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The map label for this gene is hpt [H]

Identifier: 23502833

GI number: 23502833

Start: 1913628

End: 1914164

Strand: Reverse

Name: hpt [H]

Synonym: BR1985

Alternate gene names: 23502833

Gene position: 1914164-1913628 (Counterclockwise)

Preceding gene: 23502837

Following gene: 23502828

Centisome position: 90.81

GC content: 55.68

Gene sequence:

>537_bases
ATGCCAGAAGTTGGCGGCAAGACGATAGAAGTGCTCTTTAGCCCGGACGAGATTGCAAAACGCAATCTTGAACTGGCCAC
AATCATCGCGGAGCGCAAGTTTCACAATCTGCTCACGATCTCCATTCTCAAGGGCTCGTTCATCTTCGCGGCCGATCTTA
TCCGCGCCATGCACGATGCGGGCGTGGAGCCTGACGTCGAGTTCATCACTGTGTCGAGCTATGGCAAGGGTACAACCAGT
ACGGAAGTGCGCCTGTTGCGTGATATCGACAGTGACGTGCGCGACCGCGATGTGCTCCTGATCGACGATATTCTGGAATC
CGGCAAGACGCTGAAATTCGTTCGCGAACTCATGCTGGAACGTGGCGCGCGCAGTGTTTCCATCGCCGTTCTTCTCGACA
AGAGCATGCGCCGCAAGGTCGATCTCGACGCGGATTTCGTGGCTTTCGAGTGCCCGGATTATTTTGTCGTCGGCTATGGC
ATGGATGTCGGACATGCCTTCCGGCAACTGCCTTATGTCGGCCGCGTGATGGAGTAA

Upstream 100 bases:

>100_bases
ACCGCGCCGAAAGGGCAGGGTGCATTTTTGCGAAAGCGTGATATAGAGCGTCCTTCTCGCGCCAATAAGTGCGAATTGAA
ACGATCAGGAGAAGCGGCAG

Downstream 100 bases:

>100_bases
TACCACAACCCGATGAGCCAAACTCGTCGGGTTTTGGCATCAGTCGAATTTCAGCAGGCGTTGCAGATATTCCTTCTCCA
TCTGCGGCGTCAGGGCATTG

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MPEVGGKTIEVLFSPDEIAKRNLELATIIAERKFHNLLTISILKGSFIFAADLIRAMHDAGVEPDVEFITVSSYGKGTTS
TEVRLLRDIDSDVRDRDVLLIDDILESGKTLKFVRELMLERGARSVSIAVLLDKSMRRKVDLDADFVAFECPDYFVVGYG
MDVGHAFRQLPYVGRVME

Sequences:

>Translated_178_residues
MPEVGGKTIEVLFSPDEIAKRNLELATIIAERKFHNLLTISILKGSFIFAADLIRAMHDAGVEPDVEFITVSSYGKGTTS
TEVRLLRDIDSDVRDRDVLLIDDILESGKTLKFVRELMLERGARSVSIAVLLDKSMRRKVDLDADFVAFECPDYFVVGYG
MDVGHAFRQLPYVGRVME
>Mature_177_residues
PEVGGKTIEVLFSPDEIAKRNLELATIIAERKFHNLLTISILKGSFIFAADLIRAMHDAGVEPDVEFITVSSYGKGTTST
EVRLLRDIDSDVRDRDVLLIDDILESGKTLKFVRELMLERGARSVSIAVLLDKSMRRKVDLDADFVAFECPDYFVVGYGM
DVGHAFRQLPYVGRVME

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=187, Percent_Identity=32.0855614973262, Blast_Score=90, Evalue=9e-19,
Organism=Homo sapiens, GI9910262, Length=158, Percent_Identity=26.5822784810127, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI87081689, Length=174, Percent_Identity=43.1034482758621, Blast_Score=146, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17510817, Length=152, Percent_Identity=35.5263157894737, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19971; Mature: 19840

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEVGGKTIEVLFSPDEIAKRNLELATIIAERKFHNLLTISILKGSFIFAADLIRAMHDA
CCCCCCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHC
GVEPDVEFITVSSYGKGTTSTEVRLLRDIDSDVRDRDVLLIDDILESGKTLKFVRELMLE
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHH
RGARSVSIAVLLDKSMRRKVDLDADFVAFECPDYFVVGYGMDVGHAFRQLPYVGRVME
CCCCEEEEEEEECHHHHHHCCCCCCEEEEECCCEEEEEECCCHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
PEVGGKTIEVLFSPDEIAKRNLELATIIAERKFHNLLTISILKGSFIFAADLIRAMHDA
CCCCCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHC
GVEPDVEFITVSSYGKGTTSTEVRLLRDIDSDVRDRDVLLIDDILESGKTLKFVRELMLE
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHH
RGARSVSIAVLLDKSMRRKVDLDADFVAFECPDYFVVGYGMDVGHAFRQLPYVGRVME
CCCCEEEEEEEECHHHHHHCCCCCCEEEEECCCEEEEEECCCHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]