Click here to switch to the map view.

The map label for this gene is lpxA

Identifier: 23502029

GI number: 23502029

Start: 1130903

End: 1131739

Strand: Reverse

Name: lpxA

Synonym: BR1151

Alternate gene names: 23502029

Gene position: 1131739-1130903 (Counterclockwise)

Preceding gene: 23502030

Following gene: 23502028

Centisome position: 53.69

GC content: 57.47

Gene sequence:

>837_bases
ATGAAGGAAACATTCATTCACCCCACAGCCTTGGTTGAACCGGGTGTGGAGCTGGGGCAGGGCGTGTCCGTGGGGCCGTT
CTGCCATGTCCAGTCTGGTGCCATTATCGGTAATGATTGCGAGCTGATGAGCCATGTGGTTATTACCGGCGCCACGACGC
TTGGCGCGGGCACCAAGGTTTATCCTCATGCAATTCTGGGCTGCGATCCGCAGAACAACAAGCACAAGGGCGGCCCGACC
CGGCTCAATGTCGGTGTGAACTGCATAATCCGCGAAGGCGTAACCATGCACAAGGGCTCGGACAATGCCCGTGGTTACAC
TTCTATCGGCGATAATTGCTCGTTCCTCGCTTATGCGCATGTCGCACATGATTGCGATATCGGCGATTATGTCACCTTCT
CGAATAATGTCATGATCGGCGGGCATACGTCCATTGGCCATCATGCCATTCTCGGTGGTGGCGCTGCCGTGCATCAGTTT
GTCCGCGTCGGGCACCATGCCTTTATCGGCGGTCTGGCAGCGGTGGTGAGCGACCTCATCCCTTATGGCATGGCAATTGG
TGTTCACGCCCATCTGGGTGGTCTCAACATCATCGGCATGAAGCGTTCCGGCATGGAGCGCAAGGAAATCCACAATTTGC
GCCATGCCGTGCGGATGCTGTTCGACCGCACCAAACCAATCCGCCAGCGCGCGCAGGATGTTTTGGCGGCTATTCCGGAC
TCCCCGACGGTGAGCGATATGATCTCGTTCATCAACGTCGATACCAAGCGCGCCTATTGCACGCCACCGCTGGATGCGGC
TCATGGCGGAGCCGGGCATGACAGCGACGAAGATTGA

Upstream 100 bases:

>100_bases
CCAAGTATGAATGCGTGGCCGAAGTCGATGGCGTAAAGGTTGCCGAAGCTGAAGTCGCTGCCATGATCAGCGTAGCTGAC
GAGAACCTGTGAGTAAATCG

Downstream 100 bases:

>100_bases
GCCAGTAGGAACAAGAAGCCCTGCGCGGGACGCGGGGCGGGTCGCCGTTGTCGGCGGCAACGGCCTGCTGCCGATCAAGG
TGGCGGAAACTCTGCAAAAT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MKETFIHPTALVEPGVELGQGVSVGPFCHVQSGAIIGNDCELMSHVVITGATTLGAGTKVYPHAILGCDPQNNKHKGGPT
RLNVGVNCIIREGVTMHKGSDNARGYTSIGDNCSFLAYAHVAHDCDIGDYVTFSNNVMIGGHTSIGHHAILGGGAAVHQF
VRVGHHAFIGGLAAVVSDLIPYGMAIGVHAHLGGLNIIGMKRSGMERKEIHNLRHAVRMLFDRTKPIRQRAQDVLAAIPD
SPTVSDMISFINVDTKRAYCTPPLDAAHGGAGHDSDED

Sequences:

>Translated_278_residues
MKETFIHPTALVEPGVELGQGVSVGPFCHVQSGAIIGNDCELMSHVVITGATTLGAGTKVYPHAILGCDPQNNKHKGGPT
RLNVGVNCIIREGVTMHKGSDNARGYTSIGDNCSFLAYAHVAHDCDIGDYVTFSNNVMIGGHTSIGHHAILGGGAAVHQF
VRVGHHAFIGGLAAVVSDLIPYGMAIGVHAHLGGLNIIGMKRSGMERKEIHNLRHAVRMLFDRTKPIRQRAQDVLAAIPD
SPTVSDMISFINVDTKRAYCTPPLDAAHGGAGHDSDED
>Mature_278_residues
MKETFIHPTALVEPGVELGQGVSVGPFCHVQSGAIIGNDCELMSHVVITGATTLGAGTKVYPHAILGCDPQNNKHKGGPT
RLNVGVNCIIREGVTMHKGSDNARGYTSIGDNCSFLAYAHVAHDCDIGDYVTFSNNVMIGGHTSIGHHAILGGGAAVHQF
VRVGHHAFIGGLAAVVSDLIPYGMAIGVHAHLGGLNIIGMKRSGMERKEIHNLRHAVRMLFDRTKPIRQRAQDVLAAIPD
SPTVSDMISFINVDTKRAYCTPPLDAAHGGAGHDSDED

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=255, Percent_Identity=36.8627450980392, Blast_Score=177, Evalue=6e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_BRUA1 (B2S601)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935072.1
- ProteinModelPortal:   B2S601
- SMR:   B2S601
- GeneID:   6328640
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I10910
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 29387; Mature: 29387

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETFIHPTALVEPGVELGQGVSVGPFCHVQSGAIIGNDCELMSHVVITGATTLGAGTKV
CCCCCCCCHHHHCCCHHHCCCCCCCCEEEECCCCEECCCHHHHHHHHEECCEECCCCCEE
YPHAILGCDPQNNKHKGGPTRLNVGVNCIIREGVTMHKGSDNARGYTSIGDNCSFLAYAH
CCCEEECCCCCCCCCCCCCEEEECCEEEEEECCEEEECCCCCCCCCCCCCCCCCEEEEEE
VAHDCDIGDYVTFSNNVMIGGHTSIGHHAILGGGAAVHQFVRVGHHAFIGGLAAVVSDLI
HHCCCCCCCEEEECCCEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PYGMAIGVHAHLGGLNIIGMKRSGMERKEIHNLRHAVRMLFDRTKPIRQRAQDVLAAIPD
HHHHEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
SPTVSDMISFINVDTKRAYCTPPLDAAHGGAGHDSDED
CCCHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKETFIHPTALVEPGVELGQGVSVGPFCHVQSGAIIGNDCELMSHVVITGATTLGAGTKV
CCCCCCCCHHHHCCCHHHCCCCCCCCEEEECCCCEECCCHHHHHHHHEECCEECCCCCEE
YPHAILGCDPQNNKHKGGPTRLNVGVNCIIREGVTMHKGSDNARGYTSIGDNCSFLAYAH
CCCEEECCCCCCCCCCCCCEEEECCEEEEEECCEEEECCCCCCCCCCCCCCCCCEEEEEE
VAHDCDIGDYVTFSNNVMIGGHTSIGHHAILGGGAAVHQFVRVGHHAFIGGLAAVVSDLI
HHCCCCCCCEEEECCCEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PYGMAIGVHAHLGGLNIIGMKRSGMERKEIHNLRHAVRMLFDRTKPIRQRAQDVLAAIPD
HHHHEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
SPTVSDMISFINVDTKRAYCTPPLDAAHGGAGHDSDED
CCCHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA