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The map label for this gene is hemK [H]

Identifier: 23502721

GI number: 23502721

Start: 1804050

End: 1804901

Strand: Reverse

Name: hemK [H]

Synonym: BR1868

Alternate gene names: 23502721

Gene position: 1804901-1804050 (Counterclockwise)

Preceding gene: 23502722

Following gene: 23502719

Centisome position: 85.63

GC content: 57.51

Gene sequence:

>852_bases
ATGGCAGAGGCCCGCGCGAAATTGCGTGCGGCGGGGGGCGAGACGCCCGATCTCGATGCGCGTCTGCTCATTGAATGGGC
GACGGGTGCGACACGCCTCGATCTTGTTTCCCAGCCGGAAAAGCTAATCGGCAGCGCCGAGGCTGAAAAGCTGCGGGCGG
CGCTGGAACGGCGTGCGGGCGGAGAGCCGGTGCACCGAATCATGGGCCAGCGTGAATTTTATGGCCTGCCTTTCCGCCTT
TCCGCCCAAACGCTGGAGCCGCGGCCGGATACGGAGGCGCTGATGGAACTGGTGATTCCCGTCCTTGAGCAGCTCATCGC
CAGGCACGGTACGGCCGAGGTGCTGGATATGGGCACCGGCACGGGTGCGATCATCATTTCGCTTCTGCATCGCTTCGAGC
ATATGCACGGGATCGGTGTCGATGTGGCCGAGGGAGCGCTTGCCACGGCGCGAATCAACGCCATAGACAATGGCGTTGGC
GAGAGGTTTGCCGGTTTGAAGAGCGACTGGTTCTCCAATGTCAGCGGGAAATTTCATCTGATTGTTTCAAATCCGCCTTA
TATTCCCCATGCTGAGATTGCCGGTTTGTCGCGCGAAGTGCGTGAGCATGATCCGCTTGCAGCACTTGATGGCGGGCCGG
ATGGACTTGATTTTTACAAAGCCCTTGCACAAGGAGTGGGTGCGTATTTATATAAAGACGGTATGGTTGCCGTAGAAATC
GGCGCCGGACAATTCCAGGATGTCGAAGCACTGTTCAAAAGCACAGGTTTTTCGCTTGCCGGCGAAGCAAATGATCTTGG
TGGCCACAGAAGAGCCATGCTTTTCGGGCAGATATCTAATACGCAATTTTGA

Upstream 100 bases:

>100_bases
AACTGGTCGATGCGCTGATTTCCGATCACCAGACCGCCCTTCTGGCCGAACTGGGCGAGCAGCCGTGAGCAGCGAAGAGG
TGGAGCGCCTTGACCGGCTG

Downstream 100 bases:

>100_bases
TAAGCGCCGACGCTAAAAAACGCTTGGAATTTACTGCGAAGCCGTTTAGTTTCCGGCCACCGTATACAGCCAGAATGGTT
TTGCCCTCGTGAGGGCGGTG

Product: hemK protein

Products: NA

Alternate protein names: M.MloHemKP [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MAEARAKLRAAGGETPDLDARLLIEWATGATRLDLVSQPEKLIGSAEAEKLRAALERRAGGEPVHRIMGQREFYGLPFRL
SAQTLEPRPDTEALMELVIPVLEQLIARHGTAEVLDMGTGTGAIIISLLHRFEHMHGIGVDVAEGALATARINAIDNGVG
ERFAGLKSDWFSNVSGKFHLIVSNPPYIPHAEIAGLSREVREHDPLAALDGGPDGLDFYKALAQGVGAYLYKDGMVAVEI
GAGQFQDVEALFKSTGFSLAGEANDLGGHRRAMLFGQISNTQF

Sequences:

>Translated_283_residues
MAEARAKLRAAGGETPDLDARLLIEWATGATRLDLVSQPEKLIGSAEAEKLRAALERRAGGEPVHRIMGQREFYGLPFRL
SAQTLEPRPDTEALMELVIPVLEQLIARHGTAEVLDMGTGTGAIIISLLHRFEHMHGIGVDVAEGALATARINAIDNGVG
ERFAGLKSDWFSNVSGKFHLIVSNPPYIPHAEIAGLSREVREHDPLAALDGGPDGLDFYKALAQGVGAYLYKDGMVAVEI
GAGQFQDVEALFKSTGFSLAGEANDLGGHRRAMLFGQISNTQF
>Mature_282_residues
AEARAKLRAAGGETPDLDARLLIEWATGATRLDLVSQPEKLIGSAEAEKLRAALERRAGGEPVHRIMGQREFYGLPFRLS
AQTLEPRPDTEALMELVIPVLEQLIARHGTAEVLDMGTGTGAIIISLLHRFEHMHGIGVDVAEGALATARINAIDNGVGE
RFAGLKSDWFSNVSGKFHLIVSNPPYIPHAEIAGLSREVREHDPLAALDGGPDGLDFYKALAQGVGAYLYKDGMVAVEIG
AGQFQDVEALFKSTGFSLAGEANDLGGHRRAMLFGQISNTQF

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=256, Percent_Identity=29.296875, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1787463, Length=276, Percent_Identity=34.7826086956522, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI87082085, Length=214, Percent_Identity=28.9719626168224, Blast_Score=84, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24582226, Length=246, Percent_Identity=27.6422764227642, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 30406; Mature: 30275

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEARAKLRAAGGETPDLDARLLIEWATGATRLDLVSQPEKLIGSAEAEKLRAALERRAG
CCCHHHHHHHCCCCCCCCCCEEEEEECCCCEEEHHHCCCHHHHCCHHHHHHHHHHHHCCC
GEPVHRIMGQREFYGLPFRLSAQTLEPRPDTEALMELVIPVLEQLIARHGTAEVLDMGTG
CCHHHHHCCCHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEEECCCC
TGAIIISLLHRFEHMHGIGVDVAEGALATARINAIDNGVGERFAGLKSDWFSNVSGKFHL
HHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEE
IVSNPPYIPHAEIAGLSREVREHDPLAALDGGPDGLDFYKALAQGVGAYLYKDGMVAVEI
EECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHEECCCEEEEEE
GAGQFQDVEALFKSTGFSLAGEANDLGGHRRAMLFGQISNTQF
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCC
>Mature Secondary Structure 
AEARAKLRAAGGETPDLDARLLIEWATGATRLDLVSQPEKLIGSAEAEKLRAALERRAG
CCHHHHHHHCCCCCCCCCCEEEEEECCCCEEEHHHCCCHHHHCCHHHHHHHHHHHHCCC
GEPVHRIMGQREFYGLPFRLSAQTLEPRPDTEALMELVIPVLEQLIARHGTAEVLDMGTG
CCHHHHHCCCHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEEECCCC
TGAIIISLLHRFEHMHGIGVDVAEGALATARINAIDNGVGERFAGLKSDWFSNVSGKFHL
HHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEE
IVSNPPYIPHAEIAGLSREVREHDPLAALDGGPDGLDFYKALAQGVGAYLYKDGMVAVEI
EECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHEECCCEEEEEE
GAGQFQDVEALFKSTGFSLAGEANDLGGHRRAMLFGQISNTQF
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]