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The map label for this gene is purR [H]

Identifier: 237811702

GI number: 237811702

Start: 1388158

End: 1389183

Strand: Reverse

Name: purR [H]

Synonym: GBP346_A1440

Alternate gene names: 237811702

Gene position: 1389183-1388158 (Counterclockwise)

Preceding gene: 237811703

Following gene: 237811701

Centisome position: 33.89

GC content: 71.83

Gene sequence:

>1026_bases
ATGACGCCCACCATCAAAGACGTCGCCGCGCTCGCCGGCTTTTCGATCGCCACCGTGTCGCGCGCGATCAACGCACCGCA
CACCGTCCATCCGGCGACGCTCGAAAAGATCCGCGCGGCGATCGGCTCGCTGCGCTTTCGCCCGAATCCGCTCGGCCGGC
AATTGCGCAGCGACCGCACGCAATTGATCGGCGTCGTGCTGCCGACGCTCGCGAATCCCGTATTCGCCGAATGCCTGCAG
GGCGTCGACGAACTCGCGACGCAGGCCGGCTTCAAGCTGATCGTGATGTCGACCGAATACGATGCGGCGCGCGAGCGCCA
TGCGATCGAGACACTGCGCGCGCAGCGCGTGGAAGGGCTGATGCTCACCGTCGCCGACGCCGACGCGCACCCGCTGCTCG
ACGAGCTCGACCGCGACGGCCCGCTCTACGTGCTGATGCACAACGACACGCCGCATCGCCCGTCGGTGGCGGTCGACAAT
CGCCGCGCCGCGTACGACGGCGTGCGGATGCTGATCGAGCGCGGCCATCGGCGCGTGCTGATGCTCGCGGGCTCGCTCGA
CGCATCCGATCGCGCGCGGCTGCGCGTGCACGGCTATGCGCAGGCACTCGACGAGCGCGGGCTCGAACCGCTGCCCGCGC
TCGAGCTCGACTTCAATGCACCCGCGCTGCCGCACGCGATGCTCGCGCATCTGAGCGCGCGCGCGACGCGCCCCACCGCG
CTCTTCTGCAGCAACGACTGGCTCGCGATGGTCGTGATTCGCGGGCTGCGCGACGCGCACCTCGCGGTGCCCGACGACAT
GTCGGTGCTCGGCTTCGACGGCCTCGCGGTCGGCGAGCTGCTCGCGCCGCCGCTCGCGAGCGTCGCGACGCCGAATCGCG
AGATCGGCCGCGCCGCGTGGCGGCGCCTTGCCGAGCGCATCGCCGGCAAGCGCCATGCGCAACCCGCGCTGACGCTGCCG
CACGCAGTGCGCGACGGCGCGACCGTCGCGCCGCCGCGCGATGCGCGCGCGGCGCGCATCGCCTGA

Upstream 100 bases:

>100_bases
CAGCCGCGCCCGCTCGCCTTCGCCGCCGTCATCAGTTCTTCATCGACGCCGCCGATAATCCCGTCGACGAAAACGTTTAC
ACACCTCCGCTTCCCGCTTC

Downstream 100 bases:

>100_bases
ACCGTGCTTTCGCTTTCCGTCGCTTTCCATTCGCTTCGCCCTCAAGGAGACCTGCCGTGACCGTCCGCCGTTCGCTTCTT
CCGCGCTCGCCGCTCGCCGC

Product: transcriptional repressor, LacI family

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTPTIKDVAALAGFSIATVSRAINAPHTVHPATLEKIRAAIGSLRFRPNPLGRQLRSDRTQLIGVVLPTLANPVFAECLQ
GVDELATQAGFKLIVMSTEYDAARERHAIETLRAQRVEGLMLTVADADAHPLLDELDRDGPLYVLMHNDTPHRPSVAVDN
RRAAYDGVRMLIERGHRRVLMLAGSLDASDRARLRVHGYAQALDERGLEPLPALELDFNAPALPHAMLAHLSARATRPTA
LFCSNDWLAMVVIRGLRDAHLAVPDDMSVLGFDGLAVGELLAPPLASVATPNREIGRAAWRRLAERIAGKRHAQPALTLP
HAVRDGATVAPPRDARAARIA

Sequences:

>Translated_341_residues
MTPTIKDVAALAGFSIATVSRAINAPHTVHPATLEKIRAAIGSLRFRPNPLGRQLRSDRTQLIGVVLPTLANPVFAECLQ
GVDELATQAGFKLIVMSTEYDAARERHAIETLRAQRVEGLMLTVADADAHPLLDELDRDGPLYVLMHNDTPHRPSVAVDN
RRAAYDGVRMLIERGHRRVLMLAGSLDASDRARLRVHGYAQALDERGLEPLPALELDFNAPALPHAMLAHLSARATRPTA
LFCSNDWLAMVVIRGLRDAHLAVPDDMSVLGFDGLAVGELLAPPLASVATPNREIGRAAWRRLAERIAGKRHAQPALTLP
HAVRDGATVAPPRDARAARIA
>Mature_340_residues
TPTIKDVAALAGFSIATVSRAINAPHTVHPATLEKIRAAIGSLRFRPNPLGRQLRSDRTQLIGVVLPTLANPVFAECLQG
VDELATQAGFKLIVMSTEYDAARERHAIETLRAQRVEGLMLTVADADAHPLLDELDRDGPLYVLMHNDTPHRPSVAVDNR
RAAYDGVRMLIERGHRRVLMLAGSLDASDRARLRVHGYAQALDERGLEPLPALELDFNAPALPHAMLAHLSARATRPTAL
FCSNDWLAMVVIRGLRDAHLAVPDDMSVLGFDGLAVGELLAPPLASVATPNREIGRAAWRRLAERIAGKRHAQPALTLPH
AVRDGATVAPPRDARAARIA

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=321, Percent_Identity=33.6448598130841, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1790369, Length=311, Percent_Identity=30.8681672025724, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1790715, Length=344, Percent_Identity=27.3255813953488, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI48994940, Length=329, Percent_Identity=30.3951367781155, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1788474, Length=296, Percent_Identity=32.0945945945946, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1787948, Length=346, Percent_Identity=30.9248554913295, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1789202, Length=295, Percent_Identity=32.2033898305085, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789068, Length=340, Percent_Identity=29.7058823529412, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1786540, Length=335, Percent_Identity=29.5522388059701, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787580, Length=322, Percent_Identity=27.9503105590062, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1787906, Length=332, Percent_Identity=26.8072289156627, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1786268, Length=328, Percent_Identity=24.6951219512195, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790689, Length=313, Percent_Identity=22.3642172523962, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36974; Mature: 36843

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTIKDVAALAGFSIATVSRAINAPHTVHPATLEKIRAAIGSLRFRPNPLGRQLRSDRT
CCCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QLIGVVLPTLANPVFAECLQGVDELATQAGFKLIVMSTEYDAARERHAIETLRAQRVEGL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCE
MLTVADADAHPLLDELDRDGPLYVLMHNDTPHRPSVAVDNRRAAYDGVRMLIERGHRRVL
EEEEECCCCCHHHHHHCCCCCEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEE
MLAGSLDASDRARLRVHGYAQALDERGLEPLPALELDFNAPALPHAMLAHLSARATRPTA
EEECCCCCCCCCEEEEHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCEE
LFCSNDWLAMVVIRGLRDAHLAVPDDMSVLGFDGLAVGELLAPPLASVATPNREIGRAAW
EEECCCHHHHHHHHCCCCCCCCCCCCCCEECCCCHHHHHHHCCCHHHHCCCCHHHHHHHH
RRLAERIAGKRHAQPALTLPHAVRDGATVAPPRDARAARIA
HHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPTIKDVAALAGFSIATVSRAINAPHTVHPATLEKIRAAIGSLRFRPNPLGRQLRSDRT
CCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QLIGVVLPTLANPVFAECLQGVDELATQAGFKLIVMSTEYDAARERHAIETLRAQRVEGL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCE
MLTVADADAHPLLDELDRDGPLYVLMHNDTPHRPSVAVDNRRAAYDGVRMLIERGHRRVL
EEEEECCCCCHHHHHHCCCCCEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEE
MLAGSLDASDRARLRVHGYAQALDERGLEPLPALELDFNAPALPHAMLAHLSARATRPTA
EEECCCCCCCCCEEEEHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCEE
LFCSNDWLAMVVIRGLRDAHLAVPDDMSVLGFDGLAVGELLAPPLASVATPNREIGRAAW
EEECCCHHHHHHHHCCCCCCCCCCCCCCEECCCCHHHHHHHCCCHHHHCCCCHHHHHHHH
RRLAERIAGKRHAQPALTLPHAVRDGATVAPPRDARAARIA
HHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA