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The map label for this gene is thiD [H]

Identifier: 237813519

GI number: 237813519

Start: 3181909

End: 3182757

Strand: Direct

Name: thiD [H]

Synonym: GBP346_A3295

Alternate gene names: 237813519

Gene position: 3181909-3182757 (Clockwise)

Preceding gene: 237813510

Following gene: 237813524

Centisome position: 77.63

GC content: 69.49

Gene sequence:

>849_bases
ATGTCCAGCAACACCCCTCCGATCGTCCTCACTTTCGGCCTGTCCGATCCGACGGGCGGCTCCGGCCTGCAGGCCGACCT
GATGACTCTGGCGAGCATGGGCTGCCATGGCGTATCCGTACTGACGGGCTACACGGTGCGCGACTCCGCCGCCTGCGACG
AAGTCACCGGTCTCGATCCCGACACCGTCGCCGCGCAGGCGCGCATGCTGCTCGAAGACATGCCCGTCGCGGCGTTCAAG
ATCGGCGCGGCGACGCGGGCGGAAGTCGTGAGCGCGATCGCCGAAGTGGTCGCCGACTACGACGGCGTGCCGCTCGTCCT
CGCGCCGGATTTCACGCTCGACGACGAGCACGTGCTCGCCGCCGACGATCTGCGCGAGTCGATCGCCGATCTGCTCGCGC
CGCAGACGACGCTTCTCGTCGCCGACCACGCGACGCTCATCGCGCTCGCGCAGCCCGACGGCGACGCCGAGGCGCCGAAC
CTCGACGCCGCGCTCTCGCATCTGCTCGGCCAGGGCTGCGAGTACATTCTGGCGACCGAGACCGGCTCGCACCGTCTCGT
CAATACGCTGTACGGCGAGGAAGGCCAGATCCGGCAGGACTTGTGGGAGCGCACGCCGCACCGGCTGATGGGCATCACCG
ACACGCTCGGCGCGGCGATCGCCGCACTGCTCGCGAACGGCCAAGAGCCGCCGGAGGCGGTGCGCGAGGCGCAGGAGTAT
CTATACCAGGCGGCGCGCGATGCATTTCGCCCCGGGATGGGCGCCTACTTGCCGGACCGCTTCTTCTGGGCCCGCAGCAA
CGAAGACGAATCGCCGGCGCCGGCCGGAATCGCCAAGCGGACGAACTGA

Upstream 100 bases:

>100_bases
GCTTCGGCCCGCCCGAATCCGCCGCATAATTGACTGCGCGGGCGCACTGGGCTGGTGCACCCCGCCAATCAGCCTGTTTG
TTTCCTCATTCCCCATTTTC

Downstream 100 bases:

>100_bases
CGCGCGATACGCCCGCCCGGGCGGCGGCTCGGTCGGCACCGGGACAGCCCTGGGCAGTGGCGGGCGAGTCCGGTGGCGGT
TCGGCGGTTCAGCAAATTAT

Product: phosphomethylpyrimidine kinase type-1

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MSSNTPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDPDTVAAQARMLLEDMPVAAFK
IGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPN
LDAALSHLLGQGCEYILATETGSHRLVNTLYGEEGQIRQDLWERTPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEY
LYQAARDAFRPGMGAYLPDRFFWARSNEDESPAPAGIAKRTN

Sequences:

>Translated_282_residues
MSSNTPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDPDTVAAQARMLLEDMPVAAFK
IGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPN
LDAALSHLLGQGCEYILATETGSHRLVNTLYGEEGQIRQDLWERTPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEY
LYQAARDAFRPGMGAYLPDRFFWARSNEDESPAPAGIAKRTN
>Mature_281_residues
SSNTPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDPDTVAAQARMLLEDMPVAAFKI
GAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPNL
DAALSHLLGQGCEYILATETGSHRLVNTLYGEEGQIRQDLWERTPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEYL
YQAARDAFRPGMGAYLPDRFFWARSNEDESPAPAGIAKRTN

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=240, Percent_Identity=29.1666666666667, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 29814; Mature: 29682

Theoretical pI: Translated: 4.04; Mature: 4.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNTPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDP
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCEECCCCCHHHHCCCCH
DTVAAQARMLLEDMPVAAFKIGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLA
HHHHHHHHHHHHHCCHHHEECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEC
ADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPNLDAALSHLLGQGCEYILATE
HHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEC
TGSHRLVNTLYGEEGQIRQDLWERTPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEY
CCCCHHHHHHCCCCCHHHHHHHHCCCHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LYQAARDAFRPGMGAYLPDRFFWARSNEDESPAPAGIAKRTN
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSNTPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDP
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCEECCCCCHHHHCCCCH
DTVAAQARMLLEDMPVAAFKIGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLA
HHHHHHHHHHHHHCCHHHEECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEC
ADDLRESIADLLAPQTTLLVADHATLIALAQPDGDAEAPNLDAALSHLLGQGCEYILATE
HHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEC
TGSHRLVNTLYGEEGQIRQDLWERTPHRLMGITDTLGAAIAALLANGQEPPEAVREAQEY
CCCCHHHHHHCCCCCHHHHHHHHCCCHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LYQAARDAFRPGMGAYLPDRFFWARSNEDESPAPAGIAKRTN
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]