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The map label for this gene is zwf [H]

Identifier: 237813415

GI number: 237813415

Start: 3085619

End: 3087088

Strand: Direct

Name: zwf [H]

Synonym: GBP346_A3190

Alternate gene names: 237813415

Gene position: 3085619-3087088 (Clockwise)

Preceding gene: 237813409

Following gene: 237813416

Centisome position: 75.29

GC content: 68.3

Gene sequence:

>1470_bases
ATGCATACCGATTCGAGCTTCACCTTCGTTCTCTTCGGCGGCACCGGCGATCTGTCGATGCGCAAGATCCTCCCCGCGCT
CTTCGAAGCGCATCGCGCGAACATGCTGTCGGAAGCCGGCAGGATCGTCGCCGTGGCCCGCCACGCGGCGGACCGCGAAG
GCTACCTGCAGTGGGTCGAGGAGCACGTGAAGCCGCACGCGGCGAAGGCGGCGGGCGGCGCGTTCGACGAAGCGGTCTGG
CGGAGCTTTCTCGAGCGCATCGTCTACGTGAAGCTCGACCTCGGCCGCGCGGAAGATTACGCGCTGCTGCGCGACACGGT
CGGCGGGCTCTCGGGCATCCGCGTGTTCTACCTGGCGACGGGCCCGTCGCTGTTCGTGCCGATCTGCAAGGCGCTCGCCG
CAGTGGGCCTGAACGAAGGCGCGCGCATCGTGCTCGAGAAGCCGCTCGGCTACGACCTGCGCTCGTCGAACGCGATCAAC
GACGCGGTGGGCGAGATCTTCGCCGAAGACCAGATCTACCGGATCGATCACTACCTCGGCAAGGAGCCGGTGCAGAACCT
GCTCGCGCTGCGCTTCGGCAACGCGCTCTTCGAGCCGCTGTGGCGCCGCGAATGGGTGGAGAGCATCCAGATCACGATCG
CCGAGGAGCTCGGCGTCGAGGCGCGCGGCGATTTCTACGACAATACCGGCGCGCTGCGCGACATGGTGCAGAACCACCTG
CTGCAGTTGCTGTCGATCGTCGCGATGGAGCCGCCGCACTCGATGGATTCCGATTCGGTGCGCGACGAGAAGCTGCGCGT
GCTGCGCGCGTTGAAGCCCGTCGATCCGCGCGACATCGGCAAGGTCGCGGTGCGCGGCCAGTACCACGCGGGCGTGATCA
AGGGCGCGCAGGTGCCCGCGTACGCGACCGAGCCCGGCGTGAAGGCGGACAGCCAGACCGAGACGTTCGTCGCGCTGAAG
GTCGAGATCGAGAACTGGCGCTGGGCCGGCGTGCCGTTCTTCCTGCGCACCGGCAAGCGCCTCGCCGACCGCGTCGCGGA
GATCGTCGTCAACTTCCGGCCGGTGCCGCACTCGGCGCTCGGCCCCACCGCGCTGCGCGCGGGCGCGAACCGTCTCGTGA
TCCGGCTGCAGCCGAACGAATCGATCCGCCTGTACTGCCTCGCGAAGCAGCCGGGCGAAGGGATGAACCTGGCGAGCGTG
CACCTCGACCTCGCGTTCGACCAGTTCTTCAAGGAAGGCCAGATGGAGGCGTACCAGCGCCTGCTGCTCGACGTGATCAA
CGGCCGCCTCGCGCTCTTCGTCCGGCGCGACGAACAGGAAGCCGCATGGCGCTGGGTCGAGCCGATCCTGAACGAATGGG
CGCGCACGACGAAGCCGCCGAAGCCGTACGCGGCCGGCACCTGGGGCCCGGCCGCGGCGAGCGCGATGCTCGCGCAGCAC
GGCACCTGCTGGCTCGAAGAAGAAAACTGA

Upstream 100 bases:

>100_bases
ACCCCTTGCGGCGGATTGTAGTTAAACTACAATTCAGTGTCAAAAATATTTTTATCGCACTACGGCCCGCGTCGCGGGCA
TCCCCAAACGGCGGAGACAC

Downstream 100 bases:

>100_bases
TGCAATGCGGCGCGCGGCTGCCGTGCGCGCGCCGCCCGATGTCCCCACGCAATTCAATCCATTCAATAAAGGCAGTCTGG
AGGAGAAGTGATCGAGGTTC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLSEAGRIVAVARHAADREGYLQWVEEHVKPHAAKAAGGAFDEAVW
RSFLERIVYVKLDLGRAEDYALLRDTVGGLSGIRVFYLATGPSLFVPICKALAAVGLNEGARIVLEKPLGYDLRSSNAIN
DAVGEIFAEDQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGAQVPAYATEPGVKADSQTETFVALK
VEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSALGPTALRAGANRLVIRLQPNESIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARTTKPPKPYAAGTWGPAAASAMLAQH
GTCWLEEEN

Sequences:

>Translated_489_residues
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLSEAGRIVAVARHAADREGYLQWVEEHVKPHAAKAAGGAFDEAVW
RSFLERIVYVKLDLGRAEDYALLRDTVGGLSGIRVFYLATGPSLFVPICKALAAVGLNEGARIVLEKPLGYDLRSSNAIN
DAVGEIFAEDQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGAQVPAYATEPGVKADSQTETFVALK
VEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSALGPTALRAGANRLVIRLQPNESIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARTTKPPKPYAAGTWGPAAASAMLAQH
GTCWLEEEN
>Mature_489_residues
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLSEAGRIVAVARHAADREGYLQWVEEHVKPHAAKAAGGAFDEAVW
RSFLERIVYVKLDLGRAEDYALLRDTVGGLSGIRVFYLATGPSLFVPICKALAAVGLNEGARIVLEKPLGYDLRSSNAIN
DAVGEIFAEDQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGAQVPAYATEPGVKADSQTETFVALK
VEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSALGPTALRAGANRLVIRLQPNESIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARTTKPPKPYAAGTWGPAAASAMLAQH
GTCWLEEEN

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=492, Percent_Identity=36.5853658536585, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI109389365, Length=492, Percent_Identity=36.5853658536585, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI52145310, Length=362, Percent_Identity=33.9779005524862, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=43.9918533604888, Blast_Score=431, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17538218, Length=491, Percent_Identity=35.6415478615071, Blast_Score=320, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6324088, Length=488, Percent_Identity=35.0409836065574, Blast_Score=292, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24643352, Length=480, Percent_Identity=37.5, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI24643350, Length=480, Percent_Identity=37.5, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI221513548, Length=491, Percent_Identity=30.142566191446, Blast_Score=209, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54485; Mature: 54485

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLSEAGRIVAVARHAADREGYLQWVE
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCHHHHHHHHH
EHVKPHAAKAAGGAFDEAVWRSFLERIVYVKLDLGRAEDYALLRDTVGGLSGIRVFYLAT
HHCCCHHHHHCCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEEC
GPSLFVPICKALAAVGLNEGARIVLEKPLGYDLRSSNAINDAVGEIFAEDQIYRIDHYLG
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHHCC
KEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHHHH
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGAQVPA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEECCCCCC
YATEPGVKADSQTETFVALKVEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSAL
CCCCCCCCCCCCCCEEEEEEEEECCEEECCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
GPTALRAGANRLVIRLQPNESIRLYCLAKQPGEGMNLASVHLDLAFDQFFKEGQMEAYQR
CCHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHH
LLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARTTKPPKPYAAGTWGPAAASAMLAQH
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHC
GTCWLEEEN
CCEEEECCC
>Mature Secondary Structure
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLSEAGRIVAVARHAADREGYLQWVE
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCHHHHHHHHH
EHVKPHAAKAAGGAFDEAVWRSFLERIVYVKLDLGRAEDYALLRDTVGGLSGIRVFYLAT
HHCCCHHHHHCCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEEC
GPSLFVPICKALAAVGLNEGARIVLEKPLGYDLRSSNAINDAVGEIFAEDQIYRIDHYLG
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHHCC
KEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHHHH
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGAQVPA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEECCCCCC
YATEPGVKADSQTETFVALKVEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSAL
CCCCCCCCCCCCCCEEEEEEEEECCEEECCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
GPTALRAGANRLVIRLQPNESIRLYCLAKQPGEGMNLASVHLDLAFDQFFKEGQMEAYQR
CCHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHH
LLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARTTKPPKPYAAGTWGPAAASAMLAQH
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHC
GTCWLEEEN
CCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]