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The map label for this gene is csd [H]

Identifier: 237813123

GI number: 237813123

Start: 2817111

End: 2818352

Strand: Direct

Name: csd [H]

Synonym: GBP346_A2885

Alternate gene names: 237813123

Gene position: 2817111-2818352 (Clockwise)

Preceding gene: 237813122

Following gene: 237813124

Centisome position: 68.73

GC content: 72.14

Gene sequence:

>1242_bases
ATGGGTGACATGCTGCGTTCGGCCACGATGATGGCGAGCGCGTTTCCGGCGCTTGCGCAGCGCGTGAACGGCGCGCCGCT
CGCGTATCTCGACAACGCGGCGACGACGCACGTGCCGCAGCCCGTCCTCGCCGCGATGCGCGGCTTCGACGAGCGCGATC
GCGCGAACATCCACCGCGGCGTCCACACGCTCAGCCAGCGGGCGACCGACGCTTACGAACGCGCGCGCGACACGCTCGCG
CGCTTCGTCGGCGCGAACGGCGAGCACCTGCTCGTCTTCACGTCGGGCGCAACCGATGCGCTGAATCTCGTCGCCAATGG
GCTATCGGTTGCCGGCCACACGCAAGCCGTGCTGCAGGAAGGCGACGAGATCATCGTCAGCGCGCTCGAGCATCACGCGA
ACCTCGTGCCGTGGCAGATGGCCGCGCGCCGTTGCGGCGCGAAGCTGCGGATCCTGCATCCGGATCCGCAGGGCAGCCTG
CATGTTCTGGACCTCGAACGATTGCTGGGGCCGCGCACGCGCGTGTTCGCGGTCACCGCGTGCTCGAACGCGACGGGCGA
GCGGCCGCCGTACGAGGCGCTGCTCGCGGCCGCGCGCGCGGGCGGCGCGCTGACGGTGCTCGACGCGGCACAGGCGGTCG
GCCACGACGTGCCCGATCTGTCCGCGCTCGCGTGCGACTTCGCCGCGTTCTCCGGCCACAAGATGTACGGGCCGATGGGC
ACCGGCGCGCTCGTCGGCCGCCGGGACGCGCTCGAGCGGCTCGTCCCGCTGCGCTTCGGCGGCGACATGGTGAGCTGGGT
GGGCGAGACGGACGCGACATTCGACGCGCTGCCCGCGCGGCTCGAAGGCGGCACGCCGAACGTCGCGGGCGCGGTCGGCA
TCGCGGCGGCCGCCGACTATATCGACGCGATCGGCCGCGCCCGGATCGACGCCCACGTGCGCGCACTGCGCGATCACGCG
GCCGCGGGCCTCGCGGCGCTCGACGGCGTGACCGTGCTCGCGCCGCGCACGTCGTCGGCGATCGTATCCTTCGTCGTCGA
CGGCGTGCATCCGCACGACATCGGCACATTGCTCGACGAGCGCGGCATCGCCGTGCGCACGGGCTTTCACTGCGCGCAGC
CGCTGCTCGAACGGCTCGGCTGCGGGCCGACGACGCGCGCGTCGTTCGCGCTCTACAACACGCACGACGAAGTCGAGCGC
CTCGTCGCGGGCGTCGCGCAAGCACTGAAGGTGTTGAGATGA

Upstream 100 bases:

>100_bases
CACGGCATCGACACGCCGGGCAGGCTGGAAGCGCTCGGCGGCGACGCGCTGCTCGCGCGCGAAGTCTCGCGGCATCTCGC
CGAACAAACGGAGGCACGCC

Downstream 100 bases:

>100_bases
ATCCGATCGAATCCCCCGCCGTCGCCGCCGATGCGCAAAGCACGCTCTACCAGGAGCTCATCGTCGAGCACAAGCGTGCG
CCGCGCCGCTTCGGCAAGCT

Product: cysteine desulfurase (Selenocysteine lyase) (Selenocysteine reductase) (Selenocysteine beta-lyase) (SCL)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MGDMLRSATMMASAFPALAQRVNGAPLAYLDNAATTHVPQPVLAAMRGFDERDRANIHRGVHTLSQRATDAYERARDTLA
RFVGANGEHLLVFTSGATDALNLVANGLSVAGHTQAVLQEGDEIIVSALEHHANLVPWQMAARRCGAKLRILHPDPQGSL
HVLDLERLLGPRTRVFAVTACSNATGERPPYEALLAAARAGGALTVLDAAQAVGHDVPDLSALACDFAAFSGHKMYGPMG
TGALVGRRDALERLVPLRFGGDMVSWVGETDATFDALPARLEGGTPNVAGAVGIAAAADYIDAIGRARIDAHVRALRDHA
AAGLAALDGVTVLAPRTSSAIVSFVVDGVHPHDIGTLLDERGIAVRTGFHCAQPLLERLGCGPTTRASFALYNTHDEVER
LVAGVAQALKVLR

Sequences:

>Translated_413_residues
MGDMLRSATMMASAFPALAQRVNGAPLAYLDNAATTHVPQPVLAAMRGFDERDRANIHRGVHTLSQRATDAYERARDTLA
RFVGANGEHLLVFTSGATDALNLVANGLSVAGHTQAVLQEGDEIIVSALEHHANLVPWQMAARRCGAKLRILHPDPQGSL
HVLDLERLLGPRTRVFAVTACSNATGERPPYEALLAAARAGGALTVLDAAQAVGHDVPDLSALACDFAAFSGHKMYGPMG
TGALVGRRDALERLVPLRFGGDMVSWVGETDATFDALPARLEGGTPNVAGAVGIAAAADYIDAIGRARIDAHVRALRDHA
AAGLAALDGVTVLAPRTSSAIVSFVVDGVHPHDIGTLLDERGIAVRTGFHCAQPLLERLGCGPTTRASFALYNTHDEVER
LVAGVAQALKVLR
>Mature_412_residues
GDMLRSATMMASAFPALAQRVNGAPLAYLDNAATTHVPQPVLAAMRGFDERDRANIHRGVHTLSQRATDAYERARDTLAR
FVGANGEHLLVFTSGATDALNLVANGLSVAGHTQAVLQEGDEIIVSALEHHANLVPWQMAARRCGAKLRILHPDPQGSLH
VLDLERLLGPRTRVFAVTACSNATGERPPYEALLAAARAGGALTVLDAAQAVGHDVPDLSALACDFAAFSGHKMYGPMGT
GALVGRRDALERLVPLRFGGDMVSWVGETDATFDALPARLEGGTPNVAGAVGIAAAADYIDAIGRARIDAHVRALRDHAA
AGLAALDGVTVLAPRTSSAIVSFVVDGVHPHDIGTLLDERGIAVRTGFHCAQPLLERLGCGPTTRASFALYNTHDEVERL
VAGVAQALKVLR

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=233, Percent_Identity=29.1845493562232, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI156713448, Length=322, Percent_Identity=27.9503105590062, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787970, Length=410, Percent_Identity=39.7560975609756, Blast_Score=314, Evalue=8e-87,
Organism=Escherichia coli, GI1789175, Length=384, Percent_Identity=41.1458333333333, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI48994898, Length=235, Percent_Identity=34.0425531914894, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI193211090, Length=346, Percent_Identity=25.7225433526012, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=233, Percent_Identity=28.3261802575107, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319831, Length=401, Percent_Identity=26.9326683291771, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20129463, Length=247, Percent_Identity=31.5789473684211, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR022471
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43408; Mature: 43277

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDMLRSATMMASAFPALAQRVNGAPLAYLDNAATTHVPQPVLAAMRGFDERDRANIHRG
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
VHTLSQRATDAYERARDTLARFVGANGEHLLVFTSGATDALNLVANGLSVAGHTQAVLQE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHC
GDEIIVSALEHHANLVPWQMAARRCGAKLRILHPDPQGSLHVLDLERLLGPRTRVFAVTA
CHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEECCCCCCCEEEEEHHHHHCCCCEEEEEEE
CSNATGERPPYEALLAAARAGGALTVLDAAQAVGHDVPDLSALACDFAAFSGHKMYGPMG
ECCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEECCCC
TGALVGRRDALERLVPLRFGGDMVSWVGETDATFDALPARLEGGTPNVAGAVGIAAAADY
CCHHHCCHHHHHHHCCHHCCCCHHHHCCCCCCHHHHCCHHCCCCCCCHHHHHHHHHHHHH
IDAIGRARIDAHVRALRDHAAAGLAALDGVTVLAPRTSSAIVSFVVDGVHPHDIGTLLDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHC
RGIAVRTGFHCAQPLLERLGCGPTTRASFALYNTHDEVERLVAGVAQALKVLR
CCCEEECCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
GDMLRSATMMASAFPALAQRVNGAPLAYLDNAATTHVPQPVLAAMRGFDERDRANIHRG
CCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
VHTLSQRATDAYERARDTLARFVGANGEHLLVFTSGATDALNLVANGLSVAGHTQAVLQE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHC
GDEIIVSALEHHANLVPWQMAARRCGAKLRILHPDPQGSLHVLDLERLLGPRTRVFAVTA
CHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEECCCCCCCEEEEEHHHHHCCCCEEEEEEE
CSNATGERPPYEALLAAARAGGALTVLDAAQAVGHDVPDLSALACDFAAFSGHKMYGPMG
ECCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEECCCC
TGALVGRRDALERLVPLRFGGDMVSWVGETDATFDALPARLEGGTPNVAGAVGIAAAADY
CCHHHCCHHHHHHHCCHHCCCCHHHHCCCCCCHHHHCCHHCCCCCCCHHHHHHHHHHHHH
IDAIGRARIDAHVRALRDHAAAGLAALDGVTVLAPRTSSAIVSFVVDGVHPHDIGTLLDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHC
RGIAVRTGFHCAQPLLERLGCGPTTRASFALYNTHDEVERLVAGVAQALKVLR
CCCEEECCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]