Reverse

Name: pcaK_1 [H]

Synonym: GBP346_A3354

Alternate gene names: 237813578

Gene position: 3242978-3241623 (Counterclockwise)

Preceding gene: 237813579

Following gene: 237813577

Centisome position: 79.12

GC content: 71.24

Gene sequence:

>1356_bases
ATGAGCGCGGCGGCGAATCCCGCGCGCGTGCTCGAGATCGAGCGCGTGATCGACGACACGCACCGGCCCGCGTTTCACGC
GATGCTGCTCGCGCTTTGCGGGCTGTGCCTCGTGATCGACGGTTTCGACGCGCAGGCGATGGGCTACGTCGCACCGAGCG
TGATCGCCGAATGGGGTGTGAAGAAGCAGGCGCTCGGGCCCGTCTTCAGCGCGAGCCTGTTCGGCATGCTGCTCGGCGCG
CTCGGCCTGTCGGTGCTCGCCGATCGGATCGGCCGGCGGCCCGTGCTGATCGGCGCGACGCTGTTCTTCGCGCTCGCGAT
ACTCGCGACGCCGTTCGCGACGTCGATCCCGATATTGATCGCGCTGCGCTTCGTCACGGGCCTGGGGCTCGGCTGCATCA
TGCCGAACGCGATGGCGCTCGTCGGCGAATGCAGCCCGAGCGCGCACCGCGTGAAGCGGATGATGATCGTGTCGTGCGGC
TTCACGCTCGGCGCGGCGCTGGGCGGGTTCGTCAGCGCCGCGCTGATTCCCGCGTTCGGCTGGCGCGCGGTGTTCTTCGT
CGGCGGCGCGGTGCCGCTCGCGCTCGCGGCCGTGATGGCCGCGAGCCTGCCCGAATCGCCGCAGTTGCTCGTGCTGCGCG
GCCGGCACGACGCGGCGCGCGCGTGGCTCGCGAAGTTCGCGCCGCGGCTCGCGGTCCCGCCCGATACGCGGCTTGTCGTG
CGCGAAGCGGGACCCCGGGGCGCGCCCGTCGCCGAGCTGTTCCGCTCGGGACGCGCGCGCGTCACGCTGCTGTTGTGGGC
GATCAACTTCATGAACCTGATCGACCTGTACTTCCTGTCGAACTGGCTGCCGACCGTGATGCGCGACGCGGGCTACGCGA
GCGGCACGGCCGTCATCGTCGGCACGGTGCTGCAGACGGGCGGCGTGATCGGCACGCTGTCGCTCGGCTGGTTCATCGAA
CGGCATGGTTTCGCGCGCGTGCTGTTCGCGTGCTTCGCGTGCGCGACGATCGCGATCGGCCTGATCGGCTCGGTCGCGCA
CGCGTTCGTCTGGCTGCTCGCAGCCGTGTTCGTCGGCGGCTTTTGCGTCGTCGGCGGACAGCCCGCGGTCAATGCGCTCG
CGGGCCATTATTACCCGACGTCGCTGCGCTCGACGGGCATCGGCTGGAGTCTCGGCGTGGGCCGCGTCGGCTCCGTGCTC
GGGCCGCTCGTCGGCGGGCAACTGATCGCGCTCGGCTGGTCGAACGACGCGCTGTTTCACGCGGCGGCCGTGCCGGTGCT
GTGCTCGGCCGTCTTCGTGATCGGCCTCGCGAGCGTGACGCGGCGGCGCGGCACGGCCGCGCCGAACGTCGCTTGA

Upstream 100 bases:

>100_bases
CGAACCAGATCGGCGATCTCGACGTGCTGCGCGAGGCGATGGCGCTCGCGCGCAGCGGCGCGGCCGTGCTCGAAGGCGCG
CCCGGCGCGCCCGCGCTGCA

Downstream 100 bases:

>100_bases
ATGGAGAGAACGACAATCATGACATTGGATTTTTCGAAACCGGGCGAAGCCGGCTATCAGAGCGGCTTCGCGAACGAATT
CGCGACCGAGGCGCTGCCGG

Product: 4-hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSAAANPARVLEIERVIDDTHRPAFHAMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGVKKQALGPVFSASLFGMLLGA
LGLSVLADRIGRRPVLIGATLFFALAILATPFATSIPILIALRFVTGLGLGCIMPNAMALVGECSPSAHRVKRMMIVSCG
FTLGAALGGFVSAALIPAFGWRAVFFVGGAVPLALAAVMAASLPESPQLLVLRGRHDAARAWLAKFAPRLAVPPDTRLVV
REAGPRGAPVAELFRSGRARVTLLLWAINFMNLIDLYFLSNWLPTVMRDAGYASGTAVIVGTVLQTGGVIGTLSLGWFIE
RHGFARVLFACFACATIAIGLIGSVAHAFVWLLAAVFVGGFCVVGGQPAVNALAGHYYPTSLRSTGIGWSLGVGRVGSVL
GPLVGGQLIALGWSNDALFHAAAVPVLCSAVFVIGLASVTRRRGTAAPNVA

Sequences:

>Translated_451_residues
MSAAANPARVLEIERVIDDTHRPAFHAMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGVKKQALGPVFSASLFGMLLGA
LGLSVLADRIGRRPVLIGATLFFALAILATPFATSIPILIALRFVTGLGLGCIMPNAMALVGECSPSAHRVKRMMIVSCG
FTLGAALGGFVSAALIPAFGWRAVFFVGGAVPLALAAVMAASLPESPQLLVLRGRHDAARAWLAKFAPRLAVPPDTRLVV
REAGPRGAPVAELFRSGRARVTLLLWAINFMNLIDLYFLSNWLPTVMRDAGYASGTAVIVGTVLQTGGVIGTLSLGWFIE
RHGFARVLFACFACATIAIGLIGSVAHAFVWLLAAVFVGGFCVVGGQPAVNALAGHYYPTSLRSTGIGWSLGVGRVGSVL
GPLVGGQLIALGWSNDALFHAAAVPVLCSAVFVIGLASVTRRRGTAAPNVA
>Mature_450_residues
SAAANPARVLEIERVIDDTHRPAFHAMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGVKKQALGPVFSASLFGMLLGAL
GLSVLADRIGRRPVLIGATLFFALAILATPFATSIPILIALRFVTGLGLGCIMPNAMALVGECSPSAHRVKRMMIVSCGF
TLGAALGGFVSAALIPAFGWRAVFFVGGAVPLALAAVMAASLPESPQLLVLRGRHDAARAWLAKFAPRLAVPPDTRLVVR
EAGPRGAPVAELFRSGRARVTLLLWAINFMNLIDLYFLSNWLPTVMRDAGYASGTAVIVGTVLQTGGVIGTLSLGWFIER
HGFARVLFACFACATIAIGLIGSVAHAFVWLLAAVFVGGFCVVGGQPAVNALAGHYYPTSLRSTGIGWSLGVGRVGSVLG
PLVGGQLIALGWSNDALFHAAAVPVLCSAVFVIGLASVTRRRGTAAPNVA

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=430, Percent_Identity=25.3488372093023, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI166064021, Length=368, Percent_Identity=29.0760869565217, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI8923870, Length=373, Percent_Identity=27.8820375335121, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI213021148, Length=446, Percent_Identity=23.7668161434978, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI7662270, Length=224, Percent_Identity=24.1071428571429, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87081723, Length=421, Percent_Identity=33.9667458432304, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI87082231, Length=404, Percent_Identity=24.5049504950495, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786229, Length=394, Percent_Identity=21.0659898477157, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788068, Length=400, Percent_Identity=23.75, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082404, Length=393, Percent_Identity=22.1374045801527, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI87082159, Length=390, Percent_Identity=24.6153846153846, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789207, Length=420, Percent_Identity=25.952380952381, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788074, Length=247, Percent_Identity=27.1255060728745, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI32564663, Length=432, Percent_Identity=22.6851851851852, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI19922874, Length=427, Percent_Identity=23.1850117096019, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24640198, Length=470, Percent_Identity=24.0425531914894, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24640196, Length=470, Percent_Identity=24.0425531914894, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24640200, Length=470, Percent_Identity=24.0425531914894, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI161077756, Length=463, Percent_Identity=22.8941684665227, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19922616, Length=378, Percent_Identity=23.8095238095238, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46876; Mature: 46745

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAANPARVLEIERVIDDTHRPAFHAMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGV
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
KKQALGPVFSASLFGMLLGALGLSVLADRIGRRPVLIGATLFFALAILATPFATSIPILI
CHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCHHHHHHHHH
ALRFVTGLGLGCIMPNAMALVGECSPSAHRVKRMMIVSCGFTLGAALGGFVSAALIPAFG
HHHHHHHCCHHHHCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
WRAVFFVGGAVPLALAAVMAASLPESPQLLVLRGRHDAARAWLAKFAPRLAVPPDTRLVV
HHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEE
REAGPRGAPVAELFRSGRARVTLLLWAINFMNLIDLYFLSNWLPTVMRDAGYASGTAVIV
ECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
GTVLQTGGVIGTLSLGWFIERHGFARVLFACFACATIAIGLIGSVAHAFVWLLAAVFVGG
HHHHHCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FCVVGGQPAVNALAGHYYPTSLRSTGIGWSLGVGRVGSVLGPLVGGQLIALGWSNDALFH
EEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCHHHH
AAAVPVLCSAVFVIGLASVTRRRGTAAPNVA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SAAANPARVLEIERVIDDTHRPAFHAMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGV
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
KKQALGPVFSASLFGMLLGALGLSVLADRIGRRPVLIGATLFFALAILATPFATSIPILI
CHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCHHHHHHHHH
ALRFVTGLGLGCIMPNAMALVGECSPSAHRVKRMMIVSCGFTLGAALGGFVSAALIPAFG
HHHHHHHCCHHHHCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
WRAVFFVGGAVPLALAAVMAASLPESPQLLVLRGRHDAARAWLAKFAPRLAVPPDTRLVV
HHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEE
REAGPRGAPVAELFRSGRARVTLLLWAINFMNLIDLYFLSNWLPTVMRDAGYASGTAVIV
ECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
GTVLQTGGVIGTLSLGWFIERHGFARVLFACFACATIAIGLIGSVAHAFVWLLAAVFVGG
HHHHHCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FCVVGGQPAVNALAGHYYPTSLRSTGIGWSLGVGRVGSVLGPLVGGQLIALGWSNDALFH
EEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCHHHH
AAAVPVLCSAVFVIGLASVTRRRGTAAPNVA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]