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The map label for this gene is lpxC

Identifier: 23502295

GI number: 23502295

Start: 1379039

End: 1379899

Strand: Reverse

Name: lpxC

Synonym: BR1424

Alternate gene names: 23502295

Gene position: 1379899-1379039 (Counterclockwise)

Preceding gene: 23502296

Following gene: 23502293

Centisome position: 65.47

GC content: 56.33

Gene sequence:

>861_bases
TTGAACGCTTATCAAAAGACAATTGGTCGTGCAGTCACGCTTTCGGGCGTCGGTGTTCATGGCGGTGCGCCGGCTTCTGC
CCGGTTATTGCCTGCGGATGCAGATACAGGCATCCTGTTTCAGCGTTCGGACATCAAGGACAGTGCGCCTGTGTGCGCTC
ACGTCTCGCAGATCGGTGCGACCGATCTTTGCACCTCGCTTGGTGCCAGGGAAGCCCGGATCGATACAGTCGAACATCTG
ATGGCGGCTATATCCGCGCTTGGTATCGATAATCTGGTGGTGGAAATAGAGGGGCCGGAAGTTCCCATTCTGGATGGCAC
GTCCGCCCGTTTTATCGAAGCCGTTGATAGTGTCGGCGTTGTCACGCAGGATGCGAAGCGCCGTTTCATCCGCATTTTAA
AGACTGTTCGTGTTGAAGCGGGCAATTCGTGGGGCGAATTCCGCCCTTATGACGGCACCCGCTTCGAGGTCGAGATTGAT
TTTGAATGCCCGCTGATCGGGCGGCAGAAATTTGCGCATGATGTGGATGAGGAAACTTTCCGCAAGGAGCTTTCCACGGC
GCGGACCTTCGGTTTCATGAAAGATGTGGAGCGTCTATGGGCTGCGGGCCTTGCGCTTGGAGCCTCGCTCGATAATTCGC
TTGTGATCGGCGACGACAATTCCATCGTCAATGCGGATGGCCTGCGCTTCAAGGATGAGTTCGTGCGCCACAAGACACTG
GATGCGGTTGGCGATCTGGCGCTCGCGGGCCTGCCGTTCATTGGCTGCTTCAGTTCCTATCGCGGCGGGCACCGCCTGAA
TTCAGAAGCCGTCAAGGCGCTTCTATCGGATGAAACGGCGTTTGAGATTATTGAGGCATAG

Upstream 100 bases:

>100_bases
GTGCTTATACAGGCGCTTCAATTGCAAAGTCCGGGCTGTCCGCATCCCGCCGATCAGGATGGCCTTTTATCCCTGTTATA
CTGAATAGATTGGAACTGTC

Downstream 100 bases:

>100_bases
ATTTCGGGTTCTATCCGCCTGGAAATTGTCAGTAAAAAGTTGAGTATCGGCGCGCGGCCTTAATTGAGCCGTGTTCGCCG
GTTCACTTCATTGCTGAGTC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MNAYQKTIGRAVTLSGVGVHGGAPASARLLPADADTGILFQRSDIKDSAPVCAHVSQIGATDLCTSLGAREARIDTVEHL
MAAISALGIDNLVVEIEGPEVPILDGTSARFIEAVDSVGVVTQDAKRRFIRILKTVRVEAGNSWGEFRPYDGTRFEVEID
FECPLIGRQKFAHDVDEETFRKELSTARTFGFMKDVERLWAAGLALGASLDNSLVIGDDNSIVNADGLRFKDEFVRHKTL
DAVGDLALAGLPFIGCFSSYRGGHRLNSEAVKALLSDETAFEIIEA

Sequences:

>Translated_286_residues
MNAYQKTIGRAVTLSGVGVHGGAPASARLLPADADTGILFQRSDIKDSAPVCAHVSQIGATDLCTSLGAREARIDTVEHL
MAAISALGIDNLVVEIEGPEVPILDGTSARFIEAVDSVGVVTQDAKRRFIRILKTVRVEAGNSWGEFRPYDGTRFEVEID
FECPLIGRQKFAHDVDEETFRKELSTARTFGFMKDVERLWAAGLALGASLDNSLVIGDDNSIVNADGLRFKDEFVRHKTL
DAVGDLALAGLPFIGCFSSYRGGHRLNSEAVKALLSDETAFEIIEA
>Mature_286_residues
MNAYQKTIGRAVTLSGVGVHGGAPASARLLPADADTGILFQRSDIKDSAPVCAHVSQIGATDLCTSLGAREARIDTVEHL
MAAISALGIDNLVVEIEGPEVPILDGTSARFIEAVDSVGVVTQDAKRRFIRILKTVRVEAGNSWGEFRPYDGTRFEVEID
FECPLIGRQKFAHDVDEETFRKELSTARTFGFMKDVERLWAAGLALGASLDNSLVIGDDNSIVNADGLRFKDEFVRHKTL
DAVGDLALAGLPFIGCFSSYRGGHRLNSEAVKALLSDETAFEIIEA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=283, Percent_Identity=43.4628975265018, Blast_Score=257, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_BRUA1 (B2S6P7)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935318.1
- ProteinModelPortal:   B2S6P7
- SMR:   B2S6P7
- GeneID:   6327295
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I13490
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- ProtClustDB:   PRK13186
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 30853; Mature: 30853

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAYQKTIGRAVTLSGVGVHGGAPASARLLPADADTGILFQRSDIKDSAPVCAHVSQIGA
CCHHHHHHCCEEEEECCCCCCCCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHCH
TDLCTSLGAREARIDTVEHLMAAISALGIDNLVVEIEGPEVPILDGTSARFIEAVDSVGV
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHHHHHHHHCCC
VTQDAKRRFIRILKTVRVEAGNSWGEFRPYDGTRFEVEIDFECPLIGRQKFAHDVDEETF
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCHHHH
RKELSTARTFGFMKDVERLWAAGLALGASLDNSLVIGDDNSIVNADGLRFKDEFVRHKTL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEECCCCCCHHHHHHHHHHH
DAVGDLALAGLPFIGCFSSYRGGHRLNSEAVKALLSDETAFEIIEA
HHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MNAYQKTIGRAVTLSGVGVHGGAPASARLLPADADTGILFQRSDIKDSAPVCAHVSQIGA
CCHHHHHHCCEEEEECCCCCCCCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHCH
TDLCTSLGAREARIDTVEHLMAAISALGIDNLVVEIEGPEVPILDGTSARFIEAVDSVGV
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHHHHHHHHCCC
VTQDAKRRFIRILKTVRVEAGNSWGEFRPYDGTRFEVEIDFECPLIGRQKFAHDVDEETF
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCHHHH
RKELSTARTFGFMKDVERLWAAGLALGASLDNSLVIGDDNSIVNADGLRFKDEFVRHKTL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEECCCCCCHHHHHHHHHHH
DAVGDLALAGLPFIGCFSSYRGGHRLNSEAVKALLSDETAFEIIEA
HHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA