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The map label for this gene is blh [H]

Identifier: 237812496

GI number: 237812496

Start: 2207604

End: 2209274

Strand: Direct

Name: blh [H]

Synonym: GBP346_A2245

Alternate gene names: 237812496

Gene position: 2207604-2209274 (Clockwise)

Preceding gene: 237812495

Following gene: 237812497

Centisome position: 53.86

GC content: 71.21

Gene sequence:

>1671_bases
ATGGAAATCCGCAAGCTGACCGACACGCTATCGGTCTCCCCCCAGCTCGTCGCCGCCGATCTGCCCGCGATCGCGCAGGC
CGGCTTTCGCGCGATCATCTGCAACCGGCCGGACGGCGAAGGCCCAGACCAGCCGACCGTCGCCGAGATCGACGCGGCCG
CGCAGCGCTTCGGCATCGCGGTCCACTATCTGCCCGTCGATTCGGGCAAGGCCACCGATGCGCAGGGCGAACAGTTCGGC
GTGCTGCTCGACACGCTCGCTTCGCCCGTGCTCGCGTACTGCCGCACCGGCATGCGCTCGGCCACGCTGTGGGGGCTGTC
GCAGGCGGGGCTGCGGCCGCTGAACGACATCGTCGCGACGGGCCGCGCGGCCGGCTACGATCTCGCCGCGCTCGGCCGCC
GGATCATGCAGCGCAGCCAGAGCGCGACGGCGCAAACCGTCGAGGCGAGCCACGACATCGTGATCGTCGGTGCGGGCGCC
GCGGGCATCGCGGTCGCCTCGAGCCTGCTCGCGCGTGAGCCCTCGCTCGACATCGCCGTCATCGATCCGGCCGACACCCA
TTACTACCAGCCCGGCTGGACGATGGTCGGCGCGGGCGTGTTCCAGCCGGGCACGACCGCGCGGCGCATGGCCGCCGTGC
TGCCGCGCGGCGTGCACTGGATCAAGGCCGCCGTCGCCGCGTTCGAGCCCGACACGCACACGGTCGTGCTCGACGGCTGC
CGGCTCGTGCGCTACCGGCAGCTCGTCGTCTGCCCGGGCCTGAAGCTCGACTGGCACGGCATCGAGGGGCTGCCCGAGAC
GCTCGGCAGGAACGGCGTCACGTCGAACTATCGCTACGATCTCGCGCCGTACACGTGGCAGCTCGTGCGCGCGTTCGCCG
GCCGGCGCGCGCTGTTCACGCAGCCGCCGATGCCGATCAAGTGCGCGGGCGCGCCGCAAAAGGCGATGTATCTGTCGGCC
GACCACTGGCGGCGCACGAACCGCCTCGACGCGATCGACATCGAGTTCTTCAATGCGGGCGCGGCGCTCTTCGGCGTCGC
CGAGTACGTGCCCGCGCTGATGGAGTACGTGAAGCGCTACGGCATCGCGCTGAATTTCGGCCACAACCTGATCGCGATCG
ACGGCGAGCGCAAGCGCGCGACGTTCGCGCGCGCGCTGCCGGAAGGCGGCACCGAGACGCTCACGCGCGAATTCGACATG
ATCCACGTCGTGCCGCCGCAGAAGGCGCCCGATTTCGTGCGCGCGAGCCCGCTCGCCGACGCGGCCGGCTGGATCGACGT
CGATCCGGCGACGCTGCGCCACCGCCGCCACGCGGACGTGTTCGCGCTCGGCGACGTGACGAACACGACGAACGCGAAGA
CCGCGGCCGCCGCGCGCAAGCAGGCGCCCGTCGTCGCGCACAACGTGCTCGCCGCGCTCGGCAAGGCCCAGGGCGACGCG
GCCTACGACGGCTACGGCTCGTGCCCGCTCACCGTCGAGCGCGGCAAGATCGTGCTCGCCGAATTCCTGTACGGCGGCAA
GCTCGCGCCGACCTTCCCCGCATGGCTCATCGACGGCAAACGCCCGTCGCGGCTCGCGTGGCTGCTCAAGGAGCGGCTGC
TGCCGCCTCTTTACTGGCAGGCGATGCTCAAGGGCCGCGAATGGCTCGCGAAACCCGAGATCGTCGGCTGA

Upstream 100 bases:

>100_bases
CCGAGGACAACGGCGTGCGCTACCTGAAGATCCCGCTCGACGCGATCTGAGCCCGCGGCCCGCCTTCCCCAACGACGCAC
GACATACGACCACGCCCATC

Downstream 100 bases:

>100_bases
CCGCCGCGCTTTGACGACCCTTGTCCGGAACGGCGCAGCATGTTGATTTCTCTGGTGTTGGGCAGCATCGTCGGCGCGGT
GCTGGGGCTGACGGGCGCGG

Product: oxidoreductase, pyridine nucleotide-disulphide family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MEIRKLTDTLSVSPQLVAADLPAIAQAGFRAIICNRPDGEGPDQPTVAEIDAAAQRFGIAVHYLPVDSGKATDAQGEQFG
VLLDTLASPVLAYCRTGMRSATLWGLSQAGLRPLNDIVATGRAAGYDLAALGRRIMQRSQSATAQTVEASHDIVIVGAGA
AGIAVASSLLAREPSLDIAVIDPADTHYYQPGWTMVGAGVFQPGTTARRMAAVLPRGVHWIKAAVAAFEPDTHTVVLDGC
RLVRYRQLVVCPGLKLDWHGIEGLPETLGRNGVTSNYRYDLAPYTWQLVRAFAGRRALFTQPPMPIKCAGAPQKAMYLSA
DHWRRTNRLDAIDIEFFNAGAALFGVAEYVPALMEYVKRYGIALNFGHNLIAIDGERKRATFARALPEGGTETLTREFDM
IHVVPPQKAPDFVRASPLADAAGWIDVDPATLRHRRHADVFALGDVTNTTNAKTAAAARKQAPVVAHNVLAALGKAQGDA
AYDGYGSCPLTVERGKIVLAEFLYGGKLAPTFPAWLIDGKRPSRLAWLLKERLLPPLYWQAMLKGREWLAKPEIVG

Sequences:

>Translated_556_residues
MEIRKLTDTLSVSPQLVAADLPAIAQAGFRAIICNRPDGEGPDQPTVAEIDAAAQRFGIAVHYLPVDSGKATDAQGEQFG
VLLDTLASPVLAYCRTGMRSATLWGLSQAGLRPLNDIVATGRAAGYDLAALGRRIMQRSQSATAQTVEASHDIVIVGAGA
AGIAVASSLLAREPSLDIAVIDPADTHYYQPGWTMVGAGVFQPGTTARRMAAVLPRGVHWIKAAVAAFEPDTHTVVLDGC
RLVRYRQLVVCPGLKLDWHGIEGLPETLGRNGVTSNYRYDLAPYTWQLVRAFAGRRALFTQPPMPIKCAGAPQKAMYLSA
DHWRRTNRLDAIDIEFFNAGAALFGVAEYVPALMEYVKRYGIALNFGHNLIAIDGERKRATFARALPEGGTETLTREFDM
IHVVPPQKAPDFVRASPLADAAGWIDVDPATLRHRRHADVFALGDVTNTTNAKTAAAARKQAPVVAHNVLAALGKAQGDA
AYDGYGSCPLTVERGKIVLAEFLYGGKLAPTFPAWLIDGKRPSRLAWLLKERLLPPLYWQAMLKGREWLAKPEIVG
>Mature_556_residues
MEIRKLTDTLSVSPQLVAADLPAIAQAGFRAIICNRPDGEGPDQPTVAEIDAAAQRFGIAVHYLPVDSGKATDAQGEQFG
VLLDTLASPVLAYCRTGMRSATLWGLSQAGLRPLNDIVATGRAAGYDLAALGRRIMQRSQSATAQTVEASHDIVIVGAGA
AGIAVASSLLAREPSLDIAVIDPADTHYYQPGWTMVGAGVFQPGTTARRMAAVLPRGVHWIKAAVAAFEPDTHTVVLDGC
RLVRYRQLVVCPGLKLDWHGIEGLPETLGRNGVTSNYRYDLAPYTWQLVRAFAGRRALFTQPPMPIKCAGAPQKAMYLSA
DHWRRTNRLDAIDIEFFNAGAALFGVAEYVPALMEYVKRYGIALNFGHNLIAIDGERKRATFARALPEGGTETLTREFDM
IHVVPPQKAPDFVRASPLADAAGWIDVDPATLRHRRHADVFALGDVTNTTNAKTAAAARKQAPVVAHNVLAALGKAQGDA
AYDGYGSCPLTVERGKIVLAEFLYGGKLAPTFPAWLIDGKRPSRLAWLLKERLLPPLYWQAMLKGREWLAKPEIVG

Specific function: Unknown

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI10864011, Length=395, Percent_Identity=37.4683544303797, Blast_Score=306, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI115534373, Length=343, Percent_Identity=35.8600583090379, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17539680, Length=432, Percent_Identity=30.787037037037, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24657386, Length=386, Percent_Identity=37.8238341968912, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI24657391, Length=386, Percent_Identity=37.8238341968912, Blast_Score=261, Evalue=8e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005939
- InterPro:   IPR001279 [H]

Pfam domain/function: PF04273 DUF442; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 60037; Mature: 60037

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRKLTDTLSVSPQLVAADLPAIAQAGFRAIICNRPDGEGPDQPTVAEIDAAAQRFGIA
CCHHHHHHHHCCCCHHEECCCCHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCEE
VHYLPVDSGKATDAQGEQFGVLLDTLASPVLAYCRTGMRSATLWGLSQAGLRPLNDIVAT
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHCCCHHHHHHHC
GRAAGYDLAALGRRIMQRSQSATAQTVEASHDIVIVGAGAAGIAVASSLLAREPSLDIAV
CCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEE
IDPADTHYYQPGWTMVGAGVFQPGTTARRMAAVLPRGVHWIKAAVAAFEPDTHTVVLDGC
ECCCCCCEECCCCEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECCH
RLVRYRQLVVCPGLKLDWHGIEGLPETLGRNGVTSNYRYDLAPYTWQLVRAFAGRRALFT
HHHHHHHEEECCCCEEECCCCCCCHHHHCCCCCCCCCEEECCHHHHHHHHHHHCCCEEEC
QPPMPIKCAGAPQKAMYLSADHWRRTNRLDAIDIEFFNAGAALFGVAEYVPALMEYVKRY
CCCCCEEECCCCCCEEEEEHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHC
GIALNFGHNLIAIDGERKRATFARALPEGGTETLTREFDMIHVVPPQKAPDFVRASPLAD
CEEEECCCEEEEECCCHHHHHHHHHCCCCCHHHHHHCCCEEEEECCCCCCCCHHCCCCCC
AAGWIDVDPATLRHRRHADVFALGDVTNTTNAKTAAAARKQAPVVAHNVLAALGKAQGDA
CCCEEECCHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCC
AYDGYGSCPLTVERGKIVLAEFLYGGKLAPTFPAWLIDGKRPSRLAWLLKERLLPPLYWQ
CCCCCCCCCEEEECCCEEEEEHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCHHHHH
AMLKGREWLAKPEIVG
HHHHCHHHCCCCCCCC
>Mature Secondary Structure
MEIRKLTDTLSVSPQLVAADLPAIAQAGFRAIICNRPDGEGPDQPTVAEIDAAAQRFGIA
CCHHHHHHHHCCCCHHEECCCCHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCEE
VHYLPVDSGKATDAQGEQFGVLLDTLASPVLAYCRTGMRSATLWGLSQAGLRPLNDIVAT
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHCCCHHHHHHHC
GRAAGYDLAALGRRIMQRSQSATAQTVEASHDIVIVGAGAAGIAVASSLLAREPSLDIAV
CCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEE
IDPADTHYYQPGWTMVGAGVFQPGTTARRMAAVLPRGVHWIKAAVAAFEPDTHTVVLDGC
ECCCCCCEECCCCEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECCH
RLVRYRQLVVCPGLKLDWHGIEGLPETLGRNGVTSNYRYDLAPYTWQLVRAFAGRRALFT
HHHHHHHEEECCCCEEECCCCCCCHHHHCCCCCCCCCEEECCHHHHHHHHHHHCCCEEEC
QPPMPIKCAGAPQKAMYLSADHWRRTNRLDAIDIEFFNAGAALFGVAEYVPALMEYVKRY
CCCCCEEECCCCCCEEEEEHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHC
GIALNFGHNLIAIDGERKRATFARALPEGGTETLTREFDMIHVVPPQKAPDFVRASPLAD
CEEEECCCEEEEECCCHHHHHHHHHCCCCCHHHHHHCCCEEEEECCCCCCCCHHCCCCCC
AAGWIDVDPATLRHRRHADVFALGDVTNTTNAKTAAAARKQAPVVAHNVLAALGKAQGDA
CCCEEECCHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCC
AYDGYGSCPLTVERGKIVLAEFLYGGKLAPTFPAWLIDGKRPSRLAWLLKERLLPPLYWQ
CCCCCCCCCEEEECCCEEEEEHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCHHHHH
AMLKGREWLAKPEIVG
HHHHCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]