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The map label for this gene is fhuB [H]

Identifier: 237812214

GI number: 237812214

Start: 1897098

End: 1899218

Strand: Direct

Name: fhuB [H]

Synonym: GBP346_A1960

Alternate gene names: 237812214

Gene position: 1897098-1899218 (Clockwise)

Preceding gene: 237812213

Following gene: 237812215

Centisome position: 46.29

GC content: 78.08

Gene sequence:

>2121_bases
ATGACGGCGCTCGCGGTTCGCAAGCGGCTGCGTCACGGCGGGCGCGCGCCGGAACCCTCGCCGGCGTCGCGCGCGGCGGC
GCCCGGGCGCGTCGGCGCGATCGCGGGCGCGCTCGTCGCGCTGATCGTCGTCACGGCGGCGATGCGGCTCGCGCCCGAGC
TGCGCGCGTGGCTTGCCGCGCCGGCGGGCGGCGACGCCGCGCAGCTCGCGCATATCATGCTGTTCGATCTCGCCGCGCCG
CGCGTCGCGGCGGCGCTCGTCGCGGGCGGCTGCCTCGCGGCCGCGGGCGCGCTGCTGCAGTCGCTCACGCGCAACCCGCT
CGCCGCGCCGGACCTGCTCGGCATCACGGGCGGCGCGCAGCTCGGGCTGATCGCCGCGATGCTCGTGCCCGCGCTCGCCG
GCCATGCGTCGGTGCCGCTCCTGTTCGTCTGCGGGCTCGCCGCGGCCGCGTGCGTGTCGGCGGCGGCGGGCGGCTGGCGC
GCGACGCCGCTGCGCCTCATTCTCGCGGGCAGCGTCTGCATGCTGCTGTTCTCGGCGGTCACGACGCTGCTGCTCGCGTT
CTTCGAGCAGACGGTGGTCGGCGCGTCGCTGTGGGCGAGCGGCAGCCTGTACCAGCCGGGCGCGGCCGGGCTGCGCGACG
CGCTGCTGTGGCTCGTCGCGCCGCTCGCCGCGCTGCCGCTCGTGATCCGGCCGCTCGATCCGCTCGCGCTCGGCGACGAC
GCCGCGGCCGCGGCTGGCGTGCGCGTCGACGCGACGCGGCTCGCCGGCACCGTCGTCGCGGTCGGCTTCGCGAGCGTCGC
GGTCAGCATCGCGGGGCCGCTGTCGTACATCGGCCTGATCGCGCCGAACCTGATCCGGCAGATGCGCGGCGCGAAGGCGT
CGAGGCTCGGCGCGCTCGTGCCGCTCGCCGCGCTCGCGGGCGGCGCGCTCGTGCTCGTCACCGATAGCGCCGTGCTCGCG
CTCGGCCTCGATGCGACGCTGTCGACGGGCGTCGCGATCGCGTTCGTCGGCACGCCGCTGATGCTCGCGATGATCCGCCG
CGGCGCCGCATGGTCGGGCGCCGCGCAGCAGCCGGCGCACGTGCGGGCGGGCACGCGCGGCGGCGCGCGGCTCGTGCGCG
CGCTCGCCGTGCTGCCGTGGCCCGCCGTCGCGGTGCTGCTGCTGGCGGCGGGCGCCGCGGTGCTCGTCGTCGGCGCGTCG
TTCGGCCCGGTGTGGATCGGCCCCGGGCGCTGGTTCGCGGCGCTCGCGCAGCGCGACGACCTCGCGCGGACGGTGCTCGA
TCTGCGCGCGCCGCGGCTCTTGTGCGCATTGCTCGCGGGCGCGCTGCTCGGCGCGTCCGGCGTGCTGATGCAGAGCATCG
TGCGCAATCCGCTCGCGGGGCCCGAGGTGCTCGGCGTCACGCAGGGCGCGGGGCTCGCGACGCTCGCCACGCTCGTCGCG
TGGCCGCTCGCCGCGCACGGCACGCTCGTCGCCGCCTCGCTCGCGGGCGGCGGCGCGACGCTCGTGCTCACGCTCGCGCT
CAACCGCCGGCATCGCTACGCGCCGCTCGCGGTCGCGCTGACGGGCATCGTGATCGGCACGCTGTGGACGACGCTCGCGC
AATGGCTGATCACGCAGGAGAGCGTGCAGCCCGCGCGCTTCGTCGTCTGGCTCGTCGGCGGCACGTATGGGCGCAGCTGG
GGCGAGGCGGCCGCGCTGCTGCCGTGGGGCGTGCTCGCGGTGCCGGCGCTCGCGCTGCTCGCGCGGCCGCTCGATCTGCT
CGCGCTCGGCGACGAACAGGCGGCCGCGCTCGGCCTGCCGATCGCCGCGCTGCGCCCGCTCGTGCTGACGATCGCGACGC
TCGCCGCCTGCGCGGCCGTGGCGGCGGTCGGCCCGGTCGGCTTCATCGGGCTGATGGCGCCGCATCTCGCGGCGATGCTC
GGCGCGCGCGCGCACGCAACGCGCCTGTGGCTCGCCGCCGCGTGCGGCGCGCTCGTGCTCGCCGCCGCCGATATCGCCGC
GCGCACGCTGCTCGCGCCGCGCGAGATTCCGGCGGGCGTGCTGACCGCGCTGATCGGCGCGCCGTACCTGCTCGCGCTGC
TGATCGCCGAAGCGCGGCGAGAGCGGCGCGGCGGCCGATGA

Upstream 100 bases:

>100_bases
ACGAGGGCGTGCTCGATACCGATCATGCCGATCCGGCGCACGCGGCCGCGCCCGGGGTGCGCGGCGCGGCCGTCGCGCGC
GCGCGTCGGGATCTCGCCGC

Downstream 100 bases:

>100_bases
GCGCGCGCATGCGCGCGACGCGCTTTTCGACGTTCGCGCCCGCCGCGATCGCGCATTATCTCGAGCACGTGTGGCTCGGT
GCGCCCGACGCATGCGACGA

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MTALAVRKRLRHGGRAPEPSPASRAAAPGRVGAIAGALVALIVVTAAMRLAPELRAWLAAPAGGDAAQLAHIMLFDLAAP
RVAAALVAGGCLAAAGALLQSLTRNPLAAPDLLGITGGAQLGLIAAMLVPALAGHASVPLLFVCGLAAAACVSAAAGGWR
ATPLRLILAGSVCMLLFSAVTTLLLAFFEQTVVGASLWASGSLYQPGAAGLRDALLWLVAPLAALPLVIRPLDPLALGDD
AAAAAGVRVDATRLAGTVVAVGFASVAVSIAGPLSYIGLIAPNLIRQMRGAKASRLGALVPLAALAGGALVLVTDSAVLA
LGLDATLSTGVAIAFVGTPLMLAMIRRGAAWSGAAQQPAHVRAGTRGGARLVRALAVLPWPAVAVLLLAAGAAVLVVGAS
FGPVWIGPGRWFAALAQRDDLARTVLDLRAPRLLCALLAGALLGASGVLMQSIVRNPLAGPEVLGVTQGAGLATLATLVA
WPLAAHGTLVAASLAGGGATLVLTLALNRRHRYAPLAVALTGIVIGTLWTTLAQWLITQESVQPARFVVWLVGGTYGRSW
GEAAALLPWGVLAVPALALLARPLDLLALGDEQAAALGLPIAALRPLVLTIATLAACAAVAAVGPVGFIGLMAPHLAAML
GARAHATRLWLAAACGALVLAAADIAARTLLAPREIPAGVLTALIGAPYLLALLIAEARRERRGGR

Sequences:

>Translated_706_residues
MTALAVRKRLRHGGRAPEPSPASRAAAPGRVGAIAGALVALIVVTAAMRLAPELRAWLAAPAGGDAAQLAHIMLFDLAAP
RVAAALVAGGCLAAAGALLQSLTRNPLAAPDLLGITGGAQLGLIAAMLVPALAGHASVPLLFVCGLAAAACVSAAAGGWR
ATPLRLILAGSVCMLLFSAVTTLLLAFFEQTVVGASLWASGSLYQPGAAGLRDALLWLVAPLAALPLVIRPLDPLALGDD
AAAAAGVRVDATRLAGTVVAVGFASVAVSIAGPLSYIGLIAPNLIRQMRGAKASRLGALVPLAALAGGALVLVTDSAVLA
LGLDATLSTGVAIAFVGTPLMLAMIRRGAAWSGAAQQPAHVRAGTRGGARLVRALAVLPWPAVAVLLLAAGAAVLVVGAS
FGPVWIGPGRWFAALAQRDDLARTVLDLRAPRLLCALLAGALLGASGVLMQSIVRNPLAGPEVLGVTQGAGLATLATLVA
WPLAAHGTLVAASLAGGGATLVLTLALNRRHRYAPLAVALTGIVIGTLWTTLAQWLITQESVQPARFVVWLVGGTYGRSW
GEAAALLPWGVLAVPALALLARPLDLLALGDEQAAALGLPIAALRPLVLTIATLAACAAVAAVGPVGFIGLMAPHLAAML
GARAHATRLWLAAACGALVLAAADIAARTLLAPREIPAGVLTALIGAPYLLALLIAEARRERRGGR
>Mature_705_residues
TALAVRKRLRHGGRAPEPSPASRAAAPGRVGAIAGALVALIVVTAAMRLAPELRAWLAAPAGGDAAQLAHIMLFDLAAPR
VAAALVAGGCLAAAGALLQSLTRNPLAAPDLLGITGGAQLGLIAAMLVPALAGHASVPLLFVCGLAAAACVSAAAGGWRA
TPLRLILAGSVCMLLFSAVTTLLLAFFEQTVVGASLWASGSLYQPGAAGLRDALLWLVAPLAALPLVIRPLDPLALGDDA
AAAAGVRVDATRLAGTVVAVGFASVAVSIAGPLSYIGLIAPNLIRQMRGAKASRLGALVPLAALAGGALVLVTDSAVLAL
GLDATLSTGVAIAFVGTPLMLAMIRRGAAWSGAAQQPAHVRAGTRGGARLVRALAVLPWPAVAVLLLAAGAAVLVVGASF
GPVWIGPGRWFAALAQRDDLARTVLDLRAPRLLCALLAGALLGASGVLMQSIVRNPLAGPEVLGVTQGAGLATLATLVAW
PLAAHGTLVAASLAGGGATLVLTLALNRRHRYAPLAVALTGIVIGTLWTTLAQWLITQESVQPARFVVWLVGGTYGRSWG
EAAALLPWGVLAVPALALLARPLDLLALGDEQAAALGLPIAALRPLVLTIATLAACAAVAAVGPVGFIGLMAPHLAAMLG
ARAHATRLWLAAACGALVLAAADIAARTLLAPREIPAGVLTALIGAPYLLALLIAEARRERRGGR

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=655, Percent_Identity=32.5190839694656, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1790740, Length=277, Percent_Identity=38.6281588447653, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788004, Length=307, Percent_Identity=36.4820846905537, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1786804, Length=287, Percent_Identity=36.2369337979094, Blast_Score=116, Evalue=6e-27,
Organism=Escherichia coli, GI1790741, Length=283, Percent_Identity=35.3356890459364, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1786805, Length=298, Percent_Identity=33.2214765100671, Blast_Score=86, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 70616; Mature: 70485

Theoretical pI: Translated: 11.83; Mature: 11.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALAVRKRLRHGGRAPEPSPASRAAAPGRVGAIAGALVALIVVTAAMRLAPELRAWLAA
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PAGGDAAQLAHIMLFDLAAPRVAAALVAGGCLAAAGALLQSLTRNPLAAPDLLGITGGAQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCHH
LGLIAAMLVPALAGHASVPLLFVCGLAAAACVSAAAGGWRATPLRLILAGSVCMLLFSAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
TTLLLAFFEQTVVGASLWASGSLYQPGAAGLRDALLWLVAPLAALPLVIRPLDPLALGDD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
AAAAAGVRVDATRLAGTVVAVGFASVAVSIAGPLSYIGLIAPNLIRQMRGAKASRLGALV
HHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
PLAALAGGALVLVTDSAVLALGLDATLSTGVAIAFVGTPLMLAMIRRGAAWSGAAQQPAH
HHHHHCCCEEEEEECCEEEEECCCHHHHCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCCH
VRAGTRGGARLVRALAVLPWPAVAVLLLAAGAAVLVVGASFGPVWIGPGRWFAALAQRDD
HCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCHHEEEEECCCCCEEECCHHHHHHHHHHHH
LARTVLDLRAPRLLCALLAGALLGASGVLMQSIVRNPLAGPEVLGVTQGAGLATLATLVA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHH
WPLAAHGTLVAASLAGGGATLVLTLALNRRHRYAPLAVALTGIVIGTLWTTLAQWLITQE
HHHHHCCHHEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SVQPARFVVWLVGGTYGRSWGEAAALLPWGVLAVPALALLARPLDLLALGDEQAAALGLP
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCHHHHHCCC
IAALRPLVLTIATLAACAAVAAVGPVGFIGLMAPHLAAMLGARAHATRLWLAAACGALVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AAADIAARTLLAPREIPAGVLTALIGAPYLLALLIAEARRERRGGR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TALAVRKRLRHGGRAPEPSPASRAAAPGRVGAIAGALVALIVVTAAMRLAPELRAWLAA
CHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PAGGDAAQLAHIMLFDLAAPRVAAALVAGGCLAAAGALLQSLTRNPLAAPDLLGITGGAQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCHH
LGLIAAMLVPALAGHASVPLLFVCGLAAAACVSAAAGGWRATPLRLILAGSVCMLLFSAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
TTLLLAFFEQTVVGASLWASGSLYQPGAAGLRDALLWLVAPLAALPLVIRPLDPLALGDD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
AAAAAGVRVDATRLAGTVVAVGFASVAVSIAGPLSYIGLIAPNLIRQMRGAKASRLGALV
HHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
PLAALAGGALVLVTDSAVLALGLDATLSTGVAIAFVGTPLMLAMIRRGAAWSGAAQQPAH
HHHHHCCCEEEEEECCEEEEECCCHHHHCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCCH
VRAGTRGGARLVRALAVLPWPAVAVLLLAAGAAVLVVGASFGPVWIGPGRWFAALAQRDD
HCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCHHEEEEECCCCCEEECCHHHHHHHHHHHH
LARTVLDLRAPRLLCALLAGALLGASGVLMQSIVRNPLAGPEVLGVTQGAGLATLATLVA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHH
WPLAAHGTLVAASLAGGGATLVLTLALNRRHRYAPLAVALTGIVIGTLWTTLAQWLITQE
HHHHHCCHHEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SVQPARFVVWLVGGTYGRSWGEAAALLPWGVLAVPALALLARPLDLLALGDEQAAALGLP
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCHHHHHCCC
IAALRPLVLTIATLAACAAVAAVGPVGFIGLMAPHLAAMLGARAHATRLWLAAACGALVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AAADIAARTLLAPREIPAGVLTALIGAPYLLALLIAEARRERRGGR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]