Click here to switch to the map view.

The map label for this gene is pgi [H]

Identifier: 237812667

GI number: 237812667

Start: 2372042

End: 2373664

Strand: Direct

Name: pgi [H]

Synonym: GBP346_A2417

Alternate gene names: 237812667

Gene position: 2372042-2373664 (Clockwise)

Preceding gene: 237812665

Following gene: 237812669

Centisome position: 57.87

GC content: 68.33

Gene sequence:

>1623_bases
ATGACGCTGAATTCGCTCCCCGTTTGGCCCGCGCTGCAAGCGCACTACGAAGAGATCCGCGACGCGCATCTGCGCGACTG
GTTCGCCCCCGCCAACGACCGCGCGCCGACGCGCGCCGAACGCTTCACGTTCGAAGGCGGCGGCCTCGCCGCCGATTTTT
CGAAGAACCGCCTCACCGACGCGACGCTCGCCCTCCTCGTGCGGCTCGCGCGCGAAGCGGGCGTCGAGGCGCGCCGCGAC
GCGATGTTCGCGGGCGAAACCGTGAATCCGACCGAAGGCCGCGCGGCGCTGCACACCGCGCTGCGCGCGAATGCGCCGGA
CGCGCCGTTCCAGGCGCAGGTCGCGGCCGAGCGCGCGAAGATGGCGCGCTTTGCCGACGCGGTGCGCAGCGGCGCATGGA
CGGGCTACACCGGCAAGCGGATCCGCCACGTCGTGAACATCGGCATCGGCGGCTCGGACCTCGGACCGAAGATGGTCGTC
CACGCGCTGCATCACGTCGCGACACCCGACATCGCGACACACTTCGTGTCGAACGTCGACGGCGCGGACCTCGCGCGCGT
GCTCGAGCGGATCGATCCCGAAGCGACGCTCGCGATCATCGTGTCGAAGACCTTCACGACGCTCGAGACGATGACGAACG
CGCGATCGCTGCGCGACTGGTTCGTCGCGAACGGCTGCCCGGAAGGCGCGCTCGCGAAGCACTTCGTCGGCGTGTCGGCG
AATCCCGCCGAAGTCGTCAAGTTCGGCATCGCCGAAGCGAACGTGTTCGAGATGTGGGATTGGGTCGGCGGTCGCTATTC
GCTGTGGTCGGCGGTCGGCCTGTCGATCATGATCGCGATCGGGCCCGAGCGCTTCGACGAACTGCTCGCCGGCGCGCGCG
ACATGGACGAGCACTTCCGCACCGCGCCGCTCGAGCGCAACCTGCCGGTGCTGCAGGGCCTCGTCGGCATCTGGTATCGG
AACTTCTTCGGCGCGCAGAGCTATCTCGTCGCGCCGTACTCGGAAGCGCTGCATTATCTGCCGTCGTACCTGCAGCAGCT
CGAGATGGAGAGCAACGGCAAGTCCGCGCGGATCGACGGCGCGTTCGTCGATTACCCGACATCCGCCGTCACGTGGGGCG
AGCCCGGCACGAACGGCCAGCACGCGTTCTTCCAGATGCTGCACCAGGGCCCGACGCTCGTGCCGATCGATTTCATCGCG
GTACTCACGCCCGAGCATCCGCTCGCGAGCCATCATCCGAAGCTGCTCGCGAACTGCTTCGCGCAAAGCGAGGCGCTGAT
GCTCGGCCGCACGCTCGACGAGGCGCACAAGATCGCCGGTCCGGCCAAGCCCGAACTCGCGCCGCATCTGACGTTCCCCG
GCAACCGGCCGACGACGACGCTCCTCGTCGACGCGCTCACGCCGCGCACGCTCGGCGCGCTGATCGCGCTGTACGAGCAC
AAGGTGCTCGTACAGGCGGCCGTGTGGAACATCAATCCGTTCGACCAATGGGGCGTCGAGCTCGGCAAGATCCTGGGCAA
GGTCGTCGAGGCGGACCTGACGGCCGCGCAGGTCGATCCGGCGAAGCACGATTCGTCGACATCGGCGCTGATCGCGCGCG
CGAGGAAGGCGCTCGGCGAATGA

Upstream 100 bases:

>100_bases
GTCCCGCCGCGCAGGCGGGCTCCTCGTCCGCCTGCACGCCGCGCGCCGGCTTGCGGGCGCGGCCCATCCCCCGGTTCACG
CCGTTTCGCTCCTGATTGCC

Downstream 100 bases:

>100_bases
CCCGCGGCCGACGCGGACGGCGGCGAGAGGCGCGGCCGTCCGCGCGGCTCGAGATGCGCGTTGGCGTGGGCTGGGGCGGT
GCGCGAGCCGGCCCGTGCGC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MTLNSLPVWPALQAHYEEIRDAHLRDWFAPANDRAPTRAERFTFEGGGLAADFSKNRLTDATLALLVRLAREAGVEARRD
AMFAGETVNPTEGRAALHTALRANAPDAPFQAQVAAERAKMARFADAVRSGAWTGYTGKRIRHVVNIGIGGSDLGPKMVV
HALHHVATPDIATHFVSNVDGADLARVLERIDPEATLAIIVSKTFTTLETMTNARSLRDWFVANGCPEGALAKHFVGVSA
NPAEVVKFGIAEANVFEMWDWVGGRYSLWSAVGLSIMIAIGPERFDELLAGARDMDEHFRTAPLERNLPVLQGLVGIWYR
NFFGAQSYLVAPYSEALHYLPSYLQQLEMESNGKSARIDGAFVDYPTSAVTWGEPGTNGQHAFFQMLHQGPTLVPIDFIA
VLTPEHPLASHHPKLLANCFAQSEALMLGRTLDEAHKIAGPAKPELAPHLTFPGNRPTTTLLVDALTPRTLGALIALYEH
KVLVQAAVWNINPFDQWGVELGKILGKVVEADLTAAQVDPAKHDSSTSALIARARKALGE

Sequences:

>Translated_540_residues
MTLNSLPVWPALQAHYEEIRDAHLRDWFAPANDRAPTRAERFTFEGGGLAADFSKNRLTDATLALLVRLAREAGVEARRD
AMFAGETVNPTEGRAALHTALRANAPDAPFQAQVAAERAKMARFADAVRSGAWTGYTGKRIRHVVNIGIGGSDLGPKMVV
HALHHVATPDIATHFVSNVDGADLARVLERIDPEATLAIIVSKTFTTLETMTNARSLRDWFVANGCPEGALAKHFVGVSA
NPAEVVKFGIAEANVFEMWDWVGGRYSLWSAVGLSIMIAIGPERFDELLAGARDMDEHFRTAPLERNLPVLQGLVGIWYR
NFFGAQSYLVAPYSEALHYLPSYLQQLEMESNGKSARIDGAFVDYPTSAVTWGEPGTNGQHAFFQMLHQGPTLVPIDFIA
VLTPEHPLASHHPKLLANCFAQSEALMLGRTLDEAHKIAGPAKPELAPHLTFPGNRPTTTLLVDALTPRTLGALIALYEH
KVLVQAAVWNINPFDQWGVELGKILGKVVEADLTAAQVDPAKHDSSTSALIARARKALGE
>Mature_539_residues
TLNSLPVWPALQAHYEEIRDAHLRDWFAPANDRAPTRAERFTFEGGGLAADFSKNRLTDATLALLVRLAREAGVEARRDA
MFAGETVNPTEGRAALHTALRANAPDAPFQAQVAAERAKMARFADAVRSGAWTGYTGKRIRHVVNIGIGGSDLGPKMVVH
ALHHVATPDIATHFVSNVDGADLARVLERIDPEATLAIIVSKTFTTLETMTNARSLRDWFVANGCPEGALAKHFVGVSAN
PAEVVKFGIAEANVFEMWDWVGGRYSLWSAVGLSIMIAIGPERFDELLAGARDMDEHFRTAPLERNLPVLQGLVGIWYRN
FFGAQSYLVAPYSEALHYLPSYLQQLEMESNGKSARIDGAFVDYPTSAVTWGEPGTNGQHAFFQMLHQGPTLVPIDFIAV
LTPEHPLASHHPKLLANCFAQSEALMLGRTLDEAHKIAGPAKPELAPHLTFPGNRPTTTLLVDALTPRTLGALIALYEHK
VLVQAAVWNINPFDQWGVELGKILGKVVEADLTAAQVDPAKHDSSTSALIARARKALGE

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=542, Percent_Identity=48.7084870848708, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI296080693, Length=535, Percent_Identity=45.0467289719626, Blast_Score=453, Evalue=1e-127,
Organism=Escherichia coli, GI1790457, Length=540, Percent_Identity=49.8148148148148, Blast_Score=525, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI71996708, Length=552, Percent_Identity=48.5507246376812, Blast_Score=513, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI71996703, Length=552, Percent_Identity=48.5507246376812, Blast_Score=512, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6319673, Length=542, Percent_Identity=49.0774907749078, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24651916, Length=545, Percent_Identity=48.6238532110092, Blast_Score=512, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24651914, Length=545, Percent_Identity=48.6238532110092, Blast_Score=512, Evalue=1e-145,
Organism=Drosophila melanogaster, GI17737445, Length=545, Percent_Identity=48.6238532110092, Blast_Score=512, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 58766; Mature: 58635

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNSLPVWPALQAHYEEIRDAHLRDWFAPANDRAPTRAERFTFEGGGLAADFSKNRLTD
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEECCCCEEECCCCCCCHH
ATLALLVRLAREAGVEARRDAMFAGETVNPTEGRAALHTALRANAPDAPFQAQVAAERAK
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHH
MARFADAVRSGAWTGYTGKRIRHVVNIGIGGSDLGPKMVVHALHHVATPDIATHFVSNVD
HHHHHHHHHCCCCCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCC
GADLARVLERIDPEATLAIIVSKTFTTLETMTNARSLRDWFVANGCPEGALAKHFVGVSA
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCC
NPAEVVKFGIAEANVFEMWDWVGGRYSLWSAVGLSIMIAIGPERFDELLAGARDMDEHFR
CHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCEEEEEECHHHHHHHHHCCHHHHHHHH
TAPLERNLPVLQGLVGIWYRNFFGAQSYLVAPYSEALHYLPSYLQQLEMESNGKSARIDG
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEECC
AFVDYPTSAVTWGEPGTNGQHAFFQMLHQGPTLVPIDFIAVLTPEHPLASHHPKLLANCF
EEEECCCCEEECCCCCCCCHHHHHHHHHCCCCEEEEHHEEEECCCCCCCCCCHHHHHHHH
AQSEALMLGRTLDEAHKIAGPAKPELAPHLTFPGNRPTTTLLVDALTPRTLGALIALYEH
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
KVLVQAAVWNINPFDQWGVELGKILGKVVEADLTAAQVDPAKHDSSTSALIARARKALGE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLNSLPVWPALQAHYEEIRDAHLRDWFAPANDRAPTRAERFTFEGGGLAADFSKNRLTD
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEECCCCEEECCCCCCCHH
ATLALLVRLAREAGVEARRDAMFAGETVNPTEGRAALHTALRANAPDAPFQAQVAAERAK
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHH
MARFADAVRSGAWTGYTGKRIRHVVNIGIGGSDLGPKMVVHALHHVATPDIATHFVSNVD
HHHHHHHHHCCCCCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCC
GADLARVLERIDPEATLAIIVSKTFTTLETMTNARSLRDWFVANGCPEGALAKHFVGVSA
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCC
NPAEVVKFGIAEANVFEMWDWVGGRYSLWSAVGLSIMIAIGPERFDELLAGARDMDEHFR
CHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCEEEEEECHHHHHHHHHCCHHHHHHHH
TAPLERNLPVLQGLVGIWYRNFFGAQSYLVAPYSEALHYLPSYLQQLEMESNGKSARIDG
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEECC
AFVDYPTSAVTWGEPGTNGQHAFFQMLHQGPTLVPIDFIAVLTPEHPLASHHPKLLANCF
EEEECCCCEEECCCCCCCCHHHHHHHHHCCCCEEEEHHEEEECCCCCCCCCCHHHHHHHH
AQSEALMLGRTLDEAHKIAGPAKPELAPHLTFPGNRPTTTLLVDALTPRTLGALIALYEH
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
KVLVQAAVWNINPFDQWGVELGKILGKVVEADLTAAQVDPAKHDSSTSALIARARKALGE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA