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The map label for this gene is livH [H]

Identifier: 237813472

GI number: 237813472

Start: 3134862

End: 3136484

Strand: Direct

Name: livH [H]

Synonym: GBP346_A3248

Alternate gene names: 237813472

Gene position: 3134862-3136484 (Clockwise)

Preceding gene: 237813471

Following gene: 237813473

Centisome position: 76.49

GC content: 70.92

Gene sequence:

>1623_bases
ATGCCTTTGAGCCGCGCCGCTCGTGCGCTCGCGGCGCTCGCCGCCTGCGCGGCGTTTTCGTTCGCCGCGCCGCGTGCGGC
GCTCGCCGTCACGGCGGCCGACGTCGCCGCGCTCGCCGGCGACGACTTCGATGCGAAGCGCGCCGCGATCGACCGTCTCG
CCGCCGGGCACGACGCCGCCGCGGCCCCGCTGCTGAACGCGCTCGCGAACGGCGACGCGCTCGCGACCGACGCCGGGCGC
ATCCTGATTCAGCATGGCGACGCCGCGCGCGACGCACTGACGAACGCGCCCGCGCAGGCGGGCGATGCGCAGCCGGTGAT
GCTCAACAACCTGCTGCGCACGAAGATCGCGAACGCACTGTCGGGGCTCGATCTCGCATCGCCCGACATCGACACGCGCC
GCCGCGCGATCGATGCGCTGCTCAAGCGCCCCGATGCCGCGCTCAAGCCGATGATCGACGCCGCGCGTGCGAAGGAAACC
GATCCCGTGCTCAAGCGCCGCCTCGACGCGCTATGGGCGATCGCCGCGCTGCGCGACGCCGATCCCGCGAAGCGCCTCGA
AGCGGTGCGGCTCGTCGCCGCGCGAAGCGATCTCGACATGATCGAGCAACTGCGCCCGCTCGTCGCGAAGCGGCCCGACG
GCGGCGACGCGGAACCCGATGCGCGCGTGCGCGAGGCCGCGCAGCAGGGGCTCGGCGCGCTCTATGCGATCCAGCGCCGC
GGCGAAATCGCGGGCACGCTGTTCGCGGGGCTCTCGCTCGGCAGCGTGCTGCTGCTCGCCGCGCTCGGCCTCGCGATCAC
GTACGGCCTCATCGGCGTCATCAACATGGCGCACGGCGAGTTCCTGATGATCGGCGCGTATGCGACCTACGTCGTGCAGA
CGTTCGTGCAGCGCTATCTGCCCGGCGCGTTCGACTGGTATCCGCTCGCCGCGATTCCCGTGTCGTTCGCCGCGGCCGCC
GCGCTCGGCATCGTGCTCGAGCGCACGGTGCTCAGGCACCTGTATGGCCGCCCGCTCGAGACGCTGCTCGCGACATTCGG
CGTGAGCCTCATCCTGATCCAGGCGACGCGGATGATCTTCGGCGCACAGAACGTGCAGGTCGTCAATCCGTCGTGGATGA
GCGGCGGCGTGACCGTGATGCAGAACCTGATCCTGCCGTACAACCGCCTCGCGATCCTCGCGTTCGCGCTCGTCGTCGTC
GGCATCGCGTGGGCCGTGCTGACGAAAACGCGCCTCGGCCTGTTCGTGCGCGCGGTCACGCAGAACCGCCGGATGGCCGC
GTGCGTCGGCGTGAAGACGGCGCGCGTCGATTCGTATGCGTTCGCGTTCGGCGCGGGCATCGCGGGCCTCGGCGGCTGCG
CGCTGTCGCAGATCGGCAACGTCGGCCCGGATCTCGGCCAGAGCTACATCGTCGATTCGTTCATGGCGGTCGTGCTGGGC
GGCGTCGGCCAGATCGCGGGCACGGTGCTCGGGGGCTTCGGCCTCGGGCTCGTCAGCAAGGCGATCGAGCCGTTCTGGGG
CGCGGTGCTCGCGAAGATCGCCGTGCTCGTGATGATCGTGCTGTTCATCCAGAAACGCCCGCAAGGGATGTTCGCCCTGA
AGGGCCGCAGCGCGGAGGCATGA

Upstream 100 bases:

>100_bases
GCCTGACGCGCGTGCGGGTGCCGCGCCAGCGCGCGGCGTCGCCGTCGCGCGCGTCCGCGCCGCGCGCTTTCTCCCCTTTC
GCGAGGACTGACCGATGCCC

Downstream 100 bases:

>100_bases
CATGACTTCGACGATCCATTCCCTTGCCGTCGCGCGCGGCGCGTCGCCCGCTTCGTCCACGGCATCCGCCGCGTCCGCTT
CACCGGCCGCGCCGCGCTTC

Product: branched-chain amino acid ABC transporter, permease protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MPLSRAARALAALAACAAFSFAAPRAALAVTAADVAALAGDDFDAKRAAIDRLAAGHDAAAAPLLNALANGDALATDAGR
ILIQHGDAARDALTNAPAQAGDAQPVMLNNLLRTKIANALSGLDLASPDIDTRRRAIDALLKRPDAALKPMIDAARAKET
DPVLKRRLDALWAIAALRDADPAKRLEAVRLVAARSDLDMIEQLRPLVAKRPDGGDAEPDARVREAAQQGLGALYAIQRR
GEIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQTFVQRYLPGAFDWYPLAAIPVSFAAAA
ALGIVLERTVLRHLYGRPLETLLATFGVSLILIQATRMIFGAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFALVVV
GIAWAVLTKTRLGLFVRAVTQNRRMAACVGVKTARVDSYAFAFGAGIAGLGGCALSQIGNVGPDLGQSYIVDSFMAVVLG
GVGQIAGTVLGGFGLGLVSKAIEPFWGAVLAKIAVLVMIVLFIQKRPQGMFALKGRSAEA

Sequences:

>Translated_540_residues
MPLSRAARALAALAACAAFSFAAPRAALAVTAADVAALAGDDFDAKRAAIDRLAAGHDAAAAPLLNALANGDALATDAGR
ILIQHGDAARDALTNAPAQAGDAQPVMLNNLLRTKIANALSGLDLASPDIDTRRRAIDALLKRPDAALKPMIDAARAKET
DPVLKRRLDALWAIAALRDADPAKRLEAVRLVAARSDLDMIEQLRPLVAKRPDGGDAEPDARVREAAQQGLGALYAIQRR
GEIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQTFVQRYLPGAFDWYPLAAIPVSFAAAA
ALGIVLERTVLRHLYGRPLETLLATFGVSLILIQATRMIFGAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFALVVV
GIAWAVLTKTRLGLFVRAVTQNRRMAACVGVKTARVDSYAFAFGAGIAGLGGCALSQIGNVGPDLGQSYIVDSFMAVVLG
GVGQIAGTVLGGFGLGLVSKAIEPFWGAVLAKIAVLVMIVLFIQKRPQGMFALKGRSAEA
>Mature_539_residues
PLSRAARALAALAACAAFSFAAPRAALAVTAADVAALAGDDFDAKRAAIDRLAAGHDAAAAPLLNALANGDALATDAGRI
LIQHGDAARDALTNAPAQAGDAQPVMLNNLLRTKIANALSGLDLASPDIDTRRRAIDALLKRPDAALKPMIDAARAKETD
PVLKRRLDALWAIAALRDADPAKRLEAVRLVAARSDLDMIEQLRPLVAKRPDGGDAEPDARVREAAQQGLGALYAIQRRG
EIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQTFVQRYLPGAFDWYPLAAIPVSFAAAAA
LGIVLERTVLRHLYGRPLETLLATFGVSLILIQATRMIFGAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFALVVVG
IAWAVLTKTRLGLFVRAVTQNRRMAACVGVKTARVDSYAFAFGAGIAGLGGCALSQIGNVGPDLGQSYIVDSFMAVVLGG
VGQIAGTVLGGFGLGLVSKAIEPFWGAVLAKIAVLVMIVLFIQKRPQGMFALKGRSAEA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=312, Percent_Identity=28.8461538461538, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 56392; Mature: 56261

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSRAARALAALAACAAFSFAAPRAALAVTAADVAALAGDDFDAKRAAIDRLAAGHDAA
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHH
AAPLLNALANGDALATDAGRILIQHGDAARDALTNAPAQAGDAQPVMLNNLLRTKIANAL
HHHHHHHHHCCCCEECCCCEEEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
SGLDLASPDIDTRRRAIDALLKRPDAALKPMIDAARAKETDPVLKRRLDALWAIAALRDA
HCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
DPAKRLEAVRLVAARSDLDMIEQLRPLVAKRPDGGDAEPDARVREAAQQGLGALYAIQRR
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHC
GEIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQTFVQRYL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHC
PGAFDWYPLAAIPVSFAAAAALGIVLERTVLRHLYGRPLETLLATFGVSLILIQATRMIF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFALVVVGIAWAVLTKTRLGLFVRAVT
CCCCEEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNRRMAACVGVKTARVDSYAFAFGAGIAGLGGCALSQIGNVGPDLGQSYIVDSFMAVVLG
CCCCHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
GVGQIAGTVLGGFGLGLVSKAIEPFWGAVLAKIAVLVMIVLFIQKRPQGMFALKGRSAEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
>Mature Secondary Structure 
PLSRAARALAALAACAAFSFAAPRAALAVTAADVAALAGDDFDAKRAAIDRLAAGHDAA
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHH
AAPLLNALANGDALATDAGRILIQHGDAARDALTNAPAQAGDAQPVMLNNLLRTKIANAL
HHHHHHHHHCCCCEECCCCEEEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
SGLDLASPDIDTRRRAIDALLKRPDAALKPMIDAARAKETDPVLKRRLDALWAIAALRDA
HCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
DPAKRLEAVRLVAARSDLDMIEQLRPLVAKRPDGGDAEPDARVREAAQQGLGALYAIQRR
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHC
GEIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQTFVQRYL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHC
PGAFDWYPLAAIPVSFAAAAALGIVLERTVLRHLYGRPLETLLATFGVSLILIQATRMIF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFALVVVGIAWAVLTKTRLGLFVRAVT
CCCCEEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNRRMAACVGVKTARVDSYAFAFGAGIAGLGGCALSQIGNVGPDLGQSYIVDSFMAVVLG
CCCCHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
GVGQIAGTVLGGFGLGLVSKAIEPFWGAVLAKIAVLVMIVLFIQKRPQGMFALKGRSAEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]