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The map label for this gene is murC

Identifier: 23502301

GI number: 23502301

Start: 1386615

End: 1388030

Strand: Reverse

Name: murC

Synonym: BR1430

Alternate gene names: 23502301

Gene position: 1388030-1386615 (Counterclockwise)

Preceding gene: 23502302

Following gene: 23502300

Centisome position: 65.85

GC content: 61.09

Gene sequence:

>1416_bases
ATGAAAATGCCGCTGAATATCGGGCTCGTCCATTTCATCGGGATTGGCGGCATCGGCATGAGCGGCATTGCCGAAGTGTT
GCATAATCTGGGCTATAAGGTACAGGGCTCGGACCAGTCCGACAGCGCGAATGTGCAGCGCCTGCGTGAAAAGGGCATTG
AGGTTTTTGTCGGCCACAAGGCCGAGAATCTCGGTGATGCCGAGGTGATCGTCGTTTCGACAGCGATCAAGAAGAACAAT
CCGGAACTGGTTGCCGCGCGTGAAAAACTGCTGCCGGTTGTGCGCCGCGCCGAAATGCTGGCCGAGCTGATGCGCTTTCG
TCGCGCGGTCGCCATCGGCGGCACCCACGGCAAGACGACGACAACCTCCCTTGTGGCGGCGCTGCTCGATGCCGGGCATC
TCGACCCGACCGTCATCAATGGCGGCATCATCAACGCCTATGGCACCAATGCGCGCATGGGCGATGGTGACTGGATGGTG
GTGGAGGCCGATGAAAGCGACGGCACGTTCCTGAAACTCCCGGCCGATATCGCGGTCGTCACCAATATCGACCCGGAGCA
TCTCGACCATTACGGCAATTTCGACGCCGTGCGCGCGGCTTTCCGCCAGTTCGTGGAGAATGTTCCCTTTTACGGCTTCG
GCGTGATGTGCCTCGATCACCCGGAAGTGCAGGCGCTGGTGAGCCGTATCGAAGACCGCCGCATCATCACCTATGGCTCC
AATCCGCAGGCCGAAGTGCGTTTCGTCAATCAGCGTATGGATGGCGCGGCCAGCCTGTTCGACGTGGTCATCCGCTCGCG
CAAGGGCGAGGCAACCGAGATCAAGGATCTGCGCCTGCCCATGCCGGGGCTACACAATGTTTCCAATGCGACGGCGGCCA
TCGCTGTTGCCCATGAGCTTGGAATTTCTTCCGACGATATCCGCCGCGGGCTCGGTTCGTTCGGCGGTGTGAAGCGCCGC
TTCACCCATACGGGTTCGTGGAACGGCGTTGAGATTTTTGACGATTACGGCCATCATCCGGTTGAAATCCGCGCTGTGCT
GAAGGCCGCGCGCGAGGCGACGAGCCAGGCTGGCGGCCGTGTCGTCGCCATTGTGCAGCCGCACCGCTATACCCGTCTGG
CAAGCCTCTTCGACGAATTTGCCGCCTGCTTCAACGACGCCGATACGGTAATTGTCGCGCCGGTCTATACGGCGGGCGAG
GAGCCGATCGAAGGCGTCAATTCCGAGGAACTGGTTTCCCGCATCAAGACGGCGGGCCACCGGGATGCGCGCTATGCCAC
GGGACCGGAGGCGCTTGCACCTCTGGTCGCCTCCATCGCGCAAGCGGGTGATTTCGTCGTCTGCCTCGGTGCGGGCAATG
TCACGCAATGGGCCTATGCCCTGCCGAAGGAACTGGCCGAACAGGGTAAGAAATAA

Upstream 100 bases:

>100_bases
AAAGCGTCGGCAAACCGGATGCCGCCCGGTTGCTTGCCGATCTGGCAGAGGCTATTGTATCCGGCAAAACTGTTCAGGAA
TTCAAGGAAGGAAACCGGCC

Downstream 100 bases:

>100_bases
TGATGGAAAGCGGCGAGGCGCTTCTAAAGAAGCTCGACGGCAGGCTGTCTGGCTTGCGCGGGCGGCTTACGCCCGATACG
GGCATGGACAAGATCACCTG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKMPLNIGLVHFIGIGGIGMSGIAEVLHNLGYKVQGSDQSDSANVQRLREKGIEVFVGHKAENLGDAEVIVVSTAIKKNN
PELVAAREKLLPVVRRAEMLAELMRFRRAVAIGGTHGKTTTTSLVAALLDAGHLDPTVINGGIINAYGTNARMGDGDWMV
VEADESDGTFLKLPADIAVVTNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQALVSRIEDRRIITYGS
NPQAEVRFVNQRMDGAASLFDVVIRSRKGEATEIKDLRLPMPGLHNVSNATAAIAVAHELGISSDDIRRGLGSFGGVKRR
FTHTGSWNGVEIFDDYGHHPVEIRAVLKAAREATSQAGGRVVAIVQPHRYTRLASLFDEFAACFNDADTVIVAPVYTAGE
EPIEGVNSEELVSRIKTAGHRDARYATGPEALAPLVASIAQAGDFVVCLGAGNVTQWAYALPKELAEQGKK

Sequences:

>Translated_471_residues
MKMPLNIGLVHFIGIGGIGMSGIAEVLHNLGYKVQGSDQSDSANVQRLREKGIEVFVGHKAENLGDAEVIVVSTAIKKNN
PELVAAREKLLPVVRRAEMLAELMRFRRAVAIGGTHGKTTTTSLVAALLDAGHLDPTVINGGIINAYGTNARMGDGDWMV
VEADESDGTFLKLPADIAVVTNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQALVSRIEDRRIITYGS
NPQAEVRFVNQRMDGAASLFDVVIRSRKGEATEIKDLRLPMPGLHNVSNATAAIAVAHELGISSDDIRRGLGSFGGVKRR
FTHTGSWNGVEIFDDYGHHPVEIRAVLKAAREATSQAGGRVVAIVQPHRYTRLASLFDEFAACFNDADTVIVAPVYTAGE
EPIEGVNSEELVSRIKTAGHRDARYATGPEALAPLVASIAQAGDFVVCLGAGNVTQWAYALPKELAEQGKK
>Mature_471_residues
MKMPLNIGLVHFIGIGGIGMSGIAEVLHNLGYKVQGSDQSDSANVQRLREKGIEVFVGHKAENLGDAEVIVVSTAIKKNN
PELVAAREKLLPVVRRAEMLAELMRFRRAVAIGGTHGKTTTTSLVAALLDAGHLDPTVINGGIINAYGTNARMGDGDWMV
VEADESDGTFLKLPADIAVVTNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQALVSRIEDRRIITYGS
NPQAEVRFVNQRMDGAASLFDVVIRSRKGEATEIKDLRLPMPGLHNVSNATAAIAVAHELGISSDDIRRGLGSFGGVKRR
FTHTGSWNGVEIFDDYGHHPVEIRAVLKAAREATSQAGGRVVAIVQPHRYTRLASLFDEFAACFNDADTVIVAPVYTAGE
EPIEGVNSEELVSRIKTAGHRDARYATGPEALAPLVASIAQAGDFVVCLGAGNVTQWAYALPKELAEQGKK

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=462, Percent_Identity=43.7229437229437, Blast_Score=321, Evalue=8e-89,
Organism=Escherichia coli, GI1790680, Length=462, Percent_Identity=27.2727272727273, Blast_Score=173, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_BRUA1 (B2S6Q3)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935324.1
- ProteinModelPortal:   B2S6Q3
- SMR:   B2S6Q3
- GeneID:   6327301
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I13550
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50794; Mature: 50794

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMPLNIGLVHFIGIGGIGMSGIAEVLHNLGYKVQGSDQSDSANVQRLREKGIEVFVGHK
CCCCCCCCCEEHEECCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCEEEECCC
AENLGDAEVIVVSTAIKKNNPELVAAREKLLPVVRRAEMLAELMRFRRAVAIGGTHGKTT
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHH
TTSLVAALLDAGHLDPTVINGGIINAYGTNARMGDGDWMVVEADESDGTFLKLPADIAVV
HHHHHHHHHHCCCCCCEEECCCEEEECCCCCEECCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQALVSRIEDRRIITYGS
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCEEEEECC
NPQAEVRFVNQRMDGAASLFDVVIRSRKGEATEIKDLRLPMPGLHNVSNATAAIAVAHEL
CCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHH
GISSDDIRRGLGSFGGVKRRFTHTGSWNGVEIFDDYGHHPVEIRAVLKAAREATSQAGGR
CCCHHHHHHHHHHHCCCHHHEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCE
VVAIVQPHRYTRLASLFDEFAACFNDADTVIVAPVYTAGEEPIEGVNSEELVSRIKTAGH
EEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCC
RDARYATGPEALAPLVASIAQAGDFVVCLGAGNVTQWAYALPKELAEQGKK
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKMPLNIGLVHFIGIGGIGMSGIAEVLHNLGYKVQGSDQSDSANVQRLREKGIEVFVGHK
CCCCCCCCCEEHEECCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCEEEECCC
AENLGDAEVIVVSTAIKKNNPELVAAREKLLPVVRRAEMLAELMRFRRAVAIGGTHGKTT
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHH
TTSLVAALLDAGHLDPTVINGGIINAYGTNARMGDGDWMVVEADESDGTFLKLPADIAVV
HHHHHHHHHHCCCCCCEEECCCEEEECCCCCEECCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQALVSRIEDRRIITYGS
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCEEEEECC
NPQAEVRFVNQRMDGAASLFDVVIRSRKGEATEIKDLRLPMPGLHNVSNATAAIAVAHEL
CCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHH
GISSDDIRRGLGSFGGVKRRFTHTGSWNGVEIFDDYGHHPVEIRAVLKAAREATSQAGGR
CCCHHHHHHHHHHHCCCHHHEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCE
VVAIVQPHRYTRLASLFDEFAACFNDADTVIVAPVYTAGEEPIEGVNSEELVSRIKTAGH
EEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCC
RDARYATGPEALAPLVASIAQAGDFVVCLGAGNVTQWAYALPKELAEQGKK
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA