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The map label for this gene is tesB [H]

Identifier: 23502749

GI number: 23502749

Start: 1832898

End: 1833833

Strand: Reverse

Name: tesB [H]

Synonym: BR1898

Alternate gene names: 23502749

Gene position: 1833833-1832898 (Counterclockwise)

Preceding gene: 23502751

Following gene: 23502747

Centisome position: 87.0

GC content: 58.97

Gene sequence:

>936_bases
ATGTCTGATGAAGAAAAGTCCGGGATCGAGCAGACGGCGGCAATGCGCGAACTGCTGTCGATCCTTGATCTCGAAACGCT
TGAAATGGATCTTTTTCGCGGCAACAGCCCGCAGGTCGGCTGGCAGCGCGTCTTTGGCGGGCAGGTCATCGGGCAGGCGC
TGATTGCGGCGCAGCGCACCGTCGATCCCGAACGCCATGTGCATTCGCTCCACGCCTATTTCGTGCGTCCGGGCGATCCT
GCCATTCCCATCATCTATGAGGTGGATCGCATCCGCGACGGTTCCAGCTTCAGCACCCGCCGCGTGCTGGCCAAGCAGCA
CGGCAAGGCGATCTTTACGCTTTCCGCTTCCTTCCAGATCGATGAAGGCGGCCTCGACCATCAAATGCCGATGCCCGAAG
GGTTGCCGCAGCCGGAGCAGCTCGTCGGCGACCATGACATCAAGGAAAAATATCTCGATATGGCACCACCCGGCGTGCGC
AAATATTGGGAACGGGAGCGCCCGATCGAAATCAAGCCGGTCTCGCTCACCCATTATTTCTCGCGCGAGAAGCTGGAGCC
GGTGCAGCATGTCTGGGTGCGGGCAAGGGGGCTTGTCCCTGATGACCGCGCATTGCAGGCCGCCATTCTCGCTTATCTTT
CCGATATGACGCTGCTCGATACCTCGCTTCACCCGCATGGCCGTTTCATTTTCGACCGCGACATGCAGGTAGCGAGCCTT
GACCATGCCATGTGGTTCCACCGCCCGTGCCGGCTGGATGACTGGCTTCTTTATACGCAGGATGCGCCGAGCGCTTCTGG
TGCGCGCGGCTTCAATCGTGGCGCGCTTTATACGCGCGATGGTGTGCTGATCGCATCGGTGGCGCAGGAAGGGCTGATCC
GCGTCCACGAAAAAACAAGTGATGGTTATTTAATCAGCAGTTTTTCTGTAGCTTAA

Upstream 100 bases:

>100_bases
TCCTTTGGCCTGCCCGGTTCTTGACAGGCCCGGATGTGCAGGCTCAAACATGCCTCTTGAACTTTGTAAAGCATATATGG
TTGCGGGAGGCAGGCTGTCC

Downstream 100 bases:

>100_bases
ATTTTAAGCAGATTGGTGATTGCGCGCAAGGTTTCATCCTTTCCGCGCATTTCATTTCAGGGAGGAGACGCGAAAACCGC
GCCCATCGCAGCACCTTCTC

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSDEEKSGIEQTAAMRELLSILDLETLEMDLFRGNSPQVGWQRVFGGQVIGQALIAAQRTVDPERHVHSLHAYFVRPGDP
AIPIIYEVDRIRDGSSFSTRRVLAKQHGKAIFTLSASFQIDEGGLDHQMPMPEGLPQPEQLVGDHDIKEKYLDMAPPGVR
KYWERERPIEIKPVSLTHYFSREKLEPVQHVWVRARGLVPDDRALQAAILAYLSDMTLLDTSLHPHGRFIFDRDMQVASL
DHAMWFHRPCRLDDWLLYTQDAPSASGARGFNRGALYTRDGVLIASVAQEGLIRVHEKTSDGYLISSFSVA

Sequences:

>Translated_311_residues
MSDEEKSGIEQTAAMRELLSILDLETLEMDLFRGNSPQVGWQRVFGGQVIGQALIAAQRTVDPERHVHSLHAYFVRPGDP
AIPIIYEVDRIRDGSSFSTRRVLAKQHGKAIFTLSASFQIDEGGLDHQMPMPEGLPQPEQLVGDHDIKEKYLDMAPPGVR
KYWERERPIEIKPVSLTHYFSREKLEPVQHVWVRARGLVPDDRALQAAILAYLSDMTLLDTSLHPHGRFIFDRDMQVASL
DHAMWFHRPCRLDDWLLYTQDAPSASGARGFNRGALYTRDGVLIASVAQEGLIRVHEKTSDGYLISSFSVA
>Mature_310_residues
SDEEKSGIEQTAAMRELLSILDLETLEMDLFRGNSPQVGWQRVFGGQVIGQALIAAQRTVDPERHVHSLHAYFVRPGDPA
IPIIYEVDRIRDGSSFSTRRVLAKQHGKAIFTLSASFQIDEGGLDHQMPMPEGLPQPEQLVGDHDIKEKYLDMAPPGVRK
YWERERPIEIKPVSLTHYFSREKLEPVQHVWVRARGLVPDDRALQAAILAYLSDMTLLDTSLHPHGRFIFDRDMQVASLD
HAMWFHRPCRLDDWLLYTQDAPSASGARGFNRGALYTRDGVLIASVAQEGLIRVHEKTSDGYLISSFSVA

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=298, Percent_Identity=43.9597315436242, Blast_Score=239, Evalue=2e-63,
Organism=Escherichia coli, GI1786657, Length=273, Percent_Identity=48.3516483516484, Blast_Score=273, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI71988741, Length=291, Percent_Identity=39.1752577319588, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17558508, Length=303, Percent_Identity=38.2838283828383, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI115532456, Length=314, Percent_Identity=35.6687898089172, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17531889, Length=314, Percent_Identity=35.6687898089172, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17531885, Length=314, Percent_Identity=35.6687898089172, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI212645202, Length=266, Percent_Identity=36.4661654135338, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71982224, Length=272, Percent_Identity=34.5588235294118, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322480, Length=332, Percent_Identity=26.8072289156627, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 35138; Mature: 35007

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEEKSGIEQTAAMRELLSILDLETLEMDLFRGNSPQVGWQRVFGGQVIGQALIAAQRT
CCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
VDPERHVHSLHAYFVRPGDPAIPIIYEVDRIRDGSSFSTRRVLAKQHGKAIFTLSASFQI
CCHHHHHHEEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEEEEE
DEGGLDHQMPMPEGLPQPEQLVGDHDIKEKYLDMAPPGVRKYWERERPIEIKPVSLTHYF
CCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEHHHHH
SREKLEPVQHVWVRARGLVPDDRALQAAILAYLSDMTLLDTSLHPHGRFIFDRDMQVASL
HHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHEECCCCCCCCEEEECCCHHHHH
DHAMWFHRPCRLDDWLLYTQDAPSASGARGFNRGALYTRDGVLIASVAQEGLIRVHEKTS
HHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEEEEHHHHCCEEEEECCC
DGYLISSFSVA
CCEEEEEECCC
>Mature Secondary Structure 
SDEEKSGIEQTAAMRELLSILDLETLEMDLFRGNSPQVGWQRVFGGQVIGQALIAAQRT
CCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
VDPERHVHSLHAYFVRPGDPAIPIIYEVDRIRDGSSFSTRRVLAKQHGKAIFTLSASFQI
CCHHHHHHEEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEEEEE
DEGGLDHQMPMPEGLPQPEQLVGDHDIKEKYLDMAPPGVRKYWERERPIEIKPVSLTHYF
CCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEHHHHH
SREKLEPVQHVWVRARGLVPDDRALQAAILAYLSDMTLLDTSLHPHGRFIFDRDMQVASL
HHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHEECCCCCCCCEEEECCCHHHHH
DHAMWFHRPCRLDDWLLYTQDAPSASGARGFNRGALYTRDGVLIASVAQEGLIRVHEKTS
HHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEEEEHHHHCCEEEEECCC
DGYLISSFSVA
CCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]