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The map label for this gene is degP [H]

Identifier: 23502084

GI number: 23502084

Start: 1184497

End: 1185921

Strand: Reverse

Name: degP [H]

Synonym: BR1207

Alternate gene names: 23502084

Gene position: 1185921-1184497 (Counterclockwise)

Preceding gene: 23502085

Following gene: 23502083

Centisome position: 56.26

GC content: 59.16

Gene sequence:

>1425_bases
ATGAATTGGCGGTGTTTGGGATTTGCAGGCGTCGTTCTGGCTTTTTTCAGCCTGGCGGCGGGGCCTGTGGCGGCGCAGGA
TAGCCCCGCAACCGCCGTAAGACAGATACCGCTCAGCCGGGGGGATATGCAGCTTTCCTTCGCGCCGCTCGTCAAGGAAA
CGGCGCCCGCCGTGGTAAATGTTTATGCGGCGCGGCAGGTACAGGCGCGCTCGCCTTTTGAGGGCGACCCCTTCTTCGAG
CAGTTCTTTGGCAGCCAGTTTGGCGCAAGCAAGCCGCGTATCCAGCAGTCGCTCGGTTCCGGTGTGATCGTTGATCGCTC
CGGTATTATTGTGACGAATAATCACGTCATCAAGGATGCAGACGAAATCAAGGTCGCGCTTTCCGACGGGCGTGAGTTTG
AAAGCAGGATACTGCTGCGCGACGAGACGACCGATCTCGCGGTGCTGAAGATCGAGGCGAAGCAGCAATTCCCTGTGCTT
GCTCTGGGAAATTCCGACGAGGTTGAGGTGGGTGATCTGGTGCTCGCCATCGGCAATCCATTCGGTGTCGGCCAGACGGT
TACGAGCGGCATCGTATCGGCGCAATCACGTACGCAGGTCGGCATTTCAGATTTTGATTTCTTCATCCAGACAGATGCCG
CCATCAACCCCGGTAATTCCGGCGGCGCACTTATCGATATGCGCGGGCGTCTGATCGGCATCAATACGGCGATCTATTCG
CGGTCGGGCGGCTCGGTCGGTATCGGCTTTGCCATTCCCTCCAACATGGTGCGCGCTGTCGTGGATGCCGCCTTGCAGGG
CAGCACGCGTTTCGAGCGGCCCTATATCGGTGCAACTTTCCAGGGGATCACGCCCGATCTGGCTGAAAGCCTCGGCATGG
AAAAACCTTATGGTGCGCTGATAACGGCGGTCGTCAAGGATGGCCCGGCCGAAACTGCGGGCCTGAAGGTTGGCGACGTG
GTTCTGTCCGTTCAAGGTGTGCGTGTCGATAATCAGGATGTGCTCGGCTACCGTCTTTCGACGGCAGGGATCGGAAAGAC
AATTTCCGTCGAAGTCATGCGCAATGGCAAGAACCTTTCGCTTCCGGTGAAGCTTACCAAGGCGCCCAAGGTCAAGCAGG
CCGAGCCGAAGGTCATTGAAGGTGATAACCCCTTTGACGGGGCTGCCGTAGGGGATCTGACAGCTTCGACGGCGGCGAAG
CTGCGGTTGAAGCGAGGCCAGCAAGGGGTTGCGGTGTTTGATGTCTATTCCGGCTCGCCGGCGGCGCGTCTTGGCTTGCG
TCCCGGCGATATTATCCGCAGCATCAACGGCAATCAGATTCGCACCGTTGACGATATGACCGCCGTGCTTGAGGCCGGAC
GTGGTCTGGCATGGCGGCTGGAAATTGAACGCAACGGCGCTTTGCTGCGCCAGTTCGTGCGCTAG

Upstream 100 bases:

>100_bases
TTTTGCTGGAAATGTCCGGAATATTGGCGGTAACCTCTGGCGGGAATCGATCATAGTTGCCCGCAATTGCCCGTGGCATC
AGGATTAGCGGAGTTTGCAC

Downstream 100 bases:

>100_bases
GCCCATTAAACGGAGACGCTGGAACGCGTTCTAACGCAAGTTACGCCCGGCAGGATTATGCTCCGGCACCGGCGGACAGA
CGTTGCATGCCGCTTCAGGG

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MNWRCLGFAGVVLAFFSLAAGPVAAQDSPATAVRQIPLSRGDMQLSFAPLVKETAPAVVNVYAARQVQARSPFEGDPFFE
QFFGSQFGASKPRIQQSLGSGVIVDRSGIIVTNNHVIKDADEIKVALSDGREFESRILLRDETTDLAVLKIEAKQQFPVL
ALGNSDEVEVGDLVLAIGNPFGVGQTVTSGIVSAQSRTQVGISDFDFFIQTDAAINPGNSGGALIDMRGRLIGINTAIYS
RSGGSVGIGFAIPSNMVRAVVDAALQGSTRFERPYIGATFQGITPDLAESLGMEKPYGALITAVVKDGPAETAGLKVGDV
VLSVQGVRVDNQDVLGYRLSTAGIGKTISVEVMRNGKNLSLPVKLTKAPKVKQAEPKVIEGDNPFDGAAVGDLTASTAAK
LRLKRGQQGVAVFDVYSGSPAARLGLRPGDIIRSINGNQIRTVDDMTAVLEAGRGLAWRLEIERNGALLRQFVR

Sequences:

>Translated_474_residues
MNWRCLGFAGVVLAFFSLAAGPVAAQDSPATAVRQIPLSRGDMQLSFAPLVKETAPAVVNVYAARQVQARSPFEGDPFFE
QFFGSQFGASKPRIQQSLGSGVIVDRSGIIVTNNHVIKDADEIKVALSDGREFESRILLRDETTDLAVLKIEAKQQFPVL
ALGNSDEVEVGDLVLAIGNPFGVGQTVTSGIVSAQSRTQVGISDFDFFIQTDAAINPGNSGGALIDMRGRLIGINTAIYS
RSGGSVGIGFAIPSNMVRAVVDAALQGSTRFERPYIGATFQGITPDLAESLGMEKPYGALITAVVKDGPAETAGLKVGDV
VLSVQGVRVDNQDVLGYRLSTAGIGKTISVEVMRNGKNLSLPVKLTKAPKVKQAEPKVIEGDNPFDGAAVGDLTASTAAK
LRLKRGQQGVAVFDVYSGSPAARLGLRPGDIIRSINGNQIRTVDDMTAVLEAGRGLAWRLEIERNGALLRQFVR
>Mature_474_residues
MNWRCLGFAGVVLAFFSLAAGPVAAQDSPATAVRQIPLSRGDMQLSFAPLVKETAPAVVNVYAARQVQARSPFEGDPFFE
QFFGSQFGASKPRIQQSLGSGVIVDRSGIIVTNNHVIKDADEIKVALSDGREFESRILLRDETTDLAVLKIEAKQQFPVL
ALGNSDEVEVGDLVLAIGNPFGVGQTVTSGIVSAQSRTQVGISDFDFFIQTDAAINPGNSGGALIDMRGRLIGINTAIYS
RSGGSVGIGFAIPSNMVRAVVDAALQGSTRFERPYIGATFQGITPDLAESLGMEKPYGALITAVVKDGPAETAGLKVGDV
VLSVQGVRVDNQDVLGYRLSTAGIGKTISVEVMRNGKNLSLPVKLTKAPKVKQAEPKVIEGDNPFDGAAVGDLTASTAAK
LRLKRGQQGVAVFDVYSGSPAARLGLRPGDIIRSINGNQIRTVDDMTAVLEAGRGLAWRLEIERNGALLRQFVR

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=296, Percent_Identity=37.1621621621622, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI24308541, Length=330, Percent_Identity=32.1212121212121, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI22129776, Length=306, Percent_Identity=34.3137254901961, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI7019477, Length=335, Percent_Identity=33.7313432835821, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1786356, Length=464, Percent_Identity=34.4827586206897, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1789629, Length=441, Percent_Identity=36.0544217687075, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1789630, Length=332, Percent_Identity=39.1566265060241, Blast_Score=196, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24646839, Length=307, Percent_Identity=31.2703583061889, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 50154; Mature: 50154

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWRCLGFAGVVLAFFSLAAGPVAAQDSPATAVRQIPLSRGDMQLSFAPLVKETAPAVVN
CCEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCEEEEEHHHHHHCCCHHEE
VYAARQVQARSPFEGDPFFEQFFGSQFGASKPRIQQSLGSGVIVDRSGIIVTNNHVIKDA
EEHHHEECCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHCCCEEEECCCEEEECCEEECCC
DEIKVALSDGREFESRILLRDETTDLAVLKIEAKQQFPVLALGNSDEVEVGDLVLAIGNP
CCEEEEECCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEECCCCCEEECEEEEEECCC
FGVGQTVTSGIVSAQSRTQVGISDFDFFIQTDAAINPGNSGGALIDMRGRLIGINTAIYS
CCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCEECCCCCCCEEEEECCEEEEEEEEEEE
RSGGSVGIGFAIPSNMVRAVVDAALQGSTRFERPYIGATFQGITPDLAESLGMEKPYGAL
CCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHHHCCCCCCHHHE
ITAVVKDGPAETAGLKVGDVVLSVQGVRVDNQDVLGYRLSTAGIGKTISVEVMRNGKNLS
EEEEECCCCCCCCCEEECEEEEEEEEEEECCCCEEEEEEECCCCCCEEEEEEEECCCCEE
LPVKLTKAPKVKQAEPKVIEGDNPFDGAAVGDLTASTAAKLRLKRGQQGVAVFDVYSGSP
EEEEECCCCCCCCCCCCEECCCCCCCCCEECCHHHHHHHHHHHHCCCCCEEEEEEECCCC
AARLGLRPGDIIRSINGNQIRTVDDMTAVLEAGRGLAWRLEIERNGALLRQFVR
HHEECCCHHHHHHCCCCCEEEEHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHC
>Mature Secondary Structure
MNWRCLGFAGVVLAFFSLAAGPVAAQDSPATAVRQIPLSRGDMQLSFAPLVKETAPAVVN
CCEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCEEEEEHHHHHHCCCHHEE
VYAARQVQARSPFEGDPFFEQFFGSQFGASKPRIQQSLGSGVIVDRSGIIVTNNHVIKDA
EEHHHEECCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHCCCEEEECCCEEEECCEEECCC
DEIKVALSDGREFESRILLRDETTDLAVLKIEAKQQFPVLALGNSDEVEVGDLVLAIGNP
CCEEEEECCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEECCCCCEEECEEEEEECCC
FGVGQTVTSGIVSAQSRTQVGISDFDFFIQTDAAINPGNSGGALIDMRGRLIGINTAIYS
CCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCEECCCCCCCEEEEECCEEEEEEEEEEE
RSGGSVGIGFAIPSNMVRAVVDAALQGSTRFERPYIGATFQGITPDLAESLGMEKPYGAL
CCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHHHCCCCCCHHHE
ITAVVKDGPAETAGLKVGDVVLSVQGVRVDNQDVLGYRLSTAGIGKTISVEVMRNGKNLS
EEEEECCCCCCCCCEEECEEEEEEEEEEECCCCEEEEEEECCCCCCEEEEEEEECCCCEE
LPVKLTKAPKVKQAEPKVIEGDNPFDGAAVGDLTASTAAKLRLKRGQQGVAVFDVYSGSP
EEEEECCCCCCCCCCCCEECCCCCCCCCEECCHHHHHHHHHHHHCCCCCEEEEEEECCCC
AARLGLRPGDIIRSINGNQIRTVDDMTAVLEAGRGLAWRLEIERNGALLRQFVR
HHEECCCHHHHHHCCCCCEEEEHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]