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The map label for this gene is ppx [H]

Identifier: 237811790

GI number: 237811790

Start: 1466399

End: 1467913

Strand: Direct

Name: ppx [H]

Synonym: GBP346_A1528

Alternate gene names: 237811790

Gene position: 1466399-1467913 (Clockwise)

Preceding gene: 237811788

Following gene: 237811792

Centisome position: 35.78

GC content: 68.45

Gene sequence:

>1515_bases
ATGGTTACATCCCCGCATCTACTGGCTGCCGTCGATCTCGGCTCGAACAGCTTCCGGCTCATCGTCGGGCGCGTCGAGGA
GACGCCCGCCGGCAGCCAGATCTATCCCGTCGACGCGCTGCGCGAACCCGTGCGGCTCGCCGCCGGCCTGTCCCGCGACA
AGATGCTCGATCGCGCGTCGCAGGAGCGCGGCTGGGAAGCGCTCAAGCGTTTCGGCGAGCGGCTGCGCGATTTCCACCCG
GATCACGTGCGCGCGGTCGCGACGAACACGCTGCGCGTCGCGAAGAACGCCGGGGAGTTTCTCGCCGAGGCGCAGGCGGC
GCTCGGCTTTCCGATCGAAGTGATCGCGGGCCGCGAGGAAGCGCGCCTCATTTACGCGGGCGCCGCGCACTCGGTGCCGG
CGAACGCCGGCAAGCGGCTCGTCGTCGACATCGGCGGCGGCTCGACCGAATTCATCATCGGCCAGCATTACACGCCGCTT
GTGATGGAGAGCCTCTACATCGGCTGCGTGAGCCACAGCCGCGCGTTCTTTCCGGCCGGCAACGTCGACGAATACACGAT
GCGCCAGGCCGAACTCGCCGCGAAGCGCGAGATCCAGATCATCTCCGGCGAATACAAGAAGGCGGGGTGGGATCAGGCGA
TCGGCTCGTCCGGCACCGCGCGCGCGCTCGCGGAACTCGTCGAGGCGAACGGCTTCAACGACGCGGGCGTGTCGCACGGC
ATCTCGCGCGGCGGCCTCGAGCGCCTGAAGCGCGCGCTCATCAAGGCCGAGAACGTGAACCGCCTGAAGCTCGTCGCGCT
GAAGCCCGATCGCGTGCCGGTGCTCGCGGGCGGGCTGTCGATCATGCTCGCGGTGTTCGAGGAACTCGGCGTCGACTATG
TCGACACGACGGACGGCGCGCTGCGCCTGGGCGTGCTGTACGACCTGCTCGGCCGCACGCAGCACGAGGACATGCGCGCG
GTGACGGTCGACGGCTTCACGCGCCGCTATGGCGTCGATCGCGCGCAGGCCGCGCGTATCGGCGCGCTTGCCGCGCGCTT
TTACGATCAGCTCGACGAGCCCGAGGGCGAGGATCGCGACGAGAGCCGCACCTTCCTCGGCTGGGCGGCCGCGCTGCACG
AGATCGGGCTGTCGATTTCGCACAGCGCGTACCACAAGCATTCCGCCTACATCGCGAGCAATGCGGACATGCCGGGGTTC
TCGCGCACCGATCAGGCGCGGCTCGCCGCGCTCGTGCTCGGGCATGCGGGCAAGCTCGGCAAGCTGTCGCAATCGCGCGA
GGTCGAATGGCCGCTGCTGTTCTGCCTGCGCCTTGCCGCGCTGCTGTGCCGGCGCCGCAACGACGCCGGCCTGCCCGACA
TCAACGTCGCGCAGATGAAAAAGGGCGGCTACGAAGTGCACCTGCCGAGCGCGTGGGTCCAGCAGAATCCGCTCACCGAC
TACAGCCTCAGCCAGGAAGCCGCCGAGTGGGAAAAGGTCGGCATTCCGTATCGCGTCGTCTATACGGACGCGTAA

Upstream 100 bases:

>100_bases
GCCGACACCGGGAGGCGCGCAGCGCTTAAAATGGCGCCTTTCATCTTTTCGGCGCGTGCAGCGTCGCCTGCGCGCGCCAG
GCGAGAACGGAGCCCCCTCG

Downstream 100 bases:

>100_bases
ATACCAGCGGCGCAACGGCGCTTCCGCTCCCGCTTTCGCCGGCACGCGAGGGGGCGTGTTCGTTGGCCGCGTTAACGGAC
CTTCGCGGGCGTTTGCGTAC

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MVTSPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSRDKMLDRASQERGWEALKRFGERLRDFHP
DHVRAVATNTLRVAKNAGEFLAEAQAALGFPIEVIAGREEARLIYAGAAHSVPANAGKRLVVDIGGGSTEFIIGQHYTPL
VMESLYIGCVSHSRAFFPAGNVDEYTMRQAELAAKREIQIISGEYKKAGWDQAIGSSGTARALAELVEANGFNDAGVSHG
ISRGGLERLKRALIKAENVNRLKLVALKPDRVPVLAGGLSIMLAVFEELGVDYVDTTDGALRLGVLYDLLGRTQHEDMRA
VTVDGFTRRYGVDRAQAARIGALAARFYDQLDEPEGEDRDESRTFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGF
SRTDQARLAALVLGHAGKLGKLSQSREVEWPLLFCLRLAALLCRRRNDAGLPDINVAQMKKGGYEVHLPSAWVQQNPLTD
YSLSQEAAEWEKVGIPYRVVYTDA

Sequences:

>Translated_504_residues
MVTSPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSRDKMLDRASQERGWEALKRFGERLRDFHP
DHVRAVATNTLRVAKNAGEFLAEAQAALGFPIEVIAGREEARLIYAGAAHSVPANAGKRLVVDIGGGSTEFIIGQHYTPL
VMESLYIGCVSHSRAFFPAGNVDEYTMRQAELAAKREIQIISGEYKKAGWDQAIGSSGTARALAELVEANGFNDAGVSHG
ISRGGLERLKRALIKAENVNRLKLVALKPDRVPVLAGGLSIMLAVFEELGVDYVDTTDGALRLGVLYDLLGRTQHEDMRA
VTVDGFTRRYGVDRAQAARIGALAARFYDQLDEPEGEDRDESRTFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGF
SRTDQARLAALVLGHAGKLGKLSQSREVEWPLLFCLRLAALLCRRRNDAGLPDINVAQMKKGGYEVHLPSAWVQQNPLTD
YSLSQEAAEWEKVGIPYRVVYTDA
>Mature_504_residues
MVTSPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSRDKMLDRASQERGWEALKRFGERLRDFHP
DHVRAVATNTLRVAKNAGEFLAEAQAALGFPIEVIAGREEARLIYAGAAHSVPANAGKRLVVDIGGGSTEFIIGQHYTPL
VMESLYIGCVSHSRAFFPAGNVDEYTMRQAELAAKREIQIISGEYKKAGWDQAIGSSGTARALAELVEANGFNDAGVSHG
ISRGGLERLKRALIKAENVNRLKLVALKPDRVPVLAGGLSIMLAVFEELGVDYVDTTDGALRLGVLYDLLGRTQHEDMRA
VTVDGFTRRYGVDRAQAARIGALAARFYDQLDEPEGEDRDESRTFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGF
SRTDQARLAALVLGHAGKLGKLSQSREVEWPLLFCLRLAALLCRRRNDAGLPDINVAQMKKGGYEVHLPSAWVQQNPLTD
YSLSQEAAEWEKVGIPYRVVYTDA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=496, Percent_Identity=37.7016129032258, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI48994966, Length=497, Percent_Identity=37.8269617706237, Blast_Score=308, Evalue=5e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 55007; Mature: 55007

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTSPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSRDKMLDRAS
CCCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHH
QERGWEALKRFGERLRDFHPDHVRAVATNTLRVAKNAGEFLAEAQAALGFPIEVIAGREE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ARLIYAGAAHSVPANAGKRLVVDIGGGSTEFIIGQHYTPLVMESLYIGCVSHSRAFFPAG
CEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEECCCC
NVDEYTMRQAELAAKREIQIISGEYKKAGWDQAIGSSGTARALAELVEANGFNDAGVSHG
CCCHHHHHHHHHHHHHEEEEECCCCHHCCCHHHHCCCCHHHHHHHHHHHCCCCCCHHHCC
ISRGGLERLKRALIKAENVNRLKLVALKPDRVPVLAGGLSIMLAVFEELGVDYVDTTDGA
CCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCEEECCCCH
LRLGVLYDLLGRTQHEDMRAVTVDGFTRRYGVDRAQAARIGALAARFYDQLDEPEGEDRD
HHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
ESRTFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGFSRTDQARLAALVLGHAGKLG
HHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCC
KLSQSREVEWPLLFCLRLAALLCRRRNDAGLPDINVAQMKKGGYEVHLPSAWVQQNPLTD
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEECCHHHHCCCCCCC
YSLSQEAAEWEKVGIPYRVVYTDA
CCCCHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MVTSPHLLAAVDLGSNSFRLIVGRVEETPAGSQIYPVDALREPVRLAAGLSRDKMLDRAS
CCCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHH
QERGWEALKRFGERLRDFHPDHVRAVATNTLRVAKNAGEFLAEAQAALGFPIEVIAGREE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ARLIYAGAAHSVPANAGKRLVVDIGGGSTEFIIGQHYTPLVMESLYIGCVSHSRAFFPAG
CEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEECCCC
NVDEYTMRQAELAAKREIQIISGEYKKAGWDQAIGSSGTARALAELVEANGFNDAGVSHG
CCCHHHHHHHHHHHHHEEEEECCCCHHCCCHHHHCCCCHHHHHHHHHHHCCCCCCHHHCC
ISRGGLERLKRALIKAENVNRLKLVALKPDRVPVLAGGLSIMLAVFEELGVDYVDTTDGA
CCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCEEECCCCH
LRLGVLYDLLGRTQHEDMRAVTVDGFTRRYGVDRAQAARIGALAARFYDQLDEPEGEDRD
HHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
ESRTFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGFSRTDQARLAALVLGHAGKLG
HHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCC
KLSQSREVEWPLLFCLRLAALLCRRRNDAGLPDINVAQMKKGGYEVHLPSAWVQQNPLTD
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEECCHHHHCCCCCCC
YSLSQEAAEWEKVGIPYRVVYTDA
CCCCHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]