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The map label for this gene is hom [H]

Identifier: 23502150

GI number: 23502150

Start: 1235979

End: 1237298

Strand: Reverse

Name: hom [H]

Synonym: BR1274

Alternate gene names: 23502150

Gene position: 1237298-1235979 (Counterclockwise)

Preceding gene: 23502151

Following gene: 23502149

Centisome position: 58.7

GC content: 58.79

Gene sequence:

>1320_bases
ATGAGTGATGCATTGCGGATCGGTGTTGCCGGCCTGGGCACCGTTGGTGCTTCGGTGTTACGTATTCTGCGTGACAAGTC
CGAGATGCTCACGCGCCAGTGCGGCAAGCCTGTAACGGTTACGGCGGTTAGCGCCCGTGACCGCAATCGGGATCGCGGCA
TCGACCTTTCAGGCATTGCATGGTTCGATGACCCGGTGGAACTTGCCAAATCTGCCGAGATCGATCTTTTTATCGAGCTG
ATCGGCGGCGAGGATGGCCCGGCCAAGGCGTCTGTGGAAGCGGCCTTGCGCGCTGGCCGCCATGTGGTCACGGCCAACAA
GGCGCTGCTTGCGCGCCATGGCGTTGCACTTGCCAGGATCGCCGAGGAGAAGGGCGTCCTGCTCAATTTTGAAGCGGCTG
TCGCAGGCGGCATTCCCGTCATCAAGGCCATGCGTGAATCGTTGACCGGAAACACGGTTTCGCGCGTTTACGGCATCATG
AACGGCACCTGTAACTATATCCTGACCCGGATGTGGGAAGAGGGGATTTCGTTTGAATCCTGCCTCAAGGATGCGCAGCG
CCTGGGATATGCCGAGGCCGACCCGACCTTCGATATTGAAGGCAACGACACAGCGCACAAGCTGGCGCTTCTCACCAGTC
TTGCCTTCGGCACGCAGATCGCCGCCGCCGATATCTATCTGGAAGGTATCAGCAATATTTCGCTGGCTGACATTCGTGCC
GCTGACGAACTTGGCTACCGCATCAAGCTTCTTGGTGTTGCACAGAAGACCGATACCGGCATCGAACAGCGCGTACATCC
GACCATGGTGCCAACCTCTTCGGTTATTGCGCAGGTTCATGGTGTGACCAATGCTGTCGCCATCGAGACCGATCTTTTGG
GTGAGCTTCTGCTTTCAGGTCCCGGTGCGGGTGGCAATGCCACGGCTTCGGCGGTGATCGGCGATGTGGCCGATATCGCC
AAGAGCCGTCCGGGTTTCCAGCATGGGCCGGTATTCGGCACGCCTGCCAAGGCCTTGCAGCCCTATAATCGCGCCAAGAT
GCGCAAACATGCGGGCGGCTATTTCATTCGCCTCACGGTACATGACCGCATTGGCGCTTTTGCGGCGATTGCCCGGCGCA
TGGCGGAAAACGACATTTCGCTGGAATCGATCGTGCAGCGCCCGCCCATGGATGACGCGCCGCGCGAAGGTGTCAAGACG
GTGATTCTGGTGACACATGAGACAACCGAATCTGCGGTCAAGAAGGCTCTGGAAGCCATTCTGAAAGACGATCATCTGGT
GGACAAGCCGCAGATGATCCGCATTGAACGCGCTGGCTGA

Upstream 100 bases:

>100_bases
GCAGGCTGGGCTATGCTTGCGGCCGCCCATGCTCGCGGGCTGGATTTATCCTGCCCGCAGTTCTCACCCGATGAAACCAC
TCCAGTAGAAGGTCGAAATA

Downstream 100 bases:

>100_bases
GTGTTGTTCCCCCATCAAGGTTTTGCGACCTCAGGATTGGACGAATTCCGTTCACATCCGACCGGTGCATGAAACGAAGC
GTGTAGAGCTCAGAGCGGTT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSDALRIGVAGLGTVGASVLRILRDKSEMLTRQCGKPVTVTAVSARDRNRDRGIDLSGIAWFDDPVELAKSAEIDLFIEL
IGGEDGPAKASVEAALRAGRHVVTANKALLARHGVALARIAEEKGVLLNFEAAVAGGIPVIKAMRESLTGNTVSRVYGIM
NGTCNYILTRMWEEGISFESCLKDAQRLGYAEADPTFDIEGNDTAHKLALLTSLAFGTQIAAADIYLEGISNISLADIRA
ADELGYRIKLLGVAQKTDTGIEQRVHPTMVPTSSVIAQVHGVTNAVAIETDLLGELLLSGPGAGGNATASAVIGDVADIA
KSRPGFQHGPVFGTPAKALQPYNRAKMRKHAGGYFIRLTVHDRIGAFAAIARRMAENDISLESIVQRPPMDDAPREGVKT
VILVTHETTESAVKKALEAILKDDHLVDKPQMIRIERAG

Sequences:

>Translated_439_residues
MSDALRIGVAGLGTVGASVLRILRDKSEMLTRQCGKPVTVTAVSARDRNRDRGIDLSGIAWFDDPVELAKSAEIDLFIEL
IGGEDGPAKASVEAALRAGRHVVTANKALLARHGVALARIAEEKGVLLNFEAAVAGGIPVIKAMRESLTGNTVSRVYGIM
NGTCNYILTRMWEEGISFESCLKDAQRLGYAEADPTFDIEGNDTAHKLALLTSLAFGTQIAAADIYLEGISNISLADIRA
ADELGYRIKLLGVAQKTDTGIEQRVHPTMVPTSSVIAQVHGVTNAVAIETDLLGELLLSGPGAGGNATASAVIGDVADIA
KSRPGFQHGPVFGTPAKALQPYNRAKMRKHAGGYFIRLTVHDRIGAFAAIARRMAENDISLESIVQRPPMDDAPREGVKT
VILVTHETTESAVKKALEAILKDDHLVDKPQMIRIERAG
>Mature_438_residues
SDALRIGVAGLGTVGASVLRILRDKSEMLTRQCGKPVTVTAVSARDRNRDRGIDLSGIAWFDDPVELAKSAEIDLFIELI
GGEDGPAKASVEAALRAGRHVVTANKALLARHGVALARIAEEKGVLLNFEAAVAGGIPVIKAMRESLTGNTVSRVYGIMN
GTCNYILTRMWEEGISFESCLKDAQRLGYAEADPTFDIEGNDTAHKLALLTSLAFGTQIAAADIYLEGISNISLADIRAA
DELGYRIKLLGVAQKTDTGIEQRVHPTMVPTSSVIAQVHGVTNAVAIETDLLGELLLSGPGAGGNATASAVIGDVADIAK
SRPGFQHGPVFGTPAKALQPYNRAKMRKHAGGYFIRLTVHDRIGAFAAIARRMAENDISLESIVQRPPMDDAPREGVKTV
ILVTHETTESAVKKALEAILKDDHLVDKPQMIRIERAG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=247, Percent_Identity=29.9595141700405, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790376, Length=359, Percent_Identity=23.6768802228412, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=191, Percent_Identity=27.7486910994764, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46767; Mature: 46636

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDALRIGVAGLGTVGASVLRILRDKSEMLTRQCGKPVTVTAVSARDRNRDRGIDLSGIA
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEE
WFDDPVELAKSAEIDLFIELIGGEDGPAKASVEAALRAGRHVVTANKALLARHGVALARI
ECCCHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCEEEECCHHHHHHCCHHHHHH
AEEKGVLLNFEAAVAGGIPVIKAMRESLTGNTVSRVYGIMNGTCNYILTRMWEEGISFES
HHHCCEEEEEHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHH
CLKDAQRLGYAEADPTFDIEGNDTAHKLALLTSLAFGTQIAAADIYLEGISNISLADIRA
HHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCHHHHHHHEECCCCCCCHHHHHH
ADELGYRIKLLGVAQKTDTGIEQRVHPTMVPTSSVIAQVHGVTNAVAIETDLLGELLLSG
HHHCCCEEEEEEECCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHCC
PGAGGNATASAVIGDVADIAKSRPGFQHGPVFGTPAKALQPYNRAKMRKHAGGYFIRLTV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHCCCCEEEEEEE
HDRIGAFAAIARRMAENDISLESIVQRPPMDDAPREGVKTVILVTHETTESAVKKALEAI
CCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHH
LKDDHLVDKPQMIRIERAG
HCCCCCCCCCCEEEEECCC
>Mature Secondary Structure 
SDALRIGVAGLGTVGASVLRILRDKSEMLTRQCGKPVTVTAVSARDRNRDRGIDLSGIA
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEE
WFDDPVELAKSAEIDLFIELIGGEDGPAKASVEAALRAGRHVVTANKALLARHGVALARI
ECCCHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCEEEECCHHHHHHCCHHHHHH
AEEKGVLLNFEAAVAGGIPVIKAMRESLTGNTVSRVYGIMNGTCNYILTRMWEEGISFES
HHHCCEEEEEHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHH
CLKDAQRLGYAEADPTFDIEGNDTAHKLALLTSLAFGTQIAAADIYLEGISNISLADIRA
HHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCHHHHHHHEECCCCCCCHHHHHH
ADELGYRIKLLGVAQKTDTGIEQRVHPTMVPTSSVIAQVHGVTNAVAIETDLLGELLLSG
HHHCCCEEEEEEECCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHCC
PGAGGNATASAVIGDVADIAKSRPGFQHGPVFGTPAKALQPYNRAKMRKHAGGYFIRLTV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHCCCCEEEEEEE
HDRIGAFAAIARRMAENDISLESIVQRPPMDDAPREGVKTVILVTHETTESAVKKALEAI
CCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHH
LKDDHLVDKPQMIRIERAG
HCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]