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The map label for this gene is degS [H]

Identifier: 237811631

GI number: 237811631

Start: 1316121

End: 1317848

Strand: Direct

Name: degS [H]

Synonym: GBP346_A1368

Alternate gene names: 237811631

Gene position: 1316121-1317848 (Clockwise)

Preceding gene: 237811630

Following gene: 237811632

Centisome position: 32.11

GC content: 67.36

Gene sequence:

>1728_bases
ATGGGCGAGTTGGCGGACGAATCGAGAATCTTCCTGTCGACGCTGCAGCCCGAGCGCCGTGAGCGCAGGCTCGCGATGAC
GGCCGTGGCGCTCTCGGTGGTCCTGTTCGCGACGCTCGCGCCGTTCGTGCGCATCCAGATGCCGCAGGTATGGGCGTTCA
TTCCGATCTATCAGTCGGCGATCGTGATCTGTGATCTCATCACGGCGGGCCTGCTGCTCGGTCAGTTCGGCATTTTGCGC
ACTCCGTCGCTCGTCGTGCTCGCGGGCGGCTATCTGTTCACCGCGTGCATGGCGAGCGTGCACATGCTCACGTTTCCCGG
CCTGTTCTTGCCGAGCGGCCTGCTCGACGCGGGCCCGCAGACCACCGCCTGGCTCTACATGTTCTGGCACAGCGGCTTTC
CGCTTTGCGTGATCTTCTATACGCTCGCCAGTCGCCGTGAGCGCGCGGAGCCGCTCTACGCGGGGCGGCTCGCGCTGCCC
GTGATCGTTTGCATCGGTACCGCGCTCGTCGCGACGGGGGCGTTCGCCGCGCTCGCGACGAGCGGCCGCGAGCTGTTGCC
GCCGATCATGGCGAACAGTCACTACACGCCGCTGATGCGCGGCGTCGTGACGACCGTCTGGCTGATGACGCTCGCCGCGC
TGATCCTGCTCACGTCGCGCCGGCCGCATTCGGTGCTCGATCTGTGGCTCATCGTCGTGCTGTGCGCGTGGCTGCTCGAC
ATCGCGCTGTCGGCCGTCCTCAATCACGGGCGTTTCGATCTCGGCTTCTACGCGGGGCGCGTTTATGGCCTCGTCGCGTC
GAGTTTCGTGCTGCTCGCGCTGTTGCTCGAAAACGGCAAGCTGTATGCGCGCACGGTCCATGCGTTGCAGGGCGAGCGCA
TCGAGCATCGGCGCGTGCAGGAGAAGACCGTCCAGTTGAACGAGGCGAACGAGTTGCTCGAGCAGCGCGTTGCCGAGCGC
ACGCGCGAGCTGCAGGCCGCGAACGACGAATTGCGGCGCGAGATCGTCGAGCGCGAGCGCGCGGAGGAGGCGCTCGCGCG
TTCGCGCGAAGAGTTGCGGGAGATCGCCGCGATCAGCTCGACCGCGCGCGAGCAGGAGCGTGGCCGGATCGCGCGCGAGC
TGCACGACGAACTCGCGCAGACGCTCGCGATGCTGCGGCTCGATCTCGAACGCGTGTCGACGACGGGCAACGAGCTCGCC
GGAAGCTTCATGGAGATGCGCGGGCTGCTCGACGGCGCGGTCGCGGCGACGCGCCGGATCGCGTCGGACCTGCGTCCGCT
GATGCTCGACGATCTCGGGCTCGTGCCGGCCATCCAGTGGCTCGTGCAGGCGTTCCAGCAGCGGCACGGTATCGATTGCA
CGCTGATCGTCGATCCGCCCGAGCTCGACCTCGTCGAGCCGCAGGCGAGCACGACGTTTCGCATCCTGCAGGAATCGCTG
ACGAACGTCGGGCGCCATGCGCGCGCATCGCATGTCGACATCCGGCTCATCGCCGACGATCGCGAGGTGATGCTGAGCGT
GCGCGACAACGGCGTCGGCTTCGATACGGAGAACCCGCGCAAGCCGAATTCGTTCGGGCTCGTCGGTTTGCGCGAGCGTG
CGTATCTGGTGCAGGGCACGCTATCGGTACAGACGGCGCCGGGGCAGGGGACGGCGATCGAGGTGCATATCCCGCTCGTG
CGCGCGCGCGAAGTCACCGTTTTGCAAAGCGGCGAGCTGCGCGAGTGA

Upstream 100 bases:

>100_bases
CGCGCTTTTCATGACGCAAGTTCGATTTCATAATAGACGCGGCGTCCGGGAACGCGCGACACGCCCGAGCGTGCAAGCTT
GCCGAATGAGGAGAACCAGC

Downstream 100 bases:

>100_bases
TGCGTTCGCGCCCGCGCGGCGCATCGCGGGTGCGGCGCGCGGGGCAGGCCCGCGCAGGCCCGCGCCGTTGAGCGGCGGGG
CGAGCGTCGCGCGATTCGGG

Product: sensory box histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MGELADESRIFLSTLQPERRERRLAMTAVALSVVLFATLAPFVRIQMPQVWAFIPIYQSAIVICDLITAGLLLGQFGILR
TPSLVVLAGGYLFTACMASVHMLTFPGLFLPSGLLDAGPQTTAWLYMFWHSGFPLCVIFYTLASRRERAEPLYAGRLALP
VIVCIGTALVATGAFAALATSGRELLPPIMANSHYTPLMRGVVTTVWLMTLAALILLTSRRPHSVLDLWLIVVLCAWLLD
IALSAVLNHGRFDLGFYAGRVYGLVASSFVLLALLLENGKLYARTVHALQGERIEHRRVQEKTVQLNEANELLEQRVAER
TRELQAANDELRREIVERERAEEALARSREELREIAAISSTAREQERGRIARELHDELAQTLAMLRLDLERVSTTGNELA
GSFMEMRGLLDGAVAATRRIASDLRPLMLDDLGLVPAIQWLVQAFQQRHGIDCTLIVDPPELDLVEPQASTTFRILQESL
TNVGRHARASHVDIRLIADDREVMLSVRDNGVGFDTENPRKPNSFGLVGLRERAYLVQGTLSVQTAPGQGTAIEVHIPLV
RAREVTVLQSGELRE

Sequences:

>Translated_575_residues
MGELADESRIFLSTLQPERRERRLAMTAVALSVVLFATLAPFVRIQMPQVWAFIPIYQSAIVICDLITAGLLLGQFGILR
TPSLVVLAGGYLFTACMASVHMLTFPGLFLPSGLLDAGPQTTAWLYMFWHSGFPLCVIFYTLASRRERAEPLYAGRLALP
VIVCIGTALVATGAFAALATSGRELLPPIMANSHYTPLMRGVVTTVWLMTLAALILLTSRRPHSVLDLWLIVVLCAWLLD
IALSAVLNHGRFDLGFYAGRVYGLVASSFVLLALLLENGKLYARTVHALQGERIEHRRVQEKTVQLNEANELLEQRVAER
TRELQAANDELRREIVERERAEEALARSREELREIAAISSTAREQERGRIARELHDELAQTLAMLRLDLERVSTTGNELA
GSFMEMRGLLDGAVAATRRIASDLRPLMLDDLGLVPAIQWLVQAFQQRHGIDCTLIVDPPELDLVEPQASTTFRILQESL
TNVGRHARASHVDIRLIADDREVMLSVRDNGVGFDTENPRKPNSFGLVGLRERAYLVQGTLSVQTAPGQGTAIEVHIPLV
RAREVTVLQSGELRE
>Mature_574_residues
GELADESRIFLSTLQPERRERRLAMTAVALSVVLFATLAPFVRIQMPQVWAFIPIYQSAIVICDLITAGLLLGQFGILRT
PSLVVLAGGYLFTACMASVHMLTFPGLFLPSGLLDAGPQTTAWLYMFWHSGFPLCVIFYTLASRRERAEPLYAGRLALPV
IVCIGTALVATGAFAALATSGRELLPPIMANSHYTPLMRGVVTTVWLMTLAALILLTSRRPHSVLDLWLIVVLCAWLLDI
ALSAVLNHGRFDLGFYAGRVYGLVASSFVLLALLLENGKLYARTVHALQGERIEHRRVQEKTVQLNEANELLEQRVAERT
RELQAANDELRREIVERERAEEALARSREELREIAAISSTAREQERGRIARELHDELAQTLAMLRLDLERVSTTGNELAG
SFMEMRGLLDGAVAATRRIASDLRPLMLDDLGLVPAIQWLVQAFQQRHGIDCTLIVDPPELDLVEPQASTTFRILQESLT
NVGRHARASHVDIRLIADDREVMLSVRDNGVGFDTENPRKPNSFGLVGLRERAYLVQGTLSVQTAPGQGTAIEVHIPLVR
AREVTVLQSGELRE

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=238, Percent_Identity=29.4117647058824, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87082311, Length=244, Percent_Identity=31.5573770491803, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788812, Length=197, Percent_Identity=31.9796954314721, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63756; Mature: 63625

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGELADESRIFLSTLQPERRERRLAMTAVALSVVLFATLAPFVRIQMPQVWAFIPIYQSA
CCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHH
IVICDLITAGLLLGQFGILRTPSLVVLAGGYLFTACMASVHMLTFPGLFLPSGLLDAGPQ
HHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCC
TTAWLYMFWHSGFPLCVIFYTLASRRERAEPLYAGRLALPVIVCIGTALVATGAFAALAT
CHHEEEEHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGRELLPPIMANSHYTPLMRGVVTTVWLMTLAALILLTSRRPHSVLDLWLIVVLCAWLLD
CCCHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
IALSAVLNHGRFDLGFYAGRVYGLVASSFVLLALLLENGKLYARTVHALQGERIEHRRVQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHH
EKTVQLNEANELLEQRVAERTRELQAANDELRREIVERERAEEALARSREELREIAAISS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAREQERGRIARELHDELAQTLAMLRLDLERVSTTGNELAGSFMEMRGLLDGAVAATRRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASDLRPLMLDDLGLVPAIQWLVQAFQQRHGIDCTLIVDPPELDLVEPQASTTFRILQESL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
TNVGRHARASHVDIRLIADDREVMLSVRDNGVGFDTENPRKPNSFGLVGLRERAYLVQGT
HHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCEEECCCCEEEEEE
LSVQTAPGQGTAIEVHIPLVRAREVTVLQSGELRE
EEEEECCCCCCEEEEEECEEECCEEEEECCCCCCC
>Mature Secondary Structure 
GELADESRIFLSTLQPERRERRLAMTAVALSVVLFATLAPFVRIQMPQVWAFIPIYQSA
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHH
IVICDLITAGLLLGQFGILRTPSLVVLAGGYLFTACMASVHMLTFPGLFLPSGLLDAGPQ
HHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCC
TTAWLYMFWHSGFPLCVIFYTLASRRERAEPLYAGRLALPVIVCIGTALVATGAFAALAT
CHHEEEEHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGRELLPPIMANSHYTPLMRGVVTTVWLMTLAALILLTSRRPHSVLDLWLIVVLCAWLLD
CCCHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
IALSAVLNHGRFDLGFYAGRVYGLVASSFVLLALLLENGKLYARTVHALQGERIEHRRVQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHH
EKTVQLNEANELLEQRVAERTRELQAANDELRREIVERERAEEALARSREELREIAAISS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAREQERGRIARELHDELAQTLAMLRLDLERVSTTGNELAGSFMEMRGLLDGAVAATRRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASDLRPLMLDDLGLVPAIQWLVQAFQQRHGIDCTLIVDPPELDLVEPQASTTFRILQESL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
TNVGRHARASHVDIRLIADDREVMLSVRDNGVGFDTENPRKPNSFGLVGLRERAYLVQGT
HHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCEEECCCCEEEEEE
LSVQTAPGQGTAIEVHIPLVRAREVTVLQSGELRE
EEEEECCCCCCEEEEEECEEECCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]