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The map label for this gene is hisC [H]

Identifier: 23501522

GI number: 23501522

Start: 627985

End: 629118

Strand: Reverse

Name: hisC [H]

Synonym: BR0635

Alternate gene names: 23501522

Gene position: 629118-627985 (Counterclockwise)

Preceding gene: 23501523

Following gene: 23501521

Centisome position: 29.85

GC content: 55.64

Gene sequence:

>1134_bases
ATGGCACAACCTCGCCTCACCCCCCTTGTCGAAAGCCTGCCCTCAACTGTCCCCTTTATCGGACCAGAAACATTGGAATT
ACAGCGCGGTAAGCCCTTCAAGGCGCGGATCGGCGCCAATGAAAGCAGCTTTGGTCCAGCGCCTTCTGTCATCGAGGCCA
TGCGGAATGAAGCAACCGAAGTGTGGAAATATGGCGATCCGGAAAATTATGCGTTGCGCCACGCCATTGCAGCCCATCAC
GGCCTGAAGGCTGAGCACATCATGCCGGGCGCTGGCGTTGATGCGTTGCTTGGTCTCATCGTCCGTCAATATGTGCAGCA
GGGCGACAAGGTCATCAACTCGCTCGGCGGTTATCCGACTTTCAATTATCATGTCGCAGGCTATGGCGGGCAGCTCGTCA
CCGTTCCTTATCGCGATGACAAGCCAGACCTCGACGCCCTTATCGATGCGGCTGCAAGGGAAAAACCAGCGCTCCTCTAT
ATCGCCAATCCCGACAACCCCATGGGAACATGGCACGAGGGGGCCGATATCCAGTCCTTCATTGAGCGTCTTCCGGAAAC
AACATTATTAATTCTCGACGAGGCCTATTGCGAAACTGCTCCGGCATCGGCATTTCCACCTTTCGAGACGGATCGTCCGA
ATGTTCTTCGGATGCGTACATTCTCCAAGGCCTATGGGCTTGCAGGCATCCGCTGCGGCTATGCGGTGGGAAATCCGGTG
GCGATAAAAACCTTCGACAAAGTCCGCGATCATTTCGCAGTCAGCCGCATGGCGCAGGCTGCCGCCATCGCAGCTTTGAA
AGATCAGGCTTATTTGCACGAGGTCGTGGGCAAGATTTGCGCCGGGCGTGATCGTATTGCGGCCATTGCCGAAGCCAATG
GCCTCCACGCTGTTGCATCAGCGACCAATTTTGTTGCAATCGATTGCGGCAGGGGGAAGGATTTTGCGCAGGCAGTACTC
AACGGATTGATTTCGCGTGATATTTTTGTGCGCAAGCCGGGCACGCCCGTGCTGGACCGCTGCATCCGTGTGAGTGTGGG
CGTGAAAGAACAGCTTGATCAATTTGAAGCGGCATTTCCCGAAGCACTTGAAGAAGCGCGCAAGATTTGCGCCGCCAACG
CAGAAAACACCTGA

Upstream 100 bases:

>100_bases
TGGGTTCGAAAAGCCTTTAATGCCGCCGAATAGCTGGCCGGGTTGGCCGGGCTTTCAATGCGCCTTTACTGTCAGACTGA
AACAGACCGGGATATCGCCC

Downstream 100 bases:

>100_bases
TCGTGGACAACAGCAAAATGCCTTCAATCAACGGCCAGCCACGCAGCGTCCTGTTCGGCACACTCGCCGGACTGTGCGGT
GCGTTGGGCATAGCATCCTA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAQPRLTPLVESLPSTVPFIGPETLELQRGKPFKARIGANESSFGPAPSVIEAMRNEATEVWKYGDPENYALRHAIAAHH
GLKAEHIMPGAGVDALLGLIVRQYVQQGDKVINSLGGYPTFNYHVAGYGGQLVTVPYRDDKPDLDALIDAAAREKPALLY
IANPDNPMGTWHEGADIQSFIERLPETTLLILDEAYCETAPASAFPPFETDRPNVLRMRTFSKAYGLAGIRCGYAVGNPV
AIKTFDKVRDHFAVSRMAQAAAIAALKDQAYLHEVVGKICAGRDRIAAIAEANGLHAVASATNFVAIDCGRGKDFAQAVL
NGLISRDIFVRKPGTPVLDRCIRVSVGVKEQLDQFEAAFPEALEEARKICAANAENT

Sequences:

>Translated_377_residues
MAQPRLTPLVESLPSTVPFIGPETLELQRGKPFKARIGANESSFGPAPSVIEAMRNEATEVWKYGDPENYALRHAIAAHH
GLKAEHIMPGAGVDALLGLIVRQYVQQGDKVINSLGGYPTFNYHVAGYGGQLVTVPYRDDKPDLDALIDAAAREKPALLY
IANPDNPMGTWHEGADIQSFIERLPETTLLILDEAYCETAPASAFPPFETDRPNVLRMRTFSKAYGLAGIRCGYAVGNPV
AIKTFDKVRDHFAVSRMAQAAAIAALKDQAYLHEVVGKICAGRDRIAAIAEANGLHAVASATNFVAIDCGRGKDFAQAVL
NGLISRDIFVRKPGTPVLDRCIRVSVGVKEQLDQFEAAFPEALEEARKICAANAENT
>Mature_376_residues
AQPRLTPLVESLPSTVPFIGPETLELQRGKPFKARIGANESSFGPAPSVIEAMRNEATEVWKYGDPENYALRHAIAAHHG
LKAEHIMPGAGVDALLGLIVRQYVQQGDKVINSLGGYPTFNYHVAGYGGQLVTVPYRDDKPDLDALIDAAAREKPALLYI
ANPDNPMGTWHEGADIQSFIERLPETTLLILDEAYCETAPASAFPPFETDRPNVLRMRTFSKAYGLAGIRCGYAVGNPVA
IKTFDKVRDHFAVSRMAQAAAIAALKDQAYLHEVVGKICAGRDRIAAIAEANGLHAVASATNFVAIDCGRGKDFAQAVLN
GLISRDIFVRKPGTPVLDRCIRVSVGVKEQLDQFEAAFPEALEEARKICAANAENT

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=332, Percent_Identity=27.4096385542169, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322075, Length=358, Percent_Identity=23.463687150838, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40807; Mature: 40676

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQPRLTPLVESLPSTVPFIGPETLELQRGKPFKARIGANESSFGPAPSVIEAMRNEATE
CCCCCCCHHHHHCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
VWKYGDPENYALRHAIAAHHGLKAEHIMPGAGVDALLGLIVRQYVQQGDKVINSLGGYPT
HHCCCCCCCHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FNYHVAGYGGQLVTVPYRDDKPDLDALIDAAAREKPALLYIANPDNPMGTWHEGADIQSF
EEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHH
IERLPETTLLILDEAYCETAPASAFPPFETDRPNVLRMRTFSKAYGLAGIRCGYAVGNPV
HHHCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCEEECCCCCCCE
AIKTFDKVRDHFAVSRMAQAAAIAALKDQAYLHEVVGKICAGRDRIAAIAEANGLHAVAS
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHC
ATNFVAIDCGRGKDFAQAVLNGLISRDIFVRKPGTPVLDRCIRVSVGVKEQLDQFEAAFP
CCCEEEEECCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHH
EALEEARKICAANAENT
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AQPRLTPLVESLPSTVPFIGPETLELQRGKPFKARIGANESSFGPAPSVIEAMRNEATE
CCCCCCHHHHHCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
VWKYGDPENYALRHAIAAHHGLKAEHIMPGAGVDALLGLIVRQYVQQGDKVINSLGGYPT
HHCCCCCCCHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FNYHVAGYGGQLVTVPYRDDKPDLDALIDAAAREKPALLYIANPDNPMGTWHEGADIQSF
EEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHH
IERLPETTLLILDEAYCETAPASAFPPFETDRPNVLRMRTFSKAYGLAGIRCGYAVGNPV
HHHCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCEEECCCCCCCE
AIKTFDKVRDHFAVSRMAQAAAIAALKDQAYLHEVVGKICAGRDRIAAIAEANGLHAVAS
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHC
ATNFVAIDCGRGKDFAQAVLNGLISRDIFVRKPGTPVLDRCIRVSVGVKEQLDQFEAAFP
CCCEEEEECCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHH
EALEEARKICAANAENT
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA