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The map label for this gene is hmgA [H]

Identifier: 237813577

GI number: 237813577

Start: 3240270

End: 3241604

Strand: Reverse

Name: hmgA [H]

Synonym: GBP346_A3353

Alternate gene names: 237813577

Gene position: 3241604-3240270 (Counterclockwise)

Preceding gene: 237813578

Following gene: 237813576

Centisome position: 79.09

GC content: 67.64

Gene sequence:

>1335_bases
ATGACATTGGATTTTTCGAAACCGGGCGAAGCCGGCTATCAGAGCGGCTTCGCGAACGAATTCGCGACCGAGGCGCTGCC
GGGCGCGTTGCCGCACGCGCGCAACTCGCCGCAGCGCGCGCCGTACGGGCTCTACGCGGAGCAGTTCTCCGGCACCGCGT
TCACCGCGCCGCGCGGCCACAACCGCCGCTCGTGGCTGTACCGGATCCGGCCCGCCGCCGTGCATCGGCCGTTCGAGCTC
GTGTCGGGCGAGCGCCGGATCGTCGCCGAGTTCGGCGATTCGGACGACGTGCCGCCGACGCCGCCGAACCAGTTGCGCTG
GGATCCGCTGCCGATGCCCGCGCAGCCGACCGATTTCGTCGACGGCTGGGTGACGATGGCGGGCAACGGCTCGGCCGCCG
CGATGAGCGGCTGCGCGATCCACCTGTACGCGGCGAACCGCTCGATGCGCGAGCGCTTCTTCTACAGCGCGGACGGCGAG
CTGCTGATCGTGCCGCAGGAAGGGCGCCTCTTCATCATGACGGAGCTCGGCCGGCTCGATGTCGAGCCGTTCGAGATCGC
GGTGATCCCGCGCGGCGTGCGCTTCGCGGTCGCGCTGCCGGACGGGCACGCGCGCGGCTATGTGTGCGAGAACTTCGGTG
CGCTGCTCAGGCTGCCGGACCTCGGGCCGATCGGCTCGAACGGCCTCGCGAATCCGCGCGACTTCCTCACGCCGCACGCG
TCGTACGAGGATCGCGAAGGCGCGTTCGAGCTCGTCGCGAAGCTGAATGGCCGGCTCTGGCGCGCGGACATCGATCATTC
GCCGTTCGACGTCGTCGCGTGGCACGGCAACTACGCGCCGTACAAGTACGACCTGCGCCACTTCAACACGATCGGCTCGA
TCAGCTACGATCATCCGGACCCGTCGATCTTCCTCGTGCTGCAGTCGCAAAGCGATACGCCGGGCGTCGACGCGATCGAC
TTCGTGATCTTCCCGCCGCGCTGGCTCGCGGCCGAGGATACATTCCGCCCGCCTTGGTTCCACCGCAACGTCGCGAGCGA
ATTCATGGGGCTCGTGCACGGCGTCTACGACGCGAAGGCCGAAGGCTTCGTGCCGGGCGGCGCGAGCCTGCACAACTGCA
TGTCCGGCCACGGGCCCGACGCGGACACGTTCGAGAAGGCTTCTTCGATCGACACGTCGAAGCCGAACAAGGTCGGCGAC
ACGATGGCGTTCATGTTCGAGACCCGCACGCTGATCCGGCCGACGCGCTTCGCGCTCGACACCGCGCAACTGCAGGCGAA
CTACTTCGAATGCTGGCAAGGCCTCAAGAAACACTTCAATCCGGAGCAACGATGA

Upstream 100 bases:

>100_bases
GGTGCTGTGCTCGGCCGTCTTCGTGATCGGCCTCGCGAGCGTGACGCGGCGGCGCGGCACGGCCGCGCCGAACGTCGCTT
GAATGGAGAGAACGACAATC

Downstream 100 bases:

>100_bases
GCGCTATTCCCGACACGCTGCGCGCGAGCCTCGATCCGTCCCGCAAGAGCTGGCTCGATACGGCGAACGCGGCCGCGTGC
GACTTCCCGATCCAGAACCT

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTLDFSKPGEAGYQSGFANEFATEALPGALPHARNSPQRAPYGLYAEQFSGTAFTAPRGHNRRSWLYRIRPAAVHRPFEL
VSGERRIVAEFGDSDDVPPTPPNQLRWDPLPMPAQPTDFVDGWVTMAGNGSAAAMSGCAIHLYAANRSMRERFFYSADGE
LLIVPQEGRLFIMTELGRLDVEPFEIAVIPRGVRFAVALPDGHARGYVCENFGALLRLPDLGPIGSNGLANPRDFLTPHA
SYEDREGAFELVAKLNGRLWRADIDHSPFDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIFLVLQSQSDTPGVDAID
FVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASSIDTSKPNKVGD
TMAFMFETRTLIRPTRFALDTAQLQANYFECWQGLKKHFNPEQR

Sequences:

>Translated_444_residues
MTLDFSKPGEAGYQSGFANEFATEALPGALPHARNSPQRAPYGLYAEQFSGTAFTAPRGHNRRSWLYRIRPAAVHRPFEL
VSGERRIVAEFGDSDDVPPTPPNQLRWDPLPMPAQPTDFVDGWVTMAGNGSAAAMSGCAIHLYAANRSMRERFFYSADGE
LLIVPQEGRLFIMTELGRLDVEPFEIAVIPRGVRFAVALPDGHARGYVCENFGALLRLPDLGPIGSNGLANPRDFLTPHA
SYEDREGAFELVAKLNGRLWRADIDHSPFDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIFLVLQSQSDTPGVDAID
FVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASSIDTSKPNKVGD
TMAFMFETRTLIRPTRFALDTAQLQANYFECWQGLKKHFNPEQR
>Mature_443_residues
TLDFSKPGEAGYQSGFANEFATEALPGALPHARNSPQRAPYGLYAEQFSGTAFTAPRGHNRRSWLYRIRPAAVHRPFELV
SGERRIVAEFGDSDDVPPTPPNQLRWDPLPMPAQPTDFVDGWVTMAGNGSAAAMSGCAIHLYAANRSMRERFFYSADGEL
LIVPQEGRLFIMTELGRLDVEPFEIAVIPRGVRFAVALPDGHARGYVCENFGALLRLPDLGPIGSNGLANPRDFLTPHAS
YEDREGAFELVAKLNGRLWRADIDHSPFDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIFLVLQSQSDTPGVDAIDF
VIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASSIDTSKPNKVGDT
MAFMFETRTLIRPTRFALDTAQLQANYFECWQGLKKHFNPEQR

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=444, Percent_Identity=52.027027027027, Blast_Score=457, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17507969, Length=435, Percent_Identity=51.9540229885057, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24583650, Length=438, Percent_Identity=50.4566210045662, Blast_Score=423, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 49380; Mature: 49249

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDFSKPGEAGYQSGFANEFATEALPGALPHARNSPQRAPYGLYAEQFSGTAFTAPRGH
CCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCEEECCCCC
NRRSWLYRIRPAAVHRPFELVSGERRIVAEFGDSDDVPPTPPNQLRWDPLPMPAQPTDFV
CCCCEEEEECHHHHCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DGWVTMAGNGSAAAMSGCAIHLYAANRSMRERFFYSADGELLIVPQEGRLFIMTELGRLD
CCEEEEECCCCCCEECCCEEEEEECCCHHHHHEEECCCCCEEEEECCCCEEEEEECCCCC
VEPFEIAVIPRGVRFAVALPDGHARGYVCENFGALLRLPDLGPIGSNGLANPRDFLTPHA
CCCEEEEEECCCEEEEEECCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCHHHCCCCC
SYEDREGAFELVAKLNGRLWRADIDHSPFDVVAWHGNYAPYKYDLRHFNTIGSISYDHPD
CCCCCCHHHHHHHHHCCEEEEEECCCCCCEEEEECCCCCCEEECHHHHCCCCCCEECCCC
PSIFLVLQSQSDTPGVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKA
CEEEEEEECCCCCCCCCEEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
EGFVPGGASLHNCMSGHGPDADTFEKASSIDTSKPNKVGDTMAFMFETRTLIRPTRFALD
CCCCCCCCHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHEEH
TAQLQANYFECWQGLKKHFNPEQR
HHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TLDFSKPGEAGYQSGFANEFATEALPGALPHARNSPQRAPYGLYAEQFSGTAFTAPRGH
CCCCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCEEECCCCC
NRRSWLYRIRPAAVHRPFELVSGERRIVAEFGDSDDVPPTPPNQLRWDPLPMPAQPTDFV
CCCCEEEEECHHHHCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DGWVTMAGNGSAAAMSGCAIHLYAANRSMRERFFYSADGELLIVPQEGRLFIMTELGRLD
CCEEEEECCCCCCEECCCEEEEEECCCHHHHHEEECCCCCEEEEECCCCEEEEEECCCCC
VEPFEIAVIPRGVRFAVALPDGHARGYVCENFGALLRLPDLGPIGSNGLANPRDFLTPHA
CCCEEEEEECCCEEEEEECCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCHHHCCCCC
SYEDREGAFELVAKLNGRLWRADIDHSPFDVVAWHGNYAPYKYDLRHFNTIGSISYDHPD
CCCCCCHHHHHHHHHCCEEEEEECCCCCCEEEEECCCCCCEEECHHHHCCCCCCEECCCC
PSIFLVLQSQSDTPGVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKA
CEEEEEEECCCCCCCCCEEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
EGFVPGGASLHNCMSGHGPDADTFEKASSIDTSKPNKVGDTMAFMFETRTLIRPTRFALD
CCCCCCCCHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHEEH
TAQLQANYFECWQGLKKHFNPEQR
HHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA