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The map label for this gene is tlpA [H]

Identifier: 23502828

GI number: 23502828

Start: 1907088

End: 1907804

Strand: Reverse

Name: tlpA [H]

Synonym: BR1980

Alternate gene names: 23502828

Gene position: 1907804-1907088 (Counterclockwise)

Preceding gene: 23502833

Following gene: 23502825

Centisome position: 90.51

GC content: 58.72

Gene sequence:

>717_bases
ATGGCAGAAGACAACGAAAAGGCGACATCCGAACAGAATGCGAAATCGGGAAATCGCAAGATCGTCCTTCTTGCCGCCCT
TGCCGGTGTCATTGCCGGTATCGGGGCAGTATACGTGATGGAGCGCCCTTCTGGCAATGTGGTTGACCAGAATGTTTCAG
CGAATCTTGCAGCCGAAAGCGATGCGGCCTCGGCCCAATGCGCCCTGAAAGCCGATGCGCTGAAGGCGCTGGATGCGGCG
GCAACCGGGGGTGTGGCTGCAATGCGCGCCGCTGAAAAGCCGATTTCGCTGGCGCATATCGCCTTCACCGGCCCGGACGG
CAAAAAGATGACGCTCGGCGACTACAAGGGCAAGACGCTTCTGGTCAATCTCTGGGCAACATGGTGTGCGCCCTGCCGCG
AGGAAATGCCAGCCCTCGACCAGTTGCAGGGCGAAAAGGGCGGCAATGATTTCGATGTTGTCGCCATCAATATCGACACC
GGTTCGGACGACAAGCCGAAGGGTTTTCTGAGCGAGATCGGCATCAAAAACCTGACGCTGCATCGCGATGCTTCCATGGC
GAGCTTCAACGAGTTGAAGCGCAAGAACCTCGCTTTCGGCCTGCCCGTCACGCTTCTGGTGGACAAGGATGGCTGCCAGA
TCGCCGCGATGAATGGCCCCGCGCCATGGGATAGCCCCGACGCCATCAAGCTCATCGACGCGGCCAAAAATCTTTGA

Upstream 100 bases:

>100_bases
GCAAAACGGCCGCCCCACATCTGGTTGCTTGATTTTTGTTCGCTCATGCTCATATGCCCCGAAGACGATTTGGCGGAATA
TTGGAAAGAAGTGACGCGAT

Downstream 100 bases:

>100_bases
TCCGCGTTCAGGATGCGTGGAAGCCCGCGCGTTTCAACCGGACTATGGCGAGATCGAGAGCCGACAGAAAAGCTGAGCGA
TCCTTCGGCGCAAACGGTGC

Product: thiol:disulfide interchange protein

Products: NA

Alternate protein names: Cytochrome c biogenesis protein tlpA [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MAEDNEKATSEQNAKSGNRKIVLLAALAGVIAGIGAVYVMERPSGNVVDQNVSANLAAESDAASAQCALKADALKALDAA
ATGGVAAMRAAEKPISLAHIAFTGPDGKKMTLGDYKGKTLLVNLWATWCAPCREEMPALDQLQGEKGGNDFDVVAINIDT
GSDDKPKGFLSEIGIKNLTLHRDASMASFNELKRKNLAFGLPVTLLVDKDGCQIAAMNGPAPWDSPDAIKLIDAAKNL

Sequences:

>Translated_238_residues
MAEDNEKATSEQNAKSGNRKIVLLAALAGVIAGIGAVYVMERPSGNVVDQNVSANLAAESDAASAQCALKADALKALDAA
ATGGVAAMRAAEKPISLAHIAFTGPDGKKMTLGDYKGKTLLVNLWATWCAPCREEMPALDQLQGEKGGNDFDVVAINIDT
GSDDKPKGFLSEIGIKNLTLHRDASMASFNELKRKNLAFGLPVTLLVDKDGCQIAAMNGPAPWDSPDAIKLIDAAKNL
>Mature_237_residues
AEDNEKATSEQNAKSGNRKIVLLAALAGVIAGIGAVYVMERPSGNVVDQNVSANLAAESDAASAQCALKADALKALDAAA
TGGVAAMRAAEKPISLAHIAFTGPDGKKMTLGDYKGKTLLVNLWATWCAPCREEMPALDQLQGEKGGNDFDVVAINIDTG
SDDKPKGFLSEIGIKNLTLHRDASMASFNELKRKNLAFGLPVTLLVDKDGCQIAAMNGPAPWDSPDAIKLIDAAKNL

Specific function: Involved in cytochrome aa3 assembly [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

None

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013740
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: NA

Molecular weight: Translated: 24863; Mature: 24731

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEDNEKATSEQNAKSGNRKIVLLAALAGVIAGIGAVYVMERPSGNVVDQNVSANLAAES
CCCCCCHHCCHHHCCCCCCEEEEHHHHHHHHHHCCEEEEEECCCCCEECCCCCCCEECCC
DAASAQCALKADALKALDAAATGGVAAMRAAEKPISLAHIAFTGPDGKKMTLGDYKGKTL
CCCCHHEEHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCCCEE
LVNLWATWCAPCREEMPALDQLQGEKGGNDFDVVAINIDTGSDDKPKGFLSEIGIKNLTL
EEEEHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEEEEECCCCCCCCCHHHHHCCCCEEEE
HRDASMASFNELKRKNLAFGLPVTLLVDKDGCQIAAMNGPAPWDSPDAIKLIDAAKNL
ECCCCHHHHHHHHHHCCEECCCEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
AEDNEKATSEQNAKSGNRKIVLLAALAGVIAGIGAVYVMERPSGNVVDQNVSANLAAES
CCCCCHHCCHHHCCCCCCEEEEHHHHHHHHHHCCEEEEEECCCCCEECCCCCCCEECCC
DAASAQCALKADALKALDAAATGGVAAMRAAEKPISLAHIAFTGPDGKKMTLGDYKGKTL
CCCCHHEEHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCCCEE
LVNLWATWCAPCREEMPALDQLQGEKGGNDFDVVAINIDTGSDDKPKGFLSEIGIKNLTL
EEEEHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEEEEECCCCCCCCCHHHHHCCCCEEEE
HRDASMASFNELKRKNLAFGLPVTLLVDKDGCQIAAMNGPAPWDSPDAIKLIDAAKNL
ECCCCHHHHHHHHHHCCEECCCEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8253065; 12597275 [H]