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The map label for this gene is uraH [C]

Identifier: 237812741

GI number: 237812741

Start: 2434254

End: 2434607

Strand: Direct

Name: uraH [C]

Synonym: GBP346_A2494

Alternate gene names: 237812741

Gene position: 2434254-2434607 (Clockwise)

Preceding gene: 237812740

Following gene: 237812742

Centisome position: 59.39

GC content: 68.36

Gene sequence:

>354_bases
ATGGGAAAGCTCACGACCCACGTACTCGACACCGCGCACGGCCGCCCGGGCGCCGCGATCAAGCTCGAGCTCCATGCGAT
CTCGGGCGACGGCAGCCGTCTGCTGAAGACCCTGCACACCAATGACGACGGCCGCTGCGACACGCCGCTGCTCGAAGGCG
ACGCGCTCGCCGCCGGCACCTACGAACTCGTGTTCCACGCGGGCGACTACTTCGCCGCGCAAGGCGTCGCGCTGCCCGAG
CCGCGCTTCGTCGATCTCGTCGTGCTGCGCTTCGGCATCGCCGATCCAACCGCGCACTATCACGTGCCGCTTCTCGTGTC
GCCGTGGTCGTACAGCACCTATCGCGGCAGCTGA

Upstream 100 bases:

>100_bases
CGCCGACGGGTATGTAGCCACTGACGTGGAGCCTCGATCCGCCGCAGCATGACCGGATCGAGCCGCCGCCGATCCTCGCG
ACTACACAAGGACATTGCGA

Downstream 100 bases:

>100_bases
GCACGCATCGCTGCCCGCCTACGACAACGATCGACTCAGGAGGAGTTTCATGGAAGGCTTCATCACCGATTGGCTGAACC
TCGCGATCCGCTGGCTGCAC

Product: hydroxyisourate hydrolase

Products: NA

Alternate protein names: HIU hydrolase 2; HIUHase 2 [H]

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MGKLTTHVLDTAHGRPGAAIKLELHAISGDGSRLLKTLHTNDDGRCDTPLLEGDALAAGTYELVFHAGDYFAAQGVALPE
PRFVDLVVLRFGIADPTAHYHVPLLVSPWSYSTYRGS

Sequences:

>Translated_117_residues
MGKLTTHVLDTAHGRPGAAIKLELHAISGDGSRLLKTLHTNDDGRCDTPLLEGDALAAGTYELVFHAGDYFAAQGVALPE
PRFVDLVVLRFGIADPTAHYHVPLLVSPWSYSTYRGS
>Mature_116_residues
GKLTTHVLDTAHGRPGAAIKLELHAISGDGSRLLKTLHTNDDGRCDTPLLEGDALAAGTYELVFHAGDYFAAQGVALPEP
RFVDLVVLRFGIADPTAHYHVPLLVSPWSYSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=114, Percent_Identity=37.719298245614, Blast_Score=77, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI115532922, Length=117, Percent_Identity=37.6068376068376, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI115532920, Length=117, Percent_Identity=37.6068376068376, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115534555, Length=117, Percent_Identity=37.6068376068376, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24652571, Length=116, Percent_Identity=37.0689655172414, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 12583; Mature: 12452

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLTTHVLDTAHGRPGAAIKLELHAISGDGSRLLKTLHTNDDGRCDTPLLEGDALAAGT
CCCCCCEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCCCCCCEECCCEECCCE
YELVFHAGDYFAAQGVALPEPRFVDLVVLRFGIADPTAHYHVPLLVSPWSYSTYRGS
EEEEEECCCEEEECCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCCCEECCC
>Mature Secondary Structure 
GKLTTHVLDTAHGRPGAAIKLELHAISGDGSRLLKTLHTNDDGRCDTPLLEGDALAAGT
CCCCCEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCCCCCCEECCCEECCCE
YELVFHAGDYFAAQGVALPEPRFVDLVVLRFGIADPTAHYHVPLLVSPWSYSTYRGS
EEEEEECCCEEEECCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431 [H]