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The map label for this gene is hemN_2 [H]

Identifier: 237813465

GI number: 237813465

Start: 3128853

End: 3130247

Strand: Direct

Name: hemN_2 [H]

Synonym: GBP346_A3241

Alternate gene names: 237813465

Gene position: 3128853-3130247 (Clockwise)

Preceding gene: 237813460

Following gene: 237813466

Centisome position: 76.34

GC content: 67.96

Gene sequence:

>1395_bases
ATGACGCAGCCGATTCCGTCCGAGGCGCTGTTTCGCCCCGACCTGCTCGCCAAGTACACGGCGAACGGCCCTCGCTATAC
GTCCTACCCCACCGCCCCTCAGTTCCGCGACAACTTCGATCCCGCCGATTACATCCGCGCGGCGGCCGATCCCGGCGCGT
CGGCGAGCGATCTGTCGCTCTATTTCCACATTCCGTTCTGCGCGACCGCCTGCTTCTATTGCGGCTGCAACAAGATCGCG
ACGCGCAACCGCAAGCGCGCGCGCCCGTATCTCGACCAGTTGAAGCACGAGATCGCGCTGCACGCCGCGCTCTTCGATCC
GGAGCGGACCGTCACGCAGCTCCACTGGGGCGGCGGCACGCCGACTTTCCTGTCGAACGCCGAGACGACCGAGCTGATGG
CGGCCACGCGCGAGTACTTCACGCTCGCGTCGGATCGCACCGGAGAATTCTCGATCGAGATCGATCCGCGCACGGCGTCG
CCCGCGACGCTCGTCCATCTGCGCACGATCGGCTTCAATCGCGTAAGCCTCGGCGTGCAGGACTTCGACCCCGACGTGCA
ACGCGCGATCAATCGCGTGCAGCCGCTCAAGATGACGTCCGACCTCGTGCGCGCCGCGCGCGCGACCGGCTATCACTCGA
TCGGCATCGATCTCATCTACGGGCTGCCGCACCAGACGGTATCGAGCTTCGCGCGCACGCTCGACACGATCGTCGAGCTC
GAGCCCGACCGGCTCTCCGTGTTCGGCTACGCGCACCTGCCGCACCTGTTCAAGATGCAGCGGCAGATCGACGCCGCCGC
GCTGCCGCCGCCCGCGACGCGCATCGCGCTGCTCGGCCTCGCGATCGAGCGGCTCACGCGCGCGGGCTATGTGTACATCG
GCATGGACCATTTCGCGCGGCCGGGCGACGAGCTCGTCCGCGCGCAGCGCAACGGCACGCTGCAGCGCAACTTCCAGGGC
TACAGCACGCGGGCGGACGCCGATCTGATCGGCATCGGCGCGTCCTCGATCGGCAAGGTCGGCGACGTCTACGCGCAGAA
CGCGAAGGATCTGCCGCGTTACGGCGCGGCGCTCGCCGACCAGCGTCTGCCGATCGCGCGCGGCGTGAAGCTCTCGGCCG
ACGACCGGCTGCGGCGCGACGTGATCACGCACCTGATGTGCAACCTCGTGCTGCCGTTCTCGCACGTCGAGGCCGCGTAC
GGCATCCGCTTCGCGAACAAGTTCGCGCGCGAGCTCGACACGCTGCGCGGCTTCGAGCGCGACGGCCTGCTGTCGATCGG
CGCCGATCGTCTGACGATTCATCCGGCCGGGCGCCTCTACGTGCGCAACATCGCGATGGTGTTCGACGCGTACCTGTCGG
GCGCGTCCGAACACCGCTATTCGAAGACGGTCTGA

Upstream 100 bases:

>100_bases
GTATTGTGCCATCCGCCGCTGCGACGTTATTACACAATTCAATGAAACCGACGGTTCCTATACTGGTCGACGTCACAGAG
CACGACTTCGAGCTTCCAGC

Downstream 100 bases:

>100_bases
GCGCGCCGGCCGCCGCGGCGCGCGCGGCCCGGGTTGTTGATAAAGTGTCGGTTTCCTCGCACTTTCGCTTTTGACGCCAC
GATGCGCACCACGCAAGCGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTQPIPSEALFRPDLLAKYTANGPRYTSYPTAPQFRDNFDPADYIRAAADPGASASDLSLYFHIPFCATACFYCGCNKIA
TRNRKRARPYLDQLKHEIALHAALFDPERTVTQLHWGGGTPTFLSNAETTELMAATREYFTLASDRTGEFSIEIDPRTAS
PATLVHLRTIGFNRVSLGVQDFDPDVQRAINRVQPLKMTSDLVRAARATGYHSIGIDLIYGLPHQTVSSFARTLDTIVEL
EPDRLSVFGYAHLPHLFKMQRQIDAAALPPPATRIALLGLAIERLTRAGYVYIGMDHFARPGDELVRAQRNGTLQRNFQG
YSTRADADLIGIGASSIGKVGDVYAQNAKDLPRYGAALADQRLPIARGVKLSADDRLRRDVITHLMCNLVLPFSHVEAAY
GIRFANKFARELDTLRGFERDGLLSIGADRLTIHPAGRLYVRNIAMVFDAYLSGASEHRYSKTV

Sequences:

>Translated_464_residues
MTQPIPSEALFRPDLLAKYTANGPRYTSYPTAPQFRDNFDPADYIRAAADPGASASDLSLYFHIPFCATACFYCGCNKIA
TRNRKRARPYLDQLKHEIALHAALFDPERTVTQLHWGGGTPTFLSNAETTELMAATREYFTLASDRTGEFSIEIDPRTAS
PATLVHLRTIGFNRVSLGVQDFDPDVQRAINRVQPLKMTSDLVRAARATGYHSIGIDLIYGLPHQTVSSFARTLDTIVEL
EPDRLSVFGYAHLPHLFKMQRQIDAAALPPPATRIALLGLAIERLTRAGYVYIGMDHFARPGDELVRAQRNGTLQRNFQG
YSTRADADLIGIGASSIGKVGDVYAQNAKDLPRYGAALADQRLPIARGVKLSADDRLRRDVITHLMCNLVLPFSHVEAAY
GIRFANKFARELDTLRGFERDGLLSIGADRLTIHPAGRLYVRNIAMVFDAYLSGASEHRYSKTV
>Mature_463_residues
TQPIPSEALFRPDLLAKYTANGPRYTSYPTAPQFRDNFDPADYIRAAADPGASASDLSLYFHIPFCATACFYCGCNKIAT
RNRKRARPYLDQLKHEIALHAALFDPERTVTQLHWGGGTPTFLSNAETTELMAATREYFTLASDRTGEFSIEIDPRTASP
ATLVHLRTIGFNRVSLGVQDFDPDVQRAINRVQPLKMTSDLVRAARATGYHSIGIDLIYGLPHQTVSSFARTLDTIVELE
PDRLSVFGYAHLPHLFKMQRQIDAAALPPPATRIALLGLAIERLTRAGYVYIGMDHFARPGDELVRAQRNGTLQRNFQGY
STRADADLIGIGASSIGKVGDVYAQNAKDLPRYGAALADQRLPIARGVKLSADDRLRRDVITHLMCNLVLPFSHVEAAYG
IRFANKFARELDTLRGFERDGLLSIGADRLTIHPAGRLYVRNIAMVFDAYLSGASEHRYSKTV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=257, Percent_Identity=26.4591439688716, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI87082341, Length=451, Percent_Identity=48.3370288248337, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1789325, Length=283, Percent_Identity=28.9752650176678, Blast_Score=109, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51462; Mature: 51331

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPIPSEALFRPDLLAKYTANGPRYTSYPTAPQFRDNFDPADYIRAAADPGASASDLSL
CCCCCCCHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEE
YFHIPFCATACFYCGCNKIATRNRKRARPYLDQLKHEIALHAALFDPERTVTQLHWGGGT
EEECHHHHHHHHHHCCCHHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
PTFLSNAETTELMAATREYFTLASDRTGEFSIEIDPRTASPATLVHLRTIGFNRVSLGVQ
CCCCCCCCHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCEEEEEEEECCCCEEECCHH
DFDPDVQRAINRVQPLKMTSDLVRAARATGYHSIGIDLIYGLPHQTVSSFARTLDTIVEL
CCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEECEEEEECCCHHHHHHHHHHHHHHHHC
EPDRLSVFGYAHLPHLFKMQRQIDAAALPPPATRIALLGLAIERLTRAGYVYIGMDHFAR
CCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHCC
PGDELVRAQRNGTLQRNFQGYSTRADADLIGIGASSIGKVGDVYAQNAKDLPRYGAALAD
CHHHHHHHHHCCCEEECCCCCCCCCCCCEEECCHHHHCHHHHHHHCCCCCCHHHHHHHHH
QRLPIARGVKLSADDRLRRDVITHLMCNLVLPFSHVEAAYGIRFANKFARELDTLRGFER
CCCCHHCCCEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DGLLSIGADRLTIHPAGRLYVRNIAMVFDAYLSGASEHRYSKTV
CCCEEECCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TQPIPSEALFRPDLLAKYTANGPRYTSYPTAPQFRDNFDPADYIRAAADPGASASDLSL
CCCCCCHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEE
YFHIPFCATACFYCGCNKIATRNRKRARPYLDQLKHEIALHAALFDPERTVTQLHWGGGT
EEECHHHHHHHHHHCCCHHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
PTFLSNAETTELMAATREYFTLASDRTGEFSIEIDPRTASPATLVHLRTIGFNRVSLGVQ
CCCCCCCCHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCEEEEEEEECCCCEEECCHH
DFDPDVQRAINRVQPLKMTSDLVRAARATGYHSIGIDLIYGLPHQTVSSFARTLDTIVEL
CCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEECEEEEECCCHHHHHHHHHHHHHHHHC
EPDRLSVFGYAHLPHLFKMQRQIDAAALPPPATRIALLGLAIERLTRAGYVYIGMDHFAR
CCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHCC
PGDELVRAQRNGTLQRNFQGYSTRADADLIGIGASSIGKVGDVYAQNAKDLPRYGAALAD
CHHHHHHHHHCCCEEECCCCCCCCCCCCEEECCHHHHCHHHHHHHCCCCCCHHHHHHHHH
QRLPIARGVKLSADDRLRRDVITHLMCNLVLPFSHVEAAYGIRFANKFARELDTLRGFER
CCCCHHCCCEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DGLLSIGADRLTIHPAGRLYVRNIAMVFDAYLSGASEHRYSKTV
CCCEEECCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]