Click here to switch to the map view.

The map label for this gene is phoR [H]

Identifier: 237811788

GI number: 237811788

Start: 1462552

End: 1463862

Strand: Direct

Name: phoR [H]

Synonym: GBP346_A1526

Alternate gene names: 237811788

Gene position: 1462552-1463862 (Clockwise)

Preceding gene: 237811787

Following gene: 237811790

Centisome position: 35.68

GC content: 66.44

Gene sequence:

>1311_bases
ATGAACATCATCTGGGCGCGCTTTCTGGTGTCGCTCGTGCTGCTCGCGCTCGTGAGCGTGATCATCGGCGCAATCGCGGG
CCCCGTGCCGGGTCTCGTCTTCGCGCTCGCGATGCTCGTCGTGCAGGGTTTCGTCAGCACCTTCCACACGCAGCGCCTCT
GGCGCCTGCTCGATGCGCCCGTCTACGGCGAAGTGCCGAGCGCGCCGGGCATCTGGGGCGAGATCTACTATCGGCTGCAC
AAACTCGCGAAGCAGTGGCACGCGCAGGTGCGCCAGGTCGAGCAGCAGCACTCGCGTTTCATCCAGGCGATCCAGGCGTC
GCCGAACGGCGTCGCGATGCTCGACGATCGCGATCAGATCGAGTGGTGCAACGCGATCGCCGAGGTGCACTTCGGGCTCG
ACGCGAAGCGCGACCTGCGCCAGCACGTCACGCATCTCGTGCGCCATCCGGATTTCGTCCGCTATCTGAACGGCCAGCAT
TACGACGAAACGCTCGTGATGCGCGGCATGGGCGGCAATCGGCAGAACGTGCTTGCCGTGCAGGTGTTTCCGTACGGCGA
GAACCGCAAGCTGCTGCTCACGCAGGATATCACCGAGCTCGAGCGCACCGATGCGATGCGGCGCGACTTCGTCGCGAACG
TGTCGCACGAACTGAAGACGCCGCTTACCGTGCTGTCGGGCTTTCTCGAGACGATGCGCGAGCTGCCGCTGTCGGACGAC
GAGCGCGCGCGCTATCTCGAACTGATGGAGCAGCAGGCGTCGCGGATGCGGCACATCGTCACCGATCTGCTCGTGCTCGC
GAAGCTCGAGGGCGAAAGCAAGCCGCCCGCCGATCGCGCGGTCGACATGCGCACGGTGCTCGACCATCTGCGGGACGATG
CGCAGACGCTATCGGGCGGCCATCACGAGATCACGTTCAAGGTTGACGAGACGCTCGCGGTGACGGGCGCGCAGACCGAG
ATCTTCAGCGCGCTCGGCAACCTCGTGACGAATGCGATCCGCTATACGCCGGAGGGCGGGACGATCCGCGTCGAATGGCG
GCGCGACGGCGCGCAGGCGGTGTTCTCGGTCACCGATAGCGGGCTCGGCATTCCGGCCGCCGAACTGCCGCGGCTCACCG
AGCGGTTCTATCGCGTCGACCGCAGCCGCTCGCGCGACACGGGCGGCACGGGGCTCGGGCTCGCGATCGTCAAGCATGTG
TTGCAACGGCACGATGCGCAACTGTCGATCCAGAGCGAGGAGGGGCGCGGCAGCACGTTTACCGCGCGTTTTCCCGCGCA
TCGGACGATCAGCCGGAGGCATGCGGCATGA

Upstream 100 bases:

>100_bases
CAGCGGCTACCGGCTCGCGAAACACGCGTAACGGCCGCGCGGCGCGCGGGGTTCGCGCCGCATCGTGCCATCCGTTTTCT
CTTTCGTCGGGCGCCGTATC

Downstream 100 bases:

>100_bases
CGTGAGCGGCGCGCGGGGGGCATGGCGTTGCTCCGGGAGGGCCGTTCGATTCGGCGGAGCCGTGCGTCGCATCGCCGTGC
GGAGCCGGCGTCTTTGCGGC

Product: phosphate regulon sensor kinase PhoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNIIWARFLVSLVLLALVSVIIGAIAGPVPGLVFALAMLVVQGFVSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDRDQIEWCNAIAEVHFGLDAKRDLRQHVTHLVRHPDFVRYLNGQH
YDETLVMRGMGGNRQNVLAVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLSDD
ERARYLELMEQQASRMRHIVTDLLVLAKLEGESKPPADRAVDMRTVLDHLRDDAQTLSGGHHEITFKVDETLAVTGAQTE
IFSALGNLVTNAIRYTPEGGTIRVEWRRDGAQAVFSVTDSGLGIPAAELPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAQLSIQSEEGRGSTFTARFPAHRTISRRHAA

Sequences:

>Translated_436_residues
MNIIWARFLVSLVLLALVSVIIGAIAGPVPGLVFALAMLVVQGFVSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDRDQIEWCNAIAEVHFGLDAKRDLRQHVTHLVRHPDFVRYLNGQH
YDETLVMRGMGGNRQNVLAVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLSDD
ERARYLELMEQQASRMRHIVTDLLVLAKLEGESKPPADRAVDMRTVLDHLRDDAQTLSGGHHEITFKVDETLAVTGAQTE
IFSALGNLVTNAIRYTPEGGTIRVEWRRDGAQAVFSVTDSGLGIPAAELPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAQLSIQSEEGRGSTFTARFPAHRTISRRHAA
>Mature_436_residues
MNIIWARFLVSLVLLALVSVIIGAIAGPVPGLVFALAMLVVQGFVSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDRDQIEWCNAIAEVHFGLDAKRDLRQHVTHLVRHPDFVRYLNGQH
YDETLVMRGMGGNRQNVLAVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLSDD
ERARYLELMEQQASRMRHIVTDLLVLAKLEGESKPPADRAVDMRTVLDHLRDDAQTLSGGHHEITFKVDETLAVTGAQTE
IFSALGNLVTNAIRYTPEGGTIRVEWRRDGAQAVFSVTDSGLGIPAAELPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAQLSIQSEEGRGSTFTARFPAHRTISRRHAA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=422, Percent_Identity=36.9668246445498, Blast_Score=271, Evalue=8e-74,
Organism=Escherichia coli, GI145693157, Length=346, Percent_Identity=28.9017341040462, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1788393, Length=271, Percent_Identity=28.0442804428044, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI48994928, Length=363, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1786783, Length=235, Percent_Identity=32.3404255319149, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790436, Length=302, Percent_Identity=27.4834437086093, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=34.070796460177, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790861, Length=221, Percent_Identity=32.1266968325792, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790346, Length=215, Percent_Identity=30.6976744186047, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788713, Length=254, Percent_Identity=26.7716535433071, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081816, Length=235, Percent_Identity=29.7872340425532, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788549, Length=396, Percent_Identity=22.2222222222222, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=251, Percent_Identity=25.4980079681275, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790551, Length=244, Percent_Identity=31.5573770491803, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787894, Length=243, Percent_Identity=27.1604938271605, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1789403, Length=239, Percent_Identity=28.8702928870293, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788279, Length=195, Percent_Identity=26.1538461538462, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=24.4444444444444, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789808, Length=225, Percent_Identity=30.2222222222222, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787374, Length=219, Percent_Identity=25.1141552511416, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49064; Mature: 49064

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIWARFLVSLVLLALVSVIIGAIAGPVPGLVFALAMLVVQGFVSTFHTQRLWRLLDAP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VYGEVPSAPGIWGEIYYRLHKLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDRDQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
EWCNAIAEVHFGLDAKRDLRQHVTHLVRHPDFVRYLNGQHYDETLVMRGMGGNRQNVLAV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHEEECCCCCCCCEEEE
QVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLSDD
EEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
ERARYLELMEQQASRMRHIVTDLLVLAKLEGESKPPADRAVDMRTVLDHLRDDAQTLSGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
HHEITFKVDETLAVTGAQTEIFSALGNLVTNAIRYTPEGGTIRVEWRRDGAQAVFSVTDS
CEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCHHHHHCCCC
GLGIPAAELPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVLQRHDAQLSIQSEEGRGSTF
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEE
TARFPAHRTISRRHAA
EEECCCHHHHHHHCCC
>Mature Secondary Structure
MNIIWARFLVSLVLLALVSVIIGAIAGPVPGLVFALAMLVVQGFVSTFHTQRLWRLLDAP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VYGEVPSAPGIWGEIYYRLHKLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDRDQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
EWCNAIAEVHFGLDAKRDLRQHVTHLVRHPDFVRYLNGQHYDETLVMRGMGGNRQNVLAV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHEEECCCCCCCCEEEE
QVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLSDD
EEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
ERARYLELMEQQASRMRHIVTDLLVLAKLEGESKPPADRAVDMRTVLDHLRDDAQTLSGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
HHEITFKVDETLAVTGAQTEIFSALGNLVTNAIRYTPEGGTIRVEWRRDGAQAVFSVTDS
CEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCHHHHHCCCC
GLGIPAAELPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVLQRHDAQLSIQSEEGRGSTF
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEE
TARFPAHRTISRRHAA
EEECCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2556368 [H]