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The map label for this gene is hemL [H]

Identifier: 237813426

GI number: 237813426

Start: 3096736

End: 3098436

Strand: Direct

Name: hemL [H]

Synonym: GBP346_A3201

Alternate gene names: 237813426

Gene position: 3096736-3098436 (Clockwise)

Preceding gene: 237813425

Following gene: 237813427

Centisome position: 75.56

GC content: 71.72

Gene sequence:

>1701_bases
GTGCGCGCGCGCCGTGGCGTCCCGTCCCGCGCATTGCGCGGCGAGCCGCGGCGAACGCCGCCACGACGCACCGACTCCCG
CCGCCGGCACAGCGAGCCGACGAATCGGCAGGCACCGCCGGCATGGAAGCGATCGGACGAATCGCCCGCACCCCGCGCCG
TTTGTCGCGAGCATGGACGTTGCGCATCGCGCAACCTTCCTCGCCTTCCTCGCCTTCCTCGCCTGCCTCGCCTGCCTCGC
CTGCCTCGCCTGCCGACAATGCCGACATCCCGCCGCAGCCCCGCCCCCGCGCGCCGAACCGCCGCAGCCGCCCCGAAACC
CGTCGCGCGCGTCTCCGGTACAATCAGTCGGATCGATACGCGCGACGCGAGCCGCGGCGCTTCGCCGCTCGCGCGCACTC
TCTCGCAGGTCCAATTCATGTCGAACAATCAAACTCTCTTCGAACGCGCCCAGCGAACCATCCCGGGCGGCGTCAATTCG
CCGGTGCGGGCGTTCCGCTCGGTCGGCGGCACGCCGCGCTTCGTCGCGCGCGCGCAGGGCGCGTACTTCTGGGACGCGGA
CGGCAAGCGCTACATCGACTACATCGGCTCGTGGGGGCCGATGATCGTCGGCCACGTGCACCCGGACGTGCTCGCGGCCG
TGCAGCGCGTGCTCGCCGACGGCTTCTCGTTCGGCGCGCCCACCGAAGCCGAAATCGAGATCGCCGAGGAGATCTGCAAG
CTCGTGCCGTCGATCGAGCAGGTGCGGATGGTGTCGAGCGGCACCGAAGCGACGATGAGCGCGCTGCGCCTCGCGCGCGG
CTTCACCGGCCGCAGCCGGATCGTCAAGTTCGAGGGCTGCTATCACGGCCATGCGGACAGCCTGCTCGTGAAGGCGGGCT
CGGGCCTGCTCACGTTCGGCAATCCGACCTCGGCGGGCGTGCCGGCCGACGTCGCGAAGCACACGACCGTGCTCGAGTAC
AACAACGTCGCGGCGCTCGAGGAAGCGTTCGCCGCGTTCGGCGGCGAGATCGCCGCGGTGATCGTCGAGCCCGTCGCGGG
CAACATGAACCTCGTGCGCGGCACGCCGGAGTTCCTGAACGCGCTGCGCGCGCTCACCGCGAAGCACGGCGCCGTGCTGA
TCTTCGACGAAGTGATGTGCGGCTTTCGCGTCGCGCTCGGCGGCGCGCAGCAGCACTACGGGATCACGCCGGATCTGACC
TGCCTCGGCAAGGTGATCGGCGGCGGCATGCCGGCCGCCGCGTTCGGCGGCCGCGGCGACATCATGTCGCACCTCGCGCC
GCTCGGCGGCGTCTATCAGGCGGGCACCCTGTCGGGCAACCCGGTCGCGGTCGCGGCGGGCCTCGCGACGCTGCGGCTGA
TCCAGGCGCCGGGCTTTCACGATGCGCTCGCCGACAAGACCCGGCGGCTCGCCGACGGCCTCGCGGCCGAGGCGCGCGCG
GCGGGCGTGCCGTTCTCGGCCGACGCGATCGGCGGGATGTTCGGCCTCTACTTCACCGAGCAGGTGCCCGCGAGCTTCGC
CGACGTGACGAAGAGCGACATCGAGCGCTTCAACCGCTTCTTCCATCTGATGCTCGACGCCGGCGTGTACTTCGCGCCCT
CCGCGTACGAAGCGGGCTTCGTGTCGAGCGCGCACGACGACGCGACGCTCGAGGCGACGCTCGACGCCGCCCGCCGCGCG
TTCGCCGCGCTGCGTGCCTGA

Upstream 100 bases:

>100_bases
GATCAAGCCGGTCGCGGAGGGCGCGCTCGAGAAACGCTGGGCGGAGCTCACCGGCAAGCGCAAGCCGCCCAAGCGCGCGT
AGTGCGCGCGTGTCGCGCGG

Downstream 100 bases:

>100_bases
CCGGCCGCACGACTGACAGGACGAACCGATGTTCTCGGAAAGCGACTTCACCCACATGCAGCGCGCGCTCGCGCTCGCCG
CGCGCGGGATGTACACGACG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MRARRGVPSRALRGEPRRTPPRRTDSRRRHSEPTNRQAPPAWKRSDESPAPRAVCREHGRCASRNLPRLPRLPRLPRLPR
LPRLPTMPTSRRSPAPARRTAAAAPKPVARVSGTISRIDTRDASRGASPLARTLSQVQFMSNNQTLFERAQRTIPGGVNS
PVRAFRSVGGTPRFVARAQGAYFWDADGKRYIDYIGSWGPMIVGHVHPDVLAAVQRVLADGFSFGAPTEAEIEIAEEICK
LVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADVAKHTTVLEY
NNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLNALRALTAKHGAVLIFDEVMCGFRVALGGAQQHYGITPDLT
CLGKVIGGGMPAAAFGGRGDIMSHLAPLGGVYQAGTLSGNPVAVAAGLATLRLIQAPGFHDALADKTRRLADGLAAEARA
AGVPFSADAIGGMFGLYFTEQVPASFADVTKSDIERFNRFFHLMLDAGVYFAPSAYEAGFVSSAHDDATLEATLDAARRA
FAALRA

Sequences:

>Translated_566_residues
MRARRGVPSRALRGEPRRTPPRRTDSRRRHSEPTNRQAPPAWKRSDESPAPRAVCREHGRCASRNLPRLPRLPRLPRLPR
LPRLPTMPTSRRSPAPARRTAAAAPKPVARVSGTISRIDTRDASRGASPLARTLSQVQFMSNNQTLFERAQRTIPGGVNS
PVRAFRSVGGTPRFVARAQGAYFWDADGKRYIDYIGSWGPMIVGHVHPDVLAAVQRVLADGFSFGAPTEAEIEIAEEICK
LVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADVAKHTTVLEY
NNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLNALRALTAKHGAVLIFDEVMCGFRVALGGAQQHYGITPDLT
CLGKVIGGGMPAAAFGGRGDIMSHLAPLGGVYQAGTLSGNPVAVAAGLATLRLIQAPGFHDALADKTRRLADGLAAEARA
AGVPFSADAIGGMFGLYFTEQVPASFADVTKSDIERFNRFFHLMLDAGVYFAPSAYEAGFVSSAHDDATLEATLDAARRA
FAALRA
>Mature_566_residues
MRARRGVPSRALRGEPRRTPPRRTDSRRRHSEPTNRQAPPAWKRSDESPAPRAVCREHGRCASRNLPRLPRLPRLPRLPR
LPRLPTMPTSRRSPAPARRTAAAAPKPVARVSGTISRIDTRDASRGASPLARTLSQVQFMSNNQTLFERAQRTIPGGVNS
PVRAFRSVGGTPRFVARAQGAYFWDADGKRYIDYIGSWGPMIVGHVHPDVLAAVQRVLADGFSFGAPTEAEIEIAEEICK
LVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADVAKHTTVLEY
NNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLNALRALTAKHGAVLIFDEVMCGFRVALGGAQQHYGITPDLT
CLGKVIGGGMPAAAFGGRGDIMSHLAPLGGVYQAGTLSGNPVAVAAGLATLRLIQAPGFHDALADKTRRLADGLAAEARA
AGVPFSADAIGGMFGLYFTEQVPASFADVTKSDIERFNRFFHLMLDAGVYFAPSAYEAGFVSSAHDDATLEATLDAARRA
FAALRA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=307, Percent_Identity=28.0130293159609, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI284507298, Length=224, Percent_Identity=27.6785714285714, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=60.7981220657277, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1789016, Length=358, Percent_Identity=33.2402234636872, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1789759, Length=311, Percent_Identity=29.903536977492, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1787560, Length=352, Percent_Identity=31.5340909090909, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788044, Length=330, Percent_Identity=30.6060606060606, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI145693181, Length=397, Percent_Identity=29.2191435768262, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786991, Length=382, Percent_Identity=28.7958115183246, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=363, Percent_Identity=25.8953168044077, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=366, Percent_Identity=23.4972677595628, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25144274, Length=210, Percent_Identity=28.0952380952381, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=332, Percent_Identity=27.710843373494, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324432, Length=420, Percent_Identity=24.2857142857143, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357415, Length=320, Percent_Identity=25.9375, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 60415; Mature: 60415

Theoretical pI: Translated: 10.72; Mature: 10.72

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARRGVPSRALRGEPRRTPPRRTDSRRRHSEPTNRQAPPAWKRSDESPAPRAVCREHGR
CCCCCCCCCHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCC
CASRNLPRLPRLPRLPRLPRLPRLPTMPTSRRSPAPARRTAAAAPKPVARVSGTISRIDT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCC
RDASRGASPLARTLSQVQFMSNNQTLFERAQRTIPGGVNSPVRAFRSVGGTPRFVARAQG
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHCCC
AYFWDADGKRYIDYIGSWGPMIVGHVHPDVLAAVQRVLADGFSFGAPTEAEIEIAEEICK
CEEECCCCCHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFG
HCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEECCCCEEEEC
NPTSAGVPADVAKHTTVLEYNNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLN
CCCCCCCCHHHHHCCEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCHHHHH
ALRALTAKHGAVLIFDEVMCGFRVALGGAQQHYGITPDLTCLGKVIGGGMPAAAFGGRGD
HHHHHHHCCCEEEEEHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHCCCCCHHHCCCCHH
IMSHLAPLGGVYQAGTLSGNPVAVAAGLATLRLIQAPGFHDALADKTRRLADGLAAEARA
HHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AGVPFSADAIGGMFGLYFTEQVPASFADVTKSDIERFNRFFHLMLDAGVYFAPSAYEAGF
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCC
VSSAHDDATLEATLDAARRAFAALRA
CCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRARRGVPSRALRGEPRRTPPRRTDSRRRHSEPTNRQAPPAWKRSDESPAPRAVCREHGR
CCCCCCCCCHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCC
CASRNLPRLPRLPRLPRLPRLPRLPTMPTSRRSPAPARRTAAAAPKPVARVSGTISRIDT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCC
RDASRGASPLARTLSQVQFMSNNQTLFERAQRTIPGGVNSPVRAFRSVGGTPRFVARAQG
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHCCC
AYFWDADGKRYIDYIGSWGPMIVGHVHPDVLAAVQRVLADGFSFGAPTEAEIEIAEEICK
CEEECCCCCHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFG
HCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEECCCCEEEEC
NPTSAGVPADVAKHTTVLEYNNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLN
CCCCCCCCHHHHHCCEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCHHHHH
ALRALTAKHGAVLIFDEVMCGFRVALGGAQQHYGITPDLTCLGKVIGGGMPAAAFGGRGD
HHHHHHHCCCEEEEEHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHCCCCCHHHCCCCHH
IMSHLAPLGGVYQAGTLSGNPVAVAAGLATLRLIQAPGFHDALADKTRRLADGLAAEARA
HHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AGVPFSADAIGGMFGLYFTEQVPASFADVTKSDIERFNRFFHLMLDAGVYFAPSAYEAGF
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCC
VSSAHDDATLEATLDAARRAFAALRA
CCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA